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Critical Care

A Narrative Review on the approach to antimicrobial use in ventilated patients with multidrug resistant organisms in respiratory samples—to treat or not to treat?

31 Mar, 2022 | 08:27h | UTC

A Narrative Review on the Approach to Antimicrobial Use in Ventilated Patients with Multidrug Resistant Organisms in Respiratory Samples—To Treat or Not to Treat? That Is the Question – Antibiotics

 

Commentary on Twitter

https://twitter.com/ABsteward/status/1508917245740818438

 

Review | Advanced heart failure: guideline-directed medical therapy, diuretics, inotropes, and palliative care.

31 Mar, 2022 | 08:09h | UTC

Advanced heart failure: guideline-directed medical therapy, diuretics, inotropes, and palliative care – ESC Heart Failure

 

Complicated and uncomplicated S. aureus bacteremia: an international Delphi survey among infectious diseases experts on definitions and treatment.

30 Mar, 2022 | 10:34h | UTC

Complicated and uncomplicated S. aureus bacteremia: an international Delphi survey among infectious diseases experts on definitions and treatment – Clinical Microbiology and Infection

 

The RECOVERY Trial – two years on.

30 Mar, 2022 | 10:38h | UTC

The RECOVERY Trial – two years on – University of Oxford

Related:

How the UK found the first effective Covid-19 treatment — and saved a million lives (about the RECOVERY trial and the effects of Dexamethasone)

Covid: The London bus trip that saved maybe a million lives (about the creation of the RECOVERY Trial)

Low-cost dexamethasone reduces death by up to one third in hospitalised patients with severe respiratory complications of COVID-19 – Recovery Trial

[Preprint] RECOVERY trial shows Baricitinib reduces deaths in patients hospitalized with COVID-19.

RCT: CPAP improved outcomes in patients with acute hypoxemic respiratory failure due to COVID-19, but high-flow nasal oxygen was not better than conventional oxygen therapy.

RECOVERY Trial: In patients admitted to hospital with COVID-19, Colchicine did not reduce 28-day mortality, duration of hospital stay, or risk of progressing to invasive mechanical ventilation or death.

RECOVERY Trial: No benefit from convalescent plasma in patients admitted to hospital with COVID-19.

RECOVERY Trial: Aspirin as an add-on therapy did not reduce mortality in patients hospitalized with COVID-19.

RECOVERY trial: In hospitalized COVID-19 patients with hypoxia and systemic inflammation (C-reactive protein ≥75 mg/L), tocilizumab improved survival and other clinical outcomes

RECOVERY trial: Azithromycin not beneficial for patients admitted to hospital with COVID-19

[Preprint] RECOVERY trial finds Regeneron’s monoclonal antibody combination reduces deaths for hospitalized COVID-19 patients who have not mounted their own immune response.

RECOVERY trial: Effect of hydroxychloroquine in hospitalized patients with Covid-19

Randomized trial: Lopinavir–ritonavir not beneficial for patients admitted to hospital with COVID-19

 

Commentary on Twitter

https://twitter.com/MartinLandray/status/1508492188560371717

 

The harms of postoperative antibiotic prophylaxis: a teachable moment.

30 Mar, 2022 | 10:36h | UTC

The Harms of Postoperative Antibiotic Prophylaxis: A Teachable Moment – JAMA Internal Medicine (free for a limited period)

 

AHA/ASA Scientific Statement: Endovascular treatment and thrombolysis for acute ischemic stroke in patients with premorbid disability or dementia.

30 Mar, 2022 | 10:33h | UTC

Endovascular Treatment and Thrombolysis for Acute Ischemic Stroke in Patients With Premorbid Disability or Dementia: A Scientific Statement From the American Heart Association/American Stroke Association – Stroke

News Release: Stroke treatments safe and effective for people with existing disability or dementia – American Heart Association

 

Commentary on Twitter (thread – click for more)

 

Extracorporeal life support organization guidelines for fluid overload, acute kidney injury, and electrolyte management.

30 Mar, 2022 | 10:20h | UTC

Extracorporeal Life Support Organization Guidelines for Fluid Overload, Acute Kidney Injury, and Electrolyte Management – ASAIO Journal

Related:

ELSO Guidelines for adult and pediatric extracorporeal membrane oxygenation circuits.

ELSO Guidelines for anticoagulation in adult and pediatric patients using extracorporeal membrane oxygenation (ECMO).

Guidelines for extracorporeal cardiopulmonary resuscitation in children and adults

 

Commentary on Twitter

https://twitter.com/ELSOOrg/status/1508860598406242306

 

End-of-life care in the cardiac intensive care unit: a contemporary view from the Critical Care Cardiology Trials Network (CCCTN) Registry.

30 Mar, 2022 | 10:08h | UTC

End-of-life care in the cardiac intensive care unit: a contemporary view from the Critical Care Cardiology Trials Network (CCCTN) Registry – European Heart Journal. Acute Cardiovascular Care

 

Commentary on Twitter

 

Cohort Study: Coronary artery and cardiac disease are common in patients with type 2 myocardial infarction.

29 Mar, 2022 | 10:14h | UTC

Coronary Artery and Cardiac Disease in Patients With Type 2 Myocardial Infarction: A Prospective Cohort Study – Circulation

Commentary: AHA News: Undiagnosed Heart Disease May Be Common in People With Heart Attacks Not Caused by Clots – HealthDay

 

Commentary on Twitter

 

Myocarditis and pericarditis after COVID-19 vaccination: clinical management guidance for healthcare professionals.

29 Mar, 2022 | 10:09h | UTC

Myocarditis and pericarditis after COVID-19 vaccination: clinical management guidance for healthcare professionals – UK Health Security Agency

Related:

Myocarditis following a third Pfizer vaccination dose in military recruits in Israel.

Myocarditis following COVID-19 BNT162b2 vaccination among adolescents in Hong Kong.

[Preprint] Post-marketing active surveillance of myocarditis and pericarditis following vaccination with COVID-19 mRNA vaccines in persons aged 12-39 years in Italy.

Myocarditis after BNT162b2 vaccination in Israeli adolescents.

Myocarditis cases reported after mRNA-Based COVID-19 vaccination in the US from December 2020 to August 2021.

A case-control study showed an increased risk of myocarditis after COVID-19 vaccination with a messenger RNA vaccine compared to an inactivated virus vaccine.

[Preprint] Risk of myocarditis following sequential COVID-19 vaccinations by age and sex.

Risks of myocarditis, pericarditis, and cardiac arrhythmias associated with COVID-19 vaccination vs. SARS-CoV-2 infection.

Case series with 139 adolescents and young adults with suspected myocarditis following mRNA vaccination showed most cases had a mild clinical course and rapid resolution of symptoms.

Heart-inflammation risk from Pfizer COVID vaccine is very low.

Large cohort study with over 2.5 million individuals showed the incidence of myocarditis after the Pfizer vaccine was 2.13 cases per 100,000 persons.

Study with over 5.1 million vaccinated individuals showed the incidence of myocarditis after the receipt of the Pfizer vaccine was low and more common after the second dose in young male recipients.

Large Observational study shows Pfizer Covid vaccine is mostly safe but is associated with increased risk of myocarditis, adenopathy, appendicitis, and herpes zoster.

 

Multidisciplinary consensus for the management of pulmonary thromboembolism.

29 Mar, 2022 | 09:54h | UTC

Multidisciplinary consensus for the management of pulmonary thromboembolism – Archivos de Bronconeumología

 

Review: Acute kidney injury in critically ill patients with cancer.

29 Mar, 2022 | 09:47h | UTC

Acute Kidney Injury in Critically Ill Patients with Cancer – Clinical Journal of the American Society of Nephrology

 

Commentary on Twitter

 

Brief Review: Challenges in the hemodynamic management of septic shock.

29 Mar, 2022 | 08:52h | UTC

Challenges in the Haemodynamic Management of Septic Shock – ICU Management & Practice

 

Commentary on Twitter

 

Review: Diagnosis and neurointerventional management of large vessel occlusion acute ischemic stroke.

29 Mar, 2022 | 08:39h | UTC

Diagnosis and Neurointerventional Management of Large Vessel Occlusion Acute Ischemic Stroke – emDocs

 

Review Series: Selected articles from the Annual Update in Intensive Care and Emergency Medicine 2022.

28 Mar, 2022 | 10:06h | UTC

Homepage: Selected articles from the Annual Update in Intensive Care and Emergency Medicine 2022 – Critical Care

Vasopressor choice and timing in vasodilatory shock

Advanced life support update

Brain injury biomarkers for predicting outcome after cardiac arrest

The importance of neuromonitoring in non-brain injured patients

Artificial intelligence in critical care medicine

Artificial intelligence in infection management in the ICU

Sepsis performance improvement programs: from evidence towards clinical implementation

How to prolong filter life during continuous renal replacement therapy? 

Immunomodulation by tetracyclines in the critically ill: an emerging treatment option?

The role of mitochondria in the immune response in critical illness

 

Is there evidence of fabricated data in a Vitamin C trial published in CHEST?

28 Mar, 2022 | 09:58h | UTC

Evidence of Fabricated Data in a Vitamin C trial by Paul E Marik et al in CHEST – This Scattrd Corn

Commentary: Infamous Vitamin C Study May Rely on Fraudulent Data— Statistician alleges data in study led by Paul Marik, MD, were fabricated – MedPage Today

 

Commentary on Twitter (thread – click for more)

 

Cohort Study: SARS-CoV-2 co-infection with influenza viruses, respiratory syncytial virus, or adenoviruses is associated with increased mortality.

28 Mar, 2022 | 10:03h | UTC

SARS-CoV-2 co-infection with influenza viruses, respiratory syncytial virus, or adenoviruses – The Lancet

Commentary: Patients with Covid and flu double the risk of dying, say scientists – The Guardian

 

Commentary from the author on Twitter (thread – click for more)

https://twitter.com/kennethbaillie/status/1507501279181955076

 

RCT: In critically ill immunocompromised patients with acute respiratory failure, outcomes were similar with the use of high-flow nasal oxygen alone vs. alternating with non-invasive ventilation.

28 Mar, 2022 | 08:51h | UTC

High-flow nasal oxygen alone or alternating with non-invasive ventilation in critically ill immunocompromised patients with acute respiratory failure: a randomised controlled trial – The Lancet Respiratory Medicine (free registration required)

 

Commentary on Twitter

https://twitter.com/LancetRespirMed/status/1506175093474414592

 

M-A: Staphylococcus aureus bacteremia mortality.

25 Mar, 2022 | 08:36h | UTC

Staphylococcus aureus bacteremia mortality: A systematic review and meta-analysis – Clinical Microbiology and Infection

 

RCT: Single-dose Liposomal Amphotericin B treatment for Cryptococcal Meningitis.

24 Mar, 2022 | 09:56h | UTC

Single-Dose Liposomal Amphotericin B Treatment for Cryptococcal Meningitis – New England Journal of Medicine (link to abstract – $ for full-text)

 

Commentary on Twitter

 

RCT: Awake prone positioning did not improve outcomes in patients with moderate hypoxemia due to covid-19.

24 Mar, 2022 | 09:48h | UTC

Prone positioning of patients with moderate hypoxaemia due to covid-19: multicentre pragmatic randomised trial (COVID-PRONE) – The BMJ

Editorial: Awake prone positioning for patients with covid-19

News Release: Lying prone long enough to improve outcomes is difficult for many covid-19 patients – BMJ

 

RCT: Among critically ill patients with Covid-19, treatment with an antiplatelet agent had a low likelihood of improving organ support–free days within 21 days.

23 Mar, 2022 | 10:38h | UTC

Effect of Antiplatelet Therapy on Survival and Organ Support–Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial – JAMA

Editorial: Thromboinflammation and Antithrombotics in COVID-19: Accumulating Evidence and Current Status – JAMA

Commentary: Aspirin may improve 3-month survival for patients critically ill with COVID-19 – Imperial College London

 

Commentaries on Twitter

https://twitter.com/JAMA_current/status/1506188937852858369

 

Review: When to operate after SARS-CoV-2 infection?

22 Mar, 2022 | 09:44h | UTC

When to operate after SARS-CoV-2 infection? A review on the recent consensus recommendation of the DGC/BDC and the DGAI/BDA – Langenbeck’s Archives of Surgery

Related:

Guideline Update: Timing of elective surgery and risk assessment after SARS-CoV-2 infection – “The guidance remains that patients should avoid elective surgery within 7 weeks of infection, unless the benefits of doing so exceed the risk of waiting”.

Perioperative cardiovascular considerations prior to elective noncardiac surgery in patients with a history of Covid-19.

Guideline: SARS‐CoV‐2 infection, COVID‐19 and timing of elective surgery

Study from 116 countries suggests surgery should be delayed for at least seven weeks following a COVID-19 diagnosis to reduce mortality risk

BJS commission on surgery and perioperative care post-COVID-19.

The risk of postoperative complications following major elective surgery in active or resolved COVID-19 in the United States – Major, elective surgery 0–4 weeks after Covid-19 is associated with greatly increased risk of postoperative complications; surgery performed 4–8 weeks after infection is still associated with an increased risk of pneumonia.

ASA Guidance: Preoperative testing for COVID-19 is essential, regardless of vaccination.

Position statement: Perioperative management of post-COVID-19 surgical patients.

Cohort study: Postoperative in-hospital mortality of patients with COVID-19 infection was more than double that in patients without COVID-19

 

Evidence-based disposition of acute pancreatitis.

22 Mar, 2022 | 08:08h | UTC

Evidence-Based Disposition of Acute Pancreatitis – emDocs

Related Guidelines:

2019 WSES guidelines for the management of severe acute pancreatitis – World Journal of Emergency Surgery

American Gastroenterological Association Institute Guideline on Initial Management of Acute Pancreatitis

Pancreatitis – National Institute for Health and Care Excellence

 

EASL Clinical Practice Guidelines on prevention and management of bleeding and thrombosis in patients with cirrhosis.

21 Mar, 2022 | 10:01h | UTC

EASL Clinical Practice Guidelines on prevention and management of bleeding and thrombosis in patients with cirrhosis – Journal of Hepatology

 

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