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Cardiology (all articles)

RCT: In patients with multivessel coronary artery disease, a Fractional Flow Reserve (FFR) guided revascularization strategy did not reduce the risk of ischemic cardiovascular events or death at 1-year follow-up compared to a traditional strategy without FFR.

19 Nov, 2021 | 10:26h | UTC

Fractional Flow Reserve to Guide Treatment of Patients With Multivessel Coronary Artery Disease – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Related:

RCT: In patients with three-vessel coronary artery disease, an FFR–guided PCI strategy was NOT noninferior to coronary bypass surgery – The 1-year incidence of the composite primary end point (death, myocardial infarction, or stroke) was 7.3% in the FFR-guided PCI group and 5.2% in the CABG group.

#ESCCongress – Systematic FFR has no additional benefit at diagnostic angiography in patients with chest pain.

#ACC21 – RCT: In patients with STEMI undergoing complete revascularization, an FFR-guided strategy did not improve outcomes compared to an angiography-guided strategy.

Randomized Trial: Five-Year Outcomes with PCI Guided by FFR

 

NICE Guideline | Heart valve disease presenting in adults: investigation and management.

18 Nov, 2021 | 08:44h | UTC

Heart valve disease presenting in adults: investigation and management – National Institute for Health and Care Excellence

Related Guidelines:

#ESCCongress – 2021 ESC/EACTS Guidelines for the management of valvular heart disease – in the new guidelines, more patients are eligible for surgical and transcatheter interventions, based not only on symptoms but also on imaging criteria.

2020 ACC/AHA Guideline for the management of patients with valvular heart disease

 

Review: A fresh look at coronary microembolization.

18 Nov, 2021 | 08:35h | UTC

A fresh look at coronary microembolization – Nature Reviews Cardiology (if this link is paywalled, try this one)

 

Commentary on Twitter

 

ESC guidance for the diagnosis and management of cardiovascular disease during the COVID-19 pandemic.

17 Nov, 2021 | 08:56h | UTC

ESC guidance for the diagnosis and management of cardiovascular disease during the COVID-19 pandemic – European Heart Journal

Part 1—epidemiology, pathophysiology, and diagnosis

Part 2—care pathways, treatment, and follow-up

News release: European Society of Cardiology COVID-19 guidance launched – European Society of Cardiology

 

Commentaries on Twitter

 

Position Statement: Preoperative Care for Cataract Surgery – “In spite of evidence debunking the utility of testing before cataract surgery, studies suggest that medical testing and the use of medical consultations before cataract surgery continue to increase”.

17 Nov, 2021 | 08:33h | UTC

Preoperative Care for Cataract Surgery: The Society for Ambulatory Anesthesia Position Statement – Anesthesia & Analgesia

 

Commentary on Twitter

 

Randomized, crossover clinical trial: In patients with heart failure with preserved ejection fraction and chronotropic incompetence, betablocker withdrawal improved maximal functional capacity.

17 Nov, 2021 | 08:27h | UTC

Effect of β-Blocker Withdrawal on Functional Capacity in Heart Failure and Preserved Ejection Fraction – Journal of the American College of Cardiology

Commentary: Peak VO2 Improved After Beta-Blocker Withdrawal in Some HFpEF Patients: Beta-blockers may not benefit HFpEF patients with chronotropic incompetence – MedPage Today (free registration required)

 

Drug-induced orthostatic hypotension: A systematic review and meta-analysis of randomized controlled trials.

17 Nov, 2021 | 08:12h | UTC

Drug-induced orthostatic hypotension: A systematic review and meta-analysis of randomised controlled trials – PLOS Medicine

 

2021 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations.

16 Nov, 2021 | 08:37h | UTC

2021 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations: Summary From the Basic Life Support; Advanced Life Support; Neonatal Life Support; Education, Implementation, and Teams; First Aid Task Forces; and the COVID-19 Working Group – Circulation (for an HTML version click here)

Top Things to Know: International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations (CoSTR) – American Heart Association

 

#AHA21 – [News release – not published yet] RCT: Long-term, low-dose aspirin did not affect risk of dementia in adults with type 2 diabetes.

16 Nov, 2021 | 08:30h | UTC

Long-term, low-dose aspirin did not affect risk of dementia in adults with type 2 diabetes – American Heart Association

Original Study: Randomized Trial: Effects of Aspirin for Primary Prevention in Persons with Diabetes

 

#AHA21 – Among patients with intermittent atrial fibrillation, n-of-1 trials with 466 patients found alcohol, but not caffeine, increased the risk of atrial fibrillation events.

16 Nov, 2021 | 08:29h | UTC

Individualized Studies of Triggers of Paroxysmal Atrial Fibrillation: The I-STOP-AFib Randomized Clinical Trial – JAMA Cardiology (free for a limited period)

Commentary: Avoiding AF Triggers Doesn’t Improve Quality of Life: I-STOP-AFib – TCTMD

 

Commentary on Twitter

 

#AHA21 – M-A: Among patients with left main coronary disease, there was no statistically significant difference in 5-year all-cause death between percutaneous coronary intervention with drug-eluting stents vs. coronary artery bypass grafting.

16 Nov, 2021 | 08:31h | UTC

Percutaneous coronary intervention with drug-eluting stents versus coronary artery bypass grafting in left main coronary artery disease: an individual patient data meta-analysis – The Lancet (free registration required)

Commentary: No Mortality Difference Between PCI and CABG for Left Main PCI: Meta-analysis – TCTMD

 

Review: Cardiac device troubleshooting in the intensive care unit.

16 Nov, 2021 | 08:21h | UTC

Cardiac device troubleshooting in the intensive care unit: an educational review – European Heart Journal. Acute Cardiovascular Care

 

Commentary on Twitter

 

#AHA21 – RCT: Among children and adolescents who had screening echocardiograms and were identified as having latent rheumatic heart disease, secondary antibiotic prophylaxis with penicillin G benzathine for 2 years was associated with reduced echocardiographic progression (0.8 vs. 8.2% in the control group).

14 Nov, 2021 | 20:03h | UTC

Secondary Antibiotic Prophylaxis for Latent Rheumatic Heart Disease – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries:

Penicillin significantly reduces rheumatic heart disease progression in children – Murdoch Children’s Research Institute

Penicillin slows devastating impacts of rheumatic heart disease in children from Uganda – Children’s National Hospital

Secondary Antibiotic Prophylaxis for Latent Rheumatic Heart Disease – American College of Cardiology

 

Commentaries on Twitter

 

#AHA21 – Pooled data from six prospective cohorts found higher sodium and lower potassium intakes were associated in a dose–response manner with a higher cardiovascular risk.

14 Nov, 2021 | 19:58h | UTC

24-Hour Urinary Sodium and Potassium Excretion and Cardiovascular Risk – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Less sodium and more potassium could be key in lowering risk of cardiovascular disease – The Harvard Gazette

Related study: Cohort Study: Joint Association of Urinary Sodium and Potassium Excretion with Cardiovascular Events and Mortality

 

Commentary on Twitter

 

#AHA21 – RCT: Concomitant tricuspid repair in patients undergoing surgery for degenerative mitral regurgitation reduced tricuspid regurgitation progression but increased the need for permanent pacemaker implantation.

14 Nov, 2021 | 20:00h | UTC

Concomitant Tricuspid Repair in Patients with Degenerative Mitral Regurgitation – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries:

Tricuspid Repair During Mitral Surgery Slows Disease Progression at 2 Years – TCTMD

Cardiothoracic Surgical Trials Network: Concomitant Tricuspid Valve Repair + Mitral Valve Surgery vs. Mitral Valve Surgery Alone – CTCR-MVS – American College of Cardiology

CTCR-MVS: Concomitant Tricuspid Repair in Patients With MR – American College of Cardiology

 

#AHA21 – RCT: In asymptomatic patients with severe aortic stenosis, early surgery improved outcomes compared to conservative treatment.

14 Nov, 2021 | 20:01h | UTC

Aortic Valve ReplAcemenT versus Conservative Treatment in Asymptomatic SeveRe Aortic Stenosis: The AVATAR Trial – Circulation (free for a limited period)

News release: Surgery to replace heart valve beneficial even with no symptoms of severe aortic stenosis – American Heart Association

Commentaries:

AVATAR Supports Early SAVR in Asymptomatic Severe AS Patients – TCTMD

Aortic Valve ReplAcemenT versus Conservative Treatment in Asymptomatic SeveRe Aortic Stenosis – AVATAR – American College of Cardiology

Related study: #AHA19 – Randomized Trial: Early Surgery Improves Outcomes in Asymptomatic Patients with Very Severe Aortic Stenosis

 

Commentary on Twitter

 

#AHA21 – RCT: Among patients undergoing cardiac surgery, routine posterior left pericardiotomy can prevent postoperative atrial fibrillation.

14 Nov, 2021 | 19:53h | UTC

Posterior left pericardiotomy for the prevention of atrial fibrillation after cardiac surgery: an adaptive, single-centre, single-blind, randomised, controlled trial – The Lancet (free registration required)

Commentaries:

A short cut to prevent postoperative atrial fibrillation – The Lancet (free registration required)

Posterior Left Pericardiotomy for the Prevention of Postoperative Atrial Fibrillation After Cardiac Surgery – PALACS – American College of Cardiology

 

#AHA21 – [Not published Yet] A small, randomized study showed stopping ticagrelor only 2-3 days before bypass surgery may be safe.

14 Nov, 2021 | 19:56h | UTC

News release: Ticaglelor may be stopped Time from stopping blood thinner to bypass surgery may be shortened for select patients – American Heart Association

Commentary: RAPID CABG: No Penalty to Early Surgery for ACS After Stopping Ticagrelor – TCTMD

 

Observational Study: In patients with shockable in-hospital cardiac arrest, epinephrine before defibrillation was associated with worse survival.

14 Nov, 2021 | 19:33h | UTC

Epinephrine before defibrillation in patients with shockable in-hospital cardiac arrest: propensity matched analysis – The BMJ

 

Commentary on Twitter

 

Cohort study: In patients with nonalcoholic steatohepatitis and obesity, bariatric surgery was associated with lower risk of incident major adverse liver outcomes and major adverse cardiovascular events.

12 Nov, 2021 | 10:24h | UTC

Association of Bariatric Surgery With Major Adverse Liver and Cardiovascular Outcomes in Patients With Biopsy-Proven Nonalcoholic Steatohepatitis – JAMA (free for a limited period)

Editorial: Bariatric Surgery as a Strategy for Improving Outcomes in Nonalcoholic Steatohepatitis – JAMA (free for a limited period)

 

Commentary on Twitter

 

Some immune checkpoint inhibitors can cause serious arrhythmias and myocarditis.

12 Nov, 2021 | 09:57h | UTC

News release: Some immune checkpoint inhibitors can cause serious arrhythmias and myocarditis – University of California San Francisco Medical Center

Original study: Electrocardiographic Manifestations of Immune Checkpoint Inhibitor Myocarditis – Circulation (link to abstract – $ for full-text)

Related:

Anticancer drug-induced life-threatening ventricular arrhythmias: a World Health Organization pharmacovigilance study.

AHA Scientific Statement: Recognition, prevention, and management of arrhythmias and autonomic disorders in cardio-oncology.

 

White-Coat Hypertension: Pathophysiological and Clinical Aspects.

12 Nov, 2021 | 09:48h | UTC

White-Coat Hypertension: Pathophysiological and Clinical Aspects: Excellence Award for Hypertension Research 2020 – Hypertension (free for a limited period)

 

RCT: In patients with acute myocardial infarction complicated by a reduced left ventricular ejection fraction, pulmonary congestion, or both, Sacubitril–valsartan was not associated with improved outcomes compared to Ramipril.

11 Nov, 2021 | 08:44h | UTC

Angiotensin Receptor–Neprilysin Inhibition in Acute Myocardial Infarction – New England Journal of Medicine (link to abstract – $ for full-text)

 

Systematic Review: Beta‐blockers in patients without heart failure after myocardial infarction.

11 Nov, 2021 | 08:25h | UTC

Summary: Benefits and harms of beta-blockers versus placebo or no intervention in the non-acute phase of a myocardial infarction – Cochrane Library

Original Study: Beta‐blockers in patients without heart failure after myocardial infarction – Cochrane Library

 

Consensus Document: Non-invasive imaging in coronary syndromes.

10 Nov, 2021 | 07:11h | UTC

Non-invasive Imaging in Coronary Syndromes — Recommendations of the European Association of Cardiovascular Imaging and the American Society of Echocardiography, in Collaboration with the American Society of Nuclear Cardiology, Society of Cardiovascular Computed Tomography and Society for Cardiovascular Magnetic Resonance – European Heart Journal: Cardiovascular Imaging

 

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