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Anticancer drug-induced life-threatening ventricular arrhythmias: a World Health Organization pharmacovigilance study.

26 Oct, 2021 | 01:26h | UTC

Anticancer drug-induced life-threatening ventricular arrhythmias: a World Health Organization pharmacovigilance study – European Heart Journal

Editorial: QT prolongation and cancer therapeutics: a coming Tempest or Much Ado About Nothing?

Commentary: Anticancer Drug-Induced Life-Threatening Ventricular Arrhythmias – American College of Cardiology

Related: AHA Scientific Statement: Recognition, prevention, and management of arrhythmias and autonomic disorders in cardio-oncology.

 

Commentary on Twitter

 

M-A: Data from randomized trials showed nonfatal myocardial infarction cannot be established as a good surrogate for all-cause and cardiovascular mortality.

26 Oct, 2021 | 01:36h | UTC

Assessment of Nonfatal Myocardial Infarction as a Surrogate for All-Cause and Cardiovascular Mortality in Treatment or Prevention of Coronary Artery Disease: A Meta-analysis of Randomized Clinical Trials – JAMA Internal Medicine (free for a limited period)

Editorial: Nonfatal Myocardial Infarction—Poor Surrogate for Mortality – JAMA Internal Medicine (free for a limited period)

 

Review: Thoracic involvement and imaging patterns in IgG4-related disease.

26 Oct, 2021 | 01:22h | UTC

Thoracic involvement and imaging patterns in IgG4-related disease – European Respiratory Review

 

Commentary on Twitter

 

Association of a sweetened beverage tax with reduction in soda consumption in high school students.

26 Oct, 2021 | 01:30h | UTC

Association of a Sweetened Beverage Tax With Soda Consumption in High School Students – JAMA Pediatrics (free for a limited period)

Commentary: Philadelphia’s ‘soda tax’ cut the number of sugar-sweetened beverages high school students drank per week by 30%, study finds – News Break

Related:

Changes in food purchases after the Chilean policies on food labelling, marketing, and sales in schools: a before and after study.

UK National Food Strategy: Tax sugar and salt and prescribe veg, report says.

Perspective – Sugar-sweetened beverage taxes: Lessons to date and the future of taxation

Cohort Study: Association Between Tax on Sugar Sweetened Beverages and Soft Drink Consumption

Meta-Analysis: Impact of Sugar‐sweetened Beverage Taxes on Purchases and Dietary Intake

Cochrane Review: Environmental Interventions to Reduce the Consumption of Sugar‐sweetened Beverages and Their Effects on Health

Study: Snack Tax May be More Effective than a Sugary Drink Tax to Tackle Obesity

Sugar Tax: Why Health Experts Want it But Politicians and Industry are Resisting

The Effect of Food Price Changes on Consumer Purchases: A Randomized Experiment

Taxes on Sugar-Sweetened Beverages Associated with Reduced Consumption

Soda Tax Linked to a 50 Percent Reduction in Sugary Drink Consumption

AAP/AHA Policy Statement: Public Policies to Reduce Sugary Drink Consumption in Children and Adolescents

Fiscal policies for diet and the prevention of noncommunicable diseases – World Health Organization

The Lancet taskforce on NCDs and economics

To improve global health, tax the things that are killing us – Financial Times

Reducing cardiovascular disease burden through targeted dietary policies

Fiscal policies for the prevention of diseases

The potential impact of food taxes and subsidies on cardiovascular disease and diabetes burden and disparities

 

Commentary on Twitter

 

Management of patients with cervical spine trauma in the emergency department: a systematic critical appraisal of guidelines with a view to developing standardized strategies for clinical practice.

26 Oct, 2021 | 01:17h | UTC

Management of patients with cervical spine trauma in the emergency department: a systematic critical appraisal of guidelines with a view to developing standardized strategies for clinical practice – Internal and Emergency Medicine

 

Opinion | COVID STEROID-2: Double the steroid, double the fun? – “Dexamethasone 6 mg/day alone is likely suboptimal for most patients with severe COVID pneumonia. Dexamethasone 12 mg/day may provide a reasonable intensity of immunomodulation”.

25 Oct, 2021 | 00:01h | UTC

COVID STEROID-2: Double the steroid, double the fun? – PulmCrit

Original study: RCT: In adults with Covid-19 and severe hypoxemia, 12 mg vs. 6 mg of Dexamethasone did not result in a statistically significant difference in the number of days alive without life support.

 

Commentary on Twitter

 

Review: Does infection with or vaccination against SARS-CoV-2 lead to lasting immunity?

25 Oct, 2021 | 00:03h | UTC

Does infection with or vaccination against SARS-CoV-2 lead to lasting immunity? – The Lancet Respiratory Medicine

 

Commentary on Twitter

 

Half doses, third doses, kids’ doses: Covid vaccine delivery goes next-level difficult.

24 Oct, 2021 | 23:52h | UTC

Half doses, third doses, kids’ doses: Covid vaccine delivery goes next-level difficult – STAT

 

Review: Cardiac involvement in the long-term implications of COVID-19.

24 Oct, 2021 | 23:59h | UTC

Cardiac involvement in the long-term implications of COVID-19 – Nature Reviews Cardiology

 

How you’ll know when Covid-19 has gone from “pandemic” to “endemic”.

24 Oct, 2021 | 23:53h | UTC

How you’ll know when Covid-19 has gone from “pandemic” to “endemic” – Vox

 

AstraZeneca vaccination not linked to reduced fertility rates and adverse birth outcomes.

24 Oct, 2021 | 23:58h | UTC

Fertility rates and birth outcomes after ChAdOx1 nCoV-19 (AZD1222) vaccination – The Lancet

Related:

A case-controlled study showed Covid-19 vaccination during early pregnancy was not associated with increased risk of first-trimester miscarriage.

Editorial: Covid-19 treatments and vaccines must be evaluated in pregnancy.

Cohort study: Vaccinated pregnant patients had 90% lower risk of severe or critical Covid-19 compared with unvaccinated pregnant patients.

Two observational studies suggest spontaneous abortion is not increased following COVID-19 mRNA vaccination during pregnancy.

Study shows high effectiveness of the Pfizer mRNA COVID-19 vaccine in pregnancy.

5 Crucial Things to Know About COVID-19 Vaccines and Pregnancy.

CDC Guidance: Pregnant people should be vaccinated against COVID-19.

ACOG and SMFM Recommend COVID-19 Vaccination for Pregnant Individuals – “ACOG encourages its members to enthusiastically recommend vaccination to their patients.”

Cohort study: Pfizer/BioNTech COVID vaccine associated with 78% lower risk of Covid-19 in pregnancy.

 

Commentary on Twitter

 

Coronavirus: Chinese residents start receiving vaccine boosters.

24 Oct, 2021 | 23:51h | UTC

Coronavirus: Chinese residents start receiving vaccine boosters – South China Morning Post

 

2021 Interim Guidance to Health Care Providers for Basic and Advanced Cardiac Life Support in Adults, Children, and Neonates With Suspected or Confirmed COVID-19.

24 Oct, 2021 | 23:49h | UTC

2021 Interim Guidance to Health Care Providers for Basic and Advanced Cardiac Life Support in Adults, Children, and Neonates With Suspected or Confirmed COVID-19 – Circulation: Cardiovascular Quality and Outcomes

Commentary: CPR on a COVID Patient: Not a Moment to Waste Looking for PPE: Updated AHA guidance says resuscitation should not be delayed by mask availability – MedPage Today (free registration required)

 

Commentary on Twitter (thread – click for more)

 

RCT: In comatose survivors of out-of-hospital cardiac arrest, there was no difference in mortality and neurologic outcomes with mild (target temperature of 34 °C) vs. moderate therapeutic hypothermia (target temperature of 31 °C).

24 Oct, 2021 | 23:46h | UTC

Effect of Moderate vs Mild Therapeutic Hypothermia on Mortality and Neurologic Outcomes in Comatose Survivors of Out-of-Hospital Cardiac Arrest: The CAPITAL CHILL Randomized Clinical Trial – JAMA (free for a limited period)

Related:

Cooling After Cardiac Arrest – The Sclerosis of Therapeutic Fashion – “The story of how an ineffective therapy persisted for decades”

RCT: In patients with coma after out-of-hospital cardiac arrest, targeted hypothermia did not improve outcomes.

Study commentary: a history of hypothermia for cardiac arrest, 2002-2021 (RIP).

M-A: Targeted temperature management following out-of-hospital cardiac arrest – “Routine use of moderate or deep hypothermia in comatose survivors of OHCA may potentially be associated with more harm than benefit”.

 

Commentary on Twitter

 

Guideline: Transfusion strategies in bleeding critically ill adults.

24 Oct, 2021 | 23:47h | UTC

Transfusion strategies in bleeding critically ill adults: a clinical practice guideline from the European Society of Intensive Care Medicine – Intensive Care Medicine

 

Commentary on Twitter

 

RCT: The association of Varenicline and Nicotine patch was not better than Varenicline alone to increase smoking abstinence; there was also no difference between 24-week vs. 12-week treatment courses in abstinence rates.

24 Oct, 2021 | 23:45h | UTC

Effects of Combined Varenicline With Nicotine Patch and of Extended Treatment Duration on Smoking Cessation: A Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Is There a Role for Combined Use of Varenicline and Nicotine Patch or Extended Treatment Duration to Enhance Smoking Cessation? – JAMA (free for a limited period)

Commentary: Varenicline Combo, Extension No Better for Quitting Smoking – HealthDay

 

Commentary on Twitter

 

Middle-aged and older women are being diagnosed with Takotsubo Syndrome more frequently, up to 10 times more often, than younger women or men of any age.

24 Oct, 2021 | 23:43h | UTC

Sex‐ and Age‐Based Temporal Trends in Takotsubo Syndrome Incidence in the United States – Journal of the American Heart Association

News release: Broken heart syndrome is on the rise, especially among older women – American Heart Association

Commentary: ‘Broken heart’ syndrome is on the rise in women – Cedars-Sinai Medical Center

Related:

International Expert Consensus Document on Takotsubo Syndrome

International Registry: 16.6% of Patients with Takotsubo Syndrome Have Underlying Malignancy

Systematic Review: Long-Term Prognosis and Outcome Predictors in Takotsubo Syndrome

Cohort Study: Hospital Readmission Following Takotsubo Syndrome

 

The cost-effectiveness of cefazolin compared to anti-staphylococcal penicillins for the treatment of methicillin-sensitive Staphylococcus aureus bacteremia.

24 Oct, 2021 | 23:41h | UTC

The cost-effectiveness of cefazolin compared to anti-staphylococcal penicillins for the treatment of methicillin-sensitive Staphylococcus aureus bacteremia – Open Forum of Infectious Diseases

Related:

Meta-Analysis: Cefazolin vs. Anti-staphylococcal Penicillins for the Treatment of Staphylococcus aureus Bacteremia

Meta-Analysis: Cefazolin vs. Antistaphylococcal Penicillins for MSSA Bacteremia

 

Commentaries on Twitter

 

M-A: In patients with Staphylococcus aureus bacteremia, combination therapy does not reduce mortality and is associated with increased risks of adverse events.

24 Oct, 2021 | 23:42h | UTC

The Effect of Combination Therapy on Mortality and Adverse Events in Patients with Staphylococcus aureus Bacteraemia: A Systematic Review and Meta-analysis of Randomized Controlled Trials – Infectious Diseases and Therapy

 

Corporate influence linked to slow implementation of public health policies globally.

24 Oct, 2021 | 23:37h | UTC

Implementation of non-communicable disease policies from 2015 to 2020: a geopolitical analysis of 194 countries – The Lancet Global Health

News Release: Corporate influence linked to slow implementation of public health policies globally – London School of Hygiene & Tropical Medicine

 

Commentary on Twitter (thread – click for more)

 

M-A: Clinical interventions for adults with comorbid alcohol use and depressive disorders.

24 Oct, 2021 | 23:39h | UTC

Clinical interventions for adults with comorbid alcohol use and depressive disorders: A systematic review and network meta-analysis – PLOS Medicine

 

Consensus statement on measures to promote equitable authorship in the publication of research from international partnerships.

24 Oct, 2021 | 23:35h | UTC

Consensus statement on measures to promote equitable authorship in the publication of research from international partnerships – Anaesthesia

 

Commentary on Twitter

 

Perspective | The flawed science of antibody testing for SARS-CoV-2 immunity.

22 Oct, 2021 | 10:30h | UTC

The Flawed Science of Antibody Testing for SARS-CoV-2 Immunity – JAMA

 

Extreme heat is broiling people in developing cities: New analysis finds the explosive growth of cities is helping drive dangerous conditions.

24 Oct, 2021 | 23:34h | UTC

Extreme heat is broiling people in developing cities – Science

Original Study: Global urban population exposure to extreme heat – Proceedings of the National Academy of Sciences

 

Commentary on Twitter

 

[Press release – not published yet] A phase 3 trial with more than 10,000 participants showed a booster dose of the Pfizer/BioNTech vaccine had an efficacy of 95.6% against disease; there were 5 cases in the booster group and 109 cases in the non-boosted group, not classified according to severity.

22 Oct, 2021 | 10:34h | UTC

Pfizer and BioNTech Announce Phase 3 Trial Data Showing High Efficacy of a Booster Dose of Their COVID-19 Vaccine

Commentary: Booster dose of Pfizer/BioNTech coronavirus vaccine shows 95.6% efficacy in Phase 3 trial, companies say – CNN

 

Commentaries on Twitter

 

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