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NEST trial in @JAMANetworkOpen by @rodwhunt explores if treatment of EEG + clinical seizures compared with only treating clinical seizures in encephalopathic infants decreased odds of severe disability at 2 years of age. https://t.co/s3yYi6R3fV #EBNEOalerts #neoEBM #neotwitter pic.twitter.com/xoxVKC2a5z

— Evidence-Based Neo (@EBNEO) December 29, 2021

The Antifungal Pipeline: Fosmanogepix, Ibrexafungerp, Olorofim, Opelconazole, and Rezafungin.

13 Jan, 2022 | 08:17h | UTC

The Antifungal Pipeline: Fosmanogepix, Ibrexafungerp, Olorofim, Opelconazole, and Rezafungin – Drugs

Consolidated Health Economic Evaluation Reporting Standards 2022 (CHEERS 2022) statement: updated reporting guidance for health economic evaluations.

13 Jan, 2022 | 08:13h | UTC

Consolidated Health Economic Evaluation Reporting Standards 2022 (CHEERS 2022) statement: updated reporting guidance for health economic evaluations – The BMJ

Systematic Review: In patients who are about to undergo noncardiac surgery, biomarkers (BNP/NT‐proBNP, troponin or their combination) may provide added prognostic value to the Revised Cardiac Risk Index for preoperative prediction of major adverse cardiac events and all‐cause mortality. The results cannot be interpreted as conclusive due to the high risks of bias in most papers.

13 Jan, 2022 | 08:15h | UTC

The comparative and added prognostic value of biomarkers to the Revised Cardiac Risk Index for preoperative prediction of major adverse cardiac events and all‐cause mortality in patients who undergo noncardiac surgery – Cochrane Library

Summary: Can biomarkers improve predictions of the RCRI tool to predict heart-related complications in patients undergoing surgery other than heart surgery? – Cochrane Library

Final overall survival analysis of the HER2CLIMB RCT: Tucatinib vs. placebo added to Trastuzumab and Capecitabine for patients with pretreated HER2+ metastatic breast cancer with and without brain metastases.

13 Jan, 2022 | 08:12h | UTC

Tucatinib vs Placebo Added to Trastuzumab and Capecitabine for Patients with Pretreated HER2+ Metastatic Breast Cancer with and without Brain Metastases (HER2CLIMB): Final Overall Survival Analysis – Annals of Oncology (link to abstract – $ for full-text)

Original Study: Randomized Trial: Tucatinib, Trastuzumab, and Capecitabine for HER2-Positive Metastatic Breast Cancer

The COVID-19 Treatment Guidelines Panel’s Statement on Anticoagulation in Hospitalized Patients With COVID-19 – in the absence of contraindications, use therapeutic-dose anticoagulation with low molecular weight heparin for hospitalized patients not in the ICU who have a D-dimer above the upper limit of normal.

12 Jan, 2022 | 09:11h | UTC

The COVID-19 Treatment Guidelines Panel’s Statement on Anticoagulation in Hospitalized Patients With COVID-19 – NIH COVID-19 Treatment Guidelines

Statement on therapies for high-risk, nonhospitalized patients with mild to moderate Covid-19.

12 Jan, 2022 | 09:14h | UTC

The COVID-19 Treatment Guidelines Panel’s Statement on Therapies for High-Risk, Nonhospitalized Patients With Mild to Moderate COVID-19 – NIH COVID-19 Treatment Guidelines

Cohort Study: In preterm premature rupture of membranes at 24-31 weeks, antibiotic prophylaxis based on third-generation cephalosporin may be associated with improved perinatal outcomes compared to amoxicillin.

13 Jan, 2022 | 08:10h | UTC

Antibiotic prophylaxis in preterm premature rupture of membranes at 24-31 weeks’ gestation: perinatal and 2-year outcomes in the EPIPAGE-2 cohort – BJOG (link to abstract – $ for full-text)

Recommendations on patient prioritization for outpatient Anti-SARS-CoV-2 therapies or preventive strategies when there are logistical or supply constraints.

12 Jan, 2022 | 09:06h | UTC

The COVID-19 Treatment Guidelines Panel’s Interim Statement on Patient Prioritization for Outpatient Anti-SARS-CoV-2 Therapies or Preventive Strategies When There Are Logistical or Supply Constraints – COVID-19 Treatment Guidelines Panel

Commentary on Twitter

https://twitter.com/NIHCOVIDTxGuide/status/1475510894121697287

International study identifies predictors of severe outcomes in children with COVID-19.

12 Jan, 2022 | 09:05h | UTC

News Release: International study identifies predictors of severe outcomes in children with COVID-19 – University of Calgary

Original Study: Outcomes of SARS-CoV-2–Positive Youths Tested in Emergency Departments: The Global PERN–COVID-19 Study – JAMA Network Open

How do death rates from COVID-19 differ between people who are vaccinated and those who are not?

12 Jan, 2022 | 09:02h | UTC

How do death rates from COVID-19 differ between people who are vaccinated and those who are not? – Our World in Data

Commentary from the author on Twitter

Updated: Now the ratio is 20.

The COVID death rate among unvaccinated people is 20-times higher than among vaccinated people.

This is the latest age-standardized data from Swizerland.

[From our post with @redouad on death rates by vaccination status: https://t.co/nNmfYAk0m1] pic.twitter.com/dRwkOWIRBa

— Max Roser (@MaxCRoser) December 26, 2021

Statement on potential drug-drug interactions between Ritonavir-boosted Nirmatrelvir (Paxlovid) and concomitant medications; antiarrhythmics, oral anticoagulants, immunosuppressants, anticonvulsants, antineoplastics, and neuropsychiatric drugs are among the drugs of concern.

12 Jan, 2022 | 09:09h | UTC

The COVID-19 Treatment Guidelines Panel’s Statement on Potential Drug-Drug Interactions Between Ritonavir-Boosted Nirmatrelvir (Paxlovid) and Concomitant Medications – NIH COVID-19 Treatment Guidelines Panel

Commentaries:

Pfizer antiviral pills may be risky with other medications – NBC News

The New COVID-19 Pill, Paxlovid, Interacts with Many Medications: Cardiac Patients Take Note – The Skeptical Cardiologist

Podcast: Long COVID Pearls.

12 Jan, 2022 | 09:04h | UTC

#315 Long COVID with Dr. Monica Verduzco-Gutierrez – The Curbsiders

[Preprint] Saliva swabs may be the preferred sample for Omicron detection.

12 Jan, 2022 | 08:58h | UTC

Saliva swabs are the preferred sample for Omicron detection – medRxiv

Commentary: Study suggests saliva swabs may be more suitable for omicron detection – News Medical

Perspective | Covid-19: Is it safe to reduce the self-isolation period?

12 Jan, 2022 | 09:00h | UTC

Covid-19: Is it safe to reduce the self-isolation period? – The BMJ

RCT: High-dose weekly Semaglutide (2.4 mg) resulted in increased weight loss compared to daily Liraglutide (3.0 mg).

12 Jan, 2022 | 08:55h | UTC

Effect of Weekly Subcutaneous Semaglutide vs Daily Liraglutide on Body Weight in Adults With Overweight or Obesity Without Diabetes: The STEP 8 Randomized Clinical Trial – JAMA (free for a limited period)

Commentary on Twitter

In this randomized clinical trial of 338 participants, mean body weight change from baseline to 68 weeks was –15.8% with semaglutide vs –6.4% with liraglutide, a statistically significant difference. https://t.co/8tktjqw4mE pic.twitter.com/BxrL1XPpKv

— JAMA (@JAMA_current) January 11, 2022

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