Archives
Years of life lost to COVID-19 in 81 countries
19 Feb, 2021 | 02:55h | UTCYears of life lost to COVID-19 in 81 countries – Scientific Reports
News release: COVID-19: Over 20.5 million years of life may have been lost due to COVID-19
Commentaries: Expert reaction to study estimating years of life lost globally to COVID-19 – Science Media Centre AND 20.5m years of life may have been lost to Covid across 81 countries, study finds – The Guardian
What does 95% COVID-19 vaccine efficacy really mean?
19 Feb, 2021 | 02:58h | UTCWhat does 95% COVID-19 vaccine efficacy really mean? – The Lancet Infectious Diseases
Related: Pfizer vaccine: what an ‘efficacy rate above 90%’ really means – The Conversation
COVID‐19 convalescent plasma: Interim recommendations from the AABB
19 Feb, 2021 | 02:56h | UTCCOVID‐19 convalescent plasma: interim recommendations from the AABB – Transfusion
News release: AABB panel issues interim recommendations for Covid-19 convalescent plasma use
Fauci: There’s evidence COVID-19 vaccines don’t just protect you — they may stop you from spreading the virus to others, too
19 Feb, 2021 | 02:46h | UTCRelated: [Preprint] Covid-19 vaccination associated with reduced viral load, may reduce transmission (study and commentary)
How many people get ‘long COVID’ – and who is most at risk?
19 Feb, 2021 | 02:54h | UTCHow many people get ‘long COVID’ – and who is most at risk? – The Conversation
The price of success—how to evaluate Covid-19 vaccines when they’re available outside of clinical trials
19 Feb, 2021 | 02:43h | UTC
SOFA score is not accurate enough for mortality prediction in severely ill patients with COVID-19 pneumonia
19 Feb, 2021 | 02:44h | UTC
Commentary on Twitter
'The discriminant accuracy of the #SOFA score for
mortality prediction in patients prior to intubation for#COVID-19 pneumonia was poor and significantly inferior to simply using age.' Age, apparently can't be used because 'discrimination'. #bioethics https://t.co/QJIxqupoVx— udo schuklenk 🏳️🌈🇨🇦🇦🇺🇩🇪 (@schuklenk) February 17, 2021
SR: Integrating palliative care in ambulatory care of noncancer serious chronic illness
19 Feb, 2021 | 02:28h | UTCFull report: Integrating Palliative Care in Ambulatory Care of Noncancer Serious Chronic Illness
Evidence summary: Integrating Palliative Care in Ambulatory Care of Noncancer Serious Illness
Voices in Cardiology: How feeling like an imposter can impede your success
19 Feb, 2021 | 02:26h | UTCHow Feeling Like an Imposter Can Impede Your Success – JACC: Case Reports
Meta-analysis: Sustained lung inflations during neonatal resuscitation at birth
19 Feb, 2021 | 02:21h | UTCSustained Lung Inflations During Neonatal Resuscitation at Birth: A Meta-analysis – Pediatrics (link to abstract – $ for full-text)
Commentaries on Twitter
#Metaanalysis by @KapadiaNeo & @Ilcor_org colleagues finds Sustained lung inflation is a potential harmful intervention in babies, particularly in extreme preterm infants who are at increased risk of death@AAPJournals @EBNEO #NeoEBM @wyllie_jonathan https://t.co/rsDYtDRgm0 pic.twitter.com/fO6mu4ICil
— Abdul Razak (@DrAbdulRazak_MD) December 23, 2020
https://twitter.com/NICU_Musings/status/1347554874125217795
Bleeding in critically ill children—review of literature, knowledge gaps, and suggestions for future investigation
19 Feb, 2021 | 02:23h | UTC
Review: Oxygen administration for patients with ARDS
19 Feb, 2021 | 02:24h | UTCOxygen administration for patients with ARDS – Journal of Intensive Care
A food allergy epidemic… or just another case of overdiagnosis?
19 Feb, 2021 | 02:13h | UTCA food allergy epidemic… or just another case of overdiagnosis? – The BMJ Opinion
Original study: Food anaphylaxis in the United Kingdom: analysis of national data, 1998-2018 – The BMJ
M-A: Risk factors for suicide in prisons
19 Feb, 2021 | 02:10h | UTC
Commentary on Twitter (thread – click for more)
New paper! Meta-analysis of risk factors for completed suicide in prison. Included data on >35,000 suicides, 77 studies from 27 countries. Some potentially important findings, esp. differences with risk factors in general population. #OA @TheLancetPH: https://t.co/G26576gOrH 1/ pic.twitter.com/gB7efLHkqK
— Seena Fazel (@seenafazel) February 10, 2021
M-A: Not enough evidence there are individual differences in response to antidepressants
19 Feb, 2021 | 02:15h | UTCIndividual Differences in Response to Antidepressants: A Meta-analysis of Placebo-Controlled Randomized Clinical Trials – JAMA Psychiatry (free for a limited period)
Editorial: New Directions in Research on Heterogeneity of Treatment Effects for Major Depression (free for a limited period)
Commentary: Antidepressants for MDD: Time to Rethink Personalized Therapy? – Physician’s Weekly
Related studies: What are the chances for personalised treatment with antidepressants? Detection of patient-by-treatment interaction with a variance ratio meta-analysis – BMJ Open AND Individual response to antidepressants for depression in adults-a meta-analysis and simulation study – PLOS One
Commentary on Twitter (thread – click for more)
https://twitter.com/PloederlM/status/1362294365255852032
Defining the optimal total number of chemotherapy courses in younger patients with Acute Myeloid Leukemia: A comparison of 3 vs. 4 courses
19 Feb, 2021 | 02:06h | UTCDefining the Optimal Total Number of Chemotherapy Courses in Younger Patients With Acute Myeloid Leukemia: A Comparison of Three Versus Four Courses – Journal of Clinical Oncology (link to abstract – $ for full-text)
Commentary: Optimal Number of Treatment Courses Explored in Younger Patients with AML – CancerNetwork
Commentary on Twitter
What is the optimal number of chemotherapy courses in younger patients with acute myeloid leukemia (AML)? This study evaluates 3 vs 4 courses https://t.co/peC7Xo3BbX #leusm #JCO pic.twitter.com/OGChNkYS0X
— Journal of Clinical Oncology (@JCO_ASCO) January 6, 2021
RCT: Treatment of uterine fibroid symptoms with Relugolix combination therapy
19 Feb, 2021 | 02:08h | UTC
Review: Diagnosis and treatment of metastatic colorectal cancer
19 Feb, 2021 | 02:07h | UTCDiagnosis and Treatment of Metastatic Colorectal Cancer: A Review – JAMA (free for a limited period)
Therapy for Stage IV Non–Small-Cell Lung Cancer With Driver Alterations: ASCO and OH (CCO) Joint Guideline Update
19 Feb, 2021 | 02:04h | UTC
BRUGADA-RISK: A primary prevention clinical risk score model for patients with Brugada Syndrome
18 Feb, 2021 | 02:57h | UTCCommentary: Risk Score Model for Brugada Syndrome – American College of Cardiology
RCT: Levothyroxine does not reduce the risk of developing depressive symptoms in older adults with subclinical hypothyroidism
18 Feb, 2021 | 02:46h | UTCRelated Studies: Association Between Levothyroxine Treatment and Thyroid-Related Symptoms Among Adults Aged 80 Years and Older With Subclinical Hypothyroidism – JAMA AND Thyroid Hormone Therapy for Older Adults with Subclinical Hypothyroidism – New England Journal of Medicine AND L-Thyroxine Therapy for Older Adults With Subclinical Hypothyroidism and Hypothyroid Symptoms: Secondary Analysis of a Randomized Trial – Annals of Internal Medicine
Guidelines (conflicting viewpoints): BMJ Guideline: Treatment of Subclinical Hypothyroidism AND Society for Endocrinology & British Thyroid Association issue statement against new treatment recommendations for subclinical hypothyroidism
Commentary on Twitter
Ancillary study of the TRUST RCT of levothyroxine therapy finds it does not reduce depression risk among older adults with subclinical hypothyroidism and shouldn't be prescribed for this purpose. #VisualAbstract https://t.co/yu3EChdkm1
— JAMA Network Open (@JAMANetworkOpen) February 10, 2021
AAP: 2021 Recommendations for Preventive Pediatric Health Care
18 Feb, 2021 | 03:01h | UTCRecommendations: Periodicity Schedule
RCT: Vitamin D3 does not improve outcomes in hospitalized patients with moderate to severe COVID-19
18 Feb, 2021 | 03:20h | UTCEditorial: Vitamin D3 to Treat COVID-19: Different Disease, Same Answer
In this RCT a single high dose of #vitaminD3 (100K IU) raised mean serum 25OH D levels but had no effect on hospital LOS (primary outcome), in-hospital mortality, ICU admission, or need for mechanical ventilation (secondary outcomes) https://t.co/eozVaYnb25
— JAMA (@JAMA_current) February 17, 2021
Clinical decisions: Delayed second dose vs. standard regimen for Covid-19 vaccination
18 Feb, 2021 | 03:17h | UTC
World’s first coronavirus “Human Challenge” study receives ethics approval in the UK
18 Feb, 2021 | 03:14h | UTCWorld’s first coronavirus Human Challenge study receives ethics approval in the UK – GOV.UK
Commentaries: Covid-19: World’s first human trials given green light in UK – BBC AND UK to infect up to 90 healthy volunteers with Covid in world first trial – The Guardian
WHO Guidance on the subject: Feasibility, potential value and limitations of establishing a closely monitored challenge model of experimental COVID-19 infection and illness in healthy young adult volunteers – World Health Organization AND Key criteria for the ethical acceptability of COVID-19 human challenge studies – World Health Organization
See also: Challenge Trials—Could Deliberate Coronavirus Exposure Hasten Vaccine Development? – JAMA AND Ethical guidelines for deliberately infecting volunteers with COVID-19 – Journal of Medical Ethics AND Challenge trials can speed development of a Covid-19 vaccine. Planning for them needs to start now – STAT AND Accelerating Development of SARS-CoV-2 Vaccines — The Role for Controlled Human Infection Models – New England Journal of Medicine AND Human Challenge Studies to Accelerate Coronavirus Vaccine Licensure – The Journal of Infectious Diseases AND Ethics of controlled human infection to address COVID-19 – Science AND Extraordinary diseases require extraordinary solutions – Vaccine