Opinion | COVID STEROID-2: Double the steroid, double the fun? – “Dexamethasone 6 mg/day alone is likely suboptimal for most patients with severe COVID pneumonia. Dexamethasone 12 mg/day may provide a reasonable intensity of immunomodulation”.
25 Oct, 2021 | 00:01h | UTCCOVID STEROID-2: Double the steroid, double the fun? – PulmCrit
Commentary on Twitter
COVID-STEROID 2
?5% lower mortality with 12 mg dexamethasone (vs 6 mg) – which is *huge* – but p=0.09 ?
?RCTs with toci/bari show that 6 mg dex alone is suboptimal.
?If using dex monotherapy, 12 mg is now a sensible dose for sicker pts.
Fresh blog: https://t.co/oPz7vAYHGN pic.twitter.com/diDqqUxSTC— ???? ?????? ? (@PulmCrit) October 23, 2021