Randomized, crossover clinical trial: In patients with heart failure with preserved ejection fraction and chronotropic incompetence, betablocker withdrawal improved maximal functional capacity.

Effect of β-Blocker Withdrawal on Functional Capacity in Heart Failure and Preserved Ejection Fraction – Journal of the American College of Cardiology

Commentary: Peak VO2 Improved After Beta-Blocker Withdrawal in Some HFpEF Patients: Beta-blockers may not benefit HFpEF patients with chronotropic incompetence – MedPage Today (free registration required)