RCT: In comatose survivors of out-of-hospital cardiac arrest, there was no difference in mortality and neurologic outcomes with mild (target temperature of 34 °C) vs. moderate therapeutic hypothermia (target temperature of 31 °C).

Effect of Moderate vs Mild Therapeutic Hypothermia on Mortality and Neurologic Outcomes in Comatose Survivors of Out-of-Hospital Cardiac Arrest: The CAPITAL CHILL Randomized Clinical Trial – JAMA (free for a limited period)

Related:

Cooling After Cardiac Arrest – The Sclerosis of Therapeutic Fashion – “The story of how an ineffective therapy persisted for decades”

RCT: In patients with coma after out-of-hospital cardiac arrest, targeted hypothermia did not improve outcomes.

Study commentary: a history of hypothermia for cardiac arrest, 2002-2021 (RIP).

M-A: Targeted temperature management following out-of-hospital cardiac arrest – “Routine use of moderate or deep hypothermia in comatose survivors of OHCA may potentially be associated with more harm than benefit”.

Commentary on Twitter

therapeutic hypothermia after cardiac arrest is a nonbeneficial form of iatrogenesis that prolongs ICU length of stay (findings entirely consistent with TTM & TTM2). currently it should not be performed outside the context of an RCT. https://t.co/GZbpgHXWoD https://t.co/kRwRpLz6hV

— ???? ?????? ? (@PulmCrit) October 20, 2021