Tue October 22 – 10 Stories of The Day!

1 – Management of Nonvariceal Upper Gastrointestinal Bleeding: Guideline Recommendations from the International Consensus Group – Annals of Internal Medicine (free)

Commentary: Guideline on Managing Acute Upper Gastrointestinal Bleeding Updated – NEJM Journal Watch (free)

2 – Gastro-oesophageal reflux disease and dyspepsia in adults: investigation and management – National Institute for Health and Care Excellence (free)

3 – Neurodegenerative Disease Mortality among Former Professional Soccer Players – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Dementia in football: Ex-players three and a half times more likely to die of condition – BBC (free) AND Study shows more thinking problems in former pro soccer players – Reuters (free)

4 – Pan-viral serology implicates enteroviruses in acute flaccid myelitis – Nature (link to abstract – $ for full-text)

Commentaries: ‘Missing’ Virus Detected in Dozens of Children Paralyzed by Polio-Like Illness – UC San Francisco (free) AND What Causes a Mysterious Paralysis in Children? Researchers Find Viral Clues – The New York Times (10 articles per month are free) AND Virus could be the cause of mysterious polio-like illness AFM, study says – CNN (free)

5 – Episiotomy use among vaginal deliveries and the association with anal sphincter injury: a population-based retrospective cohort study – Canadian Medical Association Journal (free)

News Release: Episiotomy may be beneficial in reducing severe perineal tears among forceps and vacuum deliveries – Canadian Medical Association Journal (free)

6 – #178 Tuberculosis Updates with Laila Woc-Colburn MD – The Curbsiders Internal Medicine Podcast (free audio)

7 – Super-precise new CRISPR tool could tackle a plethora of genetic diseases – Nature News (free)

Original Article: Search-and-replace genome editing without double-strand breaks or donor DNA – Nature (link to abstract – $ for full-text)

See also: New CRISPR genome editing system offers a wide range of versatility in human cells – Broad Institute of MIT and Harvard (free) AND Prime editing: DNA tool could correct 89% of genetic defects – BBC (free) AND New CRISPR tool has the potential to correct almost all disease-causing DNA glitches, scientists report – STAT (free)

Related: Simple guide to CRISPR, one of the biggest science stories of the decade – VOX (free)

8 – Update on management of stable chronic obstructive pulmonary disease – Journal of Thoracic Disease (free)

Related Guidelines: 2019 Global Strategy for Prevention, Diagnosis and Management of COPD – GOLD Reports 2019 (free PDF) AND Chronic obstructive pulmonary disease in over 16s: diagnosis and management – National Institute for Health and Care Excellence (free)

9 – Effect of the Tailored, Family-Involved Hospital Elder Life Program on Postoperative Delirium and – Function in Older Adults: A Randomized Clinical Trial – JAMA Internal Medicine (free for a limited period)

Commentaries: Including the Family in Perioperative Care of Older Adults—A Call for HELP – JAMA Internal Medicine (free for a limited period) AND Family members can help reduce the incidence of post-operative delirium by up to 16.8% – News Medical (free)

10 – Effect of Depression Screening After Acute Coronary Syndromes on Quality of Life: The CODIACS-QoL Randomized Clinical Trial – JAMA Internal Medicine (free for a limited Period)

Commentary: Depression Intervention Flops for Heart Attack Survivors – MedPage Today (free registration required)