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Short Review: Ketamine for the treatment of acute pain.

2 Nov, 2021 | 02:43h | UTC

Ketamine for the treatment of acute pain – Canadian Medical Association Journal

 

Commentary on Twitter

 

Observational study suggests a third dose of the Pfizer COVID-19 vaccine can prevent severe COVID-19-related outcomes, compared with only two doses received at least 5 months before.

31 Oct, 2021 | 20:14h | UTC

Effectiveness of a third dose of the BNT162b2 mRNA COVID-19 vaccine for preventing severe outcomes in Israel: an observational study – The Lancet

Invited Commentary: Boosters appear effective, but are they always needed? – The Lancet

 

Commentaries on Twitter

 

Study shows fully vaccinated individuals can still catch SARS-CoV-2 delta variant and efficiently transmit infection in household settings, including to fully vaccinated contacts.

31 Oct, 2021 | 20:16h | UTC

Community transmission and viral load kinetics of the SARS-CoV-2 delta (B.1.617.2) variant in vaccinated and unvaccinated individuals in the UK: a prospective, longitudinal, cohort study – The Lancet Infectious Diseases

Commentaries:

COVID vaccines effective but household transmission of delta a risk for 1 in 4 – Imperial College London

What is the vaccine effect on reducing transmission in the context of the SARS-CoV-2 delta variant? – The Lancet Infectious Diseases

CoVID-19 vaccines lower risk of infection with delta variant, but infection can still be passed on in household settings – the Lancet

COVID vaccines protect against Delta but don’t fully stop disease spread – CIDRAP

Covid: Double vaccinated can still spread virus at home – BBC

 

Commentary on Twitter

 

Editorial: Safety and efficacy of antivirals against SARS-CoV-2 – “we need evidence not optimism”.

31 Oct, 2021 | 20:11h | UTC

Safety and efficacy of antivirals against SARS-CoV-2 – The BMJ

 

Commentary on Twitter

 

CDC Study: COVID-19 vaccine associated with 5 times the protection of ‘natural immunity’.

31 Oct, 2021 | 20:09h | UTC

Laboratory-Confirmed COVID-19 Among Adults Hospitalized with COVID-19–Like Illness with Infection-Induced or mRNA Vaccine-Induced SARS-CoV-2 Immunity — Nine States, January–September 2021 – CDC Morbidity and Mortality Weekly Report

Commentaries:

COVID-19 vaccine gives 5 times the protection of ‘natural immunity,’ data show – CIDRAP

COVID shots more protective than past infection, study shows – Associated Press

 

Commentary on Twitter

 

Cohort Study: Among patients with ST-segment elevation myocardial infarction, a concomitant Covid-19 diagnosis is associated with increased in-hospital mortality.

31 Oct, 2021 | 20:10h | UTC

Association Between COVID-19 Diagnosis and In-Hospital Mortality in Patients Hospitalized With ST-Segment Elevation Myocardial Infarction – JAMA

Editorial: Myocardial Infarction During the COVID-19 Pandemic – JAMA

Commentary: STEMI and COVID-19 Often a Lethal Combo, Affirms Largest Study Yet – TCTMD

 

Commentary from the author on Twitter (thread – click for more)

 

Opinion | Is Moderna really better than Pfizer—or is it just a higher dose?

31 Oct, 2021 | 20:06h | UTC

Is Moderna Really Better Than Pfizer—Or Is It Just a Higher Dose? – The Atlantic

Related: CDC Report: Moderna’s vaccine associated with greater effectiveness (93%) against Covid-19 hospitalization compared to Pfizer (88%) and J&J (71%) vaccines.

 

Commentary on Twitter

 

NICE Guideline | Myalgic encephalomyelitis (or encephalopathy)/chronic fatigue syndrome: diagnosis and management.

31 Oct, 2021 | 20:03h | UTC

Myalgic encephalomyelitis (or encephalopathy)/chronic fatigue syndrome: diagnosis and management – National Institute for Health and Care Excellence

Commentaries:

Chronic fatigue syndrome advice scraps exercise therapy – BBC

ME exercise therapy guidance scrapped by health watchdog Nice – The Guardian

 

RCT: Targeting higher intraoperative blood pressures does not reduce adverse cardiovascular events following noncardiac surgery.

31 Oct, 2021 | 20:00h | UTC

Targeting Higher Intraoperative Blood Pressures Does Not Reduce Adverse Cardiovascular Events Following Noncardiac Surgery – Journal of the American College of Cardiology

 

Cardiovascular clinical examination: the need for an evidence-based approach.

31 Oct, 2021 | 19:57h | UTC

Cardiovascular clinical examination: the need for an evidence-based approach – European Heart Journal

 

Commentary on Twitter

 

Study suggests smoking cessation, but not reduction, is associated with reduced risk of cardiovascular disease.

31 Oct, 2021 | 19:59h | UTC

Smoking cessation, but not reduction, reduces cardiovascular disease incidence – European Heart Journal (link to abstract – $ for full-text)

 

Commentary on Twitter

 

Review: Clinical management of pancreatic premalignant lesions.

31 Oct, 2021 | 19:56h | UTC

Clinical Management of Pancreatic Premalignant Lesions – Gastroenterology

 

Imaging of congenital lung diseases presenting in the adulthood: a pictorial review.

31 Oct, 2021 | 19:53h | UTC

Imaging of congenital lung diseases presenting in the adulthood: a pictorial review – Insights into Imaging

 

Update to post-acute sequelae of SARS-CoV-2 infection: Caring for the ‘long-haulers’.

29 Oct, 2021 | 10:20h | UTC

Update to post-acute sequelae of SARS-CoV-2 infection: Caring for the ‘long-haulers’ – Cleveland Clinic Journal of Medicine

Related:

Systematic Review: Short-term and long-term rates of postacute sequelae of SARS-CoV-2 infection.

WHO Consensus: A clinical case definition of post COVID-19 condition (Long Covid).

Characterizing long COVID: a living systematic review.

Long Covid – The illness narratives.

New guidelines to help doctors manage long COVID patients published.

M-A: More than 50 long-term effects of COVID-19. (several articles on the subject)

 

Review: How I manage a patient with MRSA bacteremia.

31 Oct, 2021 | 19:54h | UTC

How I manage a patient with MRSA bacteraemia – Clinical Microbiology and Infection

 

The effectiveness of the AstraZeneca vaccine in older adults during SARS-CoV-2 Gamma variant circulation in São Paulo was 77.9% against symptomatic Covid-19, 87.6% against hospitalization, and 93.6% against death.

29 Oct, 2021 | 10:25h | UTC

Effectiveness of ChAdOx1 vaccine in older adults during SARS-CoV-2 Gamma variant circulation in São Paulo – Nature Medicine

 

Commentary on Twitter (thread – click for more)

https://twitter.com/MHitchingsEpi/status/1453779176826105857

 

Under-reporting of deaths limits our understanding of true burden of covid-19.

29 Oct, 2021 | 10:18h | UTC

Under-reporting of deaths limits our understanding of true burden of covid-19 – The BMJ

Related:

Study shows COVID-19 has caused the biggest decrease in life expectancy since World War II.

Just how do deaths due to COVID-19 stack up?

Tracking excess mortality across countries during the COVID-19 pandemic with the World Mortality Dataset.

Exploring the gap between excess mortality and COVID-19 deaths in 67 countries.

Report: Three new estimates of India’s all-cause excess mortality during the COVID-19 Pandemic – pandemic death toll estimated to be between 3.4 million and 4.9 million excess deaths.

COVID-19 has caused 6.9 million deaths globally, more than double what official reports show

 

Commentary on Twitter

 

Complications of critical COVID-19: Diagnostic and therapeutic considerations for the mechanically ventilated patient.

29 Oct, 2021 | 10:14h | UTC

Complications of critical COVID-19: Diagnostic and therapeutic considerations for the mechanically ventilated patient – Chest

 

mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern.

29 Oct, 2021 | 10:16h | UTC

mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern – Science

 

Commentary from the author on Twitter (thread – click for more)

 

2021 AHA/ACC Guideline for the Evaluation and Diagnosis of Chest Pain.

29 Oct, 2021 | 09:57h | UTC

2021 AHA/ACC/ASE/CHEST/SAEM/SCCT/SCMR Guideline for the Evaluation and Diagnosis of Chest Pain: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines – Journal of the American College of Cardiology

Executive Summary: 2021 AHA/ACC/ASE/CHEST/SAEM/SCCT/SCMR Guideline for the Evaluation and Diagnosis of Chest Pain – Journal of the American College of Cardiology

News Release: First-Ever Guideline Focused Solely on Chest Pain Evaluation, Diagnosis Released

Guideline Hub: Guideline for the Evaluation and Diagnosis of Chest Pain

Key Points: 2021 AHA/ACC Chest Pain Guideline – American College of Cardiology

Commentary: New Chest Pain Guidelines Out at Last: Most Tests Have a Role – TCTMD

 

Commentary on Twitter (thread – click for more)

 

Nine Pandemic Words That Almost No One Gets Right.

29 Oct, 2021 | 10:12h | UTC

Nine Pandemic Words That Almost No One Gets Right – The Atlantic

 

Systematic Review: Not enough evidence to inform the decision to either interrupt or continue anticoagulation before catheter ablation in patients with arrhythmia.

29 Oct, 2021 | 09:50h | UTC

Interrupted versus uninterrupted anticoagulation therapy for catheter ablation in adults with arrhythmias – Cochrane Library

Summary: The continuation or discontinuation of oral anticoagulants for people with arrhythmia and undergoing catheter ablation – Cochrane Library

 

Systematic Review: GLP-1 receptor agonists and SGLT-2 inhibitors are likely to reduce the risk of death from cardiovascular disease and death from any cause in people with both diabetes and established cardiovascular disease.

29 Oct, 2021 | 09:52h | UTC

Dipeptidyl peptidase‐4 inhibitors, glucagon‐like peptide 1 receptor agonists and sodium‐glucose co‐transporter‐2 inhibitors for people with cardiovascular disease: a network meta‐analysis – Cochrane Library

Summary: The effects of DPP-4 inhibitors, GLP-1 receptor agonists and SGLT-2 inhibitors for people with cardiovascular disease – Cochrane Library

 

Commentary on Twitter

 

WHO Guideline for clinical management of exposure to lead.

29 Oct, 2021 | 09:56h | UTC

Guideline for clinical management of exposure to lead – World Health Organization

Executive Summary: Guideline for clinical management of exposure to lead

See also: International Lead Poisoning Prevention Week 2021

 

Commentary on Twitter (thread – click for more)

 

Systematic Review: Management of cutaneous immune-related adverse events in patients with cancer treated with immune checkpoint inhibitors.

29 Oct, 2021 | 09:46h | UTC

Management of Cutaneous Immune-Related Adverse Events in Patients With Cancer Treated With Immune Checkpoint Inhibitors: A Systematic Review – JAMA Oncology (free for a limited period)

 

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