RCT: Levothyroxine does not reduce the risk of developing depressive symptoms in older adults with subclinical hypothyroidism

Effect of Levothyroxine Therapy on the Development of Depressive Symptoms in Older Adults With Subclinical Hypothyroidism: An Ancillary Study of a Randomized Clinical Trial – JAMA Network Open

Related Studies: Association Between Levothyroxine Treatment and Thyroid-Related Symptoms Among Adults Aged 80 Years and Older With Subclinical Hypothyroidism – JAMA AND Thyroid Hormone Therapy for Older Adults with Subclinical Hypothyroidism – New England Journal of Medicine AND L-Thyroxine Therapy for Older Adults With Subclinical Hypothyroidism and Hypothyroid Symptoms: Secondary Analysis of a Randomized Trial – Annals of Internal Medicine

Guidelines (conflicting viewpoints): BMJ Guideline: Treatment of Subclinical Hypothyroidism AND Society for Endocrinology & British Thyroid Association issue statement against new treatment recommendations for subclinical hypothyroidism

Commentary on Twitter

Ancillary study of the TRUST RCT of levothyroxine therapy finds it does not reduce depression risk among older adults with subclinical hypothyroidism and shouldn't be prescribed for this purpose. #VisualAbstract https://t.co/yu3EChdkm1

— JAMA Network Open (@JAMANetworkOpen) February 10, 2021