Editor's Choice
WHO recommendations on maternal and newborn care for a positive postnatal experience.
31 Mar, 2022 | 08:47h | UTCNews Release: WHO urges quality care for women and newborns in critical first weeks after childbirth – World Health Organization
Commentary: Postnatal care: WHO highlights urgency of physical and mental support – The BMJ
RCT: Early treatment with ivermectin does not improve outcomes in patients with Covid-19.
31 Mar, 2022 | 08:41h | UTCCommentary: Ivermectin does not prevent COVID-19 hospitalization, a new study says – NPR
Commentary on Twitter
Ivermectin: the largest randomized, double-blind trial yet conducted, with early treatment, indicates there is no difference compared with placebo. It doesn't work. Period. https://t.co/wiFygjRgkk
just published @NEJM pic.twitter.com/uZ0mMZnO0E— Eric Topol (@EricTopol) March 30, 2022
RCT: Early outpatient treatment with convalescent plasma reduces the risk of hospitalization in patients with Covid-19.
31 Mar, 2022 | 08:39h | UTCEarly Outpatient Treatment for Covid-19 with Convalescent Plasma – New England Journal of Medicine
Commentaries:
Early Use of High-Titer Plasma Reduced COVID Hospitalizations— Randomized trial that influenced indication shows benefits in a mostly unvaccinated population – MedPage Today (free registration required)
Commentary on Twitter
https://twitter.com/NEJM/status/1509278140433981444
USPSTF Draft Recommendation Statement: the current evidence is insufficient to recommend screening for obstructive sleep apnea in asymptomatic individuals.
31 Mar, 2022 | 08:42h | UTCCommentary: USPSTF: Evidence Lacking for OSA Screening in Asymptomatic Adults – HealthDay
RCT: Single-incision mini-slings for stress urinary incontinence in women.
31 Mar, 2022 | 08:35h | UTCSingle-Incision Mini-Slings for Stress Urinary Incontinence in Women – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Single-incision mini-slings effective for stress urinary incontinence in women – Healio (free registration required)
Commentary on Twitter
For stress urinary incontinence in women, mini-slings were noninferior to midurethral slings with respect to patient-reported success at 15 months. https://t.co/Ag5p2u2WZW pic.twitter.com/PcajqXTiLW
— NEJM (@NEJM) March 30, 2022
Risk of SARS-CoV-2 reinfections in children: a prospective national surveillance study in England.
31 Mar, 2022 | 08:29h | UTCInvited Commentary: Importance of understanding the reinfection risk of COVID-19 in children – The Lancet Child & Adolescent Health
Commentary on Twitter
Everything we know about #SARSCoV2 tells us that first infection reduces (but doesn’t eliminate) the risk & SEVERITY of further infections, even with new variants. Here is our paper showing this with delta reinfections in kids (work on omicron reinfections in progress)👇 https://t.co/3gDPBHRu18
— Shamez Ladhani (@ShamezLadhani) March 30, 2022
Meta-analysis of randomized trials: Clopidogrel is better than aspirin for the secondary prevention of cardiovascular events.
31 Mar, 2022 | 08:31h | UTCCommentary: Clopidogrel Superior to ‘Divine’ Aspirin Monotherapy in Secondary Prevention – TCTMD
Commentary on Twitter
Happy to share our paper in @ESC_Journals. In this meta-analysis of randomized trials, we found that as compared with aspirin, P2Y12i was associated with 11% and 19% reduction in MACE and MI respectively. https://t.co/Y3Gstzgfu6
— Devika Aggarwal (@devikagg) March 30, 2022
Case-control study: In children 5 to 11 years of age, the Pfizer vaccine showed an effectiveness of 68% against hospitalization caused by the Omicron variant.
31 Mar, 2022 | 08:37h | UTCCommentary: COVID vaccination of children age 5-11 cut omicron hospitalizations by 68% – Children’s Hospital Boston
Commentary on Twitter
BNT162b2 vaccination reduced the risk of omicron-associated hospitalization by two thirds among children 5 to 11 years of age. https://t.co/mQcchQqbtH pic.twitter.com/Qzy8qKg1wC
— NEJM (@NEJM) March 30, 2022
A Narrative Review on the approach to antimicrobial use in ventilated patients with multidrug resistant organisms in respiratory samples—to treat or not to treat?
31 Mar, 2022 | 08:27h | UTC
Commentary on Twitter
https://twitter.com/ABsteward/status/1508917245740818438
[Preprint] Retrospective cohort study: second booster vaccine and Covid-19 mortality in adults 60 to 100 years old.
30 Mar, 2022 | 10:44h | UTCSecond Booster Vaccine and Covid-19 Mortality in Adults 60 to 100 Years Old – Research Square
Commentaries:
Huge Study Finds Second COVID-19 Booster is ‘Life-saving’ for Over 60s – Health Policy Watch
Fourth COVID-19 vaccine dose substantially reduces mortality in the elderly – News Medical
Cohort Study: Short-term outcomes of corticosteroid monotherapy in multisystem inflammatory syndrome in children.
30 Mar, 2022 | 10:40h | UTC
Commentary on Twitter
In this study, corticosteroid monotherapy successfully treated a subset of patients with mild multisystem inflammatory syndrome in children. https://t.co/fuhHeBSaRp
— JAMA Pediatrics (@JAMAPediatrics) March 28, 2022
U.S. approves second Covid-19 booster for people 50 and older and immunocompromised individuals.
30 Mar, 2022 | 10:42h | UTCU.S. approves second Covid-19 booster for people 50 and older – STAT
FDA OKs second COVID booster shot for older Americans – CIDRAP
Complicated and uncomplicated S. aureus bacteremia: an international Delphi survey among infectious diseases experts on definitions and treatment.
30 Mar, 2022 | 10:34h | UTC
The RECOVERY Trial – two years on.
30 Mar, 2022 | 10:38h | UTCThe RECOVERY Trial – two years on – University of Oxford
Related:
[Preprint] RECOVERY trial shows Baricitinib reduces deaths in patients hospitalized with COVID-19.
RECOVERY Trial: No benefit from convalescent plasma in patients admitted to hospital with COVID-19.
RECOVERY trial: Azithromycin not beneficial for patients admitted to hospital with COVID-19
RECOVERY trial: Effect of hydroxychloroquine in hospitalized patients with Covid-19
Randomized trial: Lopinavir–ritonavir not beneficial for patients admitted to hospital with COVID-19
Commentary on Twitter
https://twitter.com/MartinLandray/status/1508492188560371717
The harms of postoperative antibiotic prophylaxis: a teachable moment.
30 Mar, 2022 | 10:36h | UTCThe Harms of Postoperative Antibiotic Prophylaxis: A Teachable Moment – JAMA Internal Medicine (free for a limited period)
M-A: Parenchymal lung abnormalities following hospitalization for COVID-19 and viral pneumonitis.
30 Mar, 2022 | 10:26h | UTC
AHA/ASA Scientific Statement: Endovascular treatment and thrombolysis for acute ischemic stroke in patients with premorbid disability or dementia.
30 Mar, 2022 | 10:33h | UTCNews Release: Stroke treatments safe and effective for people with existing disability or dementia – American Heart Association
Commentary on Twitter (thread – click for more)
1/ Endovascular Treatment and Thrombolysis for Acute Ischemic Stroke in Patients with Pre-morbid Disability or Dementia
Authors: @draravindganesh @pecouille @SMGreenbergNeur @Doctorjfred @mayank_G0 @NAsdaghi @GPerue
Published today in @StrokeAHA_ASA: https://t.co/9VdIvGDNoN pic.twitter.com/CgET4ygCHu
— AHA Science (@AHAScience) March 28, 2022
Study shows overtreatment of diabetes common in nursing home residents with type 2 diabetes.
30 Mar, 2022 | 10:27h | UTCCommentaries:
Overtreatment of T2DM Common Among VA Nursing Home Residents – HealthDay
Diabetes treatment deintensification uncommon in nursing home residents – medwire News
Global, regional, and national burden of diseases and injuries for adults 70 years and older: systematic analysis for the Global Burden of Disease 2019 Study.
30 Mar, 2022 | 10:24h | UTC
Commentary on Twitter
See our new paper prepared within @IHME_UW! #BMJ
Life expectancy ≥70 has continued to rise globally. #Disability burden remained constant, suggesting the need to enhance public health and intervention programmes to improve wellbeing among older adults.https://t.co/TegmWQ3048
— Maciej Banach (@maciejbanach) March 14, 2022
Cluster RCT: A household salt substitution intervention is a cost-effective intervention for preventing stroke and improving quality of life.
29 Mar, 2022 | 10:16h | UTCCommentary: ACC: Use of Salt Substitute to Prevent Stroke Is Cost-Saving – HealthDay
Related:
Former CDC director: Low sodium salt could save millions of lives – CNN
Is salt good for you after all? The evidence says no.
Systematic Review: Altered dietary salt intake for people with chronic kidney disease.
New WHO benchmarks help countries reduce salt intake and save lives.
RCT: Reduced-sodium added-potassium salt substitute reduces blood pressure in hypertensive patients
Potassium Enriched Salt Substitution Could Prevent a Large Number of Cardiovascular Deaths
Meta-Analysis: Effect of Reduction in Dietary Sodium on Blood Pressure Levels
Cohort Study: Coronary artery and cardiac disease are common in patients with type 2 myocardial infarction.
29 Mar, 2022 | 10:14h | UTC
Commentary on Twitter
#OriginalResearch: #DEMAND_MI 1st prospective study to undertake systematic cardiac imaging in patients with type 2 MI. Results show high prevalence of LV dysfunction & CAD @damini_dey @imagingmedsci @marcdweck @jdinaus @andabularga @RyanWereski @chapdoc1 https://t.co/dygODQ92vs pic.twitter.com/ny3Fsyx7wH
— Circulation (@CircAHA) March 28, 2022
Opinion: Global vaccination must be swifter.
29 Mar, 2022 | 10:12h | UTCGlobal vaccination must be swifter – Nature
Myocarditis and pericarditis after COVID-19 vaccination: clinical management guidance for healthcare professionals.
29 Mar, 2022 | 10:09h | UTCRelated:
Myocarditis following a third Pfizer vaccination dose in military recruits in Israel.
Myocarditis following COVID-19 BNT162b2 vaccination among adolescents in Hong Kong.
Myocarditis after BNT162b2 vaccination in Israeli adolescents.
[Preprint] Risk of myocarditis following sequential COVID-19 vaccinations by age and sex.
Heart-inflammation risk from Pfizer COVID vaccine is very low.
Meta-analysis of randomized trials: GLP1 receptor agonists increase the risk of gallbladder and biliary diseases (RR, 1.37; 95% CI, 1.23-1.52).
29 Mar, 2022 | 10:02h | UTCAssociation of Glucagon-Like Peptide-1 Receptor Agonist Use With Risk of Gallbladder and Biliary Diseases: A Systematic Review and Meta-analysis of Randomized Clinical Trials – JAMA Internal Medicine (free for a limited period)
Commentary: GLP-1 Receptor Agonists: How Safe Are They for the Gallbladder?— Link with gallbladder, biliary diseases could be due to weight loss associated with class of drug – MedPage Today (free registration required)
Cohort Study: Preconception paternal use of metformin linked to increased risk of congenital problems in offspring.
29 Mar, 2022 | 10:04h | UTCPreconception Antidiabetic Drugs in Men and Birth Defects in Offspring: A Nationwide Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: