Editor's Choice | Page 96 of 107 | Links Medicus Content Curation & Alerts in Medicine

#OriginalResearch: Analysis from the #ISCHEMIA trial showed that chronic #CAD patients with frequent baseline angina reported improvement in QoL when treated with invasive strategy vs conservative management @djc795 @greggwstone @sripalbangalor @DanMarkMD https://t.co/mC8ey8qUCx pic.twitter.com/jF5SiaKdV0

— Circulation (@CircAHA) March 10, 2022

Practical, evidence-based approaches to nutritional modifications to reduce atherosclerotic cardiovascular disease.

14 Mar, 2022 | 01:25h | UTC

Practical, Evidence-Based Approaches to Nutritional Modifications to Reduce Atherosclerotic Cardiovascular Disease: An American Society For Preventive Cardiology Clinical Practice Statement – American Journal of Preventive Cardiology

Cohort Study: Long-term cannabis use is associated with cognitive deficits and smaller hippocampal volume in midlife.

14 Mar, 2022 | 01:31h | UTC

Long-Term Cannabis Use and Cognitive Reserves and Hippocampal Volume in Midlife – The American Journal of Psychiatry (link to abstract – $ for full-text)

Commentary: Long-Term Cannabis Use Associated With Cognitive Deficits in Midlife – Psychiatric News Alert

RCT: Methenamine Hippurate (a non-antibiotic preventive treatment) is noninferior to prophylactic antibiotics for treating recurrent urinary tract infections in women.

11 Mar, 2022 | 10:21h | UTC

Alternative to prophylactic antibiotics for the treatment of recurrent urinary tract infections in women: multicentre, open label, randomised, non-inferiority trial – The BMJ

News Release: Antiseptic drug as good as antibiotics for preventing recurrent urinary tract infections – BMJ Newsroom

Editorial: Methenamine hippurate for recurrent urinary tract infections – The BMJ

Commentaries:

Trial supports antibiotic alternative for recurrent urinary infections – CIDRAP

Nonantibiotic Prophylaxis Noninferior for Recurrent UTI – HealthDay

Commentary on Twitter

The antiseptic drug methenamine hippurate is as good as antibiotics for preventing recurrent urinary tract infections in women, finds this trial

Includes a visual abstract displaying the findings #BMJInfographic https://t.co/LJNx2OEKhO @chrisharding123 pic.twitter.com/CjxWtjao6r

— The BMJ (@bmj_latest) March 10, 2022

Systematic Review: Inhaled corticosteroids for the treatment of COVID‐19.

11 Mar, 2022 | 10:18h | UTC

Inhaled corticosteroids for the treatment of COVID‐19 – Cochrane Library

[Preprint] M-A: Inhaled corticosteroids in COVID-19 outpatients.

PRINCIPLE RCT: Inhaled budesonide improves time to recovery from COVID-19 in people at high risk of complications in the community.

Position Paper: Recommendations for the use of topical inhalant budesonide in COVID-19.

RCT: Inhaled budesonide shortens recovery time in non-hospitalized patients with COVID-19

Phase 2 RCT: Inhaled budesonide shows promise for the treatment of early COVID-19

Commentary on Twitter (thread – click for more)

Are inhaled #corticosteroids an effective treatment for people with mild #COVID19?
New #systematicreview from @CochraneAirways looks at using this well established treatment for asthma & COPD as a #COVIDtreatment https://t.co/dxUtudHLiW 1/4 pic.twitter.com/4nUs56Xfsg

— The Cochrane Library (@CochraneLibrary) March 9, 2022

WHO Guidance: Use of SARS-CoV-2 antigen-detection rapid diagnostic tests for COVID-19 self-testing.

11 Mar, 2022 | 10:20h | UTC

Use of SARS-CoV-2 antigen-detection rapid diagnostic tests for COVID-19 self-testing – World Health Organization

Estimating excess mortality due to the COVID-19 pandemic: a systematic analysis of COVID-19-related mortality, 2020–21.

11 Mar, 2022 | 10:16h | UTC

Estimating excess mortality due to the COVID-19 pandemic: a systematic analysis of COVID-19-related mortality, 2020–21 – The Lancet

News Release: Global death toll of COVID-19 pandemic may be more than three times higher than official records, estimates of excess deaths indicate – The Lancet

Commentaries:

COVID’s true death toll: far higher than official records – Nature

Covid deaths probably three times higher than records say – BBC

Editorial: “Excess deaths” is the best metric for tracking the pandemic.

The pandemic’s true death toll: millions more than official counts.

We can be confident there have been far more than 5 million global Covid deaths – “Estimating ‘excess’ fatalities, a more robust analysis method, puts the pandemic’s grim toll between 10m and 19m people”.

Global Covid-19 deaths surpass five million.

Effects of the Covid-19 pandemic on life expectancy and premature mortality in 2020 – this time series analysis showed there were more than 28 million excess years of life lost in 2020 in 31 countries.

Under-reporting of deaths limits our understanding of true burden of covid-19.

Study shows COVID-19 has caused the biggest decrease in life expectancy since World War II.

Just how do deaths due to COVID-19 stack up?

Tracking excess mortality across countries during the COVID-19 pandemic with the World Mortality Dataset.

Exploring the gap between excess mortality and COVID-19 deaths in 67 countries.

Report: Three new estimates of India’s all-cause excess mortality during the COVID-19 Pandemic – pandemic death toll estimated to be between 3.4 million and 4.9 million excess deaths.

COVID-19 has caused 6.9 million deaths globally, more than double what official reports show

Commentary on Twitter

? @TheLancet
This week it was widely announced we surpassed 6 million global Covid deaths.
The real number is likely more than 18 million, as determined by excess mortality at the end of 2021.https://t.co/VGHm5MID9i pic.twitter.com/DyYk6fLmWX

— Eric Topol (@EricTopol) March 10, 2022

COVID pandemic 2nd anniversary: 3 things we got wrong, and 3 things to watch out for.

11 Mar, 2022 | 10:07h | UTC

COVID pandemic 2nd anniversary: 3 things we got wrong, and 3 things to watch out for – The Conversation

Misinformation: susceptibility, spread, and interventions to immunize the public.

11 Mar, 2022 | 10:03h | UTC

Misinformation: susceptibility, spread, and interventions to immunize the public – Nature Medicine

Another study suggests that a third vaccine dose is necessary to protect populations against the omicron variant.

11 Mar, 2022 | 10:14h | UTC

Clinical severity of, and effectiveness of mRNA vaccines against, covid-19 from omicron, delta, and alpha SARS-CoV-2 variants in the United States: prospective observational study – The BMJ

News Release: Third vaccine dose critical for protecting populations against omicron variant – BMJ Newsroom

Commentary on Twitter

mRNA vaccines are highly effective in preventing covid-19 associated hospital admissions related to the alpha, delta, and omicron variants. But three doses are needed to achieve a similar level of protection against omicron, finds a large US study: https://t.co/YMm176gmby

— The BMJ (@bmj_latest) March 10, 2022

Retrospective Cohort Study: Frequency and outcomes of MRI-detected axillary adenopathy following COVID-19 vaccination.

11 Mar, 2022 | 10:05h | UTC

Frequency and outcomes of MRI-detected axillary adenopathy following COVID-19 vaccination – European Radiology

Regional lymphadenopathy following COVID-19 vaccination: Literature review and considerations for patient management in breast cancer care.

2 Case Series and Guidance | Lymphadenopathy in COVID-19 Vaccine Recipients

Axillary lymphadenopathy at the time of COVID-19 vaccination: ten recommendations from the European Society of Breast Imaging.

Covid-19: Schedule breast screening before vaccine or 4 to 6 weeks after to avoid false positives, says guidance

RCT: Effect of offering care management or online dialectical behavior therapy skills training vs. usual care on self-harm among adult outpatients with suicidal ideation (important negative study).

11 Mar, 2022 | 10:01h | UTC

Effect of Offering Care Management or Online Dialectical Behavior Therapy Skills Training vs Usual Care on Self-harm Among Adult Outpatients With Suicidal Ideation: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Commentary: Low-Intensity Care Options Flop for Self-Harm Prevention— In randomized trial, two therapeutic interventions failed to help people with suicidal thoughts – MedPage Today (free registration required)

Optimizing hospital electronic prescribing systems: a systematic scoping review.

11 Mar, 2022 | 10:02h | UTC

Optimizing Hospital Electronic Prescribing Systems: A Systematic Scoping Review – Journal of Patient Safety

RCT: In patients with refractory out-of-hospital cardiac arrest, a strategy of intra-arrest transport, extracorporeal cardiopulmonary resuscitation, and immediate invasive assessment did not significantly improve survival with a favorable neurological outcome (OR 1.63; 95% CI 0.93 to 2.85; P = .09).

10 Mar, 2022 | 10:57h | UTC

Effect of Intra-arrest Transport, Extracorporeal Cardiopulmonary Resuscitation, and Immediate Invasive Assessment and Treatment on Functional Neurologic Outcome in Refractory Out-of-Hospital Cardiac Arrest: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Commentary: Early Invasive Therapy for Out-of-Hospital Cardiac Arrest – American College of Cardiology

Commentary on Twitter

In this randomized clinical trial, early intra-arrest transport, extracorporeal CPR, and invasive assessment and treatment did not significantly improve survival with neurologically favorable outcome at 180 days compared with standard resuscitation. https://t.co/qSqWSFFpOF pic.twitter.com/SLu0bGHhq8

— JAMA (@JAMA_current) February 22, 2022

RCT: In patients with low-risk thyroid cancer, thyroidectomy without ablation radioiodine was noninferior to thyroidectomy with ablation radioiodine at 3 years.

10 Mar, 2022 | 10:59h | UTC

Thyroidectomy without Radioiodine in Patients with Low-Risk Thyroid Cancer – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: New research casts doubt on a cornerstone of thyroid cancer treatment – STAT

Commentary on Twitter

In RCT involving patients with low-risk differentiated thyroid cancer undergoing thyroidectomy, a follow-up strategy that did not involve the use of radioiodine was noninferior to the use of radioiodine in the response to treatment at 3 years. https://t.co/RaJL3tdE4T pic.twitter.com/8nIPw50nkg

— NEJM (@NEJM) March 9, 2022

RCT: In children with nonsevere, drug-susceptible tuberculosis, treatment for 4 months is noninferior to treatment for 6 months.

10 Mar, 2022 | 11:03h | UTC

Shorter Treatment for Nonsevere Tuberculosis in African and Indian Children – New England Journal of Medicine

News Release: Treatment length reduced for children with tuberculosis – University College London

Commentary on Twitter

Completing 6 months of treatment for tuberculosis in children is a challenge. In this open-label trial involving 1204 children in sub-Saharan Africa and India, 4 months of antituberculosis therapy was noninferior to 6 months of therapy. https://t.co/zkD4URWMru pic.twitter.com/LFR6ZzTKgs

— NEJM (@NEJM) March 9, 2022

Meta-analysis of randomized trials: benefits and harms of direct oral anticoagulation and low molecular weight heparin for thromboprophylaxis in patients undergoing non-cardiac surgery.

10 Mar, 2022 | 10:48h | UTC

Benefits and harms of direct oral anticoagulation and low molecular weight heparin for thromboprophylaxis in patients undergoing non-cardiac surgery: systematic review and network meta-analysis of randomised trials – The BMJ

Commentary on Twitter

Led by Maura Marcucci, network meta-analysis of of 68 surgery #RCT's (45,445 patients; mainly #ortho) found that #DOAC's & #LMWH reduce #VTE but probably increase major bleeding to a similar extent. DOACs probably prevent symptomatic VTE more than #LMWH. https://t.co/7vrgVpfD3s pic.twitter.com/H5Fuq7p1hi

— Kari Tikkinen (@KariTikkinen) March 9, 2022

M-A: Comparative efficacy and tolerability of 32 oral and long-acting injectable antipsychotics for the maintenance treatment of adults with schizophrenia.

10 Mar, 2022 | 10:54h | UTC

Comparative efficacy and tolerability of 32 oral and long-acting injectable antipsychotics for the maintenance treatment of adults with schizophrenia: a systematic review and network meta-analysis – The Lancet (link to abstract – $ for full-text)

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