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Podcast: Obesity medicine pearls.

4 Mar, 2022 | 08:43h | UTC

#324: Obesity Medicine FAQ with Dr. Fatima Cody Stanford – The Curbsiders

 

JAMA Guide to Statistics and Methods: Causal Directed Acyclic Graphs.

4 Mar, 2022 | 08:40h | UTC

Causal Directed Acyclic Graphs – JAMA (free for a limited period)

 

Review: Implementing machine learning in medicine.

4 Mar, 2022 | 08:42h | UTC

Implementing machine learning in medicine – Canadian Medical Association Journal

Related:

A Clinician’s Guide to Artificial Intelligence (AI): Why and How Primary Care Should Lead the Health Care AI Revolution – The Journal of the American Board of Family Medicine

Primer for artificial intelligence in primary care.

A Clinician’s Guide to Artificial Intelligence: How to Critically Appraise Machine Learning Studies

Review | AI and the cardiologist: when mind, heart and machine unite.

Review: Artificial intelligence in health and medicine.

Artificial intelligence projects in healthcare: 10 practical tips for success in a clinical environment.

WHO issues first global report on Artificial Intelligence (AI) in health and six guiding principles for its design and use.

Opinion | AI-facilitated health care requires education of clinicians

Welcoming new guidelines for AI clinical research

 

Diagnosis, management and therapeutic strategies for congenital long QT syndrome.

4 Mar, 2022 | 08:39h | UTC

Diagnosis, management and therapeutic strategies for congenital long QT syndrome – Heart

 

Commentary on Twitter

 

Renal compression in heart failure: the renal tamponade hypothesis.

4 Mar, 2022 | 08:36h | UTC

Renal Compression in Heart Failure: The Renal Tamponade Hypothesis – JACC: Heart Failure

Summary: Review of Renal Compression in Heart Failure: Key Points – American College of Cardiology

 

Interventions for frailty among older adults with cardiovascular disease: JACC State-of-the-Art Review.

4 Mar, 2022 | 08:37h | UTC

Interventions for Frailty Among Older Adults With Cardiovascular Disease: JACC State-of-the-Art Review – Journal of the American College of Cardiology

 

M-A: Effects of media stories of hope and recovery on suicidal ideation and help-seeking attitudes and intentions.

4 Mar, 2022 | 08:35h | UTC

Effects of media stories of hope and recovery on suicidal ideation and help-seeking attitudes and intentions: systematic review and meta-analysis – The Lancet Public Health

 

Association between incident cancer and Guillain-barré syndrome development: a nationwide case-control study.

4 Mar, 2022 | 08:33h | UTC

Association Between Incident Cancer and Guillain-Barré Syndrome Development: A Nationwide Case-Control Study – Neurology (link to abstract – $ for full-text)

News Release: Certain Types of Cancer May Increase the Risk of Developing Guillain-Barré – American Academy of Neurology

 

Carbapenem-resistant Acinetobacter Baumannii: colonization, infection and current treatment options.

4 Mar, 2022 | 08:31h | UTC

Carbapenem-resistant Acinetobacter baumannii: Colonization, Infection and Current Treatment Options – Infectious Diseases and Therapy

Related:

IDSA guidance and ESCMID guidelines: complementary approaches toward a care standard for MDR Gram-negative infections – Clinical Microbiology and Infection

European guidelines for the treatment of infections caused by Multidrug-resistant Gram-negative bacilli.

IDSA Guidance on the Treatment of Antimicrobial-Resistant Gram-Negative Infections.

 

Phase 2, open-label RCT: Stereotactic body radiotherapy plus pembrolizumab and trametinib vs. stereotactic body radiotherapy plus gemcitabine for locally recurrent pancreatic cancer after surgical resection.

4 Mar, 2022 | 08:34h | UTC

Stereotactic body radiotherapy plus pembrolizumab and trametinib versus stereotactic body radiotherapy plus gemcitabine for locally recurrent pancreatic cancer after surgical resection: an open-label, randomised, controlled, phase 2 trial – The Lancet Oncology (link to abstract – $ for full-text)

 

Review: Therapeutic strategies for emerging multidrug-resistant Pseudomonas Aeruginosa.

4 Mar, 2022 | 08:32h | UTC

Therapeutic Strategies for Emerging Multidrug-Resistant Pseudomonas aeruginosa – Infectious Diseases and Therapy

Related:

IDSA guidance and ESCMID guidelines: complementary approaches toward a care standard for MDR Gram-negative infections – Clinical Microbiology and Infection

European guidelines for the treatment of infections caused by Multidrug-resistant Gram-negative bacilli.

IDSA Guidance on the Treatment of Antimicrobial-Resistant Gram-Negative Infections.

 

WHO: COVID-19 pandemic triggers a 25% increase in the prevalence of anxiety and depression worldwide.

3 Mar, 2022 | 09:44h | UTC

News Release: COVID-19 pandemic triggers 25% increase in prevalence of anxiety and depression worldwide – World Health Organization

Scientific Brief: Mental health and COVID-19: Early evidence of the pandemic’s impact – World Health Organization

 

Commentary on Twitter (thread – click for more)

 

RCT: Aspirin and unfractionated heparin increase the risk of symptomatic intracranial hemorrhage in patients undergoing endovascular treatment for ischemic stroke.

3 Mar, 2022 | 08:53h | UTC

Safety and efficacy of aspirin, unfractionated heparin, both, or neither during endovascular stroke treatment (MR CLEAN-MED): an open-label, multicentre, randomised controlled trial – The Lancet (link to abstract – $ for full-text)

 

RCT: Nirsevimab for prevention of RSV in healthy late-preterm and term infants.

3 Mar, 2022 | 09:42h | UTC

Nirsevimab for Prevention of RSV in Healthy Late-Preterm and Term Infants – New England Journal of Medicine

Commentaries:

Nirsevimab Protects Late-Preterm, Term Infants from RSV-Related Lower RTI, Study Finds – AJMC

Nirsevimab Prophylaxis Wards Off RSV Infections in Healthy Infants— Monoclonal antibody showed 74.5% efficacy against RSV infections requiring medical care – MedPage Today (free registration required)

Related: Randomized trial: Single-dose nirsevimab for prevention of RSV in preterm infants

 

National, regional, and global causes of mortality in 5–19-year-olds from 2000 to 2019: a systematic analysis.

3 Mar, 2022 | 08:51h | UTC

National, regional, and global causes of mortality in 5–19-year-olds from 2000 to 2019: a systematic analysis – The Lancet Global Health

Invited commentary: Child and adolescent deaths: a call for strengthening mortality surveillance systems – The Lancet Global Health

 

Cohort Study: High-sensitivity Troponin I after cardiac surgery and 30-day mortality.

3 Mar, 2022 | 08:54h | UTC

High-Sensitivity Troponin I after Cardiac Surgery and 30-Day Mortality – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries:

Better assessment of risk from heart surgery results in better patient outcomes – McMaster University

NEJM study evaluates levels of HS Troponin after cardiac surgery and risk of death – MedicalResearch

Related: Retrospective cohort: Serial high-sensitivity cardiac troponin I after coronary artery bypass grafting may add prognostic information for post-operative decision-making.

 

Commentary on Twitter

 

[News release – not published yet] Study finds blood pressure cuff size matters, affects blood pressure readings.

3 Mar, 2022 | 08:47h | UTC

Study finds blood pressure cuff size matters, affects blood pressure readings – AHA Newsroom

 

M-A: Use of tocilizumab and sarilumab alone or in combination with corticosteroids for covid-19.

3 Mar, 2022 | 08:49h | UTC

Use of tocilizumab and sarilumab alone or in combination with corticosteroids for covid-19: systematic review and network meta-analysis – BMJ Medicine

Editorial: Treatment of severe covid-19 with interleukin 6 receptor inhibition – BMJ Medicine

Related study (just published): Mortality Rates Among Hospitalized Patients With COVID-19 Infection Treated With Tocilizumab and Corticosteroids: A Bayesian Reanalysis of a Previous Meta-analysis – JAMA Network Open

 

Myocarditis following COVID-19 BNT162b2 vaccination among adolescents in Hong Kong.

3 Mar, 2022 | 08:43h | UTC

Myocarditis Following COVID-19 BNT162b2 Vaccination Among Adolescents in Hong Kong – JAMA Pediatrics

Commentary: Study: Dosing change could reduce COVID-19 vaccine heart side effect in teens – UPI

Related:

[Preprint] Post-marketing active surveillance of myocarditis and pericarditis following vaccination with COVID-19 mRNA vaccines in persons aged 12-39 years in Italy.

Myocarditis after BNT162b2 vaccination in Israeli adolescents.

Myocarditis cases reported after mRNA-Based COVID-19 vaccination in the US from December 2020 to August 2021.

A case-control study showed an increased risk of myocarditis after COVID-19 vaccination with a messenger RNA vaccine compared to an inactivated virus vaccine.

[Preprint] Risk of myocarditis following sequential COVID-19 vaccinations by age and sex.

Risks of myocarditis, pericarditis, and cardiac arrhythmias associated with COVID-19 vaccination vs. SARS-CoV-2 infection.

Case series with 139 adolescents and young adults with suspected myocarditis following mRNA vaccination showed most cases had a mild clinical course and rapid resolution of symptoms.

Heart-inflammation risk from Pfizer COVID vaccine is very low.

Large cohort study with over 2.5 million individuals showed the incidence of myocarditis after the Pfizer vaccine was 2.13 cases per 100,000 persons.

Study with over 5.1 million vaccinated individuals showed the incidence of myocarditis after the receipt of the Pfizer vaccine was low and more common after the second dose in young male recipients.

Large Observational study shows Pfizer Covid vaccine is mostly safe but is associated with increased risk of myocarditis, adenopathy, appendicitis, and herpes zoster.

 

COVID-19 in people with rheumatic diseases: risks, outcomes, treatment considerations.

3 Mar, 2022 | 08:46h | UTC

COVID-19 in people with rheumatic diseases: risks, outcomes, treatment considerations – Nature Reviews Rheumatology

 

Commentary on Twitter

 

RCT: Effect of therapeutic drug monitoring-based dose optimization of piperacillin/tazobactam on sepsis-related organ dysfunction in patients with sepsis.

3 Mar, 2022 | 08:40h | UTC

Effect of therapeutic drug monitoring-based dose optimization of piperacillin/tazobactam on sepsis-related organ dysfunction in patients with sepsis: a randomized controlled trial – Intensive Care Medicine

 

Commentary on Twitter

 

RCT: In patients with early-stage lung cancer, video-assisted thoracoscopic lobectomy is associated with better recovery of physical function at 5 weeks.

3 Mar, 2022 | 08:42h | UTC

Video-Assisted Thoracoscopic or Open Lobectomy in Early-Stage Lung Cancer – NEJM Evidence

 

Commentary on Twitter

 

Prevalence trends of site-specific osteoarthritis from 1990 to 2019: findings from the Global Burden of Disease Study 2019.

3 Mar, 2022 | 08:27h | UTC

Prevalence trends of site-specific osteoarthritis from 1990 to 2019: findings from the Global Burden of Disease Study 2019 – Arthritis & Rheumatism

News Release: Study reveals a persistently high burden of osteoarthritis across the globe – Wiley

 

RCT: In patients with acute coronary syndrome, clopidogrel monotherapy after 1 to 2 months of dual antiplatelet therapy was NOT noninferior to 12 months of dual antiplatelet therapy.

3 Mar, 2022 | 08:32h | UTC

Comparison of Clopidogrel Monotherapy After 1 to 2 Months of Dual Antiplatelet Therapy With 12 Months of Dual Antiplatelet Therapy in Patients With Acute Coronary Syndrome: The STOPDAPT-2 ACS Randomized Clinical Trial – JAMA Cardiology (free for a limited period)

 

Commentary on Twitter

 

Observational study suggests norepinephrine is a better choice than epinephrine in cardiac arrest patients with post-resuscitation shock.

3 Mar, 2022 | 08:38h | UTC

Epinephrine versus norepinephrine in cardiac arrest patients with post-resuscitation shock – Intensive Care Medicine (link to abstract – $ for full-text)

Related: Randomized Trial: Epinephrine vs Norepinephrine for Cardiogenic Shock After Acute Myocardial Infarction

 

 

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