TOP 10 Medical News Stories

1 – Four major results to be presented at #CCR20 – PEPTIC, 65, & VITAMINS trials, plus the IHME Sepsis Study – More Info on the Critical Care Reviews Website

Commentary: Clinical trial results in critical care medicine to be unveiled at leading UK conference – EurekAlert (free)

– Thursday January 16th (09:00 to 10:30) – 65 Results Presentation Session – https://vimeo.com/383967830

See Study Protocol: Evaluating the clinical and cost-effectiveness of permissive hypotension in critically ill patients aged 65 years or over with vasodilatory hypotension: Protocol for the 65 randomised clinical trial – Journal of the Intensive Care Society (free)

– Thursday January 16th (16:35 to 17:40 – IHME Sepsis Study Results – https://vimeo.com/383968757

– Friday January 17th (09:00 to 10:30) – PEPTIC Trial Results Session – https://vimeo.com/383968980

See Study Protocol: A cluster randomised, crossover, registry-embedded clinical trial of proton pump inhibitors versus histamine-2 receptor blockers for ulcer prophylaxis therapy in the intensive care unit (PEPTIC study): study protocol. – Critical Care and Resuscitation (free PDF)

– Friday January 17th (11:00 to 12:30) – VITAMINS Trial Results – https://vimeo.com/383969217

See Study Protocol: Vitamin C, Hydrocortisone and Thiamine in Patients with Septic Shock (VITAMINS) trial: study protocol and statistical analysis plan – Critical Care and Resuscitation (free PDF)

2 – Report Summary: What researchers think about the culture they work in – Wellcome Trust (free)

Full Report: What researchers think about the culture they work in – Wellcome Trust (free PDF)

Commentary: Researchers facing ‘shocking’ levels of stress, survey reveals – The Guardian (free)

3 – A Randomized Trial of Erythropoietin for Neuroprotection in Preterm Infants – New England Journal of Medicine (link to abstract – $ for full-text)

4 – Effect of a Behavioral Intervention to Increase Vegetable Consumption on Cancer Progression Among Men With Early-Stage Prostate Cancer: The MEAL Randomized Clinical Trial – JAMA (free for a limited period)

Commentaries: Eating more vegetables provides no extra protection for men with prostate cancer – News Medical (free) AND Does Increased Vegetable Consumption Affect Prostate Cancer Progression? – MedicalResearch.com (free)

5 – Patient-Reported Outcomes Through 5 Years for Active Surveillance, Surgery, Brachytherapy, or External Beam Radiation With or Without Androgen Deprivation Therapy for Localized Prostate Cancer – JAMA (free for a limited period)

Commentaries: Prostatectomy-associated urinary incontinence disparities persist at 5 years – MedwireNews (free) AND Prostate Cancer Treatment Side Effects Worse With Prostatectomy – Renals & Urology News (free)

6 – Interventions and Operations 5 Years After Bariatric Surgery in a Cohort From the US National Patient-Centered Clinical Research Network Bariatric Study – JAMA Surgery (free)

Author Interview: Interventions and Operations 5 Years After Bariatric Surgery (free)

Commentaries: Bariatric Surgery Is Safe and It Works – JAMA Surgery (free for a limited period) AND Procedures And Hospitalizations Common After Bariatric Procedures – MedicalResearch.com (free) AND More Interventions Follow Gastric Bypass than Gastric Sleeve, Large Study Shows – Health Sciences at the University of Pittsburgh (free)

7 – An integrated perfusion machine preserves injured human livers for 1 week – Nature Biotechnology (free for a limited period)

Commentaries: Machine keeps human livers alive for one week outside of the body – University of Zurich (free) AND Machine Could Expand Pool of Livers for Donation – HealthDay News (free)

8 – A network meta‐analysis of the effects of psychotherapies, pharmacotherapies and their combination in the treatment of adult depression – World Psychiatry (free)

9 – Management of patients undergoing same-day discharge primary total hip and knee arthroplasty – Canadian Medical Association Journal (free)

10 – The Development of a Standardized Pathway for Outpatient Ambulatory Fracture Surgery – The Journal of Bone and Joint Surgery (free)

Commentary: Strong Case for Outpatient Fracture Surgery – Orthobuzz (free)

Wed January 15 – 10 Stories of The Day!

15 Jan, 2020 | 08:20h | UTC

1 – News Release: American College of Radiology Releases New and Updated ACR Appropriateness Criteria (free)

2 – Clostridioides difficile (formerly Clostridium difficile) infection in the critically ill: an expert statement – Intensive Care Medicine (free for a limited period)

Related: Clostridioides Difficile: Diagnosis and Treatments (free BMJ review and guidelines on the subject)

3 – European Respiratory Society guideline on long-term management of children with bronchopulmonary dysplasia – European Respiratory Journal (free)

4 – Effectiveness of Combined Behavioral and Drug Therapy for Overactive Bladder Symptoms in Men: A Randomized Clinical Trial – JAMA Internal Medicine (free for a limited period)

Commentaries: What Works Best to Help Men With Overactive Bladder? – HealthDay News (free) AND For Overactive Bladder in Men, Start with Behavioral Strategies – NEJM Journal Watch (free)

5 – Physician Time Spent Using the Electronic Health Record During Outpatient Encounters: A Descriptive Study – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Doctors average 16 minutes on the computer for every patient – Reuters (free) AND How Doctors May Be Spending More Time With Electronic Health Records Than Patients – Forbes (free)

Related: Opinion – “The EMR has changed the doctor-patient duet into a ménage-à-trois” (free resources on the subject)

6 – Safety clinical trial shows possible increased risk of cancer with weight-loss medicine Belviq, Belviq XR (lorcaserin) – U.S. Food & Drug Administration (free)

Commentaries: CV Safety Trial for Lorcaserin Picks Up Cancer Signal: FDA – TCTMD (free) AND FDA Warning: Weight Loss Drug Belviq May Increase Cancer Risk- Forbes (free)

7 – Changes in Quality of Care after Hospital Mergers and Acquisitions – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Hospital mergers don’t improve readmissions, mortality or experience, study – Modern Healthcare (free) AND Patient satisfaction may decline after hospital acquisition – Reuters (free)

8 – The Effect of Coconut Oil Consumption on Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis of Clinical Trials – Circulation (free PDF for a limited period)

9 – Enhanced Recovery After Surgery (ERAS) Reduces Hospital Costs and Improve Clinical Outcomes in Liver Surgery: a Systematic Review and Meta-Analysis – Journal of Gastrointestinal Surgery (free)

10 – The application of enhanced recovery after surgery for upper gastrointestinal surgery: Meta-analysis – BMC Surgery (free)

Related: Complete List of Enhanced Recovery After Surgery (ERAS) Society Guidelines (free articles)

Tue January 14 – 10 Stories of The Day!

14 Jan, 2020 | 01:20h | UTC

1 – Urgent health challenges for the next decade – World Health Organization (free)

Commentary: ‘No shortcuts to a healthier world’: WHO chief sets out health priorities for the decade – UN News (free)

2 – Homepage: Achieving fair pricing of medicines – The BMJ (free articles)

Editorial: Can affordability and innovation coexist for medicines?

– Defining the concept of fair pricing for medicines

– Strategies to achieve fairer prices for generic and biosimilar medicines

– Pricing of pharmaceuticals is becoming a major challenge for health systems

– New business models for research and development with affordability requirements are needed to achieve fair pricing of medicines

– Price transparency is a step towards sustainable access in middle income countries

3 – Benefits of short-term or prolonged as compared to standard 1 year DAPT in patients with acute coronary syndrome treated with drug-eluting stents: a meta-analysis of 9 randomized trials – Journal of Thrombosis and Thrombolysis (free)

4 – New possibilities on transplanting kidneys from hepatitis C virus positive donors: a Systematic Review – Transplantation Reviews (free)

Related: Favorable 1-Year Outcomes with Transplantation of HCV-Viremic Kidneys (studies and commentaries on the subject)

5 – You Are Unvaccinated and Got Sick. These Are Your Odds. – The New York Times (10 articles per month are free)

“Comparing the dangerous effects of three diseases with the minimal side effects of their corresponding vaccines.”

6 – New baby: fads, fashions and evidence for new parents – Evidently Cochrane (free)

7 – Work Up of Fatty Liver by Primary Care Physicians, Review – Annals of Medicine and Surgery (free)

8 – Efficacy and Safety of Lumateperone for Treatment of Schizophrenia: A Randomized Clinical Trial – JAMA Psychiatry (free)

Editorial: The Potential Role of Lumateperone—Something Borrowed? Something New? – JAMA Psychiatry (free for a limited period)

9 – Association of Ticagrelor vs Clopidogrel With Major Adverse Coronary Events in Patients With Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention – JAMA Internal Medicine (free for a limited period)

Commentary: Brilinta Questioned for Acute Coronary Syndrome – MedPage Today (free registration required)

10 – Important Food Sources of Fructose‐Containing Sugars and Incident Hypertension: A Systematic Review and Dose‐Response Meta‐Analysis of Prospective Cohort Studies – Journal of the American Heart Association (free)

Commentary: Does sugar raise blood pressure? It depends where it comes from, researchers say – University of Toronto (free)

Mon January 13 – 10 Stories of The Day!

13 Jan, 2020 | 00:01h | UTC

1 – ACC/AHA/ASE/HRS/ISACHD/SCAI/SCCT/SCMR/SOPE 2020 Appropriate Use Criteria for Multimodality Imaging During the Follow-Up Care of Patients With Congenital Heart Disease – Journal of the American College of Cardiology (free)

Commentaries: Appropriate Use Criteria for Imaging of Congenital Heart Disease Patients: Key Points – American College of Cardiology (free) AND New AUC for Cardiac Imaging Follow-up in Congenital Heart Disease – TCTMD (free)

2 – Association of Deceased Donor Acute Kidney Injury With Recipient Graft Survival – JAMA Network Open (free)

Commentaries: Less-than-perfect kidneys can be successfully used for transplants, study shows – Johns Hopkins Medicine (free) AND Less than perfect kidneys safe for transplant, study shows – UPI (free) AND Greater Use of Deceased Donor AKI Kidneys Urged – Renal & Urology News (free)

3 – Adverse events in adults with latent tuberculosis infection receiving daily rifampicin or isoniazid: post-hoc safety analysis of two randomised controlled trials – The Lancet Infectious Diseases (free registration required)

Commentaries: What is the best regimen to treat latent tuberculosis infection? – The Lancet Infectious Diseases (free) AND Four Months of Rifampicin May Be Best Option for Latent TB – Medscape / Reuters (free registration required)

4 – Homepage: Palliative Care – Medicine (free articles)

– Palliative care: introduction

– Pain control in palliative care

– Interventional management of pain in cancer and palliative care

– Nausea and vomiting in palliative care

– Constipation and malignant bowel obstruction in palliative care

– Breathlessness in advanced disease

– Psychiatric conditions in palliative medicine

– Emergencies in palliative care

– Palliative care in non-malignant disease

– Management of less common symptoms in palliative care

– Complications of systemic anti-cancer treatment

– Care in the last hours and days of life

– Advance care-planning and clinical decision-making

– Ethical principles in end-of-life care

5 – Homepage: Uncommon Severe Infections in the Intensive Care Unit – Clinical Microbiology and Infection (free articles)

– Improving care for the ICU patient with suspected infection: a multidisciplinary perspective

– Necrotizing skin and soft-tissue infections in the intensive care unit

– Management of infected pancreatic necrosis in the intensive care unit: a narrative review

– Mediastinitis in the intensive care unit patient: a narrative review

– When not to start antibiotics: avoiding antibiotic overuse in the intensive care unit

6 – Uterine Balloon Tamponade for the Treatment of Postpartum Hemorrhage: a Systematic Review and Meta-Analysis – American Journal of Obstetrics & Gynecology (link to abstract – $ for full-text)

Commentaries: Technique is almost 86 percent effective in preventing maternal death from hemorrhaging – Massachusetts General Hospital (free) AND Uterine Balloon Tamponade for Postpartum Bleeding Seems Safe – Physician’s Briefing (free)

7 – Different strategies for pharmacological thromboprophylaxis for lower-limb immobilisation after injury: systematic review and economic evaluation – Health Technology Assessment (free)

Source: EvidenceAlerts

8 – How I set up positive end-expiratory pressure: evidence- and physiology-based! – Critical Care (free)

9 – Mechanical ventilation in patients with acute ischaemic stroke: from pathophysiology to clinical practice – Critical Care (free)

10 – Tea consumption and the risk of atherosclerotic cardiovascular disease and all-cause mortality: The China-PAR project – European Journal of Preventive Cardiology (free for a limited period)

Commentaries: Tea drinkers live longer – European Society of Cardiology (free) AND Habitual Green Tea Drinkers May Live Longer – MedicalResearch.com (free) AND Expert reaction to study looking at tea drinking, and health and longevity – Science Media Centre (free)

Fri January 10 – 10 Stories of The Day!

10 Jan, 2020 | 08:47h | UTC

1 – Clinical Practice Guideline: Nosebleed (Epistaxis) – Otolaryngology–Head and Neck Surgery (free)

Executive Summary: Clinical Practice Guideline: Nosebleed (Epistaxis) – Otolaryngology–Head and Neck Surgery (free)

News Release: Nosebleed (epistaxis): New clinical practice guideline – American Academy of Otolaryngology-Head and Neck Surgery (free)

2 – Critical Update on the Third Edition of the Guidelines for Managing Severe Traumatic Brain Injury in Children – American Journal of Critical Care (free)

Original Article: New Guidelines for the Management of Pediatric Severe Traumatic Brain Injury (free guideline and news release)

3 – Recognition and Initial Management of Fulminant Myocarditis: A Scientific Statement from the American Heart Association – Circulation (free PDF)

News Release: Fast action and the right resources are key to treating fulminant myocarditis – American Heart Association (free)

4 – Blood Pressure Measurement: A KDOQI Perspective – American Journal of Kidney Diseases (free)

5 – Outcomes Six-Months After 100% or 70% of Enteral Calorie Requirements During Critical Illness (TARGET): A Randomized Controlled Trial – American Journal of Respiratory and Critical Care Medicine (link to abstract – $ for full-text)

Original Study: Energy-Dense versus Routine Enteral Nutrition in the Critically Ill (free study and commentary)

Source: Grupo UTIclínica – HCFMUSP

6 – Findings on education, malnutrition ‘deeply disturbing’ with United Nations’ goals 10 years away – Institute for Health Metrics and Evaluation (free)

See articles: Mapping child growth failure across low- and middle-income countries – Nature (free) AND Mapping disparities in education across low- and middle-income countries – Nature (free)

7 – Morbidity and mortality from road injuries: results from the Global Burden of Disease Study 2017 – Injury Prevention (free)

News Release: Probability of dying from road injury has dropped worldwide in all but 5 nations – Institute for Health Metrics and Evaluation (free)

8 – Healthy lifestyle and life expectancy free of cancer, cardiovascular disease, and type 2 diabetes: prospective cohort study – The BMJ (free)

Commentaries: Healthy habits add up to 10 disease-free years to your life, study reveals – NHS Choices (free) AND 5 healthful living factors extend disease-free life – Medical News Today (free) AND Healthy habits ‘deliver extra disease-free decade’ – BBC (free)

9 – Appropriate use Criteria – American Academy of Orthopaedic Surgeons (free)

Commentary: AAOS releases guidelines, appropriate use criteria for care of trauma patients – Healio (free registration required)

10 – Cognition After Early Tonsillectomy for Mild OSA – Pediatrics (link to abstract – $ for full-text)

Commentary: Tonsillectomy doesn’t boost cognitive skills for preschoolers with mild apnea – Reuters (free)

Thu January 09 – 10 Stories of The Day!

9 Jan, 2020 | 09:34h | UTC

1 – Perforated and bleeding peptic ulcer: WSES guidelines – World Society of Emergency Surgery (free)

2 – 2019 American College of Rheumatology/Arthritis Foundation Guideline for the Management of Osteoarthritis of the Hand, Hip, and Knee – Arthritis & Rheumatology (free)

News Release: ACR and Arthritis foundation release updated treatment guideline for OA – American College of Rheumatology (free)

3 – American Gastroenterological Association Clinical Practice Update: Management of Pancreatic Necrosis – Gastroenterology (free)

4 – Practices to Foster Physician Presence and Connection With Patients in the Clinical Encounter – JAMA (free for a limited period)

Editorials: Can an Evidence-Based Approach Improve the Patient-Physician Relationship? (free for a limited period) AND Connecting With Patients—The Missing Links (free for a limited period)

Author Interview: Practices to Foster Physician Presence and Connection with Patients in the Clinical Encounter (free)

Video: Connecting With Patients in Medicine (free)

5 – Health Care Hotspotting — A Randomized, Controlled Trial – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Reduce Health Costs By Nurturing The Sickest? A Much-Touted Idea Disappoints – Kaiser Health News (free) AND Did a high-profile program really slash hospital spending? Or was it a cautionary tale of ‘regression to the mean’? – STAT (free)

6 – Alex Nowbar’s weekly review, 8 January 2020 – The BMJ Opinion (free)

7 – Effectiveness of Virtual vs In-Person Inhaler Education for Hospitalized Patients With Obstructive Lung Disease: A Randomized Clinical Trial – JAMA Network Open (free)

Commentary: Virtual instruction for inhaler technique nearly as effective as in-person instruction, study finds – ACP Hospitalist (free)

8 – Beyond depression: Other uses for tricyclic antidepressants – Cleveland Clinic Journal of Medicine (free)

9 – Public-access defibrillation and neurological outcomes in patients with out-of-hospital cardiac arrest in Japan: a population-based cohort study – The Lancet (link to abstract – $ for full-text)

10 – Expanding Heart Transplant in the Era of Direct-Acting Antiviral Therapy for Hepatitis C – JAMA Cardiology (link to abstract – $ for full-text)

Commentaries: Hepatitis C-positive donors a viable option to expand heart donor pool – Vanderbilt University Medical Center (free) AND Expanding heart transplant in the era of direct-acting antiviral therapy for hepatitis C – 2 Minute Medicine (free)

Related Studies: Transplant of Hepatitis C–Infected Kidneys Into Uninfected Recipients (link to abstract and commentaries) AND Heart and Lung Transplants from HCV-Infected Donors to Uninfected Recipients (link to abstract and commentaries) AND Direct-Acting Antiviral Prophylaxis in Kidney Transplantation From Hepatitis C Virus–Infected Donors to Noninfected Recipients (link to abstract and commentaries) AND Favorable 1-Year Outcomes with Transplantation of HCV-Viremic Kidneys (link to abstract and commentaries)

Wed January 08 – 10 Stories of The Day!

8 Jan, 2020 | 09:02h | UTC

1 – Testosterone Treatment in Adult Men With Age-Related Low Testosterone: A Clinical Guideline From the American College of Physicians – Annals of Internal Medicine (free)

Commentaries: ACP issues guideline on testosterone treatment for age-related low testosterone levels – ACP Internist (free) AND Most older men don’t need testosterone replacement, new guidelines say – Reuters (free)

2 – Transfusion strategies in non-bleeding critically ill adults: a clinical practice guideline from the European Society of Intensive Care Medicine – Intensive Care Medicine (free)

Editorial: Transfusion thresholds: the dangers of guidelines based on randomized controlled trials (free)

3 – ACG Clinical Guideline: Disorders of the Hepatic and Mesenteric Circulation – American College of Gastroenterology (free)

4 – Collection Homepage: The Year in Cardiology 2019 – European Heart Journal (free articles)

– The Year in Cardiology: Acute Coronary Syndromes

– The Year in Cardiology: Aorta and Peripheral Circulation

– The Year in Cardiology: Arrhythmias and Pacing

– The Year in Cardiology: Imaging

– The Year in Cardiology: Cardiovascular Prevention

– The Year in Cardiology: Interventional Cardiology

– The Year in Cardiology: Valvular Heart Disease

– The Year in Cardiology: Heart Failure

5 – The Decade’s Top 10 Biggest Changes to ID Clinical Practice – HIV and ID Observations (free)

6 – Prevalence of Potentially Unnecessary Bimanual Pelvic Examinations and Papanicolaou Tests Among Adolescent Girls and Young Women Aged 15-20 Years in the United States – JAMA Internal Medicine (free for a limited period)

Commentaries: Unnecessary Bimanual Pelvic Examinations and Papanicolaou Testing in Adolescents and Young Women—Learning How to Unlearn – JAMA Internal Medicine (free for a limited period) AND Young women still may be getting unnecessary pelvic exams – University of California – San Francisco (free) AND Many young women get unnecessary pelvic exams – Reuters (free)

7 – Randomized clinical trial analyzing maintenance of peripheral venous catheters in an internal medicine unit: Heparin vs. saline – PLOS One (free)

Related Systematic Reviews: Heparin versus 0.9% sodium chloride locking for prevention of occlusion in central venous catheters in adults – Cochrane Library (free) AND Heparin flush vs. normal saline flush to maintain the patency of central venous catheter among adult patients: A systematic review and meta-analysis – Journal of Family Medicine and Primary Care (free)

8 – Neurodevelopmental Abnormalities in Children With In Utero Zika Virus Exposure Without Congenital Zika Syndrome – JAMA Pediatrics (free for a limited period)

Editorial: Neurodevelopmental Abnormalities Associated With In Utero Zika Virus Infection in Infants and Children—The Unfolding Story (free for a limited period)

Commentaries: Study underscores the importance of long-term follow-up for Zika-exposed infants – Children’s National Hospital (free) AND New study shows Zika’s long arm in children – CIDRAP (free) AND Healthy babies exposed to Zika in the womb may suffer developmental delays – ScienceNews (free)

Related: Study: Nearly A Third of Children Exposed to Zika In-utero Develop Neurological Problems by Age 3 (link to abstract and commentary) AND Study: Neurodevelopment in Infants Exposed to Zika Virus In Utero (free study and commentaries)

9 – Thyroid nodules: diagnostic evaluation based on thyroid cancer risk assessment – The BMJ (free for a limited period)

10 – Efficacy and Safety of Switching to Dolutegravir/Lamivudine Fixed-Dose Two-Drug Regimen Versus Continuing a Tenofovir Alafenamide–Based Three- or Four-Drug Regimen for Maintenance of Virologic Suppression in Adults With HIV-1: Phase 3, Randomized, Non-inferiority TANGO Study – Clinical Infectious Diseases (free PDF)

Tue January 07 – 10 Stories of The Day!

7 Jan, 2020 | 07:07h | UTC

1 – Gastrointestinal bleeding prophylaxis for critically ill patients: a clinical practice guideline – The BMJ (free)

2 – European Society of Endocrinology Clinical Practice Guideline: Endocrine work-up in obesity – European Journal of Endocrinology (free)

3 – Homepage: Special Issue: Advances in Perioperative Care – BJS / Anaesthesia (free articles)

– Perioperative care and collaboration between surgeons and anaesthetists – it’s about time

– Role of the anaesthetist in postoperative care

– Framework for prehabilitation services

– Role of critical care in improving outcomes for high‐risk surgical patients

– Scoping review of mode of anaesthesia in emergency surgery

– Strategies to minimize intraoperative blood loss during major surgery

– Perioperative care of the obese patient

– Rational performance metrics for operating theatres, principles of efficiency, and how to achieve it

– Acute postoperative pain management

– Meta‐analysis of preoperative high‐sensitivity cardiac troponin measurement in non‐cardiac surgical patients at risk of cardiovascular complications

– Network meta‐analysis of urinary retention and mortality after Lichtenstein repair of inguinal hernia under local, regional or general anaesthesia

– Meta‐analysis of α‐blockade versus no blockade before adrenalectomy for phaeochromocytoma

– Network meta‐analysis of local and regional analgesia following colorectal resection

– Randomized clinical trial of intraoperative dexmedetomidine to prevent delirium in the elderly undergoing major non‐cardiac surgery

– Randomized clinical trial of continuous transversus abdominis plane block, epidural or patient‐controlled analgesia for patients undergoing laparoscopic colorectal cancer surgery

– Qualitative study of clinician and patient perspectives on the mode of anaesthesia for emergency surgery

– Variation in global uptake of the Surgical Safety Checklist

– Safety and efficacy of non‐steroidal anti‐inflammatory drugs to reduce ileus after colorectal surgery

– International multicentre review of perioperative management and outcome for catecholamine‐producing tumours

4 – National, regional, and global burdens of disease from 2000 to 2016 attributable to alcohol use: a comparative risk assessment study – The Lancet Public Health (free)

Commentary: The burden of alcohol use: better data and strong policies towards a sustainable development – The Lancet Public Health (free)

Related: Related: WHO Global Status Report on Alcohol and Health 2018 (free report and commentaries) AND Alcohol Use and Burden for 195 Countries and Territories – The Lancet (free study and commentaries) AND Prioritising action on alcohol for health and development – The BMJ (free)

5 – Critical Care Management of Toxicities Associated With Targeted Agents and Immunotherapies for Cancer – Critical Care Medicine (free)

Related: Immune Checkpoint Inhibitor Toxicities (free guidelines and reviews on the subject)

6 – Artificial Intelligence Is Rushing Into Patient Care – And Could Raise Risks – Scientific American (a few articles per month are free)

“AI systems are not as rigorously tested as other medical devices, and have already made serious mistakes.”

7 – Diagnosis and treatment of autoimmune hemolytic anemia in adults: Recommendations from the First International Consensus Meeting – Blood Reviews (free)

8 – Efficacy of faecal microbiota transplantation for patients with irritable bowel syndrome in a randomised, double-blind, placebo-controlled study – Gut (free)

9 – Efficacy and Safety of Early vs Elective Colonoscopy for Acute Lower Gastrointestinal Bleeding – Gastroenterology (free)

Commentary: Colonoscopy for Lower Gastrointestinal Bleeding—Time Is Not of the Essence – Gastroenterology (free)

10 – Early Colonoscopy Does Not Improve Outcomes of Patients With Lower Gastrointestinal Bleeding: Systematic Review of Randomized Trials – Clinical Gastroenterology & Hepatology (link to abstract – $ for full-text)

Commentary: Early colonoscopy did not improve outcomes in those hospitalized for lower GI bleeding – ACP Gastroenterology (free)

Mon January 06 – 10 Stories of The Day!

6 Jan, 2020 | 00:53h | UTC

1 – The Altmetric TOP 100 Articles of 2019

See the 54 articles in the List Related to Medical and Health Sciences

“In the past 12 months, Altmetric has tracked over 62.5 million mentions of 2.7 million research outputs. Here, we’ve highlighted the 100 most-discussed works of 2019 – those that have truly captured the public imagination”

2 – Guideline: ADA 2020 Standards of Medical Care in Diabetes – American Diabetes Association (free supplement)

Commentaries: ADA 2020 Standards of Care Incorporate CVD Risk Stratification, New Medications – Endocrinology Advisor (free) AND ADA releases 2020 standards of medical care in diabetes – University of North Carolina at Chapel Hill School of Medicine (free)

See ADA 2020 Guideline topics below:

Introduction: Standards of Medical Care in Diabetes—2020

Summary of Revisions: Standards of Medical Care in Diabetes—2020

3 – Acute kidney injury: prevention, detection and management – National Institute for Health and Care Excellence (free)

4 – Alcohol Abstinence in Drinkers with Atrial Fibrillation – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Cutting out alcohol may reduce atrial fibrillation episodes – Reuters (free) AND Atrial Fibrillation and Alcohol Abstinence – MedicalResearch.com (free) AND Alcohol Abstinence Linked to Lower Risk for Atrial Fibrillation Recurrence – NEJM Journal Watch (free)

5 – Percutaneous coronary angioplasty versus coronary artery bypass grafting in the treatment of unprotected left main stenosis: updated 5-year outcomes from the randomised, non-inferiority NOBLE trial – The Lancet (link to abstract – $ for full-text)

Commentary: NOBLE at 5 Years: New Data Favor CABG for Left Main Disease – TCTMD (free)

6 – Doctors Prescribe More of a Drug If They Receive Money from a Pharma Company Tied to It – ProPublica (free)

Commentary: We’ve Been Tracking Pharma Payments to Doctors For Nearly A Decade. We Just Made A Big Breakthrough – ProPublica (free)

7 – Effect of Treating Parents Colonized With Staphylococcus aureus on Transmission to Neonates in the Intensive Care Unit: A Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Decreasing Staphylococcus aureus in the Neonatal Intensive Care Unit by Decolonizing Parents – JAMA (free for a limited period)

Commentaries: Decolonizing parents could cut spread of Staph to newborns – CIDRAP (free) AND Trial suggests babies in intensive care can be better protected from parental bacteria – Johns Hopkins Medicine (free)

8 – International evaluation of an AI system for breast cancer screening – Nature (free link via STAT)

Commentaries: AI shows promise for breast cancer screening – Nature (free) AND Google AI tool can pinpoint breast cancer better than clinicians, new study suggests – STAT (free) AND Artificial intelligence could help to spot breast cancer – Imperial College London (free) AND AI can now outperform doctors at detecting breast cancer. Here’s why it won’t replace them – Vox (free) AND A.I. Is Learning to Read Mammograms – The New York Times (10 articles per month are free) AND Study finds Google system could improve breast cancer detection – Reuters (free)

9 – Prevention of tuberculosis in macaques after intravenous BCG immunization – Nature (free)

Commentaries: Tuberculosis vaccine finds an improved route – Nature (free) AND New Injection Method Makes an Old TB Vaccine Far More Powerful – New York Times (10 articles per month are free) AND Changed Route of Immunization Dramatically Improves Efficacy of TB Vaccine – NIH News Releases (free)

10 – Report: Artificial Intelligence in Health Care: The Hope, the Hype, the Promise, the Peril – A Special Publication from the National Academy of Medicine (free)

Related JAMA Viewpoint: Artificial Intelligence in Health Care: A Report From the National Academy of Medicine (free for a limited period)

Commentary: AI’s Future Potential Hinges on Consensus: NAM Report – Vanderbilt University Medical Center (free)

Fri December 13 – 10 Stories of The Day!

13 Dec, 2019 | 10:29h | UTC

1 – AGA Clinical Practice Guidelines on Management of Gastric Intestinal Metaplasia – Gastroenterology (free PDF)

News Release: AGA releases guideline on management of gastric intestinal metaplasia – American Gastroenterological Association (free)

2 – It’s time to walk the talk: WHO independent high-level commission on noncommunicable diseases – World Health Organization (free PDF)

News Release: WHO gets new advice on curbing deadly noncommunicable diseases – World Health Organization (free)

3 – WHO Health and Climate Change Survey Report: Tracking Global Progress – World Health Organization (free PDF)

News Releases: Climate risks to health are growing but prioritized funding lacking to safeguard human health from climate change – World Health Organization (free) AND Only one in five countries has a healthcare strategy to deal with climate change – UN News (free)

Related: The 2019 Report of The Lancet Countdown on Health and Climate Change (free resources – registration required) AND Climate Change — A Health Emergency (free reports and commentaries on the subject) AND NEJM Editorial: Prioritizing Health in a Changing Climate (free commentaries) AND Climate change threatens the achievement of effective universal healthcare – The BMJ (free) AND Climate Change Is Having a Major Impact on Global Health – Scientific American (free)

4 – Effect of Fresh vs Standard-issue Red Blood Cell Transfusions on Multiple Organ Dysfunction Syndrome in Critically Ill Pediatric Patients: A Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Age of Red Blood Cells for Transfusion in Critically Ill Pediatric Patients (free for a limited period)

Commentaries: Fresh red blood cell transfusions do not help critically ill children more than older cells – NIH News Releases (free) AND Blood transfusions: Fresh red blood cells no better than older ones – University of Montreal (free)

5 – Perioperative care of the geriatric patient for noncardiac surgery – Clinical Cardiology (free)

6 – Selective decontamination of the digestive tract (SDD) in critically ill patients: a narrative review – Intensive Care Medicine (free)

7 – Shortened treatment regimens versus the standard regimen for drug‐sensitive pulmonary tuberculosis – Cochrane Library (free)

Summary: Shorter treatment regimens for people with pulmonary tuberculosis – Cochrane Library (free)

8 – Global Epidemiologic Characteristics of Sexually Transmitted Infections Among Individuals Using Preexposure Prophylaxis for the Prevention of HIV Infection: A Systematic Review and Meta-analysis – JAMA Network Open (free)

Commentaries: The High Burden of Sexually Transmitted Infections in Persons Initiating Preexposure Prophylaxis—Challenge or Opportunity? – JAMA Network Open (free) AND High burden of STIs in people starting treatment to prevent HIV infection – World Health Organization (free) AND STD Infections Common Among Those Starting or Staying on Prep For HIV Prevention – MedicalResearch.com (free)

9 – Effects of physical activity calorie equivalent food labelling to reduce food selection and consumption: systematic review and meta-analysis of randomised controlled studies – Journal of Epidemiology & Community Health (free)

Commentaries: Exercise advice on food labels could ‘change eating habits’ – NHS Choices (free) AND Labelling foods with physical activity needed to burn calories linked to healthier choices – The BMJ (free) AND ‘Four hours to walk off pizza calories’ warning works, experts say – BBC (free)

10 – Relation of Total Sugars, Sucrose, Fructose, and Added Sugars With the Risk of Cardiovascular Disease: A Systematic Review and Dose-Response Meta-analysis of Prospective Cohort Studies – Mayo Clinic Proceedings (free)

Commentary: Study examines the relationship between sugars and heart health – St. Michael’s Hospital (free)

Thu December 12 – 10 Stories of The Day!

12 Dec, 2019 | 08:41h | UTC

1 – Practice Guidelines for Central Venous Access 2020: An Updated Report by the American Society of Anesthesiologists Task Force on Central Venous Access – Anesthesiology (free)

2 – Duodeno-pancreatic and extrahepatic biliary tree trauma: WSES-AAST guidelines – World Journal of Emergency Surgery (free)

3 – European Guidelines for the treatment of HIV-positive adults – European AIDS Clinical Society (free PDF)

Source: HIV Infection Clinical Practice Guidelines (2019): European AIDS Clinical Society (EACS) – Medscape (free summary – registration required)

4 – Comorbidities in Persons With HIV: The Lingering Challenge – JAMA (free for a limited period)

Author Interview: Comorbidities in Persons With HIV (free)

Commentary: Efforts to end the HIV epidemic must not ignore people already living with HIV – NIH News Releases (free)

5 – Early High-Dose Vitamin D₃ for Critically Ill, Vitamin D–Deficient Patients – New England Journal of Medicine (free)

Commentary: High doses of vitamin D for critically ill patients yield minimal benefit – CU Anschutz Medical Campus (free)

6 – Irbesartan in Marfan syndrome (AIMS): a double-blind, placebo-controlled randomised trial – The Lancet (free)

Invited Commentary: Angiotensin-II receptor blockade in Marfan syndrome – The Lancet (free)

7 – Predatory journals: no definition, no defence – Nature (free)

“Leading scholars and publishers from ten countries have agreed a definition of predatory publishing that can protect scholarship. It took 12 hours of discussion, 18 questions and 3 rounds to reach.”

8 – Effectiveness of management strategies for uninvestigated dyspepsia: systematic review and network meta-analysis – The BMJ (free)

Commentary: Managing Dyspepsia with “Test and Treat” Ranked Best Strategy – NEJM Journal Watch (free)

9 – Prioritising action on alcohol for health and development – The BMJ (free)

See Complete Collection: Solutions for Prevention and Control of Non-communicable Diseases – WHO / The BMJ (free)

Related: WHO Global Status Report on Alcohol and Health 2018 (free report and commentaries) AND Alcohol Use and Burden for 195 Countries and Territories – The Lancet (free study and commentaries)

10 – Antibiotic prescribing without documented indication in ambulatory care clinics: national cross sectional study – The BMJ (free)

Editorial: Coding infections in primary care (free)

Commentaries: Up to two-fifths of antibiotic prescriptions in the US could be inappropriate – University of Bristol (free) AND Up to 43% of Antibiotic Prescriptions in the U.S. Are Unnecessary or Improperly Written, Analysis Finds – TIME (free) AND Over 40% of Antibiotic Prescriptions Potentially Inappropriate – NEJM Journal Watch (free)

Wed December 11 – 10 Stories of The Day!

11 Dec, 2019 | 10:41h | UTC

1 – Recommendation Statement: Screening for Abdominal Aortic Aneurysm – US Preventive Services Task Force (free)

Evidence Report: Primary Care Screening for Abdominal Aortic Aneurysm – JAMA (free)

JAMA Editorials: Updated Guidelines on Screening for Abdominal Aortic Aneurysms (free) AND Updated US Preventive Services Task Force Recommendations for Abdominal Aortic Aneurysm—Are We Really Up To Date? (free) AND Screening for Abdominal Aortic Aneurysm—A Call to Arms? (free)

Author Interview: USPSTF Recommendation: Screening for Abdominal Aortic Aneurysm (free audio)

2 – AAP Policy Statement: Unique Needs of the Adolescent – Pediatrics (free)

News Releases: American Academy of Pediatrics Describes the Unique Needs of Adolescents With New Policy Statement – American Academy of Pediatrics (free) AND AAP policy: What doctors need to consider when caring for 11- to 21-year-olds – AAP News (free)

3 – European Society of Cardiology/Heart Failure Association position paper on the role and safety of new glucose‐lowering drugs in patients with heart failure – European Journal of Heart Failure (free)

4 – Risk of Nephrogenic Systemic Fibrosis in Patients With Stage 4 or 5 Chronic Kidney Disease Receiving a Group II Gadolinium-Based Contrast Agent: A Systematic Review and Meta-analysis – JAMA Internal Medicine (free for a limited period)

Invited Commentary: Risk of Gadolinium-Based Contrast Agents in Chronic Kidney Disease—Is Zero Good Enough? – JAMA Internal Medicine (free for a limited period)

5 – How Twitter is Changing Medical Research – Nature (free)

“From online journal clubs to ‘tweetorials’ to conference updates, social media is changing the dissemination and discussion of biomedicine.”

6 – BBC Investigation on the Reporting of the EXCEL Trial Raises Concerns Over the Safety of Stents for Left Main Disease in Patients at Low Risk for Surgery

Surgeons withdraw support for heart disease advice – BBC (free)

YouTube Video: European guidelines on heart disease under review – BBC Newsnight (free)

Commentary: EACTS Pulls Out of Left Main Guidelines After BBC Bombshell Alleging EXCEL Trial Cover-up – TCTMD (free)

7 – American Society of Hematology-American Society of Pediatric Hematology/Oncology: Five Things Physicians and Patients Should Question – Choosing Wisely (free)

See complete lists of low-value practices: Choosing Wisely U.S. / Choosing Wisely UK / Choosing Wisely Australia AND Choosing Wisely Canada

Source: NEJM Journal Watch

8 – Hyperkalemia: pathophysiology, risk factors and consequences – Nephrology Dialysis Transplantation (free)

Source: Critical Care Reviews

9 – Does general anesthesia affect neurodevelopment in infants and children? – The BMJ (free for a limited period)

Related Study: Randomized Trial: General Anesthesia in Infancy Does Not Seem to Impair Neurodevelopmental Outcomes (link to abstract and commentary)

10 – Novel Self‐Report Tool for Cardiovascular Risk Assessment – Journal of the American Heart Association (free)

Tue December 10 – 10 Stories of The Day!

10 Dec, 2019 | 10:22h | UTC

1 – Older Adults in the Cardiac Intensive Care Unit: Factoring Geriatric Syndromes in the Management, Prognosis, and Process of Care: A Scientific Statement from the American Heart Association – Circulation (free PDF)

News Release: Treating more than just the heart is critical for geriatric patients – American Heart Association (free)

2 – Infographics and Summaries of the New ACLS and PALS Updates

Homepage: CPR Guidelines (free summaries and infographics)

– 2019 Highlights – Guidelines Update for CPR & ECC

– 2019 FAQ – Guidelines Update for CPR & ECC

– 2019 Infographic – ACLS Guidelines Update

– 2019 Infographic – PALS Guidelines Update

Original Guidelines: AHA Updates on Advanced Cardiovascular Life Support (ACLS) (free) AND AHA Updates in Pediatric Life Support (free)

3 – Imaging in patients with suspected acute heart failure: timeline approach position statement on behalf of the Heart Failure Association of the European Society of Cardiology – European Journal of Heart Failure (free)

4 – Lung–kidney interactions in critically ill patients: consensus report of the Acute Disease Quality Initiative (ADQI) 21 Workgroup – Intensive Care Medicine (free)

5 – Missed vaccinations and critical care admission: all you may wish to know or rediscover—a narrative review – Intensive Care Medicine (free)

6 – Is tranexamic acid going to CRASH the management of traumatic brain injury? – Intensive Care Medicine (free)

Original Study: Effects of tranexamic acid on death, disability, vascular occlusive events and other morbidities in patients with acute traumatic brain injury (CRASH-3): a randomised, placebo-controlled trial – The Lancet (free study and commentaries)

7 – Mild Traumatic Brain Injury in 2019-2020 – JAMA (free for a limited period)

Related: Monitoring and Management of Severe Adult Traumatic Brain Injury Patients with Polytrauma (several guidelines on the subject)

8 – Cannabis-based medicines and the perioperative physician – Perioperative Medicine (free)

9 – Interventions for idiopathic steroid‐resistant nephrotic syndrome in children – Cochrane Library (free)

Summary: Interventions for idiopathic steroid resistant nephrotic syndrome in children – Cochrane Library (free)

Infographic: New Review Update: Idiopathic steroid-resistant nephrotic syndrome in children (free)

10 – Light to moderate amount of lifetime alcohol consumption and risk of cancer in Japan – Cancer (free)

Commentaries: Even light alcohol consumption linked to higher cancer risk in Japan – Wiley (free)

Mon December 9 – 10 Stories of The Day!

9 Dec, 2019 | 08:43h | UTC

1 – Phase 3 Efficacy Analysis of a Typhoid Conjugate Vaccine Trial in Nepal – New England Journal of Medicine (free)

Commentaries: Typhoid vaccine over 81% effective in tackling disease in Nepal – University of Oxford (free) AND Typhoid vaccine shows protection in phase 3 trial – CIDRAP (free)

2 – Endoscopic or Surgical Myotomy in Patients with Idiopathic Achalasia – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Establishment of a New Gold Standard for Achalasia Treatment – Universitätsklinikum Hamburg-Eppendorf (free) AND Less Invasive Approach as Good as Surgery for Achalasia – MedPage Today (free registration required)

3 – The chaos of hypertension guidelines for chronic kidney disease patients – Clinical Kidney Journal (free)

Original Guidelines: Kidney Disease: Improving Global Outcomes Blood Pressure Work Group. KDIGO clinical practice guideline for the management of blood pressure in chronic kidney disease (free PDF) AND 2018 ESC/ESH Guidelines for the management of arterial hypertension (free) AND 2017 Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines (free)

4 – Corticosteroids for treating sepsis in children and adults – Cochrane Library (free)

Summary: Corticosteroids for treating sepsis – Cochrane Library (free)

Related: Adjunctive Corticosteroid Treatment in Septic Shock (review, guideline and meta-analysis on the subject)

5 – Cochrane Sustainable Healthcare: evidence for action on too much medicine – Cochrane Library (free)

News Release: Launch of new Cochrane Sustainable Healthcare Field – Cochrane Library (free)

See Website: Cochrane Sustainable Healthcare (free)

6 – The ketogenic diet: Pros and cons – Atherosclerosis (free for a limited period)

7 – State of the Art Review: Cognitive symptoms of Alzheimer’s disease: clinical management and prevention – The BMJ (free for a limited period)

8 – Head and Neck Injuries Associated With Cell Phone Use – JAMA Otolaryngology-Head & Neck Surgery (free for a limited period)

Commentaries: Cellphone distraction linked to increase in head injuries – Rutgers University (free) AND As smartphones became more popular, more people were sent to the hospital after dropping their phones on themselves, study finds – Business Insider (free) AND Walking while texting and other cell phone related injuries are on the rise, especially for the young – CNN (fee) AND Distracted by Their Smartphones, Pedestrians Are Landing in the ER – U.S. News (free)

9 – Keratinocytic Skin Cancer Detection on the Face Using Region-Based Convolutional Neural Network – JAMA Dermatology (free for a limited period)

Editorial: Problems and Potentials of Automated Object Detection for Skin Cancer Recognition (free for a limited period)

Commentary: Robot vs Derms for Skin Cancer Dx: It’s a Toss-Up – MedPage Today (free registration required)

10 – Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial – The Lancet (link to abstract – $ for full-text)

“This study is ongoing to assess clinical outcomes.”

Fri December 6 – 10 Stories of The Day!

6 Dec, 2019 | 10:55h | UTC

1 – Menopause: diagnosis and management – National Institute for Health and Care Excellence (free)

2 – Progress Toward Regional Measles Elimination — Worldwide, 2000–2018 – Centers for Disease Control and Prevention (free)

News Release: More than 140,000 die from measles as cases surge worldwide – World Health Organization (free)

WHO Fact Sheet: Measles (free)

Commentaries: Global measles deaths rise to 140,000; young kids hit hard – CIDRAP (free) AND With vaccine rates stalled, measles outbreaks deliver deadly, debilitating impacts worldwide – Global ID News (free) AND WHO decries ‘collective failure’ as measles kills 140,000 – Reuters (free) AND Measles Numbers Were Bad In 2018. This Year, They’re Even Worse – NPR (free)

3 – World malaria report 2019 – World Health Organization (free PDF)

Summary: World malaria report 2019 – World Health Organization (free)

News Release: More pregnant women and children protected from malaria, but accelerated efforts and funding needed to reinvigorate global response, WHO report shows (free)

4 – The 2019 American College of Rheumatology/European League Against Rheumatism Classification Criteria for IgG4‐Related Disease – Arthritis & Rheumatology (free)

Commentary: ACR and EULAR release new classification criteria for IgG4-related disease – American College of Rheumatology (free)

5 – Effect of Thoracoscopic Talc Poudrage vs Talc Slurry via Chest Tube on Pleurodesis Failure Rate Among Patients With Malignant Pleural Effusions: A Randomized Clinical Trial – JAMA (free for a limited period)

6 – Chest imaging using signs, symbols, and naturalistic images: a practical guide for radiologists and non-radiologists – Insights into Imaging (free)

7 – Ann Robinson’s research reviews, 5 December 2019 – The BMJ Opinion (free)

Ann Robinson reviews the latest research from the top medical journals

8 – Ten-Hour Time-Restricted Eating Reduces Weight, Blood Pressure, and Atherogenic Lipids in Patients with Metabolic Syndrome – Cell Metabolism (free for a limited period)

Commentaries: Limited eating times could be a new way to fight obesity and diabetes – The Conversation (free) AND Clinical study finds eating within 10-hour window may help stave off diabetes, heart disease – Salk Institute (free) AND Expert reaction to study looking at time-restricted eating and weight loss in people with metabolic syndrome – Science Media Centre (free)

9 – Cannabis Use Disorder and Perioperative Outcomes in Major Elective Surgeries: A Retrospective Cohort Analysis – Anesthesiology (link to abstract – $ for full-text)

Commentaries: Cannabis Abuse Linked to Periprocedural MIs After Elective Surgeries – TCTMD (free) AND Prevalence of cannabis dependence or abuse increases significantly among surgical patients – News Medical (free)

10 – Growing acceptability of Undetectable = Untransmittable but widespread misunderstanding of transmission risk: Findings from a very large sample of sexual minority men in the United States – JAIDS Journal of Acquired Immune Deficiency Syndromes (link to abstract – $ for full-text)

News Release: Gay, bisexual men increasingly agree: HIV “Undetectable Equals Untransmittable” – NIH News Releases (free)

Thu December 5 – 10 Stories of The Day!

5 Dec, 2019 | 11:37h | UTC

1 – An international multidisciplinary consensus statement on fasting before procedural sedation in adults and children – Anaesthesia (free)

2 – American Society of Hematology 2019 guidelines for management of venous thromboembolism: prevention of venous thromboembolism in surgical hospitalized patients – Blood Advances (free)

3 – American Society of Hematology 2019 guidelines for sickle cell disease: cardiopulmonary and kidney disease – Blood Advances (free)

4 – American Society of Hematology 2019 guidelines for immune thrombocytopenia – Blood Advances (free)

Related: Consensus Report: Investigation and Management of Primary Immune Thrombocytopenia (guidelines and reviews on the subject)

5 – The effect of remote ischaemic preconditioning on myocardial injury in emergency hip fracture surgery (PIXIE trial): phase II randomised clinical trial – The BMJ (free)

6 – Maternal diabetes during pregnancy and early onset of cardiovascular disease in offspring: population based cohort study with 40 years of follow-up – The BMJ (free)

Commentaries: Link between diabetes in mothers and heart disease in children – OnMedica (free) AND Preventing and treating diabetes in women of childbearing age could reduce heart disease risk in the next generation – The BMJ Opinion (free)

7 – Smoking cessation is associated with lower disease activity and predicts cardiovascular risk reduction in rheumatoid arthritis patients – Rheumatology (free)

Commentary: Smoking Cessation Lowers RA Disease Activity and CV Risks – RheumNow (free)

8 – Efficacy of the Enquiring About Tolerance (EAT) study among infants at high risk of developing food allergy – The Journal of Allergy and Clinical Immunology (free)

Original EAT Study: Randomized Trial of Introduction of Allergenic Foods in Breast-Fed Infants – New England Journal of Medicine (free)

Commentaries: Introducing peanuts and eggs early can prevent food allergies in high risk infants – King’s College London (free) AND Expert reaction to three studies looking at early introduction of allergenic foods to infants – Science Media Centre (free)

9 – Hair dye and chemical straightener use and breast cancer risk in a large US population of black and white women – International Journal of Cancer (link to abstract – $ for full-text)

Commentaries: Permanent hair dye and straighteners may increase breast cancer risk – NIH News Releases (free) AND Hair Dyes And Straighteners Linked To Higher Cancer Risk, Especially For Black Women – NPR (free)

10 – Application of non-HDL cholesterol for population-based cardiovascular risk stratification: results from the Multinational Cardiovascular Risk Consortium – The Lancet (free)

Commentaries: The next treatment paradigm in cardiovascular prevention? – The Lancet (free) AND Should younger adults get their cholesterol levels checked? – NHS Choices (free)

Wed December 4 – 10 Stories of The Day!

4 Dec, 2019 | 10:23h | UTC

1 – British Society of Gastroenterology/Association of Coloproctology of Great Britain and Ireland/Public Health England post-polypectomy and post-colorectal cancer resection surveillance guidelines – Gut (free)

2 – Guidelines for the management of hereditary colorectal cancer from the British Society of Gastroenterology (BSG)/Association of Coloproctology of Great Britain and Ireland (ACPGBI)/United Kingdom Cancer Genetics Group (UKCGG) – Gut (free)

3 – Guidelines to the Practice of Anesthesia – Revised Edition 2020 – Canadian Journal of Anesthesia (free)

4 – Chest Radiograph Interpretation with Deep Learning Models: Assessment with Radiologist-adjudicated Reference Standards and Population-adjusted Evaluation – Radiology (free)

Editorial: Moving Artificial Intelligence from Feasible to Real: Time to Drill for Gas and Build Roads (free)

Commentary: AI improves chest X-ray interpretation – Radiology Society of North America (free)

5 – Metformin for prevention or delay of type 2 diabetes mellitus and its associated complications in persons at increased risk for the development of type 2 diabetes mellitus – Cochrane Library (free)

Summary: Metformin for prevention/delay of type 2 diabetes mellitus (T2DM) and associated complications in persons at increased risk for development of T2DM – Cochrane Library (free)

6 – Pathways to independence: towards producing and using trustworthy evidence – The BMJ (free)

See Complete Series: Commercial Influence in Health: from Transparency to Independence (free articles)

Commentary: Time to end drug company distortion of medical evidence – The Conversation (free)

7 – Celiac Disease – Mayo Clinic Proceedings (free)

8 – Addressing Social Determinants to Improve Population Health: The Balance Between Clinical Care and Public Health – JAMA (free for a limited period)

9 – Effect of Single-Fraction vs Multifraction Radiotherapy on Ambulatory Status Among Patients With Spinal Canal Compression From Metastatic Cancer: The SCORAD Randomized Clinical Trial – JAMA (free for a limited period)

Commentary: One dose of radiotherapy as effective as five doses for cancer in the spine – University College London (free)

10 – Synchronous versus sequential chemo-radiotherapy in patients with early stage breast cancer (SECRAB): A randomised, phase III, trial – Radiation & Oncology (free)

Tue December 3 – 10 Stories of The Day!

3 Dec, 2019 | 08:33h | UTC

1 – AAP Policy Statement: Emergency Contraception – Pediatrics (free)

Related: Committee Opinion No 707: Access to Emergency Contraception – American College of Obstetricians and Gynecologists (free) AND Interventions for emergency contraception – Cochrane Library (free)

2 – Kidney and uro-trauma: WSES-AAST guidelines – World Journal of Emergency Surgery (free)

3 – Updated guidelines for the management of paracetamol poisoning in Australia and New Zealand – The Medical Journal of Australia (free for a limited period)

4 – Safety and efficacy of fidaxomicin and vancomycin in children and adolescents with Clostridioides (Clostridium) difficile infection: a phase 3, multicenter, randomized, single-blind clinical trial (SUNSHINE) – Clinical Infectious Diseases (free)

Commentary: Phase 3 trial shows good results for fidaxomicin against C difficile in kids – CIDRAP in Stewardship / Resistance Scan for Nov 27, 2019 (free)

5 – Single Syringe Adenosine for SVT – JournalFeed (free)

Original Research Letter: Single-syringe Administration of Diluted Adenosine – Academic Emergency Medicine ($)

6 – Management of severe acute pancreatitis – The BMJ (free for a limited period)

7 – Clarifying the Meaning of Clinically Meaningful Benefit in Clinical Research: Noticeable Change vs Valuable Change – JAMA (free for a limited period)

8 – #186 Sarcopenia: Raising the Bar in Primary Care – The Curbsiders Internal Medicine Podcast (free)

See also: Episode List

9 – Antiretroviral therapy has saved millions of lives from AIDS and could save more – Our World in Data (free)

10 – Pain in Chronic Inflammatory Demyelinating Polyradiculoneuropathy: A Systematic Review and Meta-Analysis – Pain and Therapy (free)

Mon December 2 – 10 Stories of The Day!

2 Dec, 2019 | 00:01h | UTC

1 – WSES consensus conference guidelines: monitoring and management of severe adult traumatic brain injury patients with polytrauma in the first 24 hours – World Journal of Emergency Surgery (free) (via @CritCareReviews)

2 – Guidance For: Prone Positioning in Adult Critical Care – Intensive Care Society (free PDF) (via @CritCareReviews)

3 – Antimicrobial de-escalation in critically ill patients: a position statement from a task force of the European Society of Intensive Care Medicine (ESICM) and European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Critically Ill Patients Study Group (ESGCIP) – Intensive Care Medicine (free)

4 – Less empiric broad-spectrum antibiotics is more in the ICU – Intensive Care Medicine (free)

Source: Grupo UTIclínica – HCFMUSP

5 – Artificial intelligence in digital pathology — new tools for diagnosis and precision oncology – Nature Reviews Clinical Oncology (free)

6 – The case for mandatory vaccination – Nature (free)

Related Opinion: Mandate Vaccination with Care (free commentaries)

“When immunization rates dip, legislation is often strengthened. But does the evidence stack up?”

7 – Alex Nowbar’s weekly review, 29 November 2019 – The BMJ Opinion (free)

8 – Warning: Swimming and deep brain stimulation do not mix – STAT (free)

Original Case Reports: Beware of deep water after subthalamic deep brain stimulation – Neurology ($)

9 – Association of Slight to Mild Hearing Loss with Behavioral Problems and School Performance in Children – JAMA Otolaryngology-Head & Neck Surgery (free for a limited period)

Commentaries: When Slight Degrees of Hearing Impairment in Children May Actually Matter – JAMA Otolaryngology-Head & Neck Surgery (free) AND Impact of Mild Hearing Loss on Childhood Behavior And School Performance – MedicalResearch.com (free)

10 – Prevalence of problematic smartphone usage and associated mental health outcomes amongst children and young people: a systematic review, meta-analysis and GRADE of the evidence – BMC Psychiatry (free)

Commentaries: An estimated 1 in 4 children and young people have problematic smartphone usage – King’s College London (free) AND Expert reaction to problematic smart phone use in young people – Science Media Centre (free) AND Teens aren’t addicted to their phones – but we like to think they are – NewScientist (free)

Fri November 29 – 10 Stories of The Day!

29 Nov, 2019 | 10:21h | UTC

1 – Global guideline for the diagnosis and management of mucormycosis: an initiative of the European Confederation of Medical Mycology in cooperation with the Mycoses Study Group Education and Research Consortium – The Lancet Infectious Diseases (free for 50 days)

2 – Guidelines for the management of myocardial infarction/injury with non-obstructive coronary arteries (MINOCA): a position paper from the Dutch ACS working group – Netherlands Heart Journal (free)

Related: Prognosis and Predictors of Mortality in Patients Suffering Myocardial Infarction With Non‐Obstructive Coronary Arteries (studies, guidelines and reviews on the subject)

3 – A Randomized, Controlled Trial of Ebola Virus Disease Therapeutics – New England Journal of Medicine (free)

Commentaries: Investigational Drugs Reduce Risk of Death from Ebola Virus Disease – NIH News Releases (free) AND New data highlight promise of 2 Ebola treatments – CIDRAP (free) AND Two Ebola treatments yield ‘substantial decrease’ in mortality, landmark trial shows – STAT (free)

4 – Short term exposure to fine particulate matter and hospital admission risks and costs in the Medicare population: time stratified, case crossover study – The BMJ (free)

Editorial: The health effects of fine particulate air pollution (free)

Commentaries: Air pollution linked with new causes of hospital admissions – Harvard T.H. Chan School of Public Health (free) AND Yaguang Wei: The dangers of air pollution for human health – The BMJ Opinion (free) AND More reasons air pollution will send you to the hospital – CNN (free) AND Air pollution linked to increased hospital admissions for kidney disease and sepsis – NHS Choices (free)

5 – Higher versus lower fraction of inspired oxygen or targets of arterial oxygenation for adults admitted to the intensive care unit – Cochrane Library (free)

Summary: Supplemental oxygen for adults admitted to the intensive care unit – Cochrane Library (free)

6 – Ten-year Mortality, Disease Progression, and Treatment-related Side Effects in Men with Localised Prostate Cancer from the ProtecT Randomised Controlled Trial According to Treatment Received – European Urology (free)

Original Study: 10-Year Outcomes after Monitoring, Surgery, or Radiotherapy for Localized Prostate Cancer – New England Journal of Medicine (free)

7 – The clinical efficacy and safety of vancomycin loading dose: A systematic review and meta-analysis – Medicine (free)

8 – Post-extubation dysphagia: a problem needing multidisciplinary efforts – Intensive Care Medicine (free for a limited period)

9 – Association Between Acute Gastroenteritis and Continuous Use of Proton Pump Inhibitors During Winter Periods of Highest Circulation of Enteric Viruses – JAMA Network Open (free)

Commentaries: Further Evidence to Monitor Long-term Proton Pump Inhibitor Use – JAMA Network Open (free) AND Prescription antacids may increase risk for stomach infections – UPI (free)

10 – Bridging Anticoagulation Therapy: A Teachable Moment – JAMA Internal Medicine (free for a limited period)

Thu November 28 – 10 Stories of The Day!

28 Nov, 2019 | 10:51h | UTC

1 – Diagnosis of Pulmonary Embolism with d-Dimer Adjusted to Clinical Probability – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Diagnosis of Pulmonary Embolism – American College of Cardiology (free)

2 – Aupplemental MRI Screening for Women with Extremely Dense Breast Tissue – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Does MRI Screening Benefit Women With Extremely Dense Breasts? – U.S. News (free) AND Mixed Results With Mammo Plus MRI Screening – MedPage Today (free)

“The benefits need to be carefully weighed against the harms, as MRI examination is more expensive, and it requires the injection of a contrast agent into the body. MRI will also detect abnormalities that later turn out not to be breast cancer after all” (from U.S News)

3 – Randomized Trial of Three Anticonvulsant Medications for Status Epilepticus – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Head-to-head comparison finds three anti-seizure drugs equally effective for severe form of epilepsy – NIH News Release (free)

4 – Association Between Physician Depressive Symptoms and Medical Errors: A Systematic Review and Meta-analysis – JAMA Network Open (free)

Commentary: Depression in Docs Leads to Medical Errors and Vice Versa – Medscape (free registration required)

5 – Consolidated guidelines on HIV testing services for a changing epidemic – World Health Organization (free)

Commentaries: WHO Releases New HIV Testing Guidelines To Help Expand Treatment Coverage, Reduce HIV Transmission – Health Policy Watch (free) AND WHO releases new HIV testing guidelines – Global ID News (free)

6 – Updated international consensus report on the investigation and management of primary immune thrombocytopenia – Blood Advances (free)

7 – What You Need to Know (And What We’re Working to Find Out) About Products Containing Cannabis or Cannabis-derived Compounds, Including CBD – U.S. Food & Drug Administration (free)

Commentaries: FDA’s Warning On CBD: Cannabis Stocks Drop, Companies Object – Forbes (free) AND ‘CBD has the potential to harm you,’ FDA warns consumers – MarketWatch (free)

Related: Cannabidiol Products Are Everywhere, but Should People Be Using Them? – JAMA (free for a limited period) AND NICE Guideline: Cannabis-Based Medicinal Products (free Guideline and other resources)

8 – What Are the Benefits of Probiotics? – The New York Times (free)

Related: Systematic Review: Harms Reporting in Trials with Probiotics (link to abstract and commentaries) AND The Problem With Probiotics – The New York Times (free)

9 – News Release: Antibiotic-Resistant Bacteria More Prevalent in Device-Related Infections – Society for Healthcare Epidemiology of America (free)

Original Studies: Antimicrobial-resistant pathogens associated with adult healthcare-associated infections: Summary of data reported to the National Healthcare Safety Network, 2015–2017 – Infection Control & Hospital Epidemiology (free) AND Antimicrobial-resistant pathogens associated with pediatric healthcare-associated infections: Summary of data reported to the National Healthcare Safety Network, 2015–2017 – Infection Control & Hospital Epidemiology (free)

Commentary: CDC: Medical devices key source of antibiotic-resistant infections – CIDRAP (free)

10 – Associations of dairy intake with risk of mortality in women and men: three prospective cohort studies – The BMJ (free)

Wed November 27 – 10 Stories of The Day!

27 Nov, 2019 | 08:40h | UTC

1 – Searching for Atrial Fibrillation Poststroke: A White Paper of the AF-SCREEN International Collaboration – Circulation (free)

2 – Breast Cancer Screening and Diagnosis: A Synopsis of the European Breast Guidelines – Annals of Internal Medicine (free)

Commentary: European guidelines for breast cancer screening differ from U.S. recommendations – ACP Internist (free)

Related: ACP Guideline: Screening for Breast Cancer in Average-Risk Women (other guidelines on the subject)

3 – Implementation Strategies for Cardiovascular Polypills – JAMA (free for a limited period)

Author Interview: Implementation Strategies for Cardiovascular Polypills (free)

Related: The Polypill Revisited: Why We Still Need Population-Based Approaches in the Precision Medicine Era (free for a limited period) AND Randomized Trial: Polypill for Cardiovascular Disease Prevention in an Underserved Population (randomized trials, commentaries and guideline on the subject)

4 – #184 Update in Sleep Medicine: LIVE from CHEST 2019! – The Curbsiders Internal Medicine Podcast (free)

5 – Proton-pump inhibitor use is associated with a broad spectrum of neurological adverse events including impaired hearing, vision, and memory – Scientific Reports (free)

Commentary: PPIs linked to adverse neurological effects – Univadis (free registration required)

6 – O₂ No Longer the Go₂: A Systematic Review and Meta-Analysis Comparing the Effects of Giving Perioperative Oxygen Therapy of 30% FiO₂ to 80% FiO₂ on Surgical Site Infection and Mortality – World Journal of Surgery (free)

Related: WHO Guidelines for Peri-Operative Hyperoxia Questioned (free)

Source: EvidenceAlerts

7 – Refeeding Syndrome in the Critically Ill: a Literature Review and Clinician’s Guide – Current Gastroenterology Reports (free)

8 – Nonpowder Firearm Injuries to Children Treated in Emergency Departments – Pediatrics (free)

Commentaries: Pediatric eye injuries from nonpowder firearms – Nationwide Children’s Hospital (free) AND BB guns dangerous for kids as they increase risk of eye injuries – News Medical (free) AND Overall childhood injuries from nonpowder firearms are decreasing, eye injuries are increasing – 2 Minute Medicine (free)

9 – Long-term Outcomes of Cognitive Behavioral Therapy for Anxiety-Related Disorders: A Systematic Review and Meta-analysis – JAMA Psychiatry (free for a limited period)

10 – Follow‐up strategies following completion of primary cancer treatment in adult cancer survivors – Cochrane Library (free)

Summary: Follow-up strategies after completion of primary cancer treatment – Cochrane Library (free)

Tue November 26 – 10 Stories of The Day!

26 Nov, 2019 | 10:29h | UTC

1 – European Heart Rhythm Association (EHRA) international consensus document on how to prevent, diagnose, and treat cardiac implantable electronic device infections—endorsed by the Heart Rhythm Society (HRS), the Asia Pacific Heart Rhythm Society (APHRS), the Latin American Heart Rhythm Society (LAHRS), International Society for Cardiovascular Infectious Diseases (ISCVID) and the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS) (free)

2 – Health, safety and dignity of sanitation workers: An initial assessment – World Health Organization (free)

Commentaries: Toxic Conditions Expose Millions Of Sanitation Workers To Infectious Disease & Death – Health Policy Watch (free) AND On World Toilet Day, UN Highlights Plight of Sanitation Workers – IISD (free) AND Even Researchers Were Shocked By How Tough Life Is For Sanitation Workers – NPR (free)

3 – Association of the Work Schedules of Hospitalists with Patient Outcomes of Hospitalization – JAMA Internal Medicine (free for a limited period)

Author Interview: Association of the Work Schedules of Hospitalists With Patient Outcomes of Hospitalization (free audio)

Commentary: Hospitalist Schedules Allowing More Continuity of Care Linked to Better Patient Outcomes – NEJM Journal Watch (free)

Related Study: Inpatient Physician Continuity Associated with Speedier Patient Discharge (free study and commentary)

4 – Overall Survival with Osimertinib in Untreated, EGFR-Mutated Advanced NSCLC – New England Journal of Medicine (free for a limited period)

Commentary: FLAURA Trial: First-Line Osimertinib Improves Overall Survival in EGFR-Mutated Advanced Lung Cancer – The ASCO Post (free)

5 – Comparison of different human papillomavirus (HPV) vaccine types and dose schedules for prevention of HPV‐related disease in females and males – Cochrane Library (free)

Summary: Comparison of different human papillomavirus (HPV) vaccines and the number of doses administered to prevent HPV-related disease in females and males – Cochrane Library (free)

6 – Addressing Bias in Artificial Intelligence in Health Care – JAMA (free for a limited period)

Author Interview: Addressing Bias in Artificial Intelligence in Health Care (free)

7 – Machine Learning, Predictive Analytics, and Clinical Practice: Can the Past Inform the Present? – JAMA (free for a limited period)

Related: How to Read Articles That Use Machine Learning: Users’ Guides to the Medical Literature – JAMA (free for a limited period) AND Evaluating Machine Learning Articles – JAMA (free for a limited period)

8 – A Cancer Care Approach Tailored to The Elderly May Have Better Results – NPR (free)

9 – A population-based study of cardiovascular disease mortality risk in US cancer patients – European Heart Journal (free for a limited period)

Editorial: From trends to transformation: where cardio-oncology is to make a difference – European Heart Journal (free)

Commentaries: Cancer patients are at higher risk of dying from heart disease and stroke – European Society of Cardiology (free) AND Cancer survivors ‘have higher heart risk’ – BBC (free)

10 – Survival outcomes after laparoscopy-assisted distal gastrectomy versus open distal gastrectomy with nodal dissection for clinical stage IA or IB gastric cancer (JCOG0912): a multicentre, non-inferiority, phase 3 randomised controlled trial – The Lancet Gastroenterology & Hepatology (link to abstract – $ for full-text)