All Posts
Brain injury after cardiac arrest: pathophysiology, treatment, and prognosis.
29 Oct, 2021 | 09:49h | UTC
Commentary on Twitter
Post-cardiac arrest brain injury, narrative review:
🧠pathophysiology: primary (ischemic) & secondary (reperfusion)
🧠treatment options
🧠outcomes
🧠neuroprognostication
🧠@ERC_resus @ESICM 2021 algorithm for prognostication
Open #FOAMcc #FOAMres @yourICM https://t.co/b8GRhE3MuF pic.twitter.com/q10DJVRJOp— Intensive Care Medicine (@yourICM) October 27, 2021
Stimulant prescription linked to increased short-term risks of cardiovascular events in older adults.
29 Oct, 2021 | 09:47h | UTCAssessment of Stimulant Use and Cardiovascular Event Risks Among Older Adults – JAMA Network Open
Commentaries:
Stimulants Linked to Early Risk of CV Events in Elderly – TCTMD
Stimulants May Pose Short-Term Cardiovascular Risks in Older Adults – Psychiatric News Alert
Predatory publishers’ latest scam: bootlegged and rebranded papers.
29 Oct, 2021 | 09:45h | UTCPredatory publishers’ latest scam: bootlegged and rebranded papers – Nature
Related: Predatory Journals: No Definition, No Defense
RCT: Early treatment of Covid-19 with SARS-CoV-2 neutralizing antibody Sotrovimab is associated with reduced risk of hospitalization.
28 Oct, 2021 | 10:20h | UTC
Commentary on Twitter
In this phase 3 trial, sotrovimab or placebo was administered to outpatients within 5 days after the onset of #COVID19 symptoms. Patients receiving sotrovimab had a lower incidence of hospitalization for any reason. #IDTwitter https://t.co/4VcgoK3xac pic.twitter.com/W82v3jNRmB
— NEJM (@NEJM) October 27, 2021
Merck to allow other nations to produce new COVID-19 antiviral.
28 Oct, 2021 | 10:18h | UTCMerck to allow other nations to produce new COVID-19 antiviral – CIDRAP
See also:
Merck will allow drugmakers in other countries to make its COVID-19 pill – NPR
Related:
Video: Merck’s Covid pill could transform treatment. Here’s how it works.
How antiviral pill Molnupiravir shot ahead in the COVID drug hunt.
What we know — and don’t know — about Merck’s new Covid-19 pill.
Merck’s Covid-19 pill is great news but may not be a game-changer.
Video | A Pill For COVID? A Doctor Explains Molnupiravir.
RCT: Early treatment with fluvoxamine reduced the risk of emergency care and hospitalization among patients with COVID-19.
28 Oct, 2021 | 10:22h | UTCCommentaries:
The TOGETHER Trial: COVID-19 and Fluvoxamine Take Two – REBEL EM
The antidepressant fluvoxamine can keep COVID-19 patients out of the hospital – ScienceNews
Related:
Commentary on Twitter
NEW in @LancetGH: Using SSRI #fluvoxamine to treat high-risk outpatients with early-diagnosed #COVID19 reduced the need for prolonged observation in an emergency setting or hospitalisation: largest trial to date. https://t.co/BVtMju74lp @TogetherTrial pic.twitter.com/F1FnZuyqdY
— The Lancet (@TheLancet) October 27, 2021
Two observational studies cast doubt on the effects of school closures to reduce the spread of Covid-19.
28 Oct, 2021 | 10:17h | UTCStudy 2: The impact of school opening model on SARS-CoV-2 community incidence and mortality – Nature Medicine
Commentaries on Twitter
Results from a study in the US published in @NatureMedicine indicate that schools can reopen for in-person learning without substantially increasing community case rates of SARS-CoV-2. However, the impacts are variable and more study is needed. https://t.co/NFt1vNNb76 pic.twitter.com/fNgsJn6WLg
— Nature Portfolio (@NaturePortfolio) October 27, 2021
(thread – click for more)
2 new @NatureMedicine papers
First from half of US public school data
"Schools can open for in-person learning during the pandemic with minimal contribution to sustained community incidence of infections, provided other public safety measures are adopted."https://t.co/gn8MzrYVxE pic.twitter.com/qGfQLMzDEW— Eric Topol (@EricTopol) October 27, 2021
Brain fog can persist for months after COVID diagnosis.
28 Oct, 2021 | 10:13h | UTCAssessment of Cognitive Function in Patients After COVID-19 Infection – JAMA Network Open
Commentaries:
Brain fog can persist 8 months after COVID diagnosis – CIDRAP
What COVID vaccines for young kids could mean for the pandemic.
28 Oct, 2021 | 10:15h | UTCWhat COVID vaccines for young kids could mean for the pandemic – Nature
Related: FDA advisory panel recommends Pfizer Covid-19 vaccine be authorized for children ages 5 to 11.
Longitudinal respiratory subphenotypes in patients with COVID-19-related acute respiratory distress syndrome: results from three observational cohorts.
28 Oct, 2021 | 10:11h | UTCCommentaries:
Respiratory Subphenotypes of COVID-19-Related ARDS – ICU Management & Practice
Commentary on Twitter
NEW—At baseline, #COVID19-related #ARDS has no consistent resp subphenotype. Pts diverged from fairly homogenous to a more heterogeneous popn, w/ trajectories of ventilatory ratio and mechanical power being the most discriminatory.
PRoVENT–COVID study: https://t.co/v8GTVcYLxq pic.twitter.com/Tv72jOzuAC
— The Lancet Respiratory Medicine (@LancetRespirMed) October 13, 2021
Systematic Review: Prophylactic antibiotics for preventing gram‐positive infections associated with long‐term central venous catheters in adults and children receiving treatment for cancer.
28 Oct, 2021 | 09:58h | UTC
ESC Consensus Document | Frailty in cardiology: definition, assessment and clinical implications for general cardiology.
28 Oct, 2021 | 09:59h | UTC
Systematic Review: Avoidance of bottles during the establishment of breastfeeds in preterm infants – “Avoiding the use of bottles when preterm infants need supplementary feeds probably increases the extent of any breastfeeding at discharge”.
28 Oct, 2021 | 09:56h | UTCAvoidance of bottles during the establishment of breastfeeds in preterm infants – Cochrane Library
Summary: Avoidance of bottles during the establishment of breastfeeds in preterm infants – Cochrane Library
Does procalcitonin have clinical utility in the management of pediatric community-acquired pneumonia? A PRO/CON debate.
28 Oct, 2021 | 09:54h | UTCPRO: Procalcitonin has clinical utility in children with community-acquired pneumonia
CON: Procalcitonin does not have clinical utility in children with community-acquired pneumonia
RCT: Daratumumab, lenalidomide, and dexamethasone vs. lenalidomide and dexamethasone alone in newly diagnosed multiple myeloma.
28 Oct, 2021 | 09:53h | UTC
Retrospective cohort study: corticosteroid treatment linked to lower odds of surgical drainage among pediatric patients with retropharyngeal and parapharyngeal abscesses.
28 Oct, 2021 | 09:52h | UTC
RCT: A geriatric assessment–driven intervention can reduce chemotherapy-related toxic effects in older adults with cancer.
28 Oct, 2021 | 09:50h | UTCGeriatric Assessment–Driven Intervention (GAIN) on Chemotherapy-Related Toxic Effects in Older Adults With Cancer: A Randomized Clinical Trial – JAMA Oncology (link to abstract – $ for full-text)
Commentary on Twitter
Randomized trial with 604 older patients with cancer starting a new chemo regimen showed the incidence of grade 3 or higher chemo-related toxic effects was significantly lower in those who underwent a geriatric assessment-driven intervention https://t.co/QtOgmLDRU1
— JAMA Oncology (@JAMAOnc) October 1, 2021
RCT: Extended follow-up of local steroid injection for carpal tunnel syndrome.
28 Oct, 2021 | 09:46h | UTC
Commentary on Twitter
In carpal tunnel syndrome, this randomized trial of local steroid vs placebo injection shows similar symptom severity score improvement but a significant small reduction in rate of and longer time to surgery after steroid. @IsamAtroshi @jonasranstam https://t.co/s5LibRnFaV
— JAMA Network Open (@JAMANetworkOpen) October 22, 2021
Recurrent Glomerular Disease after Kidney Transplantation: Diagnostic and Management Dilemmas.
28 Oct, 2021 | 09:43h | UTC
Commentary on Twitter
Recurrent glomerular disease after kidney transplant remains an important cause of allograft failure. This Review focuses on clinical dilemmas encountered by physicians in managing recurrent glomerular disease https://t.co/QGZOjH7qyP
— CJASN (@CJASN) October 27, 2021
Review: Genome sequencing as a diagnostic test.
28 Oct, 2021 | 09:42h | UTCGenome sequencing as a diagnostic test – Canadian Medical Association Journal
Breakthrough infections occur in those with lower antibody levels.
27 Oct, 2021 | 01:45h | UTCOriginal study: Covid-19 Breakthrough Infections in Vaccinated Health Care Workers – New England Journal of Medicine
FDA advisory panel recommends Pfizer Covid-19 vaccine be authorized for children ages 5 to 11.
27 Oct, 2021 | 01:48h | UTCFDA advisory panel recommends Pfizer Covid-19 vaccine be authorized for children – STAT
See also:
Tracking the FDA advisory panel meeting on Covid-19 vaccines for kids – STAT
FDA advisory panel recommends Pfizer vaccine for kids ages 5 to 11 – NPR
Mix-and-match COVID vaccines ace the effectiveness test – “No need for brand loyalty”.
27 Oct, 2021 | 01:42h | UTCMix-and-match COVID vaccines ace the effectiveness test – Nature
Related:
Should You Mix and Match Your Booster Shot?
A primer on what we know about mixing and matching Covid vaccines.
Another study shows increased immune response with heterologous Oxford-AstraZeneca/mRNA vaccination.
RCT: Mixing 2 different Covid vaccines is associated with increased risk of side effects.
Heterologous AstraZeneca/Pfizer vaccination seems to be associated with increased effectiveness against Covid-19 compared to homologous Pfizer/Pfizer vaccination.
27 Oct, 2021 | 01:44h | UTCImmunogenicity and efficacy of heterologous ChadOx1/BNT162b2 vaccination – Nature
Related:
Should You Mix and Match Your Booster Shot?
A primer on what we know about mixing and matching Covid vaccines.
Another study shows increased immune response with heterologous Oxford-AstraZeneca/mRNA vaccination.
RCT: Mixing 2 different Covid vaccines is associated with increased risk of side effects.
Commentary on Twitter
A dose of the AstraZeneca COVID-19 vaccine followed by a dose of the Pfizer/BioNTech vaccine confers better protection against SARS-CoV-2 infection than two doses of the Pfizer vaccine, according to a study in healthcare workers published in @Nature. https://t.co/6hIVkiOLQ1 pic.twitter.com/AmsyVUMpoj
— Nature Portfolio (@NaturePortfolio) October 26, 2021
What game theory can teach us about controlling pandemics.
27 Oct, 2021 | 01:39h | UTCWhat game theory can teach us about controlling pandemics – The BMJ Opinion
Commentary on Twitter
https://twitter.com/glassmanamanda/status/1451498564044136450