RCT: High-dose weekly Semaglutide (2.4 mg) resulted in increased weight loss compared to daily Liraglutide (3.0 mg).

Effect of Weekly Subcutaneous Semaglutide vs Daily Liraglutide on Body Weight in Adults With Overweight or Obesity Without Diabetes: The STEP 8 Randomized Clinical Trial – JAMA (free for a limited period)

Commentary on Twitter

In this randomized clinical trial of 338 participants, mean body weight change from baseline to 68 weeks was –15.8% with semaglutide vs –6.4% with liraglutide, a statistically significant difference. https://t.co/8tktjqw4mE pic.twitter.com/BxrL1XPpKv

— JAMA (@JAMA_current) January 11, 2022