TOP 10 Medical News Stories
Mon November 25 – 10 Stories of The Day!
25 Nov, 2019 | 00:01h | UTC
Related: Physiology and Pathophysiology of Potassium Homeostasis: Core Curriculum 2019 – American Journal of Kidney Diseases (free)
3 – Guidelines on suicide amongst anaesthetists 2019 – Anaesthesia (free)
4 – The mental health of PhD researchers demands urgent attention – Nature (free)
Related: PhDs: the tortuous truth – Nature’s survey of more than 6,000 graduate students reveals the turbulent nature of doctoral research – Nature (free)
Commentary: Advice to pull a drug used to prevent premature birth sparks controversy – News Medical (free) AND Unexpected Findings in Confirmatory Trial of Preterm Birth Drug – MedPage Today (free registration required)
Related Study: A Randomized Trial of Progesterone in Women with Recurrent Miscarriages – New England Journal of Medicine (free)
6 – Alex Nowbar’s weekly review, 22 November 2019 – The BMJ Opinion (free)
Source: EvidenceAlerts
Related Guidelines: 2020 Global Strategy for Prevention, Diagnosis and Management of COPD – GOLD Reports 2020 (free PDF) AND Chronic obstructive pulmonary disease in over 16s: diagnosis and management – National Institute for Health and Care Excellence (free)
9 – Low-volume bowel prep appears as effective as high-volume for colonoscopy – ACP Gastroenterology (free)
Original Study: Efficacy and Tolerability of High- vs Low-Volume Split-Dose Bowel Cleansing Regimens for Colonoscopy: a Systematic Review and Meta-analysis – Clinical Gastroenterology and Hepatology (link to abstract – $ for full-text)
10 – Evaluation of Long-term Risk of Epilepsy, Psychiatric Disorders, and Mortality Among Children With Recurrent Febrile Seizures: A National Cohort Study in Denmark – JAMA Pediatrics (link to abstract – $ for full-text)
Commentaries: Risk of Epilepsy with Febrile Seizure – Journal Feed (free) AND Repeated febrile convulsions linked to epilepsy and psychiatric disorders – Aarhus University (free) AND Kids’ Fever-Related Convulsions Tied to Greater Risk of Epilepsy, Schizophrenia – PsychCentral (free)
Fri November 22 – 10 Stories of The Day!
22 Nov, 2019 | 10:34h | UTC
News Release: New WHO-led study says majority of adolescents worldwide are not sufficiently physically active, putting their current and future health at risk – World Health Organization (free)
Commentaries: Challenges in global surveillance of physical activity – The Lancet Child & Adolescent Health (free) AND Most Adolescents Around The World Are Insufficiently Active, Risking Current And Future Health – Health Policy Watch (free) AND A Majority of The World’s Teens Aren’t Getting Enough Physical Activity – TIME (free) AND More than 80% of adolescents not active enough, warns WHO – The Guardian (free) AND Sedentary teens risk health, hearts and minds: WHO study – Reuters (free)
Commentaries: Two Vaping Advisories Released by CDC – NEJM Journal Watch (free) AND CDC Updates Interim Guidance on Vaping-Linked Lung Illness – Physician’s Briefing (free)
See also: Why Understanding Sepsis Endotypes Is Important for Steroid Trials in Septic Shock (free) AND Why the Adjunctive Corticosteroid Treatment in Critically Ill Patients With Septic Shock (ADRENAL) Trial Did Not Show a Difference in Mortality (free) AND Why My Steroid Trials in Septic Shock Were “Positive” (free)
Related: Review: Adjunctive Corticosteroid Treatment in Septic Shock (free review, guideline and meta-analysis on the subject)
Commentary: Digital monitoring system helps improve hospital care of sepsis patients – OnMedica (free) AND Sepsis digital alert ‘led to faster treatment with antibiotics’ – BBC (free)
Related: ESPEN guideline on clinical nutrition in the intensive care unit – Clinical Nutrition (free) AND Special Issue: Nutrition in Critical Illness – ICU Management & Practice (free)
6 – Exposure to Tomographic Scans and Cancer Risks – JNCI Cancer Spectrum (free)
Commentary: Radiation from CT scans associated with increased risk for cancer – Oxford University Press (free)
Related: Association of Exposure to Diagnostic Low-Dose Ionizing Radiation With Risk of Cancer Among Youths in South Korea – JAMA Network Open (free) AND Retrospective Cohort: Radiation Exposure From Pediatric CT Scans and Subsequent Cancer Risk (link to abstract and commentary)
Commentary: A sound theoretical mechanism and clinical indication are not enough—the case of Platelet Rich Plasma for Achilles tendon ruptures – The BMJ Opinion (free)
9 – Systematic Review: Pharmacological interventions for the prevention of acute postoperative pain in adults following brain surgery – Cochrane Library (free)
Summary: Preventing pain after brain surgery – Cochrane Library (free)
10 – Bedside Optic Nerve Ultrasonography for Diagnosing Increased Intracranial Pressure: A Systematic Review and Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Bedside optic nerve ultrasonography may be useful for measuring intracranial pressure – ACP Hospitalist (free) AND Optic Nerve Ultrasound May ID Increased Intracranial Pressure – Physician’s Briefing (free)
Thu November 21 – 10 Stories of The Day!
21 Nov, 2019 | 10:48h | UTC
1 – Guideline: Thyroid disease: assessment and management – National Institute for Health and Care Excellence (free)
CDC Page: Core Elements of Hospital Antibiotic Stewardship Programs (free resources)
Commentary: CDC updates ‘core’ antibiotic stewardship elements for hospitals – CIDRAP (free)
Editorial: When to induce late term pregnancies (free)
Related: Randomized Trial: Induction of Labor at 41 Weeks vs. Expectant Management Until 42 Weeks (free) AND WHO Recommendations: Induction of Labor at or Beyond Term (free) AND Cochrane Review: Induction of Labor for Improving Birth Outcomes for Women at or Beyond Term (free)
Commentary: Small rise in heart attack protein linked to increased risk of early death – Imperial College London (free)
Commentaries: Nutritional Support Among Medical Inpatients—Feed the Cold (and Malnourished) and Starve the Febrile – JAMA Network Open (free) AND Nutritional Support Linked to Better Survival Among Inpatients – Medscape (free registration required)
Related: Dietary protein intake and kidney function decline after myocardial infarction: the Alpha Omega Cohort – Nephrology Dialysis Transplantation (free) AND High-protein diet with renal hyperfiltration is associated with rapid decline rate of renal function: a community-based prospective cohort study – Nephrology Dialysis Transplantation (link to abstract – $ for full-text) AND Dietary Protein Intake and Chronic Kidney Disease – Current Opinion in Clinical Nutrition & Metabolic Care (free)
7 – Cannabidiol Products Are Everywhere, but Should People Be Using Them? – JAMA (free)
Related: NICE Guideline: Cannabis-Based Medicinal Products (free Guideline and other resources)
9 – Return to work after critical illness: a systematic review and meta-analysis – Thorax (link to abstract – $ for full-text)
Commentary: ICU survivors commonly experience job loss after critical illness, study confirms – University of California San Diego School of Medicine (free)
10 – Gastric bypass versus sleeve gastrectomy in patients with type 2 diabetes (Oseberg): a single-centre, triple-blind, randomised controlled trial – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)
Wed November 20 – 10 Stories of The Day!
20 Nov, 2019 | 10:51h | UTC
Related Guidelines: Centers for Disease Control and Prevention Guideline for the Prevention of Surgical Site Infection, 2017 – JAMA Surgery (free) AND Global guidelines on the prevention of surgical site infection – World Health Organization (free) AND Surgical site infections: prevention and treatment – National Institute for Health and Care Excellence (free)
Commentary: Nonpharmaceutical interventions have strongest evidence support for poststroke rehab – ACP Internist (free)
4 – Computed tomography for diagnosis of acute appendicitis in adults – Cochrane Library (free)
Summary: How accurate is computed tomography for the diagnosis of acute appendicitis in adults? – Cochrane Library (free)
Commentaries: Smokers who switch to vaping could soon ‘have healthier hearts’ – NHS Choices (free) AND Vaping less harmful than smoking for vascular health, major study finds – University of Dundee (free) AND Switching from cigarettes to vapes may be better for heart health, study says – CNN (free)
6 – Association of Umbilical Cord Milking vs Delayed Umbilical Cord Clamping with Death or Severe Intraventricular Hemorrhage Among Preterm Infants – JAMA (free for a limited period)
Editorial: Maternal and Infant Outcomes After Different Methods of Umbilical Cord Management – JAMA (free for a limited period)
Commentary: Umbilical Cord Milking May Harm Extremely Preterm Infants – Physician’s Briefing (free)
7 – Effect of Delayed vs Immediate Umbilical Cord Clamping on Maternal Blood Loss in Term Cesarean Delivery: A Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Maternal and Infant Outcomes After Different Methods of Umbilical Cord Management – JAMA (free for a limited period)
Related Systematic Review: Effect of timing of umbilical cord clamping and other strategies to influence placental transfusion at preterm birth on maternal and infant outcomes – Cochrane Library (free)
8 – Review: Extra-cardiac endovascular infections in the critically ill – Intensive Care Medicine (free)
9 – Why is the world losing the fight against history’s most lethal disease? – The Guardian (free)
Opinion piece by Dr. Tedros Adhanom Ghebreyesus, Director-General of the World Health Organization (WHO)
Commentary: UN mosquito sterilization technology set for global testing, in battle against malaria, dengue – United Nations (free)
Related: Study: Modified Mosquitoes to Reduce Dengue Rates (free study and commentaries) AND Australian Experiment Wipes Out Over 80% of Disease-Carrying Mosquitoes (news release and commentary)
Tue November 19 – 10 Stories of The Day!
19 Nov, 2019 | 10:35h | UTC
News Release: New clinical guideline for the treatment and prevention of drug-resistant tuberculosis – American Thoracic Society (free)
Related: WHO Consolidated Guidelines on Drug-resistant Tuberculosis Treatment (free guideline and commentary) AND Randomized Trial: 9-month Treatment for Multi-drug Resistant TB is as Effective as 24-month Treatment (free article and commentaries) AND The Lancet Commission: Management of Multidrug-resistant and Incurable Tuberculosis (free registration required)
News Release: Screening for thyroid dysfunction in people without symptoms: Don’t routinely check that box – Canadian Medical Association Journal (free)
See also: Asymptomatic Thyroid Dysfunction (2019): Summary of recommendations for clinicians and policy-makers – Canadian Task Force on Preventive Health Care (free resources) AND Infographic (free PDF)
3 – Difficult Airway Society guidelines for awake tracheal intubation (ATI) in adults – Anaesthesia (free)
4 – This Week is World Antibiotic Awareness Week! – See Practical Resources
– Using Antibiotics Wisely in Primary Care – Choosing Wisely Canada (free)
– Using Antibiotics Wisely in Long-Term Care – Choosing Wisely Canada (free)
– Using Antibiotics Wisely in Hospitals – Choosing Wisely Canada (free)
– NICE Antimicrobial prescribing guidelines (resource covering many common conditions)
– NICE Summary of antimicrobial prescribing guidance – managing common infections (free PDF)
5 – A Comparison of Two LDL Cholesterol Targets after Ischemic Stroke – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: Treat Stroke to Target Finds Lower Risk of CV Events With Lower LDL-C Levels – American College of Cardiology (free) AND Treat Stroke to Target – Treat Stroke to Target – American College of Cardiology (free) AND Lower Cholesterol Cuts CV Events: Treat Stroke to Target Trial – TCTMD (free)
#AHA19 – Just Presented at the 2019 American Heart Association Annual Meeting
6 – Results of the Fontan Udenafil Exercise Longitudinal (FUEL) Trial – Circulation (free for a limited period)
Commentaries: Teens with Heart Disease Improve Exercise Capacity in Large Clinical Trial – Children’s Hospital of Philadelphia (free) AND Pediatric drug trial finds benefit in teens with heart defect – NIH News Releases (free)
#AHA19 – Just Presented at the 2019 American Heart Association Annual Meeting
7 – Association of Premature Natural and Surgical Menopause With Incident Cardiovascular Disease – JAMA (free for a limited period)
8 – Preoperative Evaluation Before Noncardiac Surgery – Mayo Clinic Proceedings (free)
Related: Guideline: Preoperative Evaluation of Adult Patients Before Elective, Noncardiothoracic Surgery (free guidelines on the subject)
9 – Coronary Microvascular Dysfunction Causing Cardiac Ischemia in Women – JAMA (free for a limited period)
Related: Prognosis and Predictors of Mortality in Patients Suffering Myocardial Infarction With Non‐Obstructive Coronary Arteries (study, guidelines and reviews on the subject)
10 – HIV Preexposure Prophylaxis—The Role of Primary Care Clinicians in Ending the HIV Epidemic – JAMA Internal Medicine (free for a limited period)
Related: USPSTF Statement: Preexposure Prophylaxis for the Prevention of HIV Infection (free) AND British Guidelines on the Use of HIV Pre–exposure Prophylaxis (PrEP) (several guidelines on the subject)
Mon November 18 – 10 Stories of The Day!
18 Nov, 2019 | 01:52h | UTC
1 – [Not Published Yet] Landmark ISCHEMIA Trial: A Routine Invasive Strategy Does Not Reduce Cardiovascular Events in Patients with Stable Coronary Artery Disease
Commentaries: International Study of Comparative Health Effectiveness With Medical and Invasive Approaches – ISCHEMIA – American College of Cardiology (free) AND ISCHEMIA Trial Examines Invasive vs. Conservative Strategy in SIHD Patients – American College of Cardiology (free) AND ISCHEMIA: Invasive Strategy No Better Than Meds for CV Events – TCTMD (free) AND Surgery for Blocked Arteries Is Often Unwarranted, Researchers Find – The New York Times (free) AND ISCHEMIA Trial Finds No Evidence of Lower Cardiac Event Rates in Patients Treated with Heart Procedures, but Better Quality of Life – PR Newswire (free) AND Big study casts doubt on need for many heart procedures – Associated Press (free) AND Stents no better than drugs for many heart patients: U.S. study – Reuters (free) AND Stents, bypass surgery show no benefit in heart disease mortality rates among stable patients – Stanford Medicine (free)
#AHA19 – Just Presented at the 2019 American Heart Association Annual Meeting
2 – Efficacy and Safety of Low-Dose Colchicine after Myocardial Infarction – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: Colchicine Cardiovascular Outcomes Trial – COLCOT – American College of Cardiology (free) AND COLCOT Renews Hope for Anti-inflammatory in Secondary Prevention: Colchicine – TCTMD (free)
#AHA19 – Just Presented at the 2019 American Heart Association Annual Meeting
3 – Early Surgery or Conservative Care for Asymptomatic Aortic Stenosis – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: RECOVERY Finds Early Surgery Beneficial For Asymptomatic Severe AS Patients – American College of Cardiology (free) AND Randomized Comparison of Early Surgery Versus Conventional Treatment in Very Severe Aortic Stenosis – RECOVERY – American College of Cardiology (free) AND Early Surgery Beats a Conservative Approach in Asymptomatic AS: RECOVERY – TCTMD (free)
#AHA19 – Just Presented at the 2019 American Heart Association Annual Meeting
4 – A Controlled Trial of Rivaroxaban after Transcatheter Aortic-Valve Replacement – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: GALILEO Trial Finds Higher Risk of Death, Bleeding With Rivaroxaban After TAVR – American College of Cardiology (free) AND Global Study Comparing a Rivaroxaban-based Antithrombotic Strategy to an Antiplatelet-based Strategy After TAVR – GALILEO – American College of Cardiology (free) AND GALILEO: Rivaroxaban-Based Antithrombotic Strategy or Antiplatelet-Based Strategy After TAVR? – Docwire (free)
#AHA19 – Just Presented at the 2019 American Heart Association Annual Meeting
5 – AHA Updates on Advanced Cardiovascular Life Support
– 2019 American Heart Association and American Red Cross Focused Update for First Aid: Presyncope – Circulation (free PDF)
6 – AHA Updates in Pediatric Life Support
– 2019 American Heart Association Focused Update on Pediatric Advanced Life Support – Circulation (free PDF)
– 2019 American Heart Association Focused Update on Neonatal Resuscitation – Circulation (free PDF)
– 2019 American Heart Association Focused Update on Pediatric Basic Life Support – Circulation (free PDF)
8 – Offline: The gravy train of systematic reviews – The Lancet (free)
9 – Moving Toward Evidence-Based Policy: The Value of Randomization for Program and Policy Implementation – JAMA (free for a limited period)
10 – Deep Brain Stimulation for Tinnitus, Tumors Hijack Neurons in Brain Cancer, and Multiple Sclerosis and Immunizations: Neuro Nook – JAMA (free for a limited period)
Fri November 15 – 10 Stories of The Day!
15 Nov, 2019 | 10:51h | UTC
1 – The 2019 report of The Lancet Countdown on health and climate change: ensuring that the health of a child born today is not defined by a changing climate – The Lancet (free registration required)
Editorial: Health and climate change: making the link matter (free)
Video: The Lancet Countdown on Health and Climate Change: 2019 report (free)
Commentaries: How the Climate Crisis Is Killing Us, in 9 Alarming Charts – Wired (free) AND Climate Change Poses Threats to Children’s Health Worldwide – The New York Times (10 articles per month are free) AND The climate crisis will profoundly affect the health of every child alive today, report says – CNN (free) AND Doctors: Warmer world is unhealthier place for children – AP (free)
Related: Climate Change — A Health Emergency (free reports and commentaries on the subject) AND NEJM Editorial: Prioritizing Health in a Changing Climate (free commentaries) AND Climate change threatens the achievement of effective universal healthcare – The BMJ (free) AND Climate Change Is Having a Major Impact on Global Health – Scientific American (free)
2 – Vegetarian diets in childhood and adolescence – Molecular and Cellular Pediatrics (free)
Related Guidelines: ACP Guideline: Screening for Colorectal Cancer in Asymptomatic Average-Risk Adults (free) AND BMJ Guideline: Colorectal Cancer Screening with Fecal Immunochemical Testing, Sigmoidoscopy or Colonoscopy (new guideline suggesting a more selective approach to screening) AND Colorectal cancer screening for average‐risk adults: 2018 guideline update from the American Cancer Society (recent guideline with recommendation to start screening at 45 years, with links to guidelines from other organizations)
“Our findings suggest that 10 year intervals for colonoscopy screening after a negative colonoscopy, as currently recommended, may be adequate”
Related Guidelines: The management of intra-abdominal infections from a global perspective: 2017 WSES guidelines – World Journal of Emergency Surgery (free) AND Management of intra-abdominal infections: recommendations by the WSES 2016 consensus conference – World Journal of Emergency Surgery (free) AND The Surgical Infection Society Revised Guidelines on the Management of Intra-Abdominal Infection – Surgical Infections (free) AND The 2018 Lebanese Society of Infectious Diseases and Clinical Microbiology Guidelines for the use of antimicrobial therapy in complicated intra-abdominal infections in the era of antimicrobial resistance – BMC Infectious Diseases (free)
8 – Alex Nowbar’s weekly review, 15 November 2019 – The BMJ Opinion (free)
Alex Nowbar reviews the latest research from the top medical journals.
9 – Association of Subclinical Hearing Loss With Cognitive Performance – JAMA Otolaryngology-Head & Neck Surgery (free for a limited period)
Commentaries: Reconsidering Individuals with Normal Hearing – JAMA Otolaryngology-Head & Neck Surgery (free) AND Hearing loss, even when mild, linked to mental decline in seniors – Reuters (free) AND Earliest stage of hearing loss is linked to cognitive decline – Columbia University (free)
Author Interview: Association of Subclinical Hearing Loss With Cognitive Performance (free audio)
Related: Association of Hearing Loss With Dementia – JAMA Network Open (free) AND Meta-Analysis: Association of Age-Related Hearing Loss With Cognitive Function – JAMA Otolaryngology-Head & Neck Surgery (free)
10 – Illiteracy, dementia risk, and cognitive trajectories among older adults with low education – Neurology (link to abstract – $ for full-text)
News Release: People who cannot read may be three times as likely to develop dementia – American Academy of Neurology (free)
“The independent effect of illiteracy on dementia risk may be through a lower range of cognitive function, which is closer to diagnostic thresholds for dementia than the range of literate participants.”
Thu November 14 – 10 Stories of The Day!
14 Nov, 2019 | 10:39h | UTC
1 – Large-Scale Assessment of a Smartwatch to Identify Atrial Fibrillation – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: What Can We Learn From The Apple Heart Study? – Cardiobrief (free)
“…nearly half a million people were required to identify a few hundred people with AF. (It should further be noted that we have no idea whether the patients identified in this group will even benefit from their diagnosis, since they may differ in important ways from AF patients identified by traditional means.)” (from Cardiobrief)
2 – Secondary Surgical Cytoreduction for Recurrent Ovarian Cancer – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: Secondary surgery does not improve overall survival for recurrent ovarian cancer patients – University of Texas M. D. Anderson Cancer Center (free) AND Second surgery for many ovarian cancers found ineffective – Reuters (free)
Commentaries: CDC spotlights ‘deadly threat’ of antibiotic resistance – CIDRAP (free) AND CDC report: 35,000 Americans die of antibiotic-resistant infections each year – STAT (free)
7 – Antibiotic Treatment and Appendectomy for Uncomplicated Acute Appendicitis in Adults and Children: A Systematic Review and Meta-analysis – Annals of Surgery (link to abstract – $ for full-text)
Related Meta-Analysis: Antibiotic therapy for acute uncomplicated appendicitis: a systematic review and meta-analysis – International Journal of Colorectal Disease (free) AND Antibiotics Versus Surgical Therapy for Uncomplicated Appendicitis (link to abstract and commentaries) AND Antibiotic Therapy versus Appendectomy for Acute Uncomplicated Appendicitis (free study and commentaries)
Related Randomized Trials: Antibiotic Therapy Alone Seems Reasonable for Uncomplicated Appendicitis (free study and commentaries) AND Randomized clinical trial of antibiotic therapy for uncomplicated appendicitis (link to abstract and commentaries)
Related Cohort Study: Study: Nonoperative Management of Uncomplicated Appendicitis (free study and commentary)
8 – Adjunctive Antithrombotic Therapy for Patients with Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement – JAMA Cardiology (free for a limited period)
9 – Association of Preoperative Patient Frailty and Operative Stress With Postoperative Mortality – JAMA Surgery (free for a limited period)
Commentaries: Looking Beyond Mortality Among Older Adults Who Are Frail and Considering Surgical Intervention – JAMA Surgery (free for a limited period) AND No such thing as a low-risk surgery for frail patients – Vanderbilt University Medical Center (free) AND Even low-stress surgery can be fatal for frail patients, study finds – University of Texas Health Center at San Antonio (free)
10 – Interplay of Coronary Artery Calcium and Risk Factors for Predicting CVD/CHD Mortality: The CAC Consortium – JACC: Cardiovascular Imaging (link to abstract – $ for full-text)
Commentary: Coronary Artery Calcium and Risk Factors for Predicting Mortality – American College of Cardiology (free)
Related Study: Association of Coronary Artery Calcium With Long-term, Cause-Specific Mortality Among Young Adults (free study and commentary)
Wed November 13 – 10 Stories of The Day!
13 Nov, 2019 | 11:07h | UTC
Commentaries: New Performance and Quality Measures For High BP Released – American College of Cardiology (free) AND Heart Groups Publish New Performance, Quality Measures for BP Management – NEJM Journal Watch (free)
Related AHA/ACC Guideline and Summaries: 2017 ACC/AHA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults (free) AND Executive Summary (free) AND Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: Synopsis of the 2017 ACC/AHA Hypertension Guideline – Annals of Internal Medicine (free)
3 – Consensus Statement on Sports-Related Concussions in Youth Sports Using a Modified Delphi Approach – JAMA Pediatrics (free for a limited period)
Commentary: Evidence Lacking on Ways to Prevent Youth Sports Concussion – NEJM Journal Watch (free)
4 – Initial Imaging-Guided Strategy Versus Routine Care in Patients with Non–ST-Segment Elevation Myocardial Infarction – Journal of the American College of Cardiology (link to abstract – $ for full-text)
Commentaries: Upfront Imaging Reduces Invasive Angiography in Patients With Unclear NSTEMI Diagnosis – TCTMD (free) AND Imaging-Guided Strategy vs. Routine Care for NSTEMI Patients – American College of Cardiology (free)
5 – STI update: Testing, treatment, and emerging threats – Cleveland Clinic Journal of Medicine (free)
6 – Appropriate laboratory testing in Lyme disease – Cleveland Clinic Journal of Medicine (free)
Related Study: Artificial Intelligence Algorithm Can Detect Patients with Atrial Fibrillation from a Sinus Rhythm ECG (link to abstract and commentaries)
8 – How to Read Articles That Use Machine Learning: Users’ Guides to the Medical Literature – JAMA (free for a limited period)
Editorial: Evaluating Machine Learning Articles (free)
9 – Drugs for Atrial Fibrillation – JAMA (free for a limited period)
Podcast: Review of Atrial Fibrillation Treatment – JAMA (free audio)
Original Guideline: 2019 AHA/ACC/HRS Focused Update of the 2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation (free)
See complete lists of low-value practices: Choosing Wisely U.S. / Choosing Wisely UK / Choosing Wisely Australia AND Choosing Wisely Canada
Tue November 12 – 10 Stories of The Day!
12 Nov, 2019 | 11:46h | UTC
1 – Cannabis-based medicinal products – National Institute for Health and Care Excellence (free)
Commentaries: Drug experts on the new guidance for medicinal cannabis – The Conversation (free) AND Ian Hamilton: New guidelines for prescribing medicinal cannabis—another dashed hope for patients – The BMJ Opinion (free)
Related: Guideline for Prescribing Medical Cannabinoids in Primary Care – Canadian Family Physician (free) AND Cannabinoids for Chronic Pain – Therapeutics Initiative AND (free) Meta-Analysis: Insufficient Evidence for The Use of Cannabinoids for Treating Mental Disorders – The Lancet Psychiatry (link to abstract and commentaries) AND The Effects of Cannabis Among Adults With Chronic Pain – Annals of Internal Medicine (link to abstract and commentaries)
“In short, NICE has concluded that more research is needed before it can recommend the use of cannabis-based products for medicinal use.” (from The Conversation)
4 – Results of a 6-week treatment with 10 mg prednisolone in patients with hand osteoarthritis (HOPE): a double-blind, randomised, placebo-controlled trial – The Lancet (free registration required)
Commentaries: Low-Dose Oral Prednisolone Substantially Improves Pain and Function in Hand Osteoarthritis – American College of Rheumatology (free) AND Short-term prednisolone offers HOPE for painful hand osteoarthritis – Medicine Matters (free) AND Short Course of Low-Dose Prednisolone for Painful Hand Osteoarthritis – MedicalResearch.com (free)
#ACR19 – Just Presented at the 2019 American College of Rheumatology Annual Meeting
5 – Association of Testosterone Therapy With Risk of Venous Thromboembolism Among Men With and Without Hypogonadism – JAMA Internal Medicine (free for a limited period)
6 – A Randomized Trial of a 1-Hour Troponin T Protocol in Suspected Acute Coronary Syndromes – Circulation (free for a limited period)
Commentaries: World-First Trial Cuts ED Wait Times and Admissions – Flinders University (free) AND Ruling Out MI Safe With 0/1-Hour High-Sensitivity Troponin: RAPID-TNT – TCTMD (free)
Related Studies/Commentaries Highlighting Problems with High-sensitivity Cardiac Troponin: Myths in Emergency Medicine: Is hs-cTnT Worth the Downstream Testing? – Emergency Medicine News (free) AND Randomized Trial: High-Sensitivity Troponin in the Evaluation of Suspected Acute Coronary Syndrome – The Lancet (free study and commentaries) AND Cohort Study: The Introduction of High-sensitive Troponins Had No Impact on Survival – Journal of the American College of Cardiology (free) AND Cohort Study: High Sensitivity Cardiac Troponin May Result in Misdiagnosis of Acute Myocardial Infarction – The BMJ (free)
Related: Acetylsalicylic acid for primary prevention of cardiovascular events – Canadian Family Physician (free) AND Evidence evolving on aspirin as prevention – ACP Internist (free) AND Benefits and Harms of Aspirin for Primary Prevention of Cardiovascular Disease – Annals of Internal Medicine (link to abstract and commentaries) AND Aspirin for Primary Prevention: Is This the End of the Road? (selection of resources on the subject)
Commentaries: Nutrient supplements significantly reduce child deaths – University of California (free) AND Children receiving small-quantity lipid-based nutrient supplementary foods have lower mortality rates – American Society for Nutrition (free)
9 – Review: Sleep-Related Disorders in Neurology and Psychiatry – Deutsches Ärzteblatt international (free)
10 – Onco-Nephrology: Cancer, chemotherapy and kidney – Nephrología (free)
Related: Onco-Nephrology: Core Curriculum – American Journal of Kidney Diseases (free) AND Onco-nephrology: an appraisal of the cancer and chronic kidney disease links – Nephrology Dialysis Transplantation (free) AND Opening an onconephrology clinic: recommendations and basic requirements – Nephrology Dialysis Transplantation (free) AND Onco-nephrology: current concepts and future perspectives – Japanese Journal of Clinical Oncology (free)
Mon November 11 – 10 Stories of The Day!
11 Nov, 2019 | 11:40h | UTC
1 – Development of Risk Prediction Equations for Incident Chronic Kidney Disease – JAMA (free for a limited period)
See Calculator: Risk of Developing Reduced Kidney Function (free tool)
Editorial: Predicting Risk of Kidney Disease: Is Risk-Based Kidney Care on the Horizon? – JAMA (free for a limited period)
Commentaries: New Tool Predicts Five-Year Risk of Chronic Kidney Disease With High Accuracy – Johns Hopkins Bloomberg School of Public Health (free) AND Researchers Develop Tool to Identify Those at Risk of Future CKD – AJMC (free)
#KidneyWk – Just presented at the American Society of Nephrology Kidney Week 2019
2 – Effect of Vitamin D and Omega-3 Fatty Acid Supplementation on Kidney Function in Patients With Type 2 Diabetes: A Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Vitamin D and Health Outcomes: Then Came the Randomized Clinical Trials – JAMA (free for a limited period)
Commentary: Supplements don’t preserve kidney health in Type 2 diabetes – University of Washington School of Medicine (free)
#KidneyWk – Just presented at the American Society of Nephrology Kidney Week 2019
3 – Association of Baclofen with Encephalopathy in Patients With Chronic Kidney Disease – JAMA (free for a limited period)
Commentary: Common muscle relaxant causes severe confusion in patients with kidney disease – University of Western Ontario (free)
#KidneyWk – Just presented at the American Society of Nephrology Kidney Week 2019
4 – A Phase 3 Trial of Difelikefalin in Hemodialysis Patients with Pruritus – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Novel Drug Eases Uremic Pruritus – Renal & Urology News (free)
#KidneyWk – Just presented at the American Society of Nephrology Kidney Week 2019
#KidneyWk – Just presented at the American Society of Nephrology Kidney Week 2019
6 – CDC Reports: Risk Factors for E-Cigarette, or Vaping, Product Use–Associated Lung Injury (EVALI) Among Adults Who Use E-Cigarette, or Vaping, Products — Illinois, July–October 2019 (free) AND Evaluation of Bronchoalveolar Lavage Fluid from Patients in an Outbreak of E-cigarette, or Vaping, Product Use–Associated Lung Injury — 10 States, August–October 2019 (free)
Commentaries: In a breakthrough, health officials identify possible culprit behind vaping illnesses: vitamin E acetate – STAT (free) AND Vaping Illnesses Are Linked to Vitamin E Acetate, C.D.C. Says – The New York Times (10 articles per month are free) AND CDC Finds Possible Culprit In Outbreak Of Vaping-Related Lung Injuries – NPR (free)
Related: Viewpoint: Vaping—Seeking Clarity in a Time of Uncertainty (free) AND “EVALI” (e-cigarette, or vaping, product use-associated lung injury): CDC Updates Guidance and Creates New Name (free)
Related Guidelines: 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease (free guideline and resources) AND Cardiovascular disease: risk assessment and reduction, including lipid modification – National Institute for Health and Care Excellence (free) AND Canadian Cardiovascular Harmonized National Guidelines Endeavour (C-CHANGE) guideline for the prevention and management of cardiovascular disease in primary care: 2018 update – Canadian Medical Association Journal (free)
8 – #181 The Multimorbidity Games with Josh Uy MD – The Curbsiders Internal Medicine Podcast (free audio)
See also: Episode List
Related: Multimorbidity: clinical assessment and management – NICE Guideline (free) AND Multimorbidity in Older Adults with Cardiovascular Disease – American College of Cardiology, Latest in Cardiology (free) AND Effectiveness of interventions for managing multiple high-burden chronic diseases in older adults: a systematic review and meta-analysis – Canadian Medical Association Journal (free) AND Multimorbidity: a priority for global health research – The Academy of Medical Sciences (free)
9 – Association of Autofluorescence-Based Detection of the Parathyroid Glands During Total Thyroidectomy With Postoperative Hypocalcemia Risk: Results of the PARAFLUO Multicenter Randomized Clinical Trial – JAMA Surgery (free for a limited period)
Invited Commentary: New Technique to Reduce the Risk For Hypocalcemia in Thyroid Surgery (free for a limited period)
Commentary: FDA Updates Warning on Biotin Interfering with Lab Results – NEJM Journal Watch (free)
“…the FDA is particularly concerned about biotin interference causing a falsely low result for troponin, a clinically important biomarker to aid in the diagnosis of heart attacks, which may lead to a missed diagnosis and potentially serious clinical implications. The FDA continues to receive adverse events reports indicating biotin interference caused falsely low troponin results.”
Fri November 8 – 10 Stories of The Day!
8 Nov, 2019 | 08:42h | UTC
Commentary: The Management of Subclinical Atrial Fibrillation: The Pathway to True Medical Expertise – American Heart Association (free)
Top Things to Know: Subclinical and Device-Detected Atrial Fibrillation (free)
Related: Apple Watch Can Spot Atrial Fibrillation, But More Research is Needed (several commentaries on the subject)
2 – Vaping—Seeking Clarity in a Time of Uncertainty – JAMA (free for a limited period)
Author Interview: Vaping—Seeking Clarity in a Time of Uncertainty (free audio)
Related: “EVALI” (e-cigarette, or vaping, product use-associated lung injury): CDC Updates Guidance and Creates New Name (free)
Commentaries: Vaping not worth potential heart risk, researchers say – Ohio State University (free) AND Vaping risks significant, says new review – News Medical (free) AND E-cigs may damage the heart, study says – MedicalXpress (free)
Related: Alveolar recruitment in acute respiratory distress syndrome: should we open the lung (no matter what) or may accept (part of) the lung closed? – Intensive Care Medicine (free) AND Recruitment maneuver does not provide any mortality benefit over lung protective strategy ventilation in adult patients with acute respiratory distress syndrome: a meta-analysis and systematic review of the randomized controlled trials – Journal of Intensive Care (free) AND Effect of Lung Recruitment and Titrated Positive End-Expiratory Pressure (PEEP) vs Low PEEP on Mortality in Patients With Acute Respiratory Distress Syndrome: A Randomized Clinical Trial – JAMA (free study and editorial)
6 – Randomized Trial of Perioperative Probiotics Among Patients Undergoing Major Abdominal Operation – Journal of the American College of Surgeons (link to abstract – $ for full-text)
Source: EvidenceAlerts
“A significantly higher readmission rate was observed among those exposed to probiotics. Additional studies remain warranted.”
7 – Genomic and epidemiological evidence of bacterial transmission from probiotic capsule to blood in ICU patients – Nature Medicine (link to abstract – $ for full-text)
Related: Systematic Review: Harms Reporting in Trials with Probiotics (link to abstract and commentaries) AND The Problem With Probiotics – The New York Times (free)
Commentary: Choosing Wisely Examines Pediatric Surgical Practices to Avoid – NEJM Journal Watch (free)
See complete lists of low-value practices: Choosing Wisely U.S. / Choosing Wisely UK / Choosing Wisely Australia AND Choosing Wisely Canada
9 – Ann Robinson’s journal review, 7 November 2019 – The BMJ Opinion (free)
Ann Robinson reviews the latest research from the top medical journals.
Commentaries: Difficulty sleeping linked with raised risk of heart attack and stroke – NHS Choices (free) AND Insomnia in adults linked to heart attack and stroke – CNN (free) AND Insomnia maybe a significant risk factor for heart attacks and strokes – News Medical (free)
Thu November 7 – 10 Stories of The Day!
7 Nov, 2019 | 10:35h | UTC
1 – Efficacy of a Tetravalent Dengue Vaccine in Healthy Children and Adolescents – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: A Takeda vaccine for dengue appears effective, but the story is nuanced – STAT (free) AND A new dengue vaccine shows promise — at least for now – ScienceNews (free) AND New dengue vaccine performs well in large trial, but safety remains key concern – Science (a few articles per month are free) AND Takeda’s dengue vaccine effective overall in study but with major limitation – Reuters (free)
2 – Prevention of Early Ventilator-Associated Pneumonia after Cardiac Arrest – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Routine Antibiotics Help Ventilated Patients After Cardiac Arrest – MedPage Today (free registration required)
Full Guideline: 2019 HRS Expert Consensus Statement on Evaluation, Risk Stratification, and Management of Arrhythmogenic Cardiomyopathy (free guideline and commentary)
Related Guidelines: Interdisciplinary consensus on indications for transfemoral transcatheter aortic valve implantation (TF-TAVI) – Clinical Research in Cardiology (free) AND 2017 AHA/ACC Focused Update of the 2014 AHA/ACC Guideline for the Management of Patients With Valvular Heart Disease (free) AND 2017 ESC/EACTS Guidelines for the management of valvular heart disease (free)
6 – Vasopressor therapy in critically ill patients with shock – Intensive Care Medicine (free)
Related: Editorial: Focus on Blood Pressure Targets and Vasopressors in Critically Ill Patients (free editorial and reviews)
7 – 150 years of Nature – A Century and a Half of Research and Discovery (free resources)
Video (interesting): A network of science: 150 years of Nature papers (free)
9 – Association of contrast and acute kidney injury in the critically ill: A propensity matched study – CHEST (link to abstract – $ for full-text)
Commentary: No association between contrast use and AKI seen in critically ill patients with normal kidney function – ACP Hospitalist (free)
Related: Does contrast cause kidney injury? The evidence – First10EM (free) AND Are the Risks Of Drugs That Enhance Imaging Tests Overblown? – NPR (free) AND Acute Kidney Injury After Computed Tomography: A Meta-analysis – Annals of Emergency Medicine (link to abstract – $ for full-text) AND Risk of Acute Kidney Injury After Intravenous Contrast Media Administration – Annals of Emergency Medicine (link to abstract – $ for full-text) AND
10 – Associations Between Screen-Based Media Use and Brain White Matter Integrity in Preschool-Aged Children – JAMA Pediatrics (free for a limited period)
Commentaries: Expert reaction to study on screen use and white brain matter in children – Science Media Centre (free) AND Preschoolers’ Screen Time Tied to Brain Structure Irregularities – MedPage Today (free registration required)
Related: Meta-Analysis: Association Between Screen Media Use and Academic Performance Among Children and Adolescents (link to abstract and commentaries)
Wed November 6 – 10 Stories of The Day!
6 Nov, 2019 | 10:44h | UTC
Related Guidelines: Prevention of Drowning – American Academy of Pediatrics (free) AND Preventing drowning: an implementation guide – World Health Organization (free PDF) AND Global report on drowning: preventing a leading killer – World Health Organization (free PDF) Report: Open Water Drowning and Risks for Children (free)
Related: Interventions for treating acute high altitude illness – Cochrane Library (free) AND Interventions for preventing high altitude illness: Part 1. Commonly‐used classes of drugs – Cochrane Library (free) AND Interventions for preventing high altitude illness: Part 2. Less commonly‐used drugs – Cochrane Library (free) AND Interventions for preventing high altitude illness: Part 3. Miscellaneous and non‐pharmacological interventions – Cochrane Library (free) AND Acute high-altitude sickness – European Respiratory Review (free) AND High-altitude illness: Management approach – Turkish Journal of Emergency Medicine (free)
Related: National Athletic Trainers’ Association Position Statement: Exertional Heat Illnesses (free) AND Heat stroke – Journal of Intensive Care (free)
5 – Benefits and harms of intensive glycemic control in patients with type 2 diabetes – The BMJ (free for a limited period)
Commentaries: Treat dizziness and vertigo with vestibular rehabilitation – The BMJ Opinion (free) AND Online Intervention Could Help Those with Chronic Vestibular Syndrome – NEJM Journal Watch (free)
Related Study: Internet-Based Vestibular Rehabilitation for Older Adults With Chronic Dizziness (free study and commentaries)
7 – Incidence of Bloodstream Infections, Length of Hospital Stay, and Survival in Patients With Recurrent Clostridioides difficile Infection Treated With Fecal Microbiota Transplantation or Antibiotics: A Prospective Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Study: Fecal Transplants Cut Sepsis Risk in Patients With C. Diff – MedPage Today (free registration required)
Related: Clostridioides Difficile: Diagnosis and Treatments (free guidelines and reviews)
8 – Early Palliative Care Consultation in the Medical ICU: A Cluster Randomized Crossover Trial – Critical Care Medicine (link to abstract – $ for full-text)
Source: EvidenceAlerts
9 – Short-Term Impact of a Flavored Tobacco Restriction: Changes in Youth Tobacco Use in a Massachusetts Community – American Journal of Preventive Medicine (free for a limited period)
Commentaries: Restricting flavored tobacco could curb youth use – Reuters (free) AND A tale of two cities: Impact of reducing teens’ access to flavored tobacco products – Elsevier (free) AND One town’s flavor ban seemed to work to cut youth tobacco use – CNN (free)
Related Opinion: Ban Flavored E-Cigarettes to Protect Our Children (free commentaries)
10 – Mind-Body Therapies for Opioid-Treated Pain: A Systematic Review and Meta-analysis – JAMA Internal Medicine (free for a limited period)
Commentaries: Study highlights role of mind-body therapies in addressing opioid-treated pain – News Medical (free) AND Meditation, Mindfulness Hold Promise for Pain Treatment, Curbing Opioid Use – U.S. News (free)
Tue November 5 – 10 Stories of The Day!
5 Nov, 2019 | 10:57h | UTC
News Release: ACP issues guidance for colorectal cancer screening – American College of Physicians (free)
Summaries for Patients: Colorectal Cancer Screening in Average-Risk Adults (free)
Commentaries: ACP issues new guidance on colorectal cancer screening – ACP Internist (free) AND Medical groups differ on when to start colon and rectal cancer screening. Here’s why – CNN (free)
Related: BMJ Guideline: Colorectal Cancer Screening with Fecal Immunochemical Testing, Sigmoidoscopy or Colonoscopy (recent guideline suggesting a more selective approach to screening) AND Colorectal cancer screening for average‐risk adults: 2018 guideline update from the American Cancer Society (recent guideline with recommendation to start screening at 45 years, with links to guidelines from other organizations)
2 – Clinical practice guideline on pregnancy and renal disease – BMC Nephrology (free)
4 – A systematic review of guidelines for managing rheumatoid arthritis – BMC Rheumatology (free)
Related Guidelines: Rheumatoid arthritis in adults: management – National Institute for Health and Care Excellence (free) AND 2015 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis (free)
5 – Podcast: Random Pearls in Pulmonary Medicine and Critical Care from #CHEST2019 in New Orleans
#179 CHEST 2019 Recap Part 1 – The Curbsiders Internal Medicine Podcast (free audio)
#180 CHEST 2019 Recap Part 2 from New Orleans – The Curbsiders Internal Medicine Podcast (free audio)
6 – Thirteen Things Physicians and Patients Should Question – Choosing Wisely Canada (free)
Related: American Academy of Family Physicians: Twenty Things Physicians and Patients Should Question (free)
See complete lists of low-value practices: Choosing Wisely U.S. / Choosing Wisely UK / Choosing Wisely Australia AND Choosing Wisely Canada
7 – Correlation confounded by timing: One reason we believe bad therapies are awesome – PulmCrit (free)
8 – Are Daylight Saving Time Changes Bad for the Brain? – JAMA Neurology (free for a limited period)
Commentaries: Daylight Saving Time Has Long-term Effects on Health – Vanderbilt University Medical Center (free) AND Some Neurologists Want To End Daylight Saving Time, Calling It Unhealthy – Newsweek (free)
News Release: Fish oil supplements have no effect on anxiety and depression – University of East Anglia (free)
Editorial: The Pressure Is On: Implications of Blood Pressure After Aortic Valve Replacement (free)
Mon November 4 – 10 Stories of The Day!
4 Nov, 2019 | 02:10h | UTC
Source: EvidenceAlerts
Related Guideline: The British Society for Rheumatology guideline for the management of adults with primary Sjögren’s Syndrome – Rheumatology (free)
5 – Therapeutic-induced hypertension in patients with noncardioembolic acute stroke – Neurology (link to abstract – $ for full-text)
6 – The EMR has changed the doctor-patient duet into a ménage-à-trois – STAT (free)
Related: How Tech Can Turn Doctors Into Clerical Workers – The New York Times Magazine (10 articles per month are free) AND Date Night with the EHR – NEJM Catalyst (free) AND Putting Patients First by Reducing Administrative Tasks in Health Care: A Position Paper of the American College of Physicians (free) AND Care-Centered Clinical Documentation in the Digital Environment: Solutions to Alleviate Burnout – National Academy of Medicine (free) AND To Combat Physician Burnout and Improve Care, Fix the Electronic Health Record – Harvard Business Review (a few articles per month are free)
7 – Podcast: Emerging Applications for Ketamine – JAMA (free audio)
Related Resources:
Ketamine for Depression: Ketamine and depression: a narrative review – Drug Design, Development and Therapy (free)
8 – Alex Nowbar’s weekly review, 1 November 2019 – The BMJ Opinion (free)
Alex Nowbar reviews the latest research from the top medical journals.
9 – Vaccines for International Travel – Mayo Clinic Proceedings (free)
See also: Just Released. 2020 Edition of CDC Traveler’s Health Yellow Book (free resources)
10 – The Incidence, Causes, and Risk Factors of Acute Kidney Injury in Patients Receiving Immune Checkpoint Inhibitors – Clinical Journal of the American Society of Nephrology (free for a limited period)
News Release: Study Examines Kidney Injury in Patients Taking Immunotherapy Cancer Medications – American Society of Nephrology (free)
Related: Immune Checkpoint Inhibitor Toxicities (free guidelines and reviews on the subject)
Fri November 1 – 10 Stories of The Day!
1 Nov, 2019 | 10:55h | UTC
Related: Complete List of Enhanced Recovery After Surgery (ERAS) Society Guidelines (free articles)
2 – Report: The Power of Cities: Tackling Noncommunicable Diseases and Road Traffic Injuries – World Health Organization (free PDF)
News Release: New WHO report to bolster efforts to tackle leading causes of urban deaths – World Health Organization (free)
Related Study: Dual Antiplatelet Therapy Should be Used for 21 Days After Minor Ischemic Stroke or High-risk Transient Ischemic Attack (link to abstract)
Related Guideline: Dual Antiplatelet Therapy for Acute High-Risk TIA and Minor Ischemic Stroke – The BMJ (free)
4 – Elexacaftor–Tezacaftor–Ivacaftor for Cystic Fibrosis with a Single Phe508del Allele – New England Journal of Medicine (link to abstract – $ for full-text)
Editorial: Realizing the Dream of Molecularly Targeted Therapies for Cystic Fibrosis (free)
Related Research: Efficacy and safety of the elexacaftor plus tezacaftor plus ivacaftor combination regimen in people with cystic fibrosis homozygous for the F508del mutation: a double-blind, randomised, phase 3 trial – The Lancet (link to abstract – $ for full-text)
Commentary: Three-drug combo improves lung function in most common genetic form of cystic fibrosis – UT Southwestern Medical Center (free)
5 – Measles virus infection diminishes preexisting antibodies that offer protection from other pathogens – Science (free for a limited period)
Related Research: Incomplete genetic reconstitution of B cell pools contributes to prolonged immunosuppression after measles – Science Immunology (free for a limited period)
Commentaries: How measles infections can wipe away immunity to other diseases – STAT (free) AND Measles wipe immune system’s memory of other illnesses, studies find – CNN (free) AND Measles Virus May Wipe Out Immune Protection For Other Diseases – NPR (free) AND Measles vaccines protect against more than just measles. Here’s how. – National Geographic (free) AND Measles Infection Could Leave Kids Vulnerable to Other Diseases – Scientific American (free)
Invited Commentary: Trends in the global burden of paediatric lower respiratory infections (free)
News Release: New study finds one in seven child deaths result from pneumonia, the flu, and other lower respiratory infections – Institute for Health Metrics and Evaluation (free)
Related: Global Burden of Pneumonia in Children Younger than 5 Years (free)
Invited Commentary: Early childhood diarrhoea: from data to interventions (free)
Related Global Burden of Disease Report: Global Burden of Diarrhea (free)
8 – Antiplatelet agents for preventing pre‐eclampsia and its complications – Cochrane Library (free)
Summary: Antiplatelet agents for preventing pre-eclampsia and its complications – Cochrane Library (free)
Related Randomized Trial: Aspirin versus Placebo in Pregnancies at High Risk for Preterm Preeclampsia – New England Journal of Medicine (free study and commentaries)
9 – Early enteral nutrition (within 48 hours) versus delayed enteral nutrition (after 48 hours) with or without supplemental parenteral nutrition in critically ill adults – Cochrane Library (free)
Related Meta-Analysis with Conflicting Results: Calcium Intake and Cardiovascular Disease Risk: An Updated Systematic Review and Meta-analysis – Annals of Internal Medicine (free)
See also: Meta-Analysis: Calcium and Vitamin D Not Helpful to Reduce the Risk of Fractures (free)
Thu October 31 – 10 Stories of The Day!
31 Oct, 2019 | 10:45h | UTC
Top Things to Know: 2019 Update to the 2018 Guidelines for the Early Management of Acute Ischemic Stroke (free)
Related WHO Guidelines: Treatment of cervical intraepithelial neoplasia 2–3 and adenocarcinoma in situ: cryotherapy, large loop excision of the transformation zone, and cold knife conization (free PDF) AND Comprehensive cervical cancer control: A guide to essential practice (free PDF) AND WHO publications on the prevention and treatment of cervical cancer (free resources)
4 – Association Between Levothyroxine Treatment and Thyroid-Related Symptoms Among Adults Aged 80 Years and Older With Subclinical Hypothyroidism – JAMA (free for a limited period)
Editorial: The Thyrotropin Reference Range Should Be Changed in Older Patients (free for a limited period)
Related Review: Subclinical Hypothyroidism – JAMA (free for a limited period)
Related Randomized Trial: Thyroid Hormone Therapy for Older Adults with Subclinical Hypothyroidism – New England Journal of Medicine (free)
Original Article: Drug-Resistant E. coli Bacteremia Transmitted by Fecal Microbiota Transplant – New England Journal of Medicine ($)
Related FDA Safety Alert: Fecal Transplant May Have Caused a Patient’s Death Due to Transmission of a Multi-Drug Resistant Organism (free)
6 – Long-term survival and cause-specific mortality of patients newly diagnosed with tuberculosis in São Paulo state, Brazil, 2010–15: a population-based, longitudinal study – The Lancet Infectious Diseases (free) (via @otavio_ranzani see Tweet)
Invited Commentary: Tuberculosis: an instrument of early mortality in life course (free)
7 – Intra‐pleural fibrinolytic therapy versus placebo, or a different fibrinolytic agent, in the treatment of adult parapneumonic effusions and empyema – Cochrane Library (free)
Summary: Clot-busting drugs for infections of the lining of the lung – Cochrane Library (free)
8 – Risk of Mortality Following Catheter Ablation of Atrial Fibrillation – Journal of the American College of Cardiology (link to abstract – $ for full-text)
Commentary: Mortality Risk After Catheter Ablation of Atrial Fibrillation – American College of Cardiology (free) AND Early mortality ‘a very real complication’ after catheter ablation of AFib – Cardiovascular Business (free) AND Afib Ablation Deaths Do Happen – MedPage Today (free registration required)
9 – Schizophrenia—An Overview – JAMA Psychiatry (free for a limited period)
10 – Association of Cord Plasma Biomarkers of In Utero Acetaminophen Exposure With Risk of Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder in Childhood – JAMA Psychiatry (free for a limited period)
Commentaries: NIH-funded study suggests acetaminophen exposure in pregnancy linked to higher risk of ADHD, autism – NIH News Releases (free) AND Babies at higher risk for ADHD, autism if pregnant moms took acetaminophen – Reuters (free) AND Expert reaction to study looking at paracetamol in pregnancy and autism, ADHD and other developmental disabilities in children – Science Media Centre (free)
Related Studies: Cohort Study: Associations Between Paracetamol Intake Between 18 and 32 Weeks Gestation and Neurocognitive Outcomes in the Child (free) AND Meta-Analysis: Prenatal Exposure to Acetaminophen and Risk for ADHD and Autistic Spectrum Disorder (free) AND Prenatal Exposure to Acetaminophen and Risk of ADHD (free)
Wed October 30 – 10 Stories of The Day!
30 Oct, 2019 | 10:26h | UTC
1 – Final Analysis of a Trial of M72/AS01E Vaccine to Prevent Tuberculosis – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: Vaccine shows promise for preventing active TB disease – Associated Press (free) AND Researchers move closer to new vaccine for killer TB – MedicalXpress (free)
Commentaries: Expert reaction to systematic review and meta-analysis of RCTs on anti-inflammatory drugs for depression – Science Media Centre (free) AND Anti-inflammatories can curb major depressive symptoms – OnMedica (free) AND Anti-inflammatory agents can effectively and safely curb major depressive symptoms, study suggests – BMJ (free)
Commentaries: Reducing infection-related morbidity and mortality in patients with myeloma – The Lancet Oncology (free) AND Abx Prophylaxis Cuts Early Death in Newly Diagnosed Myeloma – MedPage Today (free)
Commentary: Lenalidomide may delay onset of myeloma-related bone, organ damage – Mayo Clinic (free)
5 – Meta-analysis comparing double versus Triple Anti-thrombotic Therapy in Patients with Atrial Fibrillation and Coronary Artery Disease – The American Journal of Cardiology (link to abstract – $ for full-text)
Commentary: Meta-analysis: Dual therapy yields less bleeding than triple therapy in AF, CAD – Healio (free registration required)
Related Randomized Trial: Dual Antithrombotic Therapy after PCI in Atrial Fibrillation (free study and commentaries)
Related Meta-Analysis: Dual vs. Triple Antithrombotic Therapy in Patients with Atrial Fibrillation following PCI (free) AND Dual Versus Triple Antithrombotic Therapy in Patients Undergoing Percutaneous Coronary Intervention (link to abstract)
6 – It’s time to talk about physician burnout and moral injury – The Lancet Psychiatry (free)
Related: Moral Injury and Burnout in Medicine: A Year of Lessons Learned (free Commentaries) AND Consensus Study – Taking Action Against Clinician Burnout: A Systems Approach to Professional Well-Being (free)
Invited Commentary: Global burden of inflammatory bowel disease (free)
Invited Commentary: Pancreatic cancer: a growing burden (free)
Invited Commentary: 27 years of stomach cancer: painting a global picture (free)
Invited Commentary: The global challenge of colorectal cancer (free)
Tue October 29 – 10 Stories of The Day!
29 Oct, 2019 | 11:09h | UTC
1 – Discrimination, Abuse, Harassment, and Burnout in Surgical Residency Training – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: Women surgical residents suffer more mistreatment leading to burnout and suicidal thoughts – University of Northwestern (free) AND Harassment and Discrimination Are Leading to Burnout Among Female Doctors, Study Says – TIME (free)
2 – A comprehensive analysis of mortality-related health metrics associated with mental disorders: a nationwide, register-based cohort study – The Lancet (link to abstract – $ for full-text)
Commentaries: Life expectancy mapped for people with mental disorders – The University of Queensland (free) AND Mentally ill die many years earlier than others – Aarhus University (free)
3 – Cannabinoids for the treatment of mental disorders and symptoms of mental disorders: a systematic review and meta-analysis – The Lancet Psychiatry (link to abstract – $ for full-text)
Commentaries: Marijuana Cannabinoids Don’t Help With Depression, Anxiety, ADHS, Tourettes, Psychosis, Or PTSD – Scientific Blogging (free) AND There is little evidence that cannabis helps mental health problems – NewScientist (free) AND There’s ‘Scarce Evidence’ to Suggest Cannabis Improves Mental Health Symptoms, a New Research Review Says – TIME (free) AND Medicinal cannabis not proven in mental health, study finds – Reuters (free) AND Risks of cannabis use for mental health treatment outweigh benefits – The Guardian (free)
4 – Real-Time Benefit Tools for Drug Prices – JAMA (free for a limited period)
Podcast: CIDP and Update – Journal of Neurology, Neurosurgery & Psychiatry (free)
Related Reviews: Treatments for chronic inflammatory demyelinating polyradiculoneuropathy (CIDP): an overview of systematic reviews – Cochrane Library (free) AND History, Diagnosis, and Management of Chronic Inflammatory Demyelinating Polyradiculoneuropathy – Mayo Clinic Proceedings (free)
Commentary: Too much of a good thing: the cognitive impact of problematic internet use – The Mental Elf (free)
7 – Multiple health and environmental impacts of foods – Proceedings of the National Academy of Sciences (free for a limited period)
Commentaries: Research brief: Nutritious foods have lower environmental impact than unhealthy foods – University of Minnesota (free) AND Is A Diet That’s Healthy For Us Also Better For The Planet? Most Of The Time, Yes – NPR (free) AND Healthy diet means a healthy planet, study shows – The Guardian (free)
8 – Association of a Workplace Sales Ban on Sugar-Sweetened Beverages With Employee Consumption of Sugar-Sweetened Beverages and Health – JAMA Internal Medicine (free for a limited time)
Commentaries: Sugary Drink Ban Tied to Health Improvements at Medical Center – The New York Times (10 articles per month are free) AND Doctors call on workplaces to ban sale of sugary drinks – The Guardian (free)
Commentaries: With more choices of vegetarian cafeteria meals, more are sold – Reuters (free) AND Can more vegetarian options tempt carnivores away from meat? – Medical News Today (free) AND Even meat lovers go veggie when plant-heavy meals abound – Nature (free)
10 – Increasing Vegetable Intake by Emphasizing Tasty and Enjoyable Attributes: A Randomized Controlled Multisite Intervention for Taste-Focused Labeling – Psychological Science (link to abstract – $ for full-text)
Commentary: Emphasizing flavor boosts vegetable consumption – National Institutes of Health (free) AND Can simply naming vegetables differently increase healthful eating? – Medical News Today (free) AND Psychologists Show Leading with Flavor Encourages Healthy Eating – Stanford University (free) AND Touting flavor before nutrition encourages healthy eating – Association for Psychological Science (free)
Mon October 28 – 10 Stories of The Day!
28 Oct, 2019 | 01:10h | UTC
1 – Pediatric Metabolic and Bariatric Surgery: Evidence, Barriers, and Best Practices – Pediatrics (free)
Technical Report: Metabolic and Bariatric Surgery for Pediatric Patients With Severe Obesity – Pediatrics (free)
Commentary: More kids should get weight-loss surgery, even some preteens, pediatricians say – STAT / Associated Press (free)
Source: Grupo UTIclínica – HCFMUSP
3 – Sepsis hysteria: excess hype and unrealistic expectations – The Lancet (free)
Commentary: Sepsis myths create ‘unhealthy climate of fear’, say experts – The Guardian (free)
Source: Grupo UTIclínica – HCFMUSP
4 – Is Mycobacterium tuberculosis infection life long? – The BMJ (free)
Commentaries: Tuberculous infection is not life-long in most people – University of Pennsylvania School of Medicine (free) AND In the absence of a true test for latent TB we need shorter, safer preventive treatments – The BMJ Opinion (free)
See other articles in the series: Choosing Wisely: Things We Do For No Reason (free)
Related: Oxygen therapy for acutely ill medical patients: a clinical practice guideline – The BMJ (free) AND Oxygen Treatment in Intensive Care and Emergency Medicine – Deutsches Ärzteblatt International (free) AND Meta-Analysis: Liberal vs Conservative Oxygen Therapy in Acutely ill Adults (link to abstract and commentary) AND A Systematic Review of the Effects of Hyperoxia in Acutely Ill Patients: Should We Aim for Less? – BioMed Research International (free)
See other articles in the series: Choosing Wisely: Things We Do For No Reason (free)
8 – Older Patients (Still) Left Out of Cancer Clinical Trials – JAMA (free for a limited period)
Related: Exclusion of patients with concomitant chronic conditions in ongoing randomised controlled trials targeting 10 common chronic conditions and registered at ClinicalTrials.gov: a systematic review of registration details – BMJ Open (free) AND Do cancer clinical trials exaggerate the real-world benefits of drugs? – STAT News (free)
Commentary: Algorithm Identifies Cancer Patients in Need of Advance Care Planning Conversations – Penn Medicine (free)
News Release: ECRI Institute: Diagnostic Tests, Medication Pose Biggest Risks to Patients in Ambulatory Care (free)
Commentaries: ECRI Institute: Top 4 Biggest Risks in Ambulatory Care to Watch – HIT Consultant Media (free) AND Top 5 Patient Safety Risks in Ambulatory Care – Medscape (free registration required)
Fri October 25 – 10 Stories of The Day!
25 Oct, 2019 | 10:35h | UTC
1 – Comprehensive comparative effectiveness and safety of first-line antihypertensive drug classes: a systematic, multinational, large-scale analysis – The Lancet (link to abstract – $ for full-text)
Commentaries: Most Prescribed Blood Pressure Drugs May Be Less Effective than Others – Columbia University Irving Medical Center (free) AND Diuretics Better Than ACE Inhibitors as Initial Hypertension Treatment, Analysis Suggests – NEJM Journal Watch (free)
Related Cochrane Review: Thiazides best first choice for hypertension (free)
2 – Two out of three wild poliovirus strains eradicated – World Health Organization (free)
Commentaries: World Polio Day: Wild poliovirus type 3 declared eradicated – CIDRAP (free) AND WHO just declared another polio virus strain eradicated. There’s one more to go. – VOX (free) AND Two Strains of Polio Are Gone, but the End of the Disease Is Still Far Off – The New York Times (10 articles per month are free) AND Two Strains of Polio Down, One to Go – Scientific American (3 articles per month are free)
3 – Renal Association Clinical Practice Guideline on Haemodialysis – BMC Nephrology (free)
Related Review: The rising tide of opioid use and abuse: the role of the anesthesiologist – Perioperative Medicine (free)
5 – Series: Drug Use – The Lancet (free articles, commentaries and podcast – registration required)
6 – Pan-cancer whole-genome analyses of metastatic solid tumours – Nature (free)
Commentaries: Huge whole-genome study of human metastatic cancers – Nature (free) AND Whole-genome study of metastatic tumors provides a catalog of genetic features of metastatic cancer – MedicalXpress (free)
7 – The global need and availability of blood products: a modelling study – The Lancet Haematology (link to abstract – $ for full-text)
Commentaries: Hospitals Around The World Have A Dire Shortage Of Blood – NPR (free) AND 61% of countries have insufficient blood supplies – OnMedica (free)
8 – The Silent Heart Attack You Didn’t Know You Had – The New York Times (10 articles per month are free)
Related Studies: Silent Myocardial Infarction Often Precedes Sudden Cardiac Death (link to abstract and commentaries) AND Cohort Study: Long-term Outcomes of Unrecognized MI (link to abstract and commentaries)
Commentaries: Are Disinfectants Putting Nurses at Risk of COPD? – HealthDay (free) AND Nurses Exposed to Chemical Disinfectants May Have Greater Risk Of COPD – MedicalResearch.com (free)
Related Research: Cleaning at Home and at Work in Relation to Lung Function Decline and Airway Obstruction (link to abstract and commentaries)
Commentary: Suicide and mental illness in low- and middle-income countries – The Mental Elf (free)
Thu October 24 – 10 Stories of The Day!
24 Oct, 2019 | 10:33h | UTC
1 – Taking Action Against Clinician Burnout: A Systems Approach to Professional Well-Being – National Academies of Medicine (free resources)
Full Report: Taking Action Against Clinician Burnout: A Systems Approach to Professional Well-Being (free PDF – registration required)
Commentary: Improving the System to Support Clinician Well-being and Provide Better Patient Care – JAMA (free for a limited period)
Author Interview: Improving the System to Support Clinician Well-being and Provide Better Patient Care (free audio)
See also: Report Highlights | Key Messages | Report Recommendations | Press Release | Report Release Slides | Social Media Toolkit
2 – A State-of-the-Art Review Highlighting Medical Overuse in Dermatology, 2017-2018: A Systematic Review – JAMA Dermatology (free for a limited period)
3 – Prevalence and Factors Associated with Safe Infant Sleep Practices – Pediatrics (free)
Commentaries: Doctors still need to tell parents about safe infant sleep practices – Reuters (free) AND Safe infant sleep practices remain underutilized – 2 Minute Medicine (free)
4 – Effect of Fluoxetine on Obsessive-Compulsive Behaviors in Children and Adolescents With Autism Spectrum Disorders: A Randomized Clinical Trial – JAMA (free for a limited period)
Commentaries: Study finds little evidence on effectiveness of common antidepressant in autism spectrum disorders – News Medical (free) AND Prozac proves no better than a placebo in treating kids with autism – ScienceNews (free)
5 – Diagnosis and Management of Dementia: Review – JAMA (free for a limited period)
Original Guidelines: 2018 ESC/ESH Guidelines for the management of arterial hypertension – European Heart Journal (free) AND Hypertension in adults: diagnosis and management – National Institute for Health and Care Excellence (free)
7 – Mobile phone text messaging and app‐based interventions for smoking cessation – Cochrane Library (free)
Summary: Can programmes delivered by mobile phones help people to stop smoking? – Cochrane Library (free)
8 – Women Should Be Warned of Breast Implant Hazards, F.D.A. Says – The New York Times (10 articles per month are free)
Related: FDA Report: 660 Cases of Breast Implant-Associated Anaplastic Large Cell Lymphoma (free report and commentary) AND Study: Long-term Outcomes of Silicone Breast Implants (link to abstract and commentary)
9 – Association of Cigarette Type With Lung Cancer Incidence and Mortality: Secondary Analysis of the National Lung Screening Trial – JAMA Internal Medicine (free for a limited period)
Commentaries: Lung cancer incidence and mortality varies by cigarette type – OnMedica (free) AND Lung cancer risk 40% greater in unfiltered cigarette smokers – Healio (free registration required)
10 – The effectiveness of Contact Precautions on methicillin-resistant Staphylococcus aureus (MRSA) in long-term care across the United States – Clinical Infectious Diseases (free for a limited period)
Commentary: VA study finds contact precautions don’t affect MRSA in long-term care – CIDRAP (free)
Wed October 23 – 10 Stories of The Day!
23 Oct, 2019 | 10:25h | UTC
1 – Mapping 123 million neonatal, infant and child deaths between 2000 and 2017 – Nature (free)
Commentaries: Tackling inequality could save millions of children – Institute for Health Metrics and Evaluation (free) AND Where You’re Born Even Within A Country Still Matters – NPR (free)
2 – Bedtime hypertension treatment improves cardiovascular risk reduction: the Hygia Chronotherapy Trial – European Heart Journal (link to abstract – $ for full-text)
Commentaries: Blood pressure pills ‘work better at bedtime’ – BBC (free) AND You might want to change the time of day you take your blood pressure medicine – CNN (free) AND Expert reaction to study looking at the time of day when blood pressure medication is taken and cardiovascular disease risk – Science Media Centre (free)
3 – Cardiogenic Shock Classification to Predict Mortality in the Cardiac Intensive Care Unit – Journal of the American College of Cardiology (link to abstract – $ for full-text)
Commentaries: SCAI Shock Definition Tracks Well With Mortality in Cardiac ICU – TCTMD (free) AND Shock Classification Stratifies Mortality Risk – American College of Cardiology (free) AND SCAI’s new shock classification scheme used to analyze patients in cardiac intensive care unit – News Medical (free)
4 – New advances in the management of pulmonary sarcoidosis – The BMJ (free for a limited period)
Related Review: Clinical Manifestations, Diagnosis, and Treatment of Sarcoidosis – Mayo Clinic Proceedings: Innovations, Quality & Outcomes (free)
Commentary: Network meta-analysis nixes bone benefit from vitamin D, calcium – Univadis (free registration required)
Related Meta-Analysis: Calcium or Vitamin D Supplementation and Fracture Incidence in Older Adults – JAMA (free study and commentaries)
6 – How Artificial Intelligence Is Changing Health Care Delivery – NEJM Catalyst (free)
7 – Do fluid boluses before intubation help? (PREPARE trial) – PulmCrit (free)
Original Study: Randomized Trial: A Fluid Bolus Does Not Prevent Cardiovascular Collapse Among Critically Ill Adults Undergoing Tracheal Intubation (link to abstract – $ for full-text)
8 – Socially transmitted placebo effects – Nature Human Behaviour (free for a limited period)
Commentary: The Placebo Effect Works And You Can Catch It From Your Doctor – NPR (free)
9 – Prevalence of Survival Without Major Comorbidities Among Adults Born Prematurely – JAMA (free for a limited period)
Commentary: Researchers Find That Most Adults Born Prematurely Survive Without Major Comorbidities – Mount Sinai Health System (free)
10 – Risk of Developing Parkinson Disease in Bipolar Disorder: A Systematic Review and Meta-analysis – JAMA Neurology (free for a limited period)
Commentaries: Patients With Bipolar Disorder More Than 3 Times as Likely to Develop PD – AJMC (free) AND Looking for links between Parkinson’s and bipolar disorder – Medical News Today (free) AND Parkinson’s And Bipolar Disorder: Is There A Link Between The Two? – Medical Daily (free) AND Bipolar Disorder Raises Subsequent Risk of Parkinson’s – MedPage Today (free registration required)
Tue October 22 – 10 Stories of The Day!
22 Oct, 2019 | 08:49h | UTC
Commentary: Guideline on Managing Acute Upper Gastrointestinal Bleeding Updated – NEJM Journal Watch (free)
3 – Neurodegenerative Disease Mortality among Former Professional Soccer Players – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: Dementia in football: Ex-players three and a half times more likely to die of condition – BBC (free) AND Study shows more thinking problems in former pro soccer players – Reuters (free)
4 – Pan-viral serology implicates enteroviruses in acute flaccid myelitis – Nature (link to abstract – $ for full-text)
Commentaries: ‘Missing’ Virus Detected in Dozens of Children Paralyzed by Polio-Like Illness – UC San Francisco (free) AND What Causes a Mysterious Paralysis in Children? Researchers Find Viral Clues – The New York Times (10 articles per month are free) AND Virus could be the cause of mysterious polio-like illness AFM, study says – CNN (free)
News Release: Episiotomy may be beneficial in reducing severe perineal tears among forceps and vacuum deliveries – Canadian Medical Association Journal (free)
6 – #178 Tuberculosis Updates with Laila Woc-Colburn MD – The Curbsiders Internal Medicine Podcast (free audio)
7 – Super-precise new CRISPR tool could tackle a plethora of genetic diseases – Nature News (free)
Original Article: Search-and-replace genome editing without double-strand breaks or donor DNA – Nature (link to abstract – $ for full-text)
See also: New CRISPR genome editing system offers a wide range of versatility in human cells – Broad Institute of MIT and Harvard (free) AND Prime editing: DNA tool could correct 89% of genetic defects – BBC (free) AND New CRISPR tool has the potential to correct almost all disease-causing DNA glitches, scientists report – STAT (free)
Related: Simple guide to CRISPR, one of the biggest science stories of the decade – VOX (free)
Related Guidelines: 2019 Global Strategy for Prevention, Diagnosis and Management of COPD – GOLD Reports 2019 (free PDF) AND Chronic obstructive pulmonary disease in over 16s: diagnosis and management – National Institute for Health and Care Excellence (free)
9 – Effect of the Tailored, Family-Involved Hospital Elder Life Program on Postoperative Delirium and – Function in Older Adults: A Randomized Clinical Trial – JAMA Internal Medicine (free for a limited period)
Commentaries: Including the Family in Perioperative Care of Older Adults—A Call for HELP – JAMA Internal Medicine (free for a limited period) AND Family members can help reduce the incidence of post-operative delirium by up to 16.8% – News Medical (free)
10 – Effect of Depression Screening After Acute Coronary Syndromes on Quality of Life: The CODIACS-QoL Randomized Clinical Trial – JAMA Internal Medicine (free for a limited Period)
Commentary: Depression Intervention Flops for Heart Attack Survivors – MedPage Today (free registration required)