Archives
Randomized trial: Effectiveness of a nurse-led multidisciplinary intervention vs. usual care on advance care planning for vulnerable older adults
12 Jan, 2021 | 01:45h | UTCEditorial: Advance Care Planning and the Cost of Pragmatism (free for a limited period)
Commentary: Nurse Navigation Increases Advance Care Planning – Oncology Nursing News
Commentary on Twitter
End-of-Life Planning: JAMA
RCT of N=759 pts avg 78 y/o. Usual Care vs. Nurse-led Advance Care Planning (ACP) ⬆️ ACP documentation from 4% to 43%. Wow. As @AngeloVolandes says, “Just HAVE the CONVERSATION!”https://t.co/ISeh7y8hXW#medtwitter #meded #pallipulm #geriatrics pic.twitter.com/4Ae2QlETOl— WesElyMD (@WesElyMD) January 11, 2021
Atrial fibrillation and stroke prevention: state of the art—epidemiology and pathophysiology: New risk factors, concepts and controversies
12 Jan, 2021 | 01:47h | UTC
ACC Consensus: Anticoagulation and antiplatelet therapy in patients with atrial fibrillation or venous thromboembolism undergoing PCI or with atherosclerotic cardiovascular disease
12 Jan, 2021 | 01:50h | UTCCommentaries: ACC Issues New Guidance Around Antithrombotic Choices in A-fib, VTE – TCTMD AND ACC Issues Clinical Guidance For Antithrombotic Therapy in Patients With AFib or VTE Undergoing PCI or With ASCVD – American College of Cardiology
Commentary on Twitter
ICYMI: @ACCinTouch released clinical guidance for antithrombotic therapy in pts w/ #AFib/#VTE undergoing PCI or w/ #ASCVD. Doc aims to serve as a framework for decision-making among pts requiring concomitant use of an anticoagulant & antiplatelet therapy. https://t.co/PqinRIvLY9 pic.twitter.com/prbnbBPG5L
— JACC Journals (@JACCJournals) December 29, 2020
New Guidance for Type 1 Diabetes Continuous Glucose Monitoring Use During Exercise
12 Jan, 2021 | 01:40h | UTCNew Guidance for Type 1 Diabetes Continuous Glucose Monitoring Use During Exercise – JAMA
Managing conflicts of interest in the development of health guidelines
12 Jan, 2021 | 01:41h | UTCRelated Guidance: Guidelines International Network: Principles for Disclosure of Interests and Management of Conflicts in Guidelines – Annals of Internal Medicine
Another study suggests fluoroquinolone use may increase the risk of development of aortic aneurysms
12 Jan, 2021 | 01:38h | UTCAssociation of Fluoroquinolone Use With Short-term Risk of Development of Aortic Aneurysm – JAMA Surgery (free for a limited period)
Commentaries: Fluoroquinolones and Aortic Disease—Is It Time to Broaden the Warning? – JAMA (free for a limited period) AND Study links fluoroquinolones to higher risk of aneurysm – CIDRAP AND Analysis Links Fluoroquinolones to Increased Aortic Aneurysm Risk – Physician’s Weekly
The Top Nephrology Stories of 2020
12 Jan, 2021 | 01:33h | UTCThe Top Nephrology Stories of 2020 – NephJC
Randomized trial: Early interdisciplinary supportive care in patients with previously untreated metastatic esophagogastric cancer
12 Jan, 2021 | 01:36h | UTC
Commentaries on Twitter
RCT of early interdisciplinary supportive care (ESC) in metastatic esophagogastric cancer
ESC by oncologists, dietitians & psychologists
⬆️ chemo cycles from 4 to 5
⬆️ OS HR=0.68
➡️ PFS
↗️ QoL
To be considered in radiochemotherapy #radonchttps://t.co/G6WQS8ULCb— Matthias Guckenberger (@Mat_Guc) January 10, 2021
Impressive survival benefit for early integrated multidisciplinary nutritional and psychological support vs. standard of care in Phase III trial for metastatic esophagogastric cancers in @ASCO_pubs. Intervention 14.8 mo vs. SOC 11.9 mo. https://t.co/FWE6xlPH8v
— Michael Shusterman, MD (@guildsman) January 9, 2021
Year in Review: Top Infectious Diseases Articles Of 2020
12 Jan, 2021 | 01:31h | UTCYear In Review: Top Infectious Diseases Articles Of 2020 – IDStewardship
Artificial intelligence in telemetry: What clinicians should know
12 Jan, 2021 | 01:21h | UTCArtificial intelligence in telemetry: what clinicians should know – Intensive Care Medicine
Commentary on Twitter
New life for vital signs! Telemetry data ubiquitous in critical care, most collected by virtue of #ICU admission#ArtificialIntelligence advances unlocking potential of these to inform diagnosis & guide targeted treatment https://t.co/rkgHLJgH0R#MachineLearning #DataScience #AI pic.twitter.com/mgVDHMhE2n
— Intensive Care Medicine (@yourICM) January 2, 2021
Systematic Review: “For the general population of persons with elevated blood pressure, the benefits of trying to achieve a lower blood pressure target rather than a standard target (140/90 mm Hg or less) do not outweigh the harms associated with that intervention.”
12 Jan, 2021 | 01:30h | UTCBlood pressure targets in adults with hypertension – Cochrane Library
Summary: The use of lower blood pressure targets for people with hypertension – Cochrane Library
Related systematic review: Blood pressure targets in people with cardiovascular disease – Cochrane Library
Commentary on Twitter
The use of lower #bloodpressure targets for people with #hypertension https://t.co/W1bF8W7CDD Updated @CochraneHTN systematic review includes 11 randomised controlled trials involving 38,688 adult participants.
— Cochrane (@cochranecollab) December 30, 2020
Special Issue: Fundamentals and innovations in regional anesthesia
12 Jan, 2021 | 01:28h | UTCEditorial: Advancing towards the next frontier in regional anaesthesia
- The role of regional anaesthesia and multimodal analgesia in the prevention of chronic postoperative pain: a narrative review
- Regional anaesthesia: risk, consent and complications
- Updates in our understanding of local anaesthetic systemic toxicity: a narrative review
- Defining success in regional anaesthesia
- Contemporary training methods in regional anaesthesia: fundamentals and innovations
- The role of peripheral nerve stimulation in the era of ultrasound‐guided regional anaesthesia
- Fundamentals and innovations in regional anaesthesia for infants and children
- Regional anaesthesia quality indicators for adult patients undergoing non‐cardiac surgery: a systematic review
- Local anaesthetic adjuncts for peripheral regional anaesthesia: a narrative review
- Ultrasound‐guided fascial plane blocks of the chest wall: a state‐of‐the‐art review
- Regional anaesthesia in patients with diabetes
- Regional anaesthesia for labour, operative vaginal delivery and caesarean delivery: a narrative review
- The role of regional anaesthesia in the emerging subspecialty of onco‐anaesthesia: a state‐of‐the‐art review
- Novel approaches to needle tracking and visualisation
- The use of artificial intelligence and robotics in regional anaesthesia
Multiple trauma management in mountain environments – a scoping review
12 Jan, 2021 | 01:25h | UTC
Three-year follow-up of 2-dose versus 3-dose HPV vaccine
12 Jan, 2021 | 01:26h | UTCThree-Year Follow-up of 2-Dose Versus 3-Dose HPV Vaccine – Pediatrics (link to abstract – $ for full-text)
[Abstract Only] Randomized trial: No difference in long-term outcomes with endovascular revascularization plus supervised exercise vs. supervised exercise only for intermittent claudication
12 Jan, 2021 | 01:15h | UTCLong-Term Follow-up of a Randomized Clinical Trial Comparing Endovascular Revascularization Plus Supervised Exercise with Supervised Exercise only for Intermittent Claudication – Annals of Surgery (link to abstract – $ for full-text)
Randomized trial: Short-course radiotherapy followed by chemotherapy before total mesorectal excision (TME) improve outcomes vs. traditional approach in locally advanced rectal cancer
12 Jan, 2021 | 01:12h | UTCShort-course radiotherapy followed by chemotherapy before total mesorectal excision (TME) versus preoperative chemoradiotherapy, TME, and optional adjuvant chemotherapy in locally advanced rectal cancer (RAPIDO): a randomised, open-label, phase 3 trial – The Lancet Oncology (link to abstract – $ for full-text)
Commentary on Twitter
New online: phase 3 RAPIDO trial: Short-course #radiotherapy followed by #chemotherapy before total mesorectal excision (TME) vs standard of care in locally advanced #rectalcancer https://t.co/bTgUC6Lo39 #crcsm pic.twitter.com/Iu3HbQ1xjG
— The Lancet Oncology (@TheLancetOncol) December 8, 2020
Systematic review: Prevention of childhood unintentional injuries in low- and middle-income countries
12 Jan, 2021 | 01:23h | UTCRelated: World report on child injury prevention – World Health Organization
[Abstract Only] Meta-Analysis: Not enough evidence to recommend the use of a prosthetic Mesh for prevention of parastomal hernia
12 Jan, 2021 | 01:18h | UTCMeta-Analysis and Systematic Review of the Use of a Prosthetic Mesh for Prevention of Parastomal Hernia – Annals of Surgery (link to abstract – $ for full-text)
Meta-analysis: Total neoadjuvant therapy vs. standard therapy in locally advanced rectal cancer
12 Jan, 2021 | 01:10h | UTCCommentaries: Personalizing Treatment for Rectal Cancer: Total Neoadjuvant Therapy Is Leading the Way AND Total Neoadjuvant Therapy Improves Rectal Cancer Pathologic Response – Physician’s Weekly
Related meta-analysis (just published): Impact of Total Neoadjuvant Therapy vs. Standard Chemoradiotherapy in Locally Advanced Rectal Cancer: A Systematic Review and Meta-Analysis of Randomized Trials – Cancers
Commentary on Twitter
Systematic review & meta-analysis finds total neoadjuvant therapy for locally adv. rectal cancer is associated with a doubling of pathologic complete response vs standard chemoradiation plus by adjuvant chemo. @anup_kasi @KUMedCenter @geriradonc @agrothey https://t.co/oRccCh5bEb
— JAMA Network Open (@JAMANetworkOpen) December 16, 2020
[Preprint] Randomized trial: Arthritis drugs improve survival in critically ill patients with Covid-19
10 Jan, 2021 | 20:56h | UTCCommentaries: Covid-19: Arthritis drugs improve survival in intensive care patients, shows study – The BMJ AND Arthritis drugs could help save lives of Covid patients, research finds – The Guardian AND Expert comment – Two potentially life-saving drugs for critically ill COVID-19 patients – London School of Hygiene & Tropical Medicine
Commentary on Twitter
Two rheumatoid arthritis drugs will now be used to treat the patients with severe covid-19 in intensive care, after new findings have shown that they significantly improve survival and cut the time spent in hospital by a week to 10 days https://t.co/cxNM64L5S6
— The BMJ (@bmj_latest) January 8, 2021
Study suggests the intensity of active surveillance in patients with rectal cancer managed by a watch-and-wait approach could be reduced if they maintain a complete clinical response within the first 3 years
12 Jan, 2021 | 01:11h | UTCCommentaries: Rectal cancer patients who “watch and wait” may only need few years of stringent follow-up – eCancer AND Intense rectal cancer surveillance may be reduced – MDedge
New SARS-CoV-2 variants: increased transmissibility likely to cause more deaths and possibly a new wave of the disease
10 Jan, 2021 | 20:54h | UTC- SARS-CoV-2 Variants – World Health Organization
- Why epidemiologists are so worried about the new Covid-19 variants, in 2 charts – Vox
- We lost to SARS-CoV-2 in 2020. We can defeat B-117 in 2021 – STAT
- Transmission of SARS-CoV-2 Lineage B.1.1.7 in England: insights from linking epidemiological and genetic data – Imperial College of London AND Commentary: New COVID-19 variant growing rapidly in England – Imperial College London
- Genetic Variants of SARS-CoV-2—What Do They Mean? – JAMA
- Podcast: Understanding SARS-CoV-2 Genetic Variants – JAMA
- Podcast: Understanding the New SARS-CoV-2 Mutation Found in England – JAMA
- Viral mutations may cause another ‘very, very bad’ COVID-19 wave, scientists warn – Science
- Mutant coronavirus in the United Kingdom sets off alarms, but its importance remains unclear – Science
- New variant of SARS-CoV-2 in UK causes surge of COVID-19 – The Lancet Respiratory Medicine
- Scientists are monitoring a coronavirus mutation that could affect the strength of vaccines – STAT
- Instead of debating ‘first-shot’ vs. ‘set-aside’ vaccine approaches, hospitals’ study should compare them – STAT
- The Mutated Virus Is a Ticking Time Bomb – Vox
- What We Know About The New U.K. Variant Of Coronavirus — And What We Need To Find Out – NPR
- The New Mutations – Science Translational Medicine
- New Virus Strain’s Transmissibility to Cause More Deaths: Study – Bloomberg
- U.K. variant puts spotlight on immunocompromised patients’ role in the COVID-19 pandemic – Science
- When unusually severe COVID is seen, rapid identification-and-virus-sequencing are needed world-wide – Science Speaks: Global ID News
- Covid-19: New coronavirus variant is identified in UK – The BMJ
- The looming questions scientists need to answer about the new variant of the coronavirus – STAT
- With limited surveillance of Covid-19 variant, it’s déjà vu all over again – STAT
- New coronavirus variant: What do we know? – BBC
- Covid-19 in South Africa: Scientists seek to understand new variant – BBC
- New coronavirus variant: what is the spike protein and why are mutations on it important? – The Conversation
Randomized trial: Neutralizing monoclonal antibody not efficacious among hospitalized patients with covid-19
10 Jan, 2021 | 20:55h | UTCCommentaries: Covid-19: Trial of LY-CoV555 Stopped for Futility – Physician’s Weekly AND Results of NIH-sponsored ACTIV-3 trial published – NIH News Releases AND Bamlanivimab Flops in Hospitalized COVID-19 Patients – MedPage Today (free registration required)
Peter Doshi: Pfizer and Moderna’s “95% effective” vaccines—we need more details and the raw data
10 Jan, 2021 | 20:48h | UTC
Moderna COVID-19 vaccine phase III trial results published; it is 94.1% efficacious in preventing symptomatic COVID-19
10 Jan, 2021 | 20:49h | UTCEfficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine – New England Journal of Medicine
Commentaries: Peer-reviewed report on Moderna COVID-19 vaccine publishes – NIH News Releases AND Peer-reviewed data show high protection for leading COVID vaccines – CIDRAP AND The Moderna Vaccine’s Antibodies May Not Last As Long As We Hoped – Forbes
Commentary on Twitter
In the phase 3 mRNA-1273 trial participants received 2 doses of vaccine or placebo 28 days apart. The mRNA-1273 vaccine showed 94.1% efficacy in preventing #SARSCoV2, including severe disease. #IDTwitter
— NEJM (@NEJM) December 30, 2020