M-A: Not enough evidence there are individual differences in response to antidepressants

Individual Differences in Response to Antidepressants: A Meta-analysis of Placebo-Controlled Randomized Clinical Trials – JAMA Psychiatry (free for a limited period)

Editorial: New Directions in Research on Heterogeneity of Treatment Effects for Major Depression (free for a limited period)

Commentary: Antidepressants for MDD: Time to Rethink Personalized Therapy? – Physician’s Weekly

Related studies: What are the chances for personalised treatment with antidepressants? Detection of patient-by-treatment interaction with a variance ratio meta-analysis – BMJ Open AND Individual response to antidepressants for depression in adults-a meta-analysis and simulation study – PLOS One

Commentary on Twitter (thread – click for more)

1/ Treatment effect heterogeneity in antidepressant tx – a retracted paper by Maslej et al. was now re-published, with a complete reversal of the main-findings – no difference in variability in tx outcome bw antidepressant and placebo. https://t.co/ME5qawCQlL https://t.co/IgegV5kZpT

— Pfluft (@PloederlM) February 18, 2021