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COVID super-immunity: one of the pandemic’s great puzzles – “People who have previously recovered from COVID-19 have a stronger immune response after being vaccinated than those who have never been infected. Scientists are trying to find out why”.

27 Oct, 2021 | 01:41h | UTC

COVID super-immunity: one of the pandemic’s great puzzles – Nature

 

AGA Clinical Practice Update on Endoscopic Management of Perforations in Gastrointestinal Tract.

27 Oct, 2021 | 01:35h | UTC

AGA Clinical Practice Update on Endoscopic Management of Perforations in Gastrointestinal Tract: Expert Review – Clinical Gastroenterology and Hepatology

 

Bioethics | The suggestion Covid deniers should stay out of Australian public hospitals is appalling.

27 Oct, 2021 | 01:37h | UTC

The suggestion Covid deniers should stay out of Australian public hospitals is appalling – The Guardian

 

UEG Consensus on Functional Dyspepsia.

27 Oct, 2021 | 01:32h | UTC

United European Gastroenterology (UEG) and European Society for Neurogastroenterology and Motility (ESNM) consensus on functional dyspepsia – UEG Journal

 

RCT: Elective internal mammary node irradiation does not increase disease-free survival or overall survival in most women with node-positive breast cancer.

27 Oct, 2021 | 01:28h | UTC

Effect of Elective Internal Mammary Node Irradiation on Disease-Free Survival in Women With Node-Positive Breast Cancer: A Randomized Phase 3 Clinical Trial – JAMA Oncology (free for a limited period)

Commentary: No Survival Benefit for Internal Mammary Node Irradiation in Breast Cancer — Women with medially or centrally located tumors may be candidates, however, says researcher – MedPage Today (free registration required)

 

Commentary on Twitter

 

Opinion | We Need to Ground Truth Assumptions about Gene Therapy – “Researchers, practitioners and patients must balance the discipline’s promise with its reality”.

27 Oct, 2021 | 01:21h | UTC

We Need to Ground Truth Assumptions about Gene Therapy – Nature

 

RCT: Platelet-rich intra-articular plasma injections do not improve symptoms and function in patients with ankle osteoarthritis.

27 Oct, 2021 | 01:26h | UTC

Effect of Platelet-Rich Plasma Injections vs Placebo on Ankle Symptoms and Function in Patients With Ankle Osteoarthritis: A Randomized Clinical Trial – JAMA (free for a limited period)

Related:

RCT: No benefit from platelet-rich plasma injection for patients with debilitating Achilles tendinopathy.

M-A: Intra-articular saline injection is as effective as corticosteroids, platelet-rich plasma, and hyaluronic acid for hip osteoarthritis pain

 

RCT: In critically ill patients, an individualized glucose control targeting an ICU patient’s pre-admission usual glycemia did not demonstrate a survival benefit compared to conventional glucose control (targeting glycemia below 180 mg/dL).

27 Oct, 2021 | 01:17h | UTC

Individualised versus conventional glucose control in critically-ill patients: the CONTROLING study—a randomized clinical trial – Intensive Care Medicine

Editorial: The goal of personalized glucose control in the critically ill remains elusive – Intensive Care Medicine

 

Anticoagulants and diabetes agents are among the most frequent causes of emergency department visits attributed to medication harms.

27 Oct, 2021 | 01:15h | UTC

US Emergency Department Visits Attributed to Medication Harms, 2017-2019 – JAMA (link to abstract – $ for full-text)

Commentaries:

Number of emergency room visits for medication harms increases with age – MedicalResearch.com

Blood thinners, diabetes meds among top causes of drug-related ER visits – UPI

 

Systematic Review: Antibiotics for the treatment of COVID‐19 – “We are certain that risk of death in hospitalized COVID‐19 patients is not reduced by treatment with azithromycin after 28 days”.

26 Oct, 2021 | 02:07h | UTC

Antibiotics for the treatment of COVID‐19 – Cochrane Library

 

Commentary on Twitter

 

RCT: Ozanimod as induction and maintenance therapy for ulcerative colitis.

27 Oct, 2021 | 01:19h | UTC

Ozanimod as Induction and Maintenance Therapy for Ulcerative Colitis – New England Journal of Medicine

 

Commentary on Twitter

 

M-A: The efficacy of pharmacotherapies for the treatment of borderline personality disorder is limited.

27 Oct, 2021 | 01:11h | UTC

Pharmacological Treatments for Borderline Personality Disorder: A Systematic Review and Meta-Analysis – CNS Drugs

 

Podcast: Atopic Dermatitis Pearls.

27 Oct, 2021 | 01:01h | UTC

Atopic Dermatitis Pearls – The Cribsiders

 

Systematic Review: Virtual care in patients with cancer.

27 Oct, 2021 | 01:04h | UTC

Virtual Care in Patients with Cancer: A Systematic Review – Current Oncology

 

[Press release – not published yet] Moderna says its COVID vaccine produced a strong antibody response for kids 6 to 11.

26 Oct, 2021 | 02:06h | UTC

Press release: Moderna Announces Positive Top Line Data from Phase 2/3 Study of COVID-19 Vaccine in Children 6 to 11 Years of Age

Commentary: Moderna says new data supports its COVID vaccine for kids 6 to 11 – NPR

 

Case Series: Toxic effects from ivermectin use associated with prevention and treatment of Covid-19.

26 Oct, 2021 | 02:02h | UTC

Toxic Effects from Ivermectin Use Associated with Prevention and Treatment of Covid-19 – New England Journal of Medicine

 

Pragmatic randomized trial found similar rates of surgical site infectious with 2% alcoholic chlorhexidine skin preparation compared with povidone–iodine, or with triclosan-coated sutures compared with non-coated sutures.

26 Oct, 2021 | 01:52h | UTC

Reducing surgical site infections in low-income and middle-income countries (FALCON): a pragmatic, multicentre, stratified, randomised controlled trial – The Lancet

Commentaries:

Prevention of surgical site infection in low-resource settings – The Lancet

Urgent changes needed to global guidelines designed to stop surgical infection – University of Birmingham

 

Commentary on Twitter

 

Infection with Covid-19 carries a much higher risk of developing neurological complications than Covid-19 vaccines.

26 Oct, 2021 | 02:04h | UTC

News Release: Infection with Covid-19 carries a much higher risk of developing neurological complications than a vaccine, says new study – University of Nottingham

Original Study: Neurological complications after first dose of COVID-19 vaccines and SARS-CoV-2 infection – Nature Medicine

Commentaries:

Covid: Vaccine study links virus to rare neurological illness – BBC

Expert reaction to study looking at rare neurological complications after SARS-CoV-2 infection and COVID-19 vaccination – Science Media Centre

 

Commentary on Twitter

 

Cohort Study: Bacterial Superinfection Pneumonia in Patients Mechanically Ventilated for COVID-19 Pneumonia – “Bacterial superinfection within 48 hours of intubation was detected in 21 percent of patients”.

26 Oct, 2021 | 01:59h | UTC

Bacterial Superinfection Pneumonia in Patients Mechanically Ventilated for COVID-19 Pneumonia – American Journal of Respiratory and Critical Care Medicine

Commentary: Potential Overuse of Antibiotics Found in Patients with Severe COVID-19 Pneumonia – American Thoracic Society

 

Commentary on Twitter

 

COVID: how worried should we be about the new AY.4.2 lineage of the coronavirus?

26 Oct, 2021 | 02:01h | UTC

COVID: how worried should we be about the new AY.4.2 lineage of the coronavirus? – The Conversation

 

What It Means To Be Fully Vaccinated.

26 Oct, 2021 | 01:57h | UTC

What It Means To Be Fully Vaccinated – Think Global Health

 

Adult-Onset Type 1 Diabetes: Current Understanding and Challenges.

26 Oct, 2021 | 01:47h | UTC

Adult-Onset Type 1 Diabetes: Current Understanding and Challenges – Diabetes Care

Related:

ADA Consensus Report: The Management of Type 1 Diabetes in Adults.

Guideline: ADA 2021 Standards of Medical Care in Diabetes

 

RCT: Laparoscopic vs. open distal gastrectomy for locally advanced gastric cancer.

26 Oct, 2021 | 01:40h | UTC

Laparoscopic vs Open Distal Gastrectomy for Locally Advanced Gastric Cancer: Five-Year Outcomes From the CLASS-01 Randomized Clinical Trial – JAMA Surgery (free for a limited period)

 

Commentary on Twitter

 

Consensus and algorithm on the diagnosis and management of Cushing’s disease: a guideline update.

26 Oct, 2021 | 01:49h | UTC

Consensus on diagnosis and management of Cushing’s disease: a guideline update – The Lancet Diabetes & Endocrinology (free registration required)

Related:

Meta-Analysis: Effectiveness of Medical Treatment for Cushing’s Syndrome

COVID-19 and Cushing’s Syndrome Recommendations

Practice recommendations for the management of the most common forms of secondary hypertension, including primary aldosteronism, renovascular hypertension, pheochromocytoma, Cushing’s syndrome, and sleep apnea

 

Commentary on Twitter

 

M-A: Strategies for antibiotic administration for bowel preparation among patients undergoing elective colorectal surgery – “the addition of oral antibiotics to intravenous antibiotics was associated with a reduction in the incidence of incisional surgical site infection by more than 50%”.

26 Oct, 2021 | 01:42h | UTC

Strategies for Antibiotic Administration for Bowel Preparation Among Patients Undergoing Elective Colorectal Surgery: A Network Meta-analysis – JAMA Surgery (free for a limited period)

Commentaries:

Bowel Preparation for Colorectal Surgery: Have All Questions Been Answered? – JAMA Surgery (free for a limited period)

Oral Abx Cut Surgical Site Infections in Colorectal Surgeries — Network meta-analysis finds over 50% SSI reduction with addition of oral to IV antibiotics – MedPage Today (free registration required)

Oral + IV Antibiotics for Bowel Prep Significantly Reduces Surgical Site Infections – Physician’s Weekly

 

Commentary on Twitter

 

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