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M-A: Evaluating the association between LDL Cholesterol reduction and relative and absolute effects of statin treatment.

15 Mar, 2022 | 10:04h | UTC

Evaluating the Association Between Low-Density Lipoprotein Cholesterol Reduction and Relative and Absolute Effects of Statin Treatment: A Systematic Review and Meta-analysis – JAMA Internal Medicine (free for a limited period)

Commentary from the author: Benefits of statins may have been overstated – new study – The Conversation

 

Commentary on Twitter

 

Review | Resistance exercise as a treatment for sarcopenia: prescription and delivery.

15 Mar, 2022 | 09:55h | UTC

Resistance exercise as a treatment for sarcopenia: prescription and delivery – Age and Ageing

 

Extracorporeal membrane oxygenation (ECMO) in COVID-19 patients: a pocket guide for radiologists.

15 Mar, 2022 | 09:51h | UTC

Extracorporeal membrane oxygenation (ECMO) in COVID-19 patients: a pocket guide for radiologists – La Radiologia Medica

 

Caring for older adults during the COVID-19 pandemic.

15 Mar, 2022 | 09:48h | UTC

Caring for older adults during the COVID-19 pandemic – Clinical Microbiology and Infection

 

Retrospective Cohort: Asthma in children and adolescents is not associated with increased risk of SARS-CoV-2 infection.

15 Mar, 2022 | 08:55h | UTC

Asthma and the Risk of SARS-CoV-2 Infection Among Children and Adolescents – Pediatrics

Commentary: Kids with asthma not at higher risk of COVID-19, study finds – CIDRAP

Related:

We expected people with asthma to fare worse during COVID. Turns out they’ve had a break.

M-A: Asthma does not increase the risk of infection, hospitalization, ICU admission, and mortality from COVID-19

Systematic review: No evidence that patients with asthma are at increased risk of COVID-19 diagnosis, hospitalization or death

Asthma in COVID-19 hospitalizations: An overestimated risk factor?

 

Global, regional, and national prevalence of, and risk factors for, chronic obstructive pulmonary disease.

15 Mar, 2022 | 08:49h | UTC

Global, regional, and national prevalence of, and risk factors for, chronic obstructive pulmonary disease (COPD) in 2019: a systematic review and modelling analysis – The Lancet Respiratory Medicine

 

Commentary on Twitter

 

Two years later, coronavirus evolution still surprises experts. Here’s why.

15 Mar, 2022 | 08:52h | UTC

Two years later, coronavirus evolution still surprises experts. Here’s why. – National Geographic

 

‘We suppressed our scientific imagination’: four experts examine the big successes and failures of the COVID response so far.

15 Mar, 2022 | 08:47h | UTC

‘We suppressed our scientific imagination’: four experts examine the big successes and failures of the COVID response so far – The Conversation

 

Effectiveness of contact tracing in the control of infectious diseases: a systematic review.

14 Mar, 2022 | 01:45h | UTC

Effectiveness of contact tracing in the control of infectious diseases: a systematic review – The Lancet Public Health

 

Meta-analysis of randomized controlled trials comparing intraoperative red blood cell transfusion strategies.

14 Mar, 2022 | 01:47h | UTC

A Systematic Review and Meta-analysis of Randomized Controlled Trials Comparing Intraoperative Red Blood Cell Transfusion Strategies – Annals of Surgery

Related:

Systematic Review: Restrictive transfusion thresholds can safely decrease transfusions by 41% across a broad range of clinical contexts.

RCT: Among patients with acute MI and anemia, a restrictive transfusion strategy resulted in a noninferior rate of major cardiovascular events compared to a liberal transfusion strategy

Randomized trial: Liberal vs. restrictive transfusion thresholds in extremely low-birth-weight infants

Meta-Analysis: Effects of Restrictive vs. Liberal Transfusion Strategies on Longer-term Outcomes After Cardiac Surgery

Randomized Trial: In Patients Undergoing Cardiac Surgery, A Restrictive Transfusion Approach Does Not Increase the Risk of Acute Kidney Injury

Effects of restrictive red blood cell transfusion on the prognoses of adult patients undergoing cardiac surgery: a meta-analysis of randomized controlled trials – Critical Care

Research: Restrictive or Liberal Red-Cell Transfusion for Cardiac Surgery

Transfusion Requirements After Cardiac Surgery: The TRACS Randomized Controlled Trial – JAMA

 

The changing epidemiology of SARS-CoV-2.

14 Mar, 2022 | 01:37h | UTC

The changing epidemiology of SARS-CoV-2 – Science

 

Duration of effectiveness of vaccines against SARS-CoV-2 infection and COVID-19 disease: results of a systematic review and meta-regression.

14 Mar, 2022 | 01:44h | UTC

Duration of effectiveness of vaccines against SARS-CoV-2 infection and COVID-19 disease: results of a systematic review and meta-regression – The Lancet

Commentaries:

Review of pre-Omicron data finds COVID-19 vaccine protection from severe disease remains strong at six months – Johns Hopkins University Bloomberg School of Public Health

Waning of COVID-19 vaccine effectiveness: individual and public health risk – The Lancet

Related: [Preprint] Systematic Review: Duration of Effectiveness of Vaccines Against SARS-CoV-2 Infection and COVID-19 Disease – “effectiveness against COVID-19 severe disease remained high (>70%) in most studies in the six months after full vaccination, although it did decrease some (on average, 8-10 percentage points) between one and six months after full vaccination”.

 

Stopping pandemics before they start: Lessons learned from SARS-CoV-2.

14 Mar, 2022 | 01:38h | UTC

Stopping pandemics before they start: Lessons learned from SARS-CoV-2 – Science

 

Writing up your clinical trial report for a scientific journal: the REPORT trial guide for effective and transparent research reporting without spin.

14 Mar, 2022 | 01:32h | UTC

Writing up your clinical trial report for a scientific journal: the REPORT trial guide for effective and transparent research reporting without spin – British Journal of Sports Medicine

 

Review: Post-acute COVID-19 syndrome.

14 Mar, 2022 | 01:34h | UTC

Post-acute COVID-19 syndrome – European Respiratory Journal

Related:

ESCMID rapid guidelines for assessment and management of long COVID.

ERS statement on Long COVID-19 follow-up.

Proposed subtypes of long-Covid and their respective potential therapies.

EuGMS Guidance: Management of post-acute COVID-19 patients in geriatric rehabilitation.

Addressing Post-COVID Symptoms: A Guide for Primary Care Physicians.

Global surveillance, research, and collaboration needed to improve understanding and management of long COVID.

Provocative study suggests that persistent physical symptoms after COVID-19 infection may be associated more with the belief in having been infected with SARS-CoV-2 than with having laboratory-confirmed COVID-19 infection.

Update to post-acute sequelae of SARS-CoV-2 infection: Caring for the ‘long-haulers’.

Systematic Review: Short-term and long-term rates of postacute sequelae of SARS-CoV-2 infection.

WHO Consensus: A clinical case definition of post COVID-19 condition (Long Covid).

Characterizing long COVID: a living systematic review.

Long Covid – The illness narratives.

New guidelines to help doctors manage long COVID patients published.

M-A: More than 50 long-term effects of COVID-19. (several articles on the subject)

 

Comprehensive quality of life outcomes with invasive vs. conservative management of chronic coronary disease in the ISCHEMIA trial.

14 Mar, 2022 | 01:27h | UTC

Comprehensive Quality of Life Outcomes with Invasive versus Conservative Management of Chronic Coronary Disease in ISCHEMIA – Circulation (link to abstract – $ for full-text)

Original Articles:

ISCHEMIA Trial: Health-Status Outcomes with Initial Invasive vs. Conservative Care in Stable Coronary Disease

ISCHEMIA Trial: Initial Invasive vs. Conservative Strategy for Stable Coronary Disease

ISCHEMIA Trial: Health Status after Invasive or Conservative Care in Coronary and Advanced Kidney Disease

ISCHEMIA Trial: Management of Coronary Disease in Patients with Advanced Kidney Disease

 

Commentary on Twitter

 

Practical, evidence-based approaches to nutritional modifications to reduce atherosclerotic cardiovascular disease.

14 Mar, 2022 | 01:25h | UTC

Practical, Evidence-Based Approaches to Nutritional Modifications to Reduce Atherosclerotic Cardiovascular Disease: An American Society For Preventive Cardiology Clinical Practice Statement – American Journal of Preventive Cardiology

 

Cohort Study: Long-term cannabis use is associated with cognitive deficits and smaller hippocampal volume in midlife.

14 Mar, 2022 | 01:31h | UTC

Long-Term Cannabis Use and Cognitive Reserves and Hippocampal Volume in Midlife – The American Journal of Psychiatry (link to abstract – $ for full-text)

Commentary: Long-Term Cannabis Use Associated With Cognitive Deficits in Midlife – Psychiatric News Alert

 

RCT: Methenamine Hippurate (a non-antibiotic preventive treatment) is noninferior to prophylactic antibiotics for treating recurrent urinary tract infections in women.

11 Mar, 2022 | 10:21h | UTC

Alternative to prophylactic antibiotics for the treatment of recurrent urinary tract infections in women: multicentre, open label, randomised, non-inferiority trial – The BMJ

News Release: Antiseptic drug as good as antibiotics for preventing recurrent urinary tract infections – BMJ Newsroom

Editorial: Methenamine hippurate for recurrent urinary tract infections – The BMJ

Commentaries:

Trial supports antibiotic alternative for recurrent urinary infections – CIDRAP

Nonantibiotic Prophylaxis Noninferior for Recurrent UTI – HealthDay

 

Commentary on Twitter

 

Systematic Review: Inhaled corticosteroids for the treatment of COVID‐19.

11 Mar, 2022 | 10:18h | UTC

Inhaled corticosteroids for the treatment of COVID‐19 – Cochrane Library

Related:

[Preprint] M-A: Inhaled corticosteroids in COVID-19 outpatients.

PRINCIPLE RCT: Inhaled budesonide improves time to recovery from COVID-19 in people at high risk of complications in the community.

Position Paper: Recommendations for the use of topical inhalant budesonide in COVID-19.

RCT: Inhaled budesonide shortens recovery time in non-hospitalized patients with COVID-19

Phase 2 RCT: Inhaled budesonide shows promise for the treatment of early COVID-19

 

Commentary on Twitter (thread – click for more)

 

WHO Guidance: Use of SARS-CoV-2 antigen-detection rapid diagnostic tests for COVID-19 self-testing.

11 Mar, 2022 | 10:20h | UTC

Use of SARS-CoV-2 antigen-detection rapid diagnostic tests for COVID-19 self-testing – World Health Organization

 

Estimating excess mortality due to the COVID-19 pandemic: a systematic analysis of COVID-19-related mortality, 2020–21.

11 Mar, 2022 | 10:16h | UTC

Estimating excess mortality due to the COVID-19 pandemic: a systematic analysis of COVID-19-related mortality, 2020–21 – The Lancet

News Release: Global death toll of COVID-19 pandemic may be more than three times higher than official records, estimates of excess deaths indicate – The Lancet

Commentaries:

COVID’s true death toll: far higher than official records – Nature

Covid deaths probably three times higher than records say – BBC

Related:

Editorial: “Excess deaths” is the best metric for tracking the pandemic.

The pandemic’s true death toll: millions more than official counts.

We can be confident there have been far more than 5 million global Covid deaths – “Estimating ‘excess’ fatalities, a more robust analysis method, puts the pandemic’s grim toll between 10m and 19m people”.

Global Covid-19 deaths surpass five million.

Effects of the Covid-19 pandemic on life expectancy and premature mortality in 2020 – this time series analysis showed there were more than 28 million excess years of life lost in 2020 in 31 countries.

Under-reporting of deaths limits our understanding of true burden of covid-19.

Study shows COVID-19 has caused the biggest decrease in life expectancy since World War II.

Just how do deaths due to COVID-19 stack up?

Tracking excess mortality across countries during the COVID-19 pandemic with the World Mortality Dataset.

Exploring the gap between excess mortality and COVID-19 deaths in 67 countries.

Report: Three new estimates of India’s all-cause excess mortality during the COVID-19 Pandemic – pandemic death toll estimated to be between 3.4 million and 4.9 million excess deaths.

COVID-19 has caused 6.9 million deaths globally, more than double what official reports show

 

Commentary on Twitter

 

COVID pandemic 2nd anniversary: 3 things we got wrong, and 3 things to watch out for.

11 Mar, 2022 | 10:07h | UTC

COVID pandemic 2nd anniversary: 3 things we got wrong, and 3 things to watch out for – The Conversation

 

Misinformation: susceptibility, spread, and interventions to immunize the public.

11 Mar, 2022 | 10:03h | UTC

Misinformation: susceptibility, spread, and interventions to immunize the public – Nature Medicine

See also: An epidemic of uncertainty: rumors, conspiracy theories and vaccine hesitancy – Nature Medicine

 

Another study suggests that a third vaccine dose is necessary to protect populations against the omicron variant.

11 Mar, 2022 | 10:14h | UTC

Clinical severity of, and effectiveness of mRNA vaccines against, covid-19 from omicron, delta, and alpha SARS-CoV-2 variants in the United States: prospective observational study – The BMJ

News Release: Third vaccine dose critical for protecting populations against omicron variant – BMJ Newsroom

 

Commentary on Twitter

 

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