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Health care–acquired infections in low- and middle-income countries and the role of infection prevention and control.

22 Oct, 2021 | 10:09h | UTC

Health Care–Acquired Infections in Low- and Middle-Income Countries and the Role of Infection Prevention and Control – Infectious Disease Clinics of North America

Occupational health update: approach to evaluation of health care personnel and preexposure prophylaxis.

22 Oct, 2021 | 10:06h | UTC

Occupational Health Update: Approach to Evaluation of Health Care Personnel and Preexposure Prophylaxis – Infectious Disease Clinics of North America

An analysis of Scotland’s mortality in 114,000 SARS-CoV2–infected people revealed that the vaccine effectiveness against death from the Delta variant was 90% for the Pfizer vaccine and 91% for AstraZeneca.

21 Oct, 2021 | 10:15h | UTC

BNT162b2 and ChAdOx1 nCoV-19 Vaccine Effectiveness against Death from the Delta Variant – New England Journal of Medicine

Pfizer vaccine showed estimated effectiveness of 93% against symptomatic SARS-CoV-2 Delta variant infection in adolescents.

21 Oct, 2021 | 10:17h | UTC

Effectiveness of BNT162b2 Vaccine against Delta Variant in Adolescents – New England Journal of Medicine

Commentary on Twitter

The remarkably high effectiveness (VE) of vaccination for teens vs the Delta variant in over 94,000 vaccinees and 94,000 matched controls: 93% VE vs symptomatic infection (95% CI 88,97) https://t.co/wwoXlw7PH9 @NEJM pic.twitter.com/8m3fJ7avc5

— Eric Topol (@EricTopol) October 20, 2021

A case-controlled study showed Covid-19 vaccination during early pregnancy was not associated with increased risk of first-trimester miscarriage.

21 Oct, 2021 | 10:14h | UTC

Covid-19 Vaccination during Pregnancy and First-Trimester Miscarriage – New England Journal of Medicine

Editorial: Covid-19 treatments and vaccines must be evaluated in pregnancy.

Cohort study: Vaccinated pregnant patients had 90% lower risk of severe or critical Covid-19 compared with unvaccinated pregnant patients.

Two observational studies suggest spontaneous abortion is not increased following COVID-19 mRNA vaccination during pregnancy.

Study shows high effectiveness of the Pfizer mRNA COVID-19 vaccine in pregnancy.

5 Crucial Things to Know About COVID-19 Vaccines and Pregnancy.

CDC Guidance: Pregnant people should be vaccinated against COVID-19.

ACOG and SMFM Recommend COVID-19 Vaccination for Pregnant Individuals – “ACOG encourages its members to enthusiastically recommend vaccination to their patients.”

Cohort study: Pfizer/BioNTech COVID vaccine associated with 78% lower risk of Covid-19 in pregnancy.

FDA authorizes booster doses of Moderna and Johnson & Johnson vaccines, says mix and match OK.

21 Oct, 2021 | 10:09h | UTC

FDA authorizes booster doses of Moderna and Johnson & Johnson vaccines, says mix and match OK – CNN

NCCN Guideline: Cancer-Associated Venous Thromboembolic Disease.

21 Oct, 2021 | 10:06h | UTC

Cancer-Associated Venous Thromboembolic Disease, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology – Journal of the National Comprehensive Cancer Network

ASH 2021 guidelines for prevention and treatment of venous thromboembolism in patients with cancer

Review: venous and arterial thromboembolism in patients with cancer.

Systematic Review: Does testing for cancer in people with unprovoked blood clots in the legs and lungs reduce cancer- and blood clot-related death and illness?

M-A: Extended thromboprophylaxis after hospital discharge for medically ill patients with cancer – Extended thromboprophylaxis is not associated with a reduced rate of venous thromboembolic events and is associated with increased risk of hemorrhage

Systematic review: Primary prophylaxis for venous thromboembolism in ambulatory cancer patients receiving chemotherapy

COVID-19 pneumonia: pathophysiology and management.

21 Oct, 2021 | 10:12h | UTC

COVID-19 pneumonia: pathophysiology and management – European Respiratory Review

Instead of quarantine for Covid-exposed students, some schools are trying test-to-stay.

21 Oct, 2021 | 10:08h | UTC

Instead of quarantine for Covid-exposed students, some schools are trying test-to-stay – CNN

Cluster RCT: Daily contact testing of school-based contacts was non-inferior to self-isolation for control of COVID-19 transmission.

Kids are losing school days to quarantines. Here’s a way to keep them in classrooms – “Test-to-stay could dramatically reduce close contact quarantines”.

Opinion | Data from routine Covid testing can help schools stay open this year.

Guideline: Erectile Dysfunction.

21 Oct, 2021 | 10:01h | UTC

Canadian Urological Association guideline: Erectile dysfunction – Canadian Urological Association Journal

State of the Art Review: Diagnosis and management of bronchopulmonary dysplasia.

21 Oct, 2021 | 09:56h | UTC

Diagnosis and management of bronchopulmonary dysplasia – The BMJ

Commentary on Twitter

This new clinical review evaluates the various clinical definitions, imaging modalities, and biomarker data that are helpful in making an early diagnosis of bronchopulmonary dysplasia (BPD), as well as the evidence on the prevention and treatment of BPD https://t.co/ITqe8WMkNl

— The BMJ (@bmj_latest) October 20, 2021

Opinion | Understanding of research results, evidence summaries and their applicability—not critical appraisal—are core skills of medical curriculum.

21 Oct, 2021 | 09:57h | UTC

Understanding of research results, evidence summaries and their applicability—not critical appraisal—are core skills of medical curriculum – BMJ Evidence-Based Medicine

Commentary on Twitter

https://twitter.com/lucasmorin_eolc/status/1450876923798765572

Five-year follow-up of RCT: Arthroscopic subacromial decompression provided no benefit over diagnostic arthroscopy or exercise therapy on return to work in patients with shoulder impingement syndrome.

21 Oct, 2021 | 09:54h | UTC

Return to work after subacromial decompression, diagnostic arthroscopy, or exercise therapy for shoulder impingement: a randomised, placebo-surgery controlled FIMPACT clinical trial with five-year follow-up – BMC Musculoskeletal Disorders

Randomized Trial: Subacromial Decompression vs Diagnostic Arthroscopy for Shoulder Impingement

Research: Arthroscopic subacromial decompression for subacromial shoulder pain

BMJ Guideline: Subacromial Decompression Surgery For Adults With Shoulder Pain Does Not Improve Outcomes

Systematic Review: Subacromial Decompression Surgery for Rotator Cuff Disease

Systematic Review: Surgery for Rotator Cuff Tears

The International Cannabis Toolkit (iCannToolkit): a multidisciplinary expert consensus on minimum standards for measuring cannabis use.

21 Oct, 2021 | 09:48h | UTC

The International Cannabis Toolkit (iCannToolkit): a multidisciplinary expert consensus on minimum standards for measuring cannabis use – Addiction

Commentary: How to measure cannabis use: introducing the ‘International Cannabis Toolkit’ or iCannToolkit – The Mental Elf

In a major scientific advance, a pig kidney is successfully transplanted into a human.

21 Oct, 2021 | 09:52h | UTC

In a major scientific advance, a pig kidney is successfully transplanted into a human – NPR

Opinion | Is it time for Evidence-Based Medicine 2.0?

21 Oct, 2021 | 09:59h | UTC

Is it time for Evidence-Based Medicine 2.0? – Centre for Evidence-Based Medicine

CDC Study: Pfizer vaccine showed 93% effectiveness against Covid-19 hospitalization among children aged 12-18 years.

20 Oct, 2021 | 10:31h | UTC

Effectiveness of Pfizer-BioNTech mRNA Vaccination Against COVID-19 Hospitalization Among Persons Aged 12–18 Years — United States, June–September 2021 – CDC Morbidity and Mortality Weekly Report

Commentary on Twitter (thread – click for more)

Vaccination reduced the risk of hospitalization among 12–18-year-olds by 93%, according to a new CDC study. No vaccinated adolescents died or were admitted to the ICU.

— Dr. Tom Frieden (@DrTomFrieden) October 19, 2021

ESMO Clinical Practice Guideline for the diagnosis, staging and treatment of patients with metastatic breast cancer.

21 Oct, 2021 | 09:48h | UTC

ESMO Clinical Practice Guideline for the diagnosis, staging and treatment of patients with metastatic breast cancer – Annals of Oncology

Press release: metastatic breast cancer: new ESMO guideline with evidence-based recommendations – European Society of Medical Oncology

Cohort Study: Hypertensive disorders of pregnancy are associated with a 6-fold or higher increased risk of chronic hypertension in the first years following delivery.

21 Oct, 2021 | 09:51h | UTC

Hypertensive disorders of pregnancy and onset of chronic hypertension in France: the nationwide CONCEPTION study – European Heart Journal

Editorial: Impact of hypertensive disorders of pregnancy: lessons from CONCEPTION

Commentary on Twitter

Hypertensive disorders of pregnancy and onset of chronic hypertension in France: the nationwide CONCEPTION study@escardio #EHJ #cardiotwitter https://t.co/OnJRP94W6v pic.twitter.com/N3dLNTD5XU

— EHJ Editor-in-Chief (@ehj_ed) October 17, 2021

RCT: Nivolumab vs. placebo in patients with relapsed malignant mesothelioma.

21 Oct, 2021 | 09:46h | UTC

Nivolumab versus placebo in patients with relapsed malignant mesothelioma (CONFIRM): a multicentre, double-blind, randomised, phase 3 trial – The Lancet Oncology

Commentary on Twitter

CONFIRM Trial: a phase III study demonstrated longer PFS and OS with Nivolumab compared with Placebo in patients with Pleural or Peritoneal Malignant Mesothelioma who have progressed following platinum-based chemotherapy @OncoAlert #LCSM https://t.co/jKoKXEXgpB

— Dipesh Uprety MD FACP (@DipeshUpretyMD) October 15, 2021

Cohort Study: The effectiveness of heterologous AstraZeneca (AZ)/mRNA prime-boost vaccination was more significant (68%) compared to the effectiveness of homologous AZ/AZ vaccination (50%) against symptomatic Covid-19 infection in Sweden.

20 Oct, 2021 | 10:27h | UTC

Effectiveness of heterologous ChAdOx1 nCoV-19 and mRNA prime-boost vaccination against symptomatic Covid-19 infection in Sweden: A nationwide cohort study – The Lancet Regional Health Europe

Commentary: High effectiveness of mix-and-match COVID-19 vaccines – UMEA University

Study evaluated several heterologous SARS-CoV-2 vaccine regimens; no efficacy data but there was increased antibody production on study days 15 and 29 after booster shots from Moderna and Pfizer.

A primer on what we know about mixing and matching Covid vaccines.

Real-world data shows increased reactogenicity in adults after heterologous compared to homologous prime-boost COVID-19 vaccination.

RCT: Safety and immunogenicity of heterologous vs. homologous prime-boost schedules with an adenoviral vectored and mRNA COVID-19 vaccine.

Another study shows increased immune response with heterologous Oxford-AstraZeneca/mRNA vaccination.

Heterologous Oxford–AstraZeneca and Moderna Vaccination induce increased levels of neutralizing antibody compared to 2 doses of Oxford–AstraZeneca.

Heterologous Oxford–AstraZeneca and BioNTech/Pfizer Vaccination induce increased levels of neutralizing antibody compared to 2 doses of Oxford–AstraZeneca.

[Preprint] Mixing Covid jabs has good immune response, study finds – “The Com-Cov trial looked at the efficacy of either two doses of Pfizer, two of AstraZeneca, or one of them followed by the other. All combinations worked well, priming the immune system”.

Phase 2 RCT: Immunogenicity and reactogenicity of a Pfizer-BioNTech booster in patients that have received a single dose of AstraZeneca vaccine – “BNT162b2 (Pfizer) given as a second dose in individuals prime vaccinated with ChAdOx1-S (AstraZeneca) induced a robust immune response, with an acceptable and manageable reactogenicity profile”.

Lab study shows heterologous AstraZeneca/Pfizer vaccination produces strong immune response against SARS-CoV-2 Delta variant.

Lab study shows a heterologous AstraZeneca + Pfizer immunization strategy provides stronger immunogenicity against Covid compared to homologous AZ + AZ or Pfizer + Pfizer strategies.

RCT: Mixing 2 different Covid vaccines is associated with increased risk of side effects.

Commentary on Twitter

Study from Sweden assessing heterogenous vaccination in 3,445,061 individuals who received AZ as the first dose and either #pfizer, #moderna, or #AZ as second dose showed the following vaccine effectiveness:

AZ/Pfizer- 67%
AZ/Moderna- 79%
AZ/AZ- 50%https://t.co/UN0pey2kJ2

— Yan Leyfman, MD (@YLeyfman) October 19, 2021