RCT: In patients with acute coronary syndrome, clopidogrel monotherapy after 1 to 2 months of dual antiplatelet therapy was NOT noninferior to 12 months of dual antiplatelet therapy.

Comparison of Clopidogrel Monotherapy After 1 to 2 Months of Dual Antiplatelet Therapy With 12 Months of Dual Antiplatelet Therapy in Patients With Acute Coronary Syndrome: The STOPDAPT-2 ACS Randomized Clinical Trial – JAMA Cardiology (free for a limited period)

Commentary on Twitter

Study found the effectiveness of clopidogrel monotherapy after 1 to 2 months of dual antiplatelet therapy is inconclusive, and further investigation is needed to define the optimal therapy for patients with acute coronary syndromes. https://t.co/aqxk39TjY3

— JAMA Cardiology (@JAMACardio) March 2, 2022