Archives
Debate: Should we delay second vaccine doses to give one dose of the Covid-19 vaccine to more people?
10 Jan, 2021 | 20:51h | UTC- Editorial: U.S. COVID-19 Vaccination Challenges Go Beyond Supply – Annals of Internal Medicine
- Speed Versus Efficacy: Quantifying Potential Tradeoffs in COVID-19 Vaccine Deployment – Annals of Internal Medicine
- A Public Health COVID-19 Vaccination Strategy to Maximize the Health Gains for Every Single Vaccine Dose – Annals of Internal Medicine
- Alternative Dose Allocation Strategies to Increase Benefits From Constrained COVID-19 Vaccine Supply – Annals of Internal Medicine
- Delaying the second COVID vaccine dose – a medical expert answers key questions – The Conversation
- Should we give one dose of the Covid-19 vaccine to more people? The debate, explained. – Vox
- Debates intensify over dosing plans for authorized COVID-19 vaccines – Science
- Covid-19 vaccination: What’s the evidence for extending the dosing interval? – The BMJ Opinion
- Covid-19 vaccines: to delay or not to delay second doses – The BMJ Opinion
- Britain takes a gamble with Covid-19 vaccines, upping the stakes for the rest of us – STAT
- UK Delay of Second COVID-19 Vaccine Dose – A Risky Strategy That Could Give Rise To More Virus Mutations, Some Experts Warn – Health Policy Watch
- What’s the scientific basis for delaying the Covid vaccine second dose? – The Guardian
- FDA says people need both doses of coronavirus vaccines – CNN
- WHO experts weigh in on COVID-19 vaccine dose interval – CIDRAP
- For mRNA vaccines, we should stick to the schedule – The Guardian
- Expert comment on whether giving two doses of COVID vaccine separated by a longer period is sensible – Science Media Centre
- How safe is it to switch and space COVID-19 vaccine doses? – Reuters
[Press release – results not published yet] International trials of blood thinners in critically ill COVID-19 patients pause due to futility
10 Jan, 2021 | 20:44h | UTC
Commentary on Twitter
The 3 largest RCTs of therapeutic #anticoagulation for #COVID19 pts in the ICU have ALL been stopped early for futility. (@remap_cap @ATTACC_COVID & #ACTIV4)
Nothing published yet, but given the large n of these RCTs, I'm increasingly skeptical about anticoagulation in COVID19. pic.twitter.com/RrLSoOsp3v
— Nick Mark MD (@nickmmark) December 22, 2020
Sinovac vaccine 78% effective in Brazil trial, experts call for more details
10 Jan, 2021 | 20:46h | UTCSinovac vaccine 78% effective in Brazil trial, experts call for more details – Reuters
Long Covid: 6-month consequences of COVID-19 in patients discharged from hospital
10 Jan, 2021 | 20:43h | UTC6-month consequences of COVID-19 in patients discharged from hospital: a cohort study – The Lancet
Commentaries: Most patients hospitalized for Covid-19 still have symptoms six months later, China study finds AND Long-term follow-up of recovered patients with COVID-19 – The Lancet
Commentary on Twitter
Largest #LongCovid cohort @TheLancet just published:
6 months post-hospital,
—76% still had ≥ 1 symptom
—63% fatigue/muscle weakness
—sleep, anxiety, depression common
—Sig % w/CT lung abnormalities
—13% had abnormal kidney function https://t.co/zfRf7MGdxB pic.twitter.com/LI4DaJPis8— Eric Topol (@EricTopol) January 8, 2021
Randomized trial: Low-dose digoxin results in similar patient-reported quality of life compared to bisoprolol for heart rate control in atrial fibrillation
10 Jan, 2021 | 20:37h | UTCEffect of Digoxin vs Bisoprolol for Heart Rate Control in Atrial Fibrillation on Patient-Reported Quality of Life: The RATE-AF Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)
Editorial: Digitalis Glycosides for Heart Rate Control in Atrial Fibrillation
Commentary: Digoxin Could Sub for Beta-Blockers in Certain Afib Patients – Physician’s Weekly
Commentary on Twitter
In this RCT, low-dose #digoxin led to no difference in patient-reported quality of life at 6 months vs bisoprolol in patients with permanent atrial fibrillation and symptoms of heart failure. @ICVS_UoB #afib https://t.co/XtCPdba5xg
— JAMA (@JAMA_current) December 28, 2020
WHO: 10 global health issues to track in 2021
10 Jan, 2021 | 20:38h | UTC10 global health issues to track in 2021 – World Health Organization
Commentary on Twitter (thread – click for more)
As an unprecedented year comes to a close and a New Year beckons, here are 🔟 global health issues WHO and our partners will focus on in 2021
— World Health Organization (WHO) (@WHO) December 28, 2020
[Preprint] Characterizing Long COVID in an International Cohort: 7 Months of Symptoms and Their Impact
10 Jan, 2021 | 20:41h | UTCRelated: Explanations for ‘long Covid’ remain elusive. For now, believing patients and treating symptoms is the best doctors can do – STAT AND Long COVID: who is at risk? – The Conversation
Commentary on Twitter
How long is #LongCovid?
The most extensive symptom assessment and longest duration (7 months) of nearly 3,800 individuals shows how debilitating this is in young, predominantly women, w/ most unable to return to full prior work https://t.co/o0YUNse1EA @ahandvanish @AthenaAkrami pic.twitter.com/3miXJFdVp0— Eric Topol (@EricTopol) December 29, 2020
Randomized trial: In extremely-low-birth-weight infants, a higher hemoglobin threshold for red-cell transfusion does not improve outcomes
10 Jan, 2021 | 20:36h | UTCHigher or Lower Hemoglobin Transfusion Thresholds for Preterm Infants – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Higher red cell transfusion threshold offers no advantage for treating preterm infants – NIH News Releases
Randomized trial: Proton pump inhibitors do not benefit patients with persistent throat symptoms
10 Jan, 2021 | 20:32h | UTC
Commentary on Twitter
Medicating random throat symptoms with proton pump inhibitors (for months) has, somehow, become routine care despite no gd evidence it actually helps.
So guess what happens if you compare 16 wk of double dose PPI with placebo in a proper trial?
…Yeah.https://t.co/mrnq4tcEUk pic.twitter.com/uZo630Sg9j
— Jussi Mustonen (@JusiMD) January 8, 2021
Randomized trial: Ultra-early tranexamic acid does not improve outcomes after subarachnoid hemorrhage
10 Jan, 2021 | 21:02h | UTCUltra-early tranexamic acid after subarachnoid haemorrhage (ULTRA): a randomised controlled trial – The Lancet (link to abstract – $ for full-text)
Tranexamic acid treatment in spontaneous subarachnoid haemorrhage, started immediately after CT diagnosis and continued until start of the aneurysm treatment as early as possible, does not improve clinical outcome, finds new randomised controlled trial: https://t.co/R0AhtszaY5 pic.twitter.com/Bnft9XgBA9
— The Lancet (@TheLancet) December 22, 2020
Open Access: Textbook of Patient Safety and Clinical Risk Management
10 Jan, 2021 | 20:34h | UTCTextbook of Patient Safety and Clinical Risk Management – Springer
Commentary on Twitter
https://twitter.com/helenbevan/status/1343127378650935298
Editorial – Two decades since “To Err Is Human”: Progress, but still a “chasm”
10 Jan, 2021 | 20:33h | UTCTwo Decades Since “To Err Is Human”: Progress, but Still a “Chasm” – JAMA
Author interview: To Err Is Human: 20 Years of Health Care Quality
Toward a bias-free and inclusive medical curriculum: Development and implementation of student-initiated guidelines and monitoring mechanisms at one institution
10 Jan, 2021 | 20:28h | UTC
Commentary on Twitter
Authors present an approach and resources from which other institutions can learn, with the goal of reducing #ImplicitBias and improving inclusiveness throughout #MedEd: https://t.co/d3LdImmU86. #inclusion @ColumbiaPS
— Academic Medicine (@AcadMedJournal) October 8, 2020
AAP Guideline: Identification and management of eating disorders in children and adolescents
10 Jan, 2021 | 20:30h | UTCIdentification and Management of Eating Disorders in Children and Adolescents – Pediatrics
Commentary: Pediatrics Group Offers Guidance on Managing Eating Disorders in Youth – NEJM Journal Watch
Systematic review: Effectiveness of hospital clowns for symptom management in pediatrics
10 Jan, 2021 | 20:24h | UTCCommentaries: Clowns may help children cope with the pain and anxiety of hospital treatment – The BMJ AND Clowns Make Hospitals Less Scary For Young Patients – Forbes AND Laughter As Medicine: Clowns Help Hospitalized Kids Cope – U.S News
Commentary on Twitter
As a gift 🎁 to children everywhere, a @bmj_latest study shows that sending in the clowns – in pediatric hospital settings – may reduce children's stress, fatigue, #pain, and distress during a range of medical procedures"
By @lopesjr_phd, @Naramata4 et al#bioethics #ChronicPain pic.twitter.com/hmnXRv3J8Q— Sandra Woods, CIPP/C; she/her (@SandraWoodsMtl) December 25, 2020
Randomized trial: Laparoscopic lavage vs. primary resection for perforated purulent diverticulitis; similar long-term results, but recurrence was more common after laparoscopic lavage
10 Jan, 2021 | 20:25h | UTCLaparoscopic Lavage vs Primary Resection for Acute Perforated Diverticulitis: Long-term Outcomes From the Scandinavian Diverticulitis (SCANDIV) Randomized Clinical Trial – JAMA Surgery (link to abstract – $ for full-text)
Commentary: Laparoscopic Lavage a Safe Option in Perforated Diverticulitis — No difference versus resection in long-term severe complications, but recurrence more common – MedPage Today (free registration required)
Observational study: Childhood growth hormone treatment linked to increased risks of cardiovascular events in early adulthood
10 Jan, 2021 | 20:27h | UTCAssociation of Childhood Growth Hormone Treatment With Long-term Cardiovascular Morbidity – JAMA Pediatrics (link to abstract – $ for full-text)
Commentaries: Childhood Tx with Growth Hormone May Up Cardiovascular Risks Later – Physician’s Weekly AND Growth Hormones in Childhood Tied to Heart Problems Later On – MedPage Today (free registration required)
Axial spondyloarthritis: New advances in diagnosis and management
10 Jan, 2021 | 20:22h | UTCState of the Art Review: Axial spondyloarthritis: new advances in diagnosis and management – The BMJ
Review: Management of Crohn Disease
10 Jan, 2021 | 20:20h | UTCManagement of Crohn Disease: A Review – JAMA (free for a limited period)
Podcast: Crohn Disease Management – JAMA
Guideline Synopsis: Management of patients with a patent foramen ovale with history of stroke or TIA
10 Jan, 2021 | 20:19h | UTCManagement of Patients With a Patent Foramen Ovale With History of Stroke or TIA – JAMA (free for a limited period)
Original Guideline: Practice advisory update summary: Patent foramen ovale and secondary stroke prevention: Report of the Guideline Subcommittee of the American Academy of Neurology – Neurology
Medical errors in the pediatric emergency department: Don’t make these mistakes!
10 Jan, 2021 | 20:21h | UTC
Study suggests that 7 days of home blood pressure monitoring is likely better than 24h ambulatory monitoring or 3 office measurements
10 Jan, 2021 | 20:17h | UTCEditorial: Which Blood Pressure Measurement Best Predicts Cardiovascular Outcomes?
Commentary: Is Home BP Monitoring the Best Approach For Diagnosing HTN? – American College of Cardiology
Meta-analysis: Effectiveness of bundle interventions on ICU delirium
10 Jan, 2021 | 20:16h | UTCEffectiveness of Bundle Interventions on ICU Delirium: A Meta-Analysis – Critical Care Medicine
Commentary: ICU bundles do not appear to improve delirium but may help other outcomes – ACP Hospitalist
Commentary on Twitter
Meta-Analysis incl 11 studies and 26,384 patients for bundle-interventions of delirium treatment showed no effects on delirum duration ( –1.42 d; 95% CI –3.06 to 0.22) or prevalence (risk ratio = 0.92; 95% CI, 0.68–1.24)https://t.co/PzZBGttOL8
— Peter Nydahl (@NydahlPeter) December 18, 2020
NICE Guideline: Managing the long-term effects of COVID-19
18 Dec, 2020 | 10:27h | UTC
Systematic review: Melatonin may have a similar effect to benzodiazepines in reducing preoperative and postoperative anxiety in adults
10 Jan, 2021 | 20:14h | UTCMelatonin for preoperative and postoperative anxiety in adults – Cochrane Library
Summary: Melatonin for preoperative and postoperative anxiety in adults – Cochrane Library