Open access
Open access
Powered by Google Translator Translator

Archives

Preliminary findings from a randomized trial showed promising results from dual PD-1 and HER2 blockade in HER2-positive gastric cancer.

14 Jan, 2022 | 08:03h | UTC

The KEYNOTE-811 trial of dual PD-1 and HER2 blockade in HER2-positive gastric cancer – Nature

Commentary: KEYNOTE-811: Pembrolizumab combination as a potentially transformative treatment for HER2-positive gastric cancer – Vall d’Hebron University Hospital

 

Commentary on Twitter

 

In a study with 1110 children with prolonged fever, MRP8/14 serum levels were validated as a diagnostic marker for systemic juvenile idiopathic arthritis.

14 Jan, 2022 | 08:07h | UTC

MRP8/14 serum levels as diagnostic markers for systemic juvenile idiopathic arthritis in children with prolonged fever – Rheumatology (link to abstract – $ for full-text)

Commentary: It is about time: the first validated biomarker for early diagnosis of sJIA – Rheumatology

 

Phase 2 RCT: In patients with generalized pustular psoriasis, Spesolimab improved lesions at one week but was associated with infections and systemic drug reactions.

14 Jan, 2022 | 08:01h | UTC

Trial of Spesolimab for Generalized Pustular Psoriasis – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Trial of Spesolimab for Generalized Pustular Psoriasis – Mount Sinai

 

Systematic Review: In patients with intermittent claudication, Propionyl‐L‐carnitine may improve walking distance when compared to placebo (moderate overall certainty of evidence).

14 Jan, 2022 | 08:02h | UTC

Propionyl‐L‐carnitine for intermittent claudication – Cochrane Library

Summary: Propionyl-L-carnitine for intermittent claudication – Cochrane Library

 

RCT: In patients with immune-mediated inflammatory diseases (rheumatoid arthritis, spondyloarthritis, psoriatic arthritis, ulcerative colitis, Crohn disease, or psoriasis) treated with Infliximab, a proactive therapeutic drug monitoring protocol was more likely to lead to sustained disease control.

14 Jan, 2022 | 07:57h | UTC

Effect of Therapeutic Drug Monitoring vs Standard Therapy During Maintenance Infliximab Therapy on Disease Control in Patients With Immune-Mediated Inflammatory Diseases: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

 

Commentary on Twitter

 

5 years later, researchers assess how children exposed to Zika are developing.

14 Jan, 2022 | 07:53h | UTC

5 years later, researchers assess how children exposed to Zika are developing – NPR

Related: Study: Neurodevelopmental Abnormalities in Children with in Utero Zika Virus Exposure Without Congenital Zika Syndrome

 

RCT: In patients with acromegaly who previously tolerated and responded to both regimens, oral octreotide was non-inferior for maintaining biochemical response and symptomatic control compared to injectable somatostatin receptor ligands.

14 Jan, 2022 | 07:55h | UTC

Maintenance of response to oral octreotide compared with injectable somatostatin receptor ligands in patients with acromegaly: a phase 3, multicentre, randomised controlled trial – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)

 

Review: Tumor burden and efficacy of immune-checkpoint inhibitors.

14 Jan, 2022 | 07:48h | UTC

Tumour burden and efficacy of immune-checkpoint inhibitors – Nature Reviews Clinical Oncology (if the link is paywalled, try this one)

 

M-A: Combined oral contraceptives may improve overall premenstrual symptomatology but are not helpful for premenstrual depressive symptoms.

14 Jan, 2022 | 07:49h | UTC

Efficacy of combined oral contraceptives for depressive symptoms and overall symptomatology in premenstrual syndrome: pairwise and network meta-analysis of randomized trials – American Journal of Obstetrics & Gynecology

Commentary: ‘Optimal’ treatment for premenstrual depressive symptoms remains elusive – Healio (free registration required)

 

Risk of reoperation 10 years after surgical treatment for stress urinary incontinence: a national population-based cohort study.

14 Jan, 2022 | 07:51h | UTC

Risk of reoperation 10 years after surgical treatment for stress urinary incontinence: a national population-based cohort study – American Journal of Obstetrics & Gynecology

 

Commentary on Twitter

 

Observational study in adolescents showed the Pfizer-BioNTech vaccine had an overall effectiveness of 94% against hospitalization and 98% against critical Covid-19.

13 Jan, 2022 | 09:00h | UTC

Effectiveness of BNT162b2 Vaccine against Critical Covid-19 in Adolescents – New England Journal of Medicine

Editorial: Sparing of Severe Covid-19 in Vaccinated Adolescents – New England Journal of Medicine

 

Study shows COVID-19 vaccines offer lasting protection against hospitalization and death.

13 Jan, 2022 | 09:01h | UTC

Duration of Protection against Mild and Severe Disease by Covid-19 Vaccines – New England Journal of Medicine

News Release: Study shows COVID-19 vaccines offer lasting protection – University of North Carolina at Chapel Hill

 

An observational study in South Africa estimates the Pfizer vaccine had an effectiveness of 70% against hospitalization for Covid-19 caused by the omicron variant.

13 Jan, 2022 | 08:56h | UTC

Effectiveness of BNT162b2 Vaccine against Omicron Variant in South Africa – New England Journal of Medicine

Commentary: BNT162b2 still effective, but less so, against Omicron – HealthDay

 

The COVID generation: how is the pandemic affecting kids’ brains?

13 Jan, 2022 | 08:53h | UTC

The COVID generation: how is the pandemic affecting kids’ brains? – Nature

 

Omicron Infection Curve ‘Staggering’ – 36 Countries Have Vaccinated Less than 10% of Citizens.

13 Jan, 2022 | 08:49h | UTC

Omicron Infection Curve ‘Staggering’ – 36 Countries Have Vaccinated Less than 10% of Citizens – Health Policy Watch

 

RCT: Early Remdesivir in outpatients can prevent progression to severe Covid-19.

13 Jan, 2022 | 08:54h | UTC

Early Remdesivir to Prevent Progression to Severe Covid-19 in Outpatients – New England Journal of Medicine

Editorial: The Goldilocks Time for Remdesivir — Is Any Indication Just Right?

Commentary: Three days of remdesivir cuts risk for severe COVID-19 in outpatients – MedicalXpress

 

Commentary on Twitter

 

Another study showed neutralizing monoclonal antibody therapies are not effective when given after the patient is already hospitalized.

13 Jan, 2022 | 08:48h | UTC

Efficacy and safety of two neutralising monoclonal antibody therapies, sotrovimab and BRII-196 plus BRII-198, for adults hospitalised with COVID-19 (TICO): a randomised controlled trial – The Lancet Infectious Diseases

Invited Commentary: Time to knock monoclonal antibodies off the platform for patients hospitalised with COVID-19

 

‘Killer’ immune cells still recognize Omicron variant.

13 Jan, 2022 | 08:51h | UTC

‘Killer’ immune cells still recognize Omicron variant – Nature

See also: T-cells: the superheroes in the battle against omicron – The Conversation

 

RCT: A single dose of a novel adenovirus type 5 vectored SARS-CoV-2 vaccine was safe and had 57.5% efficacy against symptomatic Covid-19 and 91.7% efficacy against severe disease in adults.

13 Jan, 2022 | 08:44h | UTC

Final efficacy analysis, interim safety analysis, and immunogenicity of a single dose of recombinant novel coronavirus vaccine in adults 18 years and older: an international, multicentre, randomised, double-blinded, placebo-controlled phase 3 trial – The Lancet

Commentaries:

Efficacy of an adenovirus type 5 vectored SARS-CoV-2 vaccine – The Lancet

Phase 3 trial reports one dose of Ad5-nCoV COVID-19 vaccine is safe and effective, including against severe disease – The Lancet

 

A clinical case definition of post-COVID-19 condition by a Delphi consensus.

13 Jan, 2022 | 08:45h | UTC

A clinical case definition of post-COVID-19 condition by a Delphi consensus – The Lancet Infectious Diseases

 

Commentary on Twitter

 

RCT: Pancreatoduodenectomy with or without prophylactic falciform ligament wrap around the hepatic artery for prevention of postpancreatectomy haemorrhage.

13 Jan, 2022 | 08:35h | UTC

Pancreatoduodenectomy with or without prophylactic falciform ligament wrap around the hepatic artery for prevention of postpancreatectomy haemorrhage: randomized clinical trial (PANDA trial) – British Journal of Surgery (link to abstract – $ for full-text)

 

Commentary on Twitter

 

Global, regional, and national burden of 12 mental disorders in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019.

13 Jan, 2022 | 08:42h | UTC

Global, regional, and national burden of 12 mental disorders in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019 – The Lancet Psychiatry

Invited Commentary: The true global disease burden of mental illness: still elusive – The Lancet Psychiatry (free registration required)

 

Review: Diagnosis and treatment of sexually transmitted infections.

13 Jan, 2022 | 08:38h | UTC

Diagnosis and Treatment of Sexually Transmitted Infections: A Review – JAMA (free for a limited period)

 

Cohort Study: Patient factors associated with appendectomy within 30 days of initiating antibiotic treatment for appendicitis – the presence of an appendicolith was associated with a nearly 2-fold increased risk of undergoing appendectomy within 30 days.

13 Jan, 2022 | 08:39h | UTC

Patient Factors Associated With Appendectomy Within 30 Days of Initiating Antibiotic Treatment for Appendicitis – JAMA Surgery (free for a limited period)

Invited commentary: Appendicoliths, Antibiotic Treatment Failure, and Appendectomy—Is the Glass Half Full or Half Empty? – JAMA Surgery

 

Review: Bowel decontamination before colonic and rectal surgery.

13 Jan, 2022 | 08:36h | UTC

Bowel decontamination before colonic and rectal surgery – British Journal of Surgery

 

Stay Updated in Your Specialty

Telegram Channels
Free

WhatsApp alerts 10-day free trial

No spam, just news.