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Future of clinical trial methodology.

21 Mar, 2022 | 09:59h | UTC

Future of Clinical Trial Methodology – Anesthesia & Analgesia

Commentary: Looking to the Future of Clinical Research Methodology – Anesthesia & Analgesia

 

Guideline: Management of chronic low back, osteoarthritic, and neuropathic pain in primary care.

21 Mar, 2022 | 10:02h | UTC

PEER simplified chronic pain guideline: Management of chronic low back, osteoarthritic, and neuropathic pain in primary care – Canadian Family Physician

 

Infographic: IDSA COVID-19 outpatient treatment guidelines roadmap.

21 Mar, 2022 | 09:51h | UTC

COVID-19 Outpatient Treatment Guidelines Roadmap – Infectious Diseases Society of America

 

Commentary on Twitter

 

CDC Report: Effectiveness of mRNA vaccination in preventing COVID-19–associated invasive mechanical ventilation and death in the US.

21 Mar, 2022 | 09:38h | UTC

Effectiveness of mRNA Vaccination in Preventing COVID-19–Associated Invasive Mechanical Ventilation and Death — United States, March 2021–January 2022 – CDC Morbidity and Mortality Weekly Report

Related Study: COVID-19–Associated Hospitalizations Among Adults During SARS-CoV-2 Delta and Omicron Variant Predominance, by Race/Ethnicity and Vaccination Status — COVID-NET, 14 States, July 2021–January 2022 – CDC Morbidity and Mortality Weekly Report

Commentary: Studies show vaccines protect against serious Omicron illness – CIDRAP

 

Commentary on Twitter

 

Effectiveness of the Johnson & Johnson vaccine in health-care workers in South Africa in a period when the beta and then the delta SARS-CoV-2 variants of concerns were dominant.

21 Mar, 2022 | 09:43h | UTC

Effectiveness of the Ad26.COV2.S vaccine in health-care workers in South Africa (the Sisonke study): results from a single-arm, open-label, phase 3B, implementation study – The Lancet

Invited Commentary: Sisonke: reaching several goals together – The Lancet

 

Commentary on Twitter (thread – click for more)

 

RCT: Efficacy and acceptability of dietary therapies in non-constipated irritable bowel syndrome: a randomized trial of traditional dietary advice, the low FODMAP diet and the gluten-free diet.

21 Mar, 2022 | 08:53h | UTC

Efficacy and Acceptability of Dietary Therapies in Non-Constipated Irritable Bowel Syndrome: A Randomized Trial of Traditional Dietary Advice, the Low FODMAP Diet and the Gluten-Free Diet – Clinical Gastroenterology and Hepatology

Commentary: Traditional Dietary Advice Optimal as an Irritable Bowel Syndrome Therapy – HCPLivre

Related:

10 mistakes in dietary management of irritable bowel syndrome and how to avoid them.

Supplement: Irritable bowel syndrome and related conditions.

RCT: FODMAPs, but not gluten, elicit modest symptoms of irritable bowel syndrome.

RCT: Among patients with diarrhea-predominant irritable bowel syndrome, a low FODMAP diet achieved earlier symptomatic improvements in stool frequency and excessive wind.

British Society of Gastroenterology guidelines on the management of irritable bowel syndrome

Guidelines for the treatment of irritable bowel syndrome

ACG Clinical Guideline: Management of irritable bowel syndrome

M-A: Efficacy of a low-FODMAP diet in adult irritable bowel syndrome

 

Myocarditis following a third Pfizer vaccination dose in military recruits in Israel.

21 Mar, 2022 | 09:37h | UTC

Myocarditis Following a Third BNT162b2 Vaccination Dose in Military Recruits in Israel – JAMA

Related:

Myocarditis following COVID-19 BNT162b2 vaccination among adolescents in Hong Kong.

[Preprint] Post-marketing active surveillance of myocarditis and pericarditis following vaccination with COVID-19 mRNA vaccines in persons aged 12-39 years in Italy.

Myocarditis after BNT162b2 vaccination in Israeli adolescents.

Myocarditis cases reported after mRNA-Based COVID-19 vaccination in the US from December 2020 to August 2021.

A case-control study showed an increased risk of myocarditis after COVID-19 vaccination with a messenger RNA vaccine compared to an inactivated virus vaccine.

[Preprint] Risk of myocarditis following sequential COVID-19 vaccinations by age and sex.

Risks of myocarditis, pericarditis, and cardiac arrhythmias associated with COVID-19 vaccination vs. SARS-CoV-2 infection.

Case series with 139 adolescents and young adults with suspected myocarditis following mRNA vaccination showed most cases had a mild clinical course and rapid resolution of symptoms.

Heart-inflammation risk from Pfizer COVID vaccine is very low.

Large cohort study with over 2.5 million individuals showed the incidence of myocarditis after the Pfizer vaccine was 2.13 cases per 100,000 persons.

Study with over 5.1 million vaccinated individuals showed the incidence of myocarditis after the receipt of the Pfizer vaccine was low and more common after the second dose in young male recipients.

Large Observational study shows Pfizer Covid vaccine is mostly safe but is associated with increased risk of myocarditis, adenopathy, appendicitis, and herpes zoster.

 

Review: Challenging management dogma where evidence is non-existent, weak or outdated.

21 Mar, 2022 | 08:55h | UTC

Challenging management dogma where evidence is non-existent, weak or outdated – Intensive Care Medicine (if the link is paywalled, try this one)

 

More data suggests reduced risks of hospitalization and death due to SARS-CoV-2 Omicron compared to the Delta variant.

18 Mar, 2022 | 09:36h | UTC

Comparative analysis of the risks of hospitalisation and death associated with SARS-CoV-2 omicron (B.1.1.529) and delta (B.1.617.2) variants in England: a cohort study – The Lancet

Invited Commentary: Omicron: fewer adverse outcomes come with new dangers – The Lancet

 

Commentary on Twitter

 

Guideline: Management of anticoagulants and antiplatelets during acute gastrointestinal bleeding and the periendoscopic period.

18 Mar, 2022 | 09:39h | UTC

American College of Gastroenterology-Canadian Association of Gastroenterology Clinical Practice Guideline: Management of Anticoagulants and Antiplatelets During Acute Gastrointestinal Bleeding and the Periendoscopic Period – Journal of the Canadian Association of Gastroenterology

 

Commentary on Twitter

 

M-A: Awake prone positioning for non-intubated patients with COVID-19-related acute hypoxemic respiratory failure.

18 Mar, 2022 | 09:32h | UTC

Awake prone positioning for non-intubated patients with COVID-19-related acute hypoxaemic respiratory failure: a systematic review and meta-analysis – The Lancet Respiratory Medicine

Invited Commentary: The pandemic and the great awakening in the management of acute hypoxaemic respiratory failure – The Lancet Respiratory Medicine

Related:

[Preprint] RCT: In hypoxic but not critically ill patients with COVID-19, an intervention to increase prone positioning did not improve outcomes.

RCT: Awake prone positioning reduces the need for intubation in patients with COVID-19.

RCT: Awake prone positioning in patients with hypoxemic respiratory failure due to COVID-19 – no difference in intubation rates compared to standard care.

M-A: Prone positioning of nonintubated patients with Covid-19 improve oxygenation variables without any reported serious adverse events – randomized trials with patient-relevant outcomes such as the need for intubation or mortality rates are required

 

Study on traumatic brain injury highlights global inequality in causes and treatment.

18 Mar, 2022 | 09:37h | UTC

News Release: Largest ever study on traumatic brain injury highlights global inequality in causes and treatment – University of Cambridge

Original Study: Casemix, management, and mortality of patients receiving emergency neurosurgery for traumatic brain injury in the Global Neurotrauma Outcomes Study: a prospective observational cohort stud – The Lancet Neurology

 

Study finds no increased risk of rare neurological events after covid vaccination.

18 Mar, 2022 | 09:31h | UTC

News Release: Study finds no increased risk of rare neurological events after covid vaccination – BMJ Newsroom

Original Study: Association between covid-19 vaccination, SARS-CoV-2 infection, and risk of immune mediated neurological events: population based cohort and self-controlled case series analysis – The BMJ

Editorial: The neurological safety of covid-19 vaccines

 

RCT: Cocoa flavanol supplementation shows promise for the prevention of cardiovascular disease events.

18 Mar, 2022 | 08:54h | UTC

Effect of cocoa flavanol supplementation for prevention of cardiovascular disease events: The COSMOS randomized clinical trial – American Journal of Clinical Nutrition

Commentary: New trial finds signs of preventive cardiovascular effects for cocoa flavanols – Brigham and Women’s Hospital

 

Commentary on Twitter (thread – click for more)

 

Maintaining oral hydration in older adults in surgical wards: a best practice implementation project.

18 Mar, 2022 | 08:50h | UTC

Maintaining oral hydration in older adults in surgical wards: a best practice implementation project – JBI Evidence Implementation (free for a limited period)

 

Commentary on Twitter

 

Using absolute risk reduction to guide the equitable distribution of COVID-19 vaccines.

18 Mar, 2022 | 09:28h | UTC

Using absolute risk reduction to guide the equitable distribution of COVID-19 vaccines – BMJ Evidence-Based Medicine

News Release: Researchers find equitable COVID-19 vaccine distribution can target risks in different geographical areas – University of New Mexico

 

Commentary on Twitter

 

Study shows low risk of complications after ipsilateral intravenous catheter placement in breast cancer surgery patients.

18 Mar, 2022 | 08:48h | UTC

Ipsilateral Intravenous Catheter Placement in Breast Cancer Surgery Patients – Anesthesia & Analgesia (link to abstract – $ for full-text)

 

Commentary on Twitter

 

Assessing the magnitude of reporting bias in trials of homeopathy: a cross-sectional study and meta-analysis.

18 Mar, 2022 | 08:46h | UTC

Assessing the magnitude of reporting bias in trials of homeopathy: a cross-sectional study and meta-analysis – BMJ Evidence-Based Medicine

News Release: Poor research practice suggests true impact of homeopathy may be “substantially” overestimated – BMJ Newsroom

 

Commentary on Twitter

 

State of the Art Review: Recent advances in the diagnosis and management of cluster headache.

17 Mar, 2022 | 09:21h | UTC

Recent advances in the diagnosis and management of cluster headache – The BMJ

 

2022 ACC expert consensus decision pathway on cardiovascular sequelae of COVID-19 in adults: myocarditis and other myocardial involvement, post-acute sequelae of SARS-CoV-2 infection, and return to play.

17 Mar, 2022 | 09:26h | UTC

2022 ACC Expert Consensus Decision Pathway on Cardiovascular Sequelae of COVID-19 in Adults: Myocarditis and Other Myocardial Involvement, Post-Acute Sequelae of SARS-CoV-2 Infection, and Return to Play: A Report of the American College of Cardiology Solution Set Oversight Committee – Journal of the American College of Cardiology

Commentaries:

ACC Issues Clinical Guidance on CV Consequences of COVID-19 – American College of Cardiology

ACC Releases Guidance on CV Issues With COVID-19 – TCTMD

Key Points: 2022 ACC Decision Pathway on Cardiovascular Sequelae of COVID-19

Related:

Review | Long COVID: post-acute sequelae of COVID-19 with a cardiovascular focus.

The pathogenesis and long-term consequences of Covid-19 cardiac injury: state-of-the-art review.

COVID-19 infections increase risk of heart conditions up to a year later, study finds.

 

Commentary on Twitter (thread – click for more)

 

Among health care workers, a fourth dose vaccine effectiveness against any SARS-CoV-2 Omicron variant infection was 30% for the Pfizer–BioNTech and 11% for the Moderna.

17 Mar, 2022 | 09:12h | UTC

Efficacy of a Fourth Dose of Covid-19 mRNA Vaccine against Omicron – New England Journal of Medicine

Related: [Preprint] Fourth dose of COVID vaccine offers only slight boost against Omicron infection.

 

Treatments for moderate to severe COVID-19: Cochrane evidence.

17 Mar, 2022 | 09:19h | UTC

Treatments for moderate to severe COVID-19: Cochrane evidence – Evidently Cochrane

 

Effectiveness of the Sputnik V, AstraZeneca, and Sinopharm vaccines for the risk of infection and death due to COVID-19 in people older than 60 years in Argentina.

17 Mar, 2022 | 09:10h | UTC

Effectiveness of rAd26-rAd5, ChAdOx1 nCoV-19, and BBIBP-CorV vaccines for risk of infection with SARS-CoV-2 and death due to COVID-19 in people older than 60 years in Argentina: a test-negative, case-control, and retrospective longitudinal study – The Lancet

Commentary: Evaluating COVID-19 vaccines in the real world – The Lancet

 

Treatments for mild COVID-19: Cochrane evidence.

17 Mar, 2022 | 09:17h | UTC

Treatments for mild COVID-19: Cochrane evidence – Cochrane Library

 

[News release – not published yet] Empagliflozin phase III EMPA-KIDNEY trial will stop early due to evidence of efficacy in people with chronic kidney disease.

17 Mar, 2022 | 09:07h | UTC

Jardiance® phase III EMPA-KIDNEY trial will stop early due to clear positive efficacy in people with chronic kidney disease – Lilly

See also: Design, recruitment, and baseline characteristics of the EMPA-KIDNEY trial – Nephrology Dialysis Transplantation

 

Commentary on Twitter

 

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