Systematic review: “Early or very early pharmacotherapeutic treatment of a hemodynamically significant patent ductus arteriosus probably does not reduce mortality in preterm infants”

Early treatment versus expectant management of hemodynamically significant patent ductus arteriosus for preterm infants – Cochrane Library

Commentary on Twitter (thread – click for more)

So @CochraneNeonate evidence suggest no benefit of early (<7 days) PDA Rx, possible harm: https://t.co/oRc5HlCQ5l
Would our #neoEBM community apply this to <26 wk infants? 113 from across the ? responded (39??, 23??, 13??, 8??), and the results are striking! A thread.. @EBNEO

— Souvik Mitra (@souvik_neo) December 11, 2020