RCT: In patients with multivessel coronary artery disease, a Fractional Flow Reserve (FFR) guided revascularization strategy did not reduce the risk of ischemic cardiovascular events or death at 1-year follow-up compared to a traditional strategy without FFR.

Fractional Flow Reserve to Guide Treatment of Patients With Multivessel Coronary Artery Disease – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Related:

RCT: In patients with three-vessel coronary artery disease, an FFR–guided PCI strategy was NOT noninferior to coronary bypass surgery – The 1-year incidence of the composite primary end point (death, myocardial infarction, or stroke) was 7.3% in the FFR-guided PCI group and 5.2% in the CABG group.

#ESCCongress – Systematic FFR has no additional benefit at diagnostic angiography in patients with chest pain.

#ACC21 – RCT: In patients with STEMI undergoing complete revascularization, an FFR-guided strategy did not improve outcomes compared to an angiography-guided strategy.

Randomized Trial: Five-Year Outcomes with PCI Guided by FFR