Archives
RCT: In comatose survivors of out-of-hospital cardiac arrest, there was no difference in mortality and neurologic outcomes with mild (target temperature of 34 °C) vs. moderate therapeutic hypothermia (target temperature of 31 °C).
24 Oct, 2021 | 23:46h | UTCEffect of Moderate vs Mild Therapeutic Hypothermia on Mortality and Neurologic Outcomes in Comatose Survivors of Out-of-Hospital Cardiac Arrest: The CAPITAL CHILL Randomized Clinical Trial – JAMA (free for a limited period)
Related:
Study commentary: a history of hypothermia for cardiac arrest, 2002-2021 (RIP).
Commentary on Twitter
therapeutic hypothermia after cardiac arrest is a nonbeneficial form of iatrogenesis that prolongs ICU length of stay (findings entirely consistent with TTM & TTM2). currently it should not be performed outside the context of an RCT. https://t.co/GZbpgHXWoD https://t.co/kRwRpLz6hV
— 𝙟𝙤𝙨𝙝 𝙛𝙖𝙧𝙠𝙖𝙨 💊 (@PulmCrit) October 20, 2021
Guideline: Transfusion strategies in bleeding critically ill adults.
24 Oct, 2021 | 23:47h | UTC
Commentary on Twitter
Transfusion strategies in bleeding critically ill adults current evidence/research areas from @ESICM clinical practice guideline
🩸massive bleedings
🩸non‑massive bleedings
🩸tranexamic acid in traumatic/non‑traumatic hemorrhages
Open #FOAMcc on @yourICM
🖇️https://t.co/LtEzrLcaM5 pic.twitter.com/Po7eFYpdeW— Intensive Care Medicine (@yourICM) October 22, 2021
RCT: The association of Varenicline and Nicotine patch was not better than Varenicline alone to increase smoking abstinence; there was also no difference between 24-week vs. 12-week treatment courses in abstinence rates.
24 Oct, 2021 | 23:45h | UTCEffects of Combined Varenicline With Nicotine Patch and of Extended Treatment Duration on Smoking Cessation: A Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Is There a Role for Combined Use of Varenicline and Nicotine Patch or Extended Treatment Duration to Enhance Smoking Cessation? – JAMA (free for a limited period)
Commentary: Varenicline Combo, Extension No Better for Quitting Smoking – HealthDay
Commentary on Twitter
Study findings do not support the use of combined varenicline plus nicotine patch therapy (vs varenicline monotherapy) or of extended treatment duration (24 vs 12 weeks) for smoking cessation https://t.co/XcQMQZgQb9
— JAMA (@JAMA_current) October 19, 2021
Middle-aged and older women are being diagnosed with Takotsubo Syndrome more frequently, up to 10 times more often, than younger women or men of any age.
24 Oct, 2021 | 23:43h | UTCNews release: Broken heart syndrome is on the rise, especially among older women – American Heart Association
Commentary: ‘Broken heart’ syndrome is on the rise in women – Cedars-Sinai Medical Center
Related:
International Expert Consensus Document on Takotsubo Syndrome
International Registry: 16.6% of Patients with Takotsubo Syndrome Have Underlying Malignancy
Systematic Review: Long-Term Prognosis and Outcome Predictors in Takotsubo Syndrome
Cohort Study: Hospital Readmission Following Takotsubo Syndrome
The cost-effectiveness of cefazolin compared to anti-staphylococcal penicillins for the treatment of methicillin-sensitive Staphylococcus aureus bacteremia.
24 Oct, 2021 | 23:41h | UTCRelated:
Meta-Analysis: Cefazolin vs. Antistaphylococcal Penicillins for MSSA Bacteremia
Commentaries on Twitter
While Cefazolin and anti-staphylococcal penicillins (ASPs), such as nafcillin, are the preferred treatments for MSSA bacteremia it looks more and more like Cefazolin is really the preferred approach. https://t.co/6FVVEWMxBY
— Daniel Griffin MD PhD (@DanielGriffinMD) October 8, 2021
New in OFID: The use of cefazolin is a cost-effective strategy for the treatment of methicillin-sensitive S. aureus bacteremia and, when clinically appropriate, results in health care cost-savings.
📄: https://t.co/lRfsZdMjLJ#IDSAJournals @PaulSaxMD @DrJLi @ElMylonakis pic.twitter.com/hhzik4ppUW
— IDSA (@IDSAInfo) October 8, 2021
M-A: In patients with Staphylococcus aureus bacteremia, combination therapy does not reduce mortality and is associated with increased risks of adverse events.
24 Oct, 2021 | 23:42h | UTC
Corporate influence linked to slow implementation of public health policies globally.
24 Oct, 2021 | 23:37h | UTC
Commentary on Twitter (thread – click for more)
🔥 Major New @LancetGH study with @hampusholmer & @sdwigley
📈 How has #NCD #Policy Implementation changed from 2015 – 2020?
🎯Which policies are being ignored?
🥇Country ranking
🗺️Regional assessment
💰 Corporate permeation
Summary below🧵…https://t.co/6pbwi5ybUM
— Luke Allen (@drlukeallen) October 20, 2021
M-A: Clinical interventions for adults with comorbid alcohol use and depressive disorders.
24 Oct, 2021 | 23:39h | UTC
Consensus statement on measures to promote equitable authorship in the publication of research from international partnerships.
24 Oct, 2021 | 23:35h | UTC
Commentary on Twitter
"Equitable authorship in international research partnerships"
In this consensus statement, we call on academic journals (& funders/employers) to ensure that an author reflexivity statement is submitted along with any manuscript from HIC-LMIC partnerships. https://t.co/IOKB04gSOm pic.twitter.com/musrVpCObz
— Ṣẹ̀yẹ Abímbọ́lá (@seyeabimbola) October 14, 2021
Perspective | The flawed science of antibody testing for SARS-CoV-2 immunity.
22 Oct, 2021 | 10:30h | UTCThe Flawed Science of Antibody Testing for SARS-CoV-2 Immunity – JAMA
Extreme heat is broiling people in developing cities: New analysis finds the explosive growth of cities is helping drive dangerous conditions.
24 Oct, 2021 | 23:34h | UTCExtreme heat is broiling people in developing cities – Science
Original Study: Global urban population exposure to extreme heat – Proceedings of the National Academy of Sciences
Commentary on Twitter
People in major cities are exposed to deadly temperatures 3X more often than in the 1980s—with cities in South Asia, Africa, and the Middle East bearing the brunt, according to a new analysis of 13,000+ cities. https://t.co/C864clE4Cq
— Global Health NOW (@ghn_news) October 9, 2021
[Press release – not published yet] A phase 3 trial with more than 10,000 participants showed a booster dose of the Pfizer/BioNTech vaccine had an efficacy of 95.6% against disease; there were 5 cases in the booster group and 109 cases in the non-boosted group, not classified according to severity.
22 Oct, 2021 | 10:34h | UTC
Commentaries on Twitter
This will presumably mean everyone gets boosters early next year. That’s great, because they do work. Except it’s likely to be boosters for rich countries at the expense of primary vaccination for poorer countries. You won’t stop the pandemic when half the world is unvaccinated https://t.co/F31DMSI2zf
— Niall Conroy (@NICU_doc_salone) October 21, 2021
The 1st randomized trial of a booster (3rd) shot in 10,000 people, placebo-controlled, shows 95.6% efficacy, with 5 cases (Pfizer vaccine) vs 109 in placebo group, Delta variant, broad benefit across age groups https://t.co/TQpF35d8Jk pic.twitter.com/3RkqvXNfsU
— Eric Topol (@EricTopol) October 21, 2021
WHO estimates that between 80 000 to 180 000 health and care workers could have died from Covid-19.
22 Oct, 2021 | 10:29h | UTCNews release: WHO and partners call for action to better protect health and care workers from COVID-19 – World Health Organization
WHO Statement: joint statement on WHO’s estimates of health and care worker deaths due to covid-19
Commentaries:
WHO calls for health worker protection against COVID-19 – CIDRAP
Covid may have killed up to 180,000 health workers globally, WHO says – The Guardian
Commentary on Twitter
.@WHO estimates 115,000 health workers have died from #Covid19. Huge, tragic loss.
And while some health workers in the US are QUITTING jobs because they don't want to be vaccinated, many HCWs around the world are still waiting for vaccine. Unconscionable. https://t.co/z4u9XSX2Wj— Helen Branswell 🇨🇦 (@HelenBranswell) October 21, 2021
Vaccine apartheid: This is not the way to end the pandemic.
22 Oct, 2021 | 10:26h | UTCVaccine apartheid: This is not the way to end the pandemic – Journal of Paediatrics and Child Health
Commentary on Twitter
Vaccine apartheid is devastating, especially for children@VSLanziotti @yoncabulutmd @surf4children @sgdambrauskas call for everyone to advocate for vaccine equity https://t.co/jzJd9kwcCi pic.twitter.com/0hEPk8B4xv
— Madhu Pai, MD, PhD (@paimadhu) October 21, 2021
RCT: In adults with Covid-19 and severe hypoxemia, 12 mg vs. 6 mg of Dexamethasone did not result in a statistically significant difference in the number of days alive without life support.
22 Oct, 2021 | 10:32h | UTCEditorial: Glucocorticoid Dose in COVID-19: Lessons for Clinical Trials During a Pandemic – JAMA
Commentary on Twitter
In a randomized trial of patients with #COVID19 and severe hypoxemia, compared with 6 mg of dexamethasone, 12 mg of dexamethasone did not statistically significantly reduce the number of days alive without life support at 28 days https://t.co/BMgLTel4aU pic.twitter.com/WKwI8xCUYO
— JAMA (@JAMA_current) October 21, 2021
Opinion | Politics is derailing a crucial debate over the immunity you get from recovering from Covid-19.
22 Oct, 2021 | 10:22h | UTC
Cluster RCT: Increasing the dietary sources of calcium and protein (by providing additional milk, yogurt, and cheese) reduced hip fractures and falls in older adults in residential care.
22 Oct, 2021 | 10:21h | UTCNews release: Increasing dairy intake reduces falls and fractures among older care home residents – British Medical Journal
Commentary on Twitter
Increasing intake of foods rich in calcium and protein such as milk, yoghurt, and cheese, reduces falls and fractures in older adults living in residential care, finds a randomised controlled trial published @bmj_latest today https://t.co/QzozG4Odjb
— BMJ Group (@bmj_company) October 21, 2021
M-A: Risk factors for poor prognosis in children and adolescents with COVID-19.
22 Oct, 2021 | 10:24h | UTC
RCT: Mirtazapine not better than placebo for the treatment of agitation in people with dementia and was possibly associated with increased mortality (7 vs.1 deaths, difference not statistically significant; p=0·065).
22 Oct, 2021 | 10:19h | UTCCommentary: Common antidepressant should no longer be used to treat people with dementia – University of Exeter
Degree of Myopia and Glaucoma Risk: A Dose-Response Meta-Analysis.
22 Oct, 2021 | 10:17h | UTC
Radiotherapy: Clinical pearls for primary care.
22 Oct, 2021 | 10:12h | UTCRadiotherapy: Clinical pearls for primary care – Canadian Family Physician
Systematic Review: Malnutrition in Hospitalized Adults.
22 Oct, 2021 | 10:14h | UTCMalnutrition in Hospitalized Adults – Agency for Healthcare Research and Quality
See also:
M-A: Diagnostic accuracy of handheld cardiac ultrasound device for assessment of left ventricular structure and function.
22 Oct, 2021 | 10:15h | UTC
Podcast: Managing Pediatric Hypertension in Your Primary Care Clinic.
22 Oct, 2021 | 10:10h | UTC#36: Off the Cuff – Managing Pediatric Hypertension in Your Primary Care Clinic – The Cribsiders
Health care environmental hygiene: new insights and centers for disease control and prevention guidance.
22 Oct, 2021 | 10:07h | UTC