RCT: The association of Varenicline and Nicotine patch was not better than Varenicline alone to increase smoking abstinence; there was also no difference between 24-week vs. 12-week treatment courses in abstinence rates.

Effects of Combined Varenicline With Nicotine Patch and of Extended Treatment Duration on Smoking Cessation: A Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Is There a Role for Combined Use of Varenicline and Nicotine Patch or Extended Treatment Duration to Enhance Smoking Cessation? – JAMA (free for a limited period)

Commentary: Varenicline Combo, Extension No Better for Quitting Smoking – HealthDay

Commentary on Twitter

Study findings do not support the use of combined varenicline plus nicotine patch therapy (vs varenicline monotherapy) or of extended treatment duration (24 vs 12 weeks) for smoking cessation https://t.co/XcQMQZgQb9

— JAMA (@JAMA_current) October 19, 2021