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RCT | A lower glycemic criteria in not better than higher glycemic criteria for the diagnosis of gestational diabetes.

18 Aug, 2022 | 13:04h | UTC

Lower versus Higher Glycemic Criteria for Diagnosis of Gestational Diabetes – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Pros and cons with lower vs higher threshold for gestational diabetes diagnosis – medwire News

 

Commentary on Twitter (thread – click for more)

 


RCT | Metformin, Ivermectin, and Fluvoxamine are not beneficial for obese outpatients with Covid-19.

18 Aug, 2022 | 13:00h | UTC

Randomized Trial of Metformin, Ivermectin, and Fluvoxamine for Covid-19 – New England Journal of Medicine

Editorial: Time to Stop Using Ineffective Covid-19 Drugs – New England Journal of Medicine

 

Commentary on Twitter

 


Executive Summary | Guidelines for adrenalectomy.

18 Aug, 2022 | 12:58h | UTC

American Association of Endocrine Surgeons Guidelines for Adrenalectomy: Executive Summary – JAMA Surgery (free for a limited period)

Author interview: American Association of Endocrine Surgeons Guidelines for Adrenalectomy – JAMA

 


Cohort Study | Clinical presentation and virological assessment of confirmed human monkeypox virus cases in Spain.

18 Aug, 2022 | 12:56h | UTC

Clinical presentation and virological assessment of confirmed human monkeypox virus cases in Spain: a prospective observational cohort study – The Lancet

Commentaries:

Treating monkeypox like an STI may help control the outbreak, but stigma is a danger – The Conversation

Anal and oral sex spread monkeypox. Let’s talk about it. – Vox

Related:

CDC Report | Epidemiologic and clinical characteristics of Monkeypox cases in the US.

Update on the Monkeypox Outbreak – JAMA

Author Interview: Diagnosis, Prevention, and Treatment of Monkeypox – JAMA

Antivirals with Activity Against Monkeypox: A Clinically Oriented Review – Clinical Infectious Diseases

Clinical features and novel presentations of human monkeypox in a central London centre during the 2022 outbreak: descriptive case series – The BMJ

WHO Declares Global Public Health Emergency Over Monkeypox Virus Outbreak – Health Policy Watch

Monkeypox Virus Infection in Humans across 16 Countries — April–June 2022 – New England Journal of Medicine

Monkeypox: A Contemporary Review for Healthcare Professionals – Open Forum Infectious Diseases

 

Commentary on Twitter

 


M-A | Performance of confirmatory tests for diagnosing primary aldosteronism.

18 Aug, 2022 | 12:54h | UTC

Performance of Confirmatory Tests for Diagnosing Primary Aldosteronism: a Systematic Review and Meta-Analysis – Hypertension

 

Commentary on Twitter

 


Retrospective cohort study | Risk of preterm birth, small for gestational age at birth, and stillbirth after covid-19 vaccination during pregnancy.

18 Aug, 2022 | 12:51h | UTC

Risk of preterm birth, small for gestational age at birth, and stillbirth after covid-19 vaccination during pregnancy: population based retrospective cohort study – The BMJ

News Release: No link between COVID-19 vaccination in pregnancy and higher risk of preterm birth or stillbirth – British Medical Journal

Related:

SARS-CoV-2 infection and COVID-19 vaccination in pregnancy – Nature Reviews Immunology

Cohort Study: COVID-19 vaccination during early pregnancy was not associated with increased risk of congenital fetal anomalies.

Retrospective Cohort: A population-based study in Sweden and Norway did not find an increased risk of pregnancy complications after COVID-19 vaccination.

WHO Questions and Answers: COVID-19 vaccines and pregnancy.

COVID vaccines safely protect pregnant people: the data are in.

COVID-19 vaccination in pregnancy—number needed to vaccinate to avoid harm.

A case-controlled study showed Covid-19 vaccination during early pregnancy was not associated with increased risk of first-trimester miscarriage.

Editorial: Covid-19 treatments and vaccines must be evaluated in pregnancy.

AstraZeneca vaccination not linked to reduced fertility rates and adverse birth outcomes.

Cohort study: Vaccinated pregnant patients had 90% lower risk of severe or critical Covid-19 compared with unvaccinated pregnant patients.

Two observational studies suggest spontaneous abortion is not increased following COVID-19 mRNA vaccination during pregnancy.

Study shows high effectiveness of the Pfizer mRNA COVID-19 vaccine in pregnancy.

5 Crucial Things to Know About COVID-19 Vaccines and Pregnancy.

CDC Guidance: Pregnant people should be vaccinated against COVID-19.

ACOG and SMFM Recommend COVID-19 Vaccination for Pregnant Individuals – “ACOG encourages its members to enthusiastically recommend vaccination to their patients.”

Cohort study: Pfizer/BioNTech COVID vaccine associated with 78% lower risk of Covid-19 in pregnancy.

 

Commentary on Twitter

 


Neurological and psychiatric risk trajectories after SARS-CoV-2 infection: an analysis of 2-year retrospective cohort studies including 1 284 437 patients.

18 Aug, 2022 | 12:49h | UTC

Neurological and psychiatric risk trajectories after SARS-CoV-2 infection: an analysis of 2-year retrospective cohort studies including 1 284 437 patients – The Lancet Psychiatry

News Release: Increased risk of some neurological and psychiatric disorders remains two years after COVID-19 infection – University of Oxford

Commentary: Covid-19: Increased risk of some neurological and psychiatric disorders remains two years after infection, study finds – The BMJ

 

Commentary on Twitter

 


Pooled analysis of drug-related interstitial lung disease and/or pneumonitis in nine trastuzumab deruxtecan monotherapy studies.

18 Aug, 2022 | 12:47h | UTC

Pooled analysis of drug-related interstitial lung disease and/or pneumonitis in nine trastuzumab deruxtecan monotherapy studies – ESMO Open

Commentaries:

Prompt recognition and treatment found effective for lung disease in patients who received new drug for advanced cancer – The Mount Sinai Health System

Trastuzumab deruxtecan-related ILD/pneumonitis characterized – medwire News

Related: Trastuzumab Deruxtecan-Induced Interstitial Lung Disease/Pneumonitis in ERBB2-Positive Advanced Solid Malignancies: A Systematic Review – Drugs

 


M-A | Interventions for the prevention or treatment of epidural-related maternal fever.

18 Aug, 2022 | 12:45h | UTC

Interventions for the prevention or treatment of epidural-related maternal fever: a systematic review and meta-analysis – British Journal of Anaesthesia

 


RCT | Effectiveness of a long-term home-based exercise training program in patients with COPD following pulmonary rehabilitation.

18 Aug, 2022 | 12:43h | UTC

Effectiveness of a long-term home-based exercise training program in patients with COPD following pulmonary rehabilitation: A multi-center randomized controlled trial – CHEST

 

Commentary on Twitter

Under a Creative Commons license

 


Modeling Study | Reducing daily salt intake in China by 1 g could prevent almost 9 million cardiovascular events by 2030.

18 Aug, 2022 | 12:42h | UTC

Reducing daily salt intake in China by 1 g could prevent almost 9 million cardiovascular events by 2030: a modelling study – BMJ Nutrition Prevention & Health

News Release: 1 g cut in daily salt intake could ward off nearly 9 million cases of stroke/heart disease in China – BMJ Newsroom

 


Single-arm phase 2 study | Safety and efficacy of mitapivat, an oral pyruvate kinase activator, in adults with non-transfusion dependent alpha-thalassaemia or beta-thalassaemia.

18 Aug, 2022 | 12:40h | UTC

Safety and efficacy of mitapivat, an oral pyruvate kinase activator, in adults with non-transfusion dependent α-thalassaemia or β-thalassaemia: an open-label, multicentre, phase 2 study – The Lancet (link to abstract – $ for full-text)

Commentary: PK Modulator Shows Promise in Thalassemia — In small study, mitapivat increased hemoglobin in 80% of non-transfusion-dependent patients – MedPage Today (free registration required)

 


RCT | Ceftolozane/Tazobactam plus Metronidazole vs. Meropenem in patients with complicated intra-abdominal infections.

18 Aug, 2022 | 12:37h | UTC

A Phase 3, Multicenter, Double-blind, Randomized Clinical Trial to Evaluate the Efficacy and Safety of Ceftolozane/Tazobactam Plus Metronidazole Versus Meropenem in Chinese Participants With Complicated Intra-abdominal Infections – International Journal of Infectious Diseases

 


Preventing stillbirth: a review of screening and prevention strategies.

18 Aug, 2022 | 12:36h | UTC

Preventing Stillbirth: A Review of Screening and Prevention Strategies – Maternal-Fetal Medicine

 


Review | Autoimmune/autoinflammatory syndrome induced by adjuvants: a focus on silicone.

18 Aug, 2022 | 12:34h | UTC

Autoimmune/autoinflammatory syndrome induced by adjuvants: a focus on silicone – Clinical Rheumatology

 

Commentary on Twitter

 


Trends in active treatment of live-born neonates between 22 weeks 0 days and 25 weeks 6 days by gestational age and maternal race and ethnicity in the US, 2014 to 2020.

18 Aug, 2022 | 12:32h | UTC

Trends in Active Treatment of Live-born Neonates Between 22 Weeks 0 Days and 25 Weeks 6 Days by Gestational Age and Maternal Race and Ethnicity in the US, 2014 to 2020 – JAMA (link to abstract – $ for full-text)

Commentaries:

Study finds racial, ethnic disparities in rate of medical intervention among earliest premature babies – The Ohio State University

Active Treatment for Extremely Preterm Babies on the Rise — Yet researchers find racial and ethnic disparities in treatment initiation – MedPage Today (free registration required)

 

Commentary on Twitter

 


Launch of first WHO position paper on optimizing brain health across life.

17 Aug, 2022 | 14:41h | UTC

News Release: Launch of first WHO position paper on optimizing brain health across life – World Health Organization

WHO position paper: Optimizing brain health across the life course – World Health Organization

 

Commentary on Twitter (thread – click for more)

 


Guideline | Recommendation on instrument-based screening for depression during pregnancy and the postpartum period.

17 Aug, 2022 | 14:39h | UTC

Recommendation on instrument-based screening for depression during pregnancy and the postpartum period – Canadian Medical Association Journal

Editorial: Do ask, but don’t screen: identifying peripartum depression in primary care – Canadian Medical Association Journal

News Release: Regular enquiry about well-being vs. universal screening recommended to detect depression in pregnancy and after birth – Canadian Medical Association Journal

See also: Canadian Task Force on Preventive Health Care page with summary and tools

 


CDC Report | Epidemiologic and clinical characteristics of Monkeypox cases in the US.

17 Aug, 2022 | 14:37h | UTC

Epidemiologic and Clinical Characteristics of Monkeypox Cases — United States, May 17–July 22, 2022 – Morbidity and Mortality Weekly Report

Commentaries:

CDC releases interim monkeypox guidance, reports epidemiologic and clinical characteristics – ACP Internist

Global experts race to understand rare cases when monkeypox leads to death – CNN

Related:

Update on the Monkeypox Outbreak – JAMA

Author Interview: Diagnosis, Prevention, and Treatment of Monkeypox – JAMA

Antivirals with Activity Against Monkeypox: A Clinically Oriented Review – Clinical Infectious Diseases

Clinical features and novel presentations of human monkeypox in a central London centre during the 2022 outbreak: descriptive case series – The BMJ

WHO Declares Global Public Health Emergency Over Monkeypox Virus Outbreak – Health Policy Watch

Monkeypox Virus Infection in Humans across 16 Countries — April–June 2022 – New England Journal of Medicine

Monkeypox: A Contemporary Review for Healthcare Professionals – Open Forum Infectious Diseases

 

Commentary on Twitter

 


CDC interim guidance for prevention and treatment of Monkeypox in persons with HIV infection.

17 Aug, 2022 | 14:36h | UTC

Interim Guidance for Prevention and Treatment of Monkeypox in Persons with HIV Infection — United States, August 2022 – Morbidity and Mortality Weekly Report

 


RCT | Effect of remote ischemic conditioning vs. usual care on neurologic function in patients with acute moderate ischemic stroke.

17 Aug, 2022 | 14:32h | UTC

Effect of Remote Ischemic Conditioning vs Usual Care on Neurologic Function in Patients With Acute Moderate Ischemic Stroke: The RICAMIS Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Remote Ischemic Conditioning: Feasible and Potentially Beneficial for Ischemic Stroke – JAMA (free for a limited period)

Video Summary: Effect of Remote Ischemic Conditioning vs Usual Care on Neurologic Function in Patients With Acute Moderate Ischemic Stroke – JAMA

 


Review | Acute respiratory distress syndrome.

17 Aug, 2022 | 14:30h | UTC

Acute Respiratory Distress Syndrome – Emergency Medicine Clinics of North America

 


Guideline | Use of COVID-19 convalescent plasma.

17 Aug, 2022 | 14:28h | UTC

Clinical Practice Guidelines From the Association for the Advancement of Blood and Biotherapies (AABB): COVID-19 Convalescent Plasma – Annals of Internal Medicine

Editorial: The Fast and the Furious: Chasing a Clinical Niche for COVID-19 Convalescent Plasma – Annals of Internal Medicine

News Release: The AABB releases clinical practice guidelines for the appropriate use of COVID-19 convalescent plasma – American College of Physicians

 


Review | Barrett Esophagus.

17 Aug, 2022 | 14:26h | UTC

Barrett Esophagus: A Review – JAMA (free for a limited period)

Audio clinical review: Barrett Esophagus – JAMA

Related: Diagnosis and Management of Barrett’s Esophagus: An Updated ACG Guideline – American Journal of Gastroenterology

 


Perspective | Is there an optimal diet for primordial prevention of atherosclerosis?

17 Aug, 2022 | 14:23h | UTC

Is there an optimal diet for primordial prevention of atherosclerosis? – European Journal of Cardiology

 


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