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Effects of low sodium diet vs. high sodium diet on blood pressure, renin, aldosterone, catecholamines, cholesterol, and triglyceride

10 Jan, 2021 | 20:12h | UTC

Effects of low sodium diet versus high sodium diet on blood pressure, renin, aldosterone, catecholamines, cholesterol, and triglyceride – Cochrane Library

Summary: The effect of a low salt diet on blood pressure and some hormones and lipids in people with normal and elevated blood pressure – Cochrane Library

NICE Guideline: Do not use Vitamin D to prevent or treat COVID 19

18 Dec, 2020 | 10:03h | UTC

COVID-19 rapid guideline: vitamin D – National Institute for Health and Care Excellence

News release: NICE, PHE and SACN publish rapid COVID-19 guidance on vitamin D

Commentaries: Covid and vitamin D: ‘Not enough evidence’ for treatment – BBC AND Covid-19: Evidence is lacking to support vitamin D’s role in treatment and prevention – The BMJ

Commentary on Twitter

https://twitter.com/onisillos/status/1339485382501666816

Vaccines are here. We have to talk about side effects

18 Dec, 2020 | 09:59h | UTC

Vaccines Are Here. We Have to Talk About Side Effects – Wired

Commentary on Twitter

All vaccines have side effects and trust comes from freely discussing them. Nice piece by ⁦@marynmck⁩ https://t.co/eUISXTiFVP

— Madhu Pai, MD, PhD (@paimadhu) December 17, 2020

“Racial Bias in Pulse Oximetry Measurement”. In two large cohorts, Black patients had nearly three times the frequency of occult hypoxemia that was not detected by pulse oximetry as White patients

18 Dec, 2020 | 10:01h | UTC

Racial Bias in Pulse Oximetry Measurement – New England Journal of Medicine

Commentary: Devices Used In COVID-19 Treatment Can Give Errors For Patients With Dark Skin – NPR

Commentary on Twitter (thread – click for more)

1/ Our research letter on racial bias in pulse oximetry measurement, out today in NEJM https://t.co/6dLuNGosxp pic.twitter.com/XXsfWfc5dv

— Michael Sjoding (@msjoding) December 17, 2020

COVID 5 times deadlier than flu for hospital patients, study finds

18 Dec, 2020 | 09:53h | UTC

COVID 5 times deadlier than flu for hospital patients, study finds – CIDRAP

Original study: Comparative evaluation of clinical manifestations and risk of death in patients admitted to hospital with covid-19 and seasonal influenza: cohort study – The BMJ

Commentary on Twitter

Among people admitted to hospital, #COVID19 was associated with increased risk of various extrapulmonary clinical manifestations, compared with seasonal influenza #BMJResearch https://t.co/R0J9HCvsH2

— The BMJ (@bmj_latest) December 16, 2020

Studies reveal deadliness of COVID-19, even in young adults

18 Dec, 2020 | 09:57h | UTC

Data reveal deadliness of COVID-19, even in young adults – CIDRAP

Study 1: All-Cause Excess Mortality and COVID-19–Related Mortality Among US Adults Aged 25-44 Years, March-July 2020 – JAMA

Study 2: Impact of Population Growth and Aging on Estimates of Excess U.S. Deaths During the COVID-19 Pandemic, March to August 2020 – Annals of Internal Medicine

Studies warn of COVID vaccine access issues for low-income nations

18 Dec, 2020 | 09:54h | UTC

Studies warn of COVID vaccine access issues for low-income nations – CIDRAP

Study 1: Reserving coronavirus disease 2019 vaccines for global access: cross sectional analysis – The BMJ

Study 2: Global, regional, and national estimates of target population sizes for covid-19 vaccination: descriptive study – The BMJ

Editorial: Equitable global access to coronavirus disease 2019 vaccines – The BMJ

Inclusion of pregnant women in COVID-19 treatment trials: a review and global call to action

18 Dec, 2020 | 09:52h | UTC

Inclusion of pregnant women in COVID-19 treatment trials: a review and global call to action – The Lancet Global Health

Commentaries: Pregnant women excluded from three-quarters of COVID-19 treatment trials – The Lancet AND Expert reaction to opinion piece on pregnant women and COVID-19 treatment trials – Science Media Centre

Commentary on Twitter (thread – click for more)

NEW—Pregnant women are among those most in need of safe and effective therapies against #COVID19, but are routinely excluded from 3/4 of treatment trials. Read the review published in @LancetGH: https://t.co/xvBfHqnHMe @WHO pic.twitter.com/pBuTcsUZ0O

— The Lancet (@TheLancet) December 17, 2020

Survey: Around 1 in 5 COVID-19 patients exhibit symptoms for a period of 5 weeks or longer; Around 1 in 10 COVID-19 patients exhibit symptoms for a period of 12 weeks or longer

18 Dec, 2020 | 09:49h | UTC

The prevalence of long COVID symptoms and COVID-19 complications – Office of National Statistics

Commentary on Twitter

The prevalence of long COVID symptoms & COVID-19 complications published by @ONS

10% of covid positive patients exhibit symptoms for a period of > 12 weeks
20% for > 5 weeks

Great work by @DanAyoubkhani @Vnafilyan https://t.co/8YgxkCG847

@martinmckee pic.twitter.com/Itizxkk8xC

— Prof Kamlesh Khunti (@kamleshkhunti) December 17, 2020

Neuroimaging manifestations in children with SARS-CoV-2 infection: a multinational, multicenter collaborative study

18 Dec, 2020 | 09:50h | UTC

Neuroimaging manifestations in children with SARS-CoV-2 infection: a multinational, multicentre collaborative study – The Lancet Child & Adolescent Health

Commentary: Study highlights neurological impact of COVID-19 on children – University of Manchester

Commentary on Twitter (thread – click for more)

New #COVID19 Research: An international call for cases identified 38 children with neurological disease related to #SARSCoV2 infection

Recurring patterns of disease were identified, with #neuroimaging abnormalities ranging from mild to severehttps://t.co/a3bjPlOY0z pic.twitter.com/W0lxLP4aAh

— The Lancet Child & Adolescent Health (@LancetChildAdol) December 16, 2020

2020 ACC/AHA Guideline for the management of patients with valvular heart disease

18 Dec, 2020 | 09:45h | UTC

2020 ACC/AHA Guideline for the Management of Patients With Valvular Heart Disease: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines – Journal of the American College of Cardiology

News release: Updated guideline for heart valve disease spotlights less invasive treatments

Key Perspectives: Part 1

Key Perspectives: Part 2

Key Perspectives: Part 3

Commentary on Twitter

New ACC/@American_Heart Guideline for the Management of patients with #cvVHD includes expanded treatment options; recommends less invasive interventions, when possible; and stresses the importance of #SharedDecisionMaking. Read it in #JACC: https://t.co/g9RE9buXNC pic.twitter.com/jnwt8d5QC7

— JACC Journals (@JACCJournals) December 17, 2020

Publication bias: a problem that leaves us without the full picture on the benefits and harms of treatments

18 Dec, 2020 | 09:37h | UTC

Publication bias: a problem that leaves us without the full picture on the benefits and harms of treatments – Evidently Cochrane

Commentary on Twitter

Publication bias: a problem that leaves us without the full picture on the benefits & harms of treatments https://t.co/ShKZLEiXiv The last blog in @CochraneUK's special series explores why publication bias is so problematic for people making decisions about health care. #OhReally pic.twitter.com/isS1eT4ObZ

— Students4BE (@Students4BE) December 17, 2020

Randomized trial: In kidney transplantation, oxygenated cold perfusion preservation is safe and reduces post-transplant complications compared to standard cold perfusion preservation in kidney transplantation

16 Dec, 2020 | 10:06h | UTC

Oxygenated versus standard cold perfusion preservation in kidney transplantation (COMPARE): a randomised, double-blind, paired, phase 3 trial – The Lancet (link to abstract – $ for full-text)

Commentary: Oxygenated hypothermic perfusion reduces post-kidney transplant complications – 2 Minute Medicine

CDC Guidelines for Gonococcal Infection, 2020. CDC recommends a single 500 mg intramuscular dose of ceftriaxone for uncomplicated gonorrhea, with oral doxycycline for 7 days when chlamydial coinfection has not been excluded

18 Dec, 2020 | 09:40h | UTC

Update to CDC’s Treatment Guidelines for Gonococcal Infection, 2020 – Centers for Disease Control and Prevention

Commentary: CDC Guidelines Recommend Ceftriaxone Monotherapy for Uncomplicated Gonorrhea – NEJM Journal Watch

Commentary on Twitter

https://twitter.com/GarrettHile/status/1339732944613720064

Meta-analysis: Lung cancer screening using low-dose computed tomography reduces lung cancer–specific mortality, albeit with a tradeoff of likely overdiagnosis

16 Dec, 2020 | 10:08h | UTC

Cancer-Specific Mortality, All-Cause Mortality, and Overdiagnosis in Lung Cancer Screening Trials: A Meta-Analysis – Annals of Family Medicine

ACG Clinical Guideline: Management of irritable bowel syndrome

16 Dec, 2020 | 10:09h | UTC

ACG Clinical Guideline: Management of Irritable Bowel Syndrome – The American Journal of Gastroenterology

Brazilian guidelines for the management of brain-dead potential organ donors

17 Dec, 2020 | 09:00h | UTC

Brazilian guidelines for the management of brain-dead potential organ donors. The task force of the AMIB, ABTO, BRICNet, and the General Coordination of the National Transplant System – Annals of Intensive Care

Scientists fear that ‘covidization’ is distorting research: Some researchers worry that shifting priorities towards pandemic-focused science comes at the expense of other disciplines.

17 Dec, 2020 | 08:47h | UTC

Scientists fear that ‘covidization’ is distorting research – Nature

Randomized trial: Dexamethasone for chronic subdural hematoma resulted in fewer favorable outcomes and more adverse events than placebo at 6 months

17 Dec, 2020 | 09:02h | UTC

Trial of Dexamethasone for Chronic Subdural Hematoma – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Dexamethasone should be avoided in patients with chronic subdural haematoma – University of Cambridge AND Dexamethasone for Chronic Subdural Hematoma? – NEJM Journal Watch

Commentary on Twitter

In a trial that compared a 2-week course of dexamethasone with placebo in patients with a chronic subdural hematoma, a favorable outcome on the modified Rankin scale at 6 months was more common in the placebo group than in the dexamethasone group.

— NEJM (@NEJM) December 17, 2020

Guideline: ADA 2021 Standards of Medical Care in Diabetes

10 Dec, 2020 | 00:11h | UTC

Just published! New ADA 2022 Guideline for the Management of Diabetes

Guideline Homepage: ADA 2021 Standards of Medical Care in Diabetes – American Diabetes Association (free supplement)

See ADA 2021 Guideline topics below:

Introduction: Standards of Medical Care in Diabetes—2021

Summary of Revisions: Standards of Medical Care in Diabetes—2021

Commentary on Twitter

ADA's "Standards of Medical Care in Diabetes—2021" is finally here! Featuring American Diabetes Association's latest clinical practice recommendations, the global standard for diabetes care. #ADASOC2021

📖 READ NOW (OPEN ACCESS): https://t.co/VyIT2yJnW8 pic.twitter.com/vOM5XXKLoU

— ADA Professional Publications (@ADA_Pubs) December 9, 2020

Randomized trial: In small infants, orotracheal intubation assisted with video laryngoscopy improves first-attempt success rate and reduces complications

17 Dec, 2020 | 08:56h | UTC

First-attempt success rate of video laryngoscopy in small infants (VISI): a multicentre, randomised controlled trial – The Lancet (link to abstract – $ for full-text)

Commentary on Twitter

Fascinating paediatric VL study
VL
-improved FPS (esp <6.5kg)
& reduced
-attempts
-failures
-manipulations
-complications
-severe complications

The evidence grows that VL is simply better
Everywherehttps://t.co/f9nj6l2zk3

— Tim Cook (@doctimcook) December 11, 2020

Systematic review: “Early or very early pharmacotherapeutic treatment of a hemodynamically significant patent ductus arteriosus probably does not reduce mortality in preterm infants”

17 Dec, 2020 | 08:58h | UTC

Early treatment versus expectant management of hemodynamically significant patent ductus arteriosus for preterm infants – Cochrane Library

Commentary on Twitter (thread – click for more)

So @CochraneNeonate evidence suggest no benefit of early (<7 days) PDA Rx, possible harm: https://t.co/oRc5HlCQ5l
Would our #neoEBM community apply this to <26 wk infants? 113 from across the 🌏 responded (39🇨🇦, 23🇺🇸, 13🇸🇦, 8🇬🇧), and the results are striking! A thread.. @EBNEO

— Souvik Mitra (@souvik_neo) December 11, 2020

Trends in prevalence of blindness and distance and near vision impairment over 30 years: an analysis for the Global Burden of Disease Study

16 Dec, 2020 | 09:57h | UTC

Trends in prevalence of blindness and distance and near vision impairment over 30 years: an analysis for the Global Burden of Disease Study – The Lancet Global Health

Commentary: Researchers Say We’re Watching The World Go Blind – Michigan Medicine – University of Michigan

Commentaries on Twitter

Two new studies on the causes and trends of blindness and vision impairment show the world is not meeting targets to reduce avoidable sight loss. Both studies are available online in @LancetGH.
Causes: https://t.co/j0y0poscj1
Trends: https://t.co/DPT8jKLyVx pic.twitter.com/aKxlvqvv2B

— Institute for Health Metrics and Evaluation (IHME) (@IHME_UW) December 2, 2020

(thread – click for more)

https://twitter.com/DrJSteinmetz/status/1334272298141016069

Comprehensive overview of current pharmacological augmentation recommendations for major depression

17 Dec, 2020 | 08:55h | UTC

Pharmacological Augmentation in Unipolar Depression: A Guide to the Guidelines – The International Journal of Neuropsychopharmacology

Commentary on Twitter

Pharmacological augmentation in unipolar depression – our new review of treatment guidelines compares current recommendations and discusses future guideline development @LindseyMarwood @valeriadeangel @roland_zahn @TCleare @ijnp_neuropsych https://t.co/ui5mGUP8nW

— Rachael Taylor (@rachael_wallis) June 5, 2020

Survey study: Sleep-related impairment among doctors linked to increased clinically significant medical errors

17 Dec, 2020 | 08:53h | UTC

Assessment of Physician Sleep and Wellness, Burnout, and Clinically Significant Medical Errors – JAMA Network Open

Commentaries: Lack of sleep tied to physician burnout, medical errors – MedicalXpress AND Poor Physician Sleep Associated with More Medical Errors – NEJM Journal Watch

Commentary on Twitter

Survey study: sleep-related impairment associated with higher burnout & lower professional fulfillment, as well as independent dose-response association with self-reported physician medical errors. @StanfordMed https://t.co/FPk4tYnDT1

— JAMA Network Open (@JAMANetworkOpen) December 9, 2020

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