Thu October 31 – 10 Stories of The Day!

1 – Guidelines for the Early Management of Patients With Acute Ischemic Stroke: 2019 Update to the 2018 Guidelines for the Early Management of Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association – Stroke (free PDF)

Top Things to Know: 2019 Update to the 2018 Guidelines for the Early Management of Acute Ischemic Stroke (free)

2 – A management algorithm for patients with intracranial pressure monitoring: the Seattle International Severe Traumatic Brain Injury Consensus Conference (SIBICC) – Intensive Care Medicine (free)

3 – WHO guidelines for the use of thermal ablation for cervical pre-cancer lesions – World Health Organization (free PDF)

Related WHO Guidelines: Treatment of cervical intraepithelial neoplasia 2–3 and adenocarcinoma in situ: cryotherapy, large loop excision of the transformation zone, and cold knife conization (free PDF) AND Comprehensive cervical cancer control: A guide to essential practice (free PDF) AND WHO publications on the prevention and treatment of cervical cancer (free resources)

4 – Association Between Levothyroxine Treatment and Thyroid-Related Symptoms Among Adults Aged 80 Years and Older With Subclinical Hypothyroidism – JAMA (free for a limited period)

Editorial: The Thyrotropin Reference Range Should Be Changed in Older Patients (free for a limited period)

Related Review: Subclinical Hypothyroidism – JAMA (free for a limited period)

Related Randomized Trial: Thyroid Hormone Therapy for Older Adults with Subclinical Hypothyroidism – New England Journal of Medicine (free)

5 – Massachusetts General Hospital oversaw trial that led to the first death from a fecal transplant, a new paper shows – STAT (free)

Original Article: Drug-Resistant E. coli Bacteremia Transmitted by Fecal Microbiota Transplant – New England Journal of Medicine ($)

Related FDA Safety Alert: Fecal Transplant May Have Caused a Patient’s Death Due to Transmission of a Multi-Drug Resistant Organism (free)

6 – Long-term survival and cause-specific mortality of patients newly diagnosed with tuberculosis in São Paulo state, Brazil, 2010–15: a population-based, longitudinal study – The Lancet Infectious Diseases (free) (via @otavio_ranzani see Tweet)

Invited Commentary: Tuberculosis: an instrument of early mortality in life course (free)

7 – Intra‐pleural fibrinolytic therapy versus placebo, or a different fibrinolytic agent, in the treatment of adult parapneumonic effusions and empyema – Cochrane Library (free)

Summary: Clot-busting drugs for infections of the lining of the lung – Cochrane Library (free)

8 – Risk of Mortality Following Catheter Ablation of Atrial Fibrillation – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentary: Mortality Risk After Catheter Ablation of Atrial Fibrillation – American College of Cardiology (free) AND Early mortality ‘a very real complication’ after catheter ablation of AFib – Cardiovascular Business (free) AND Afib Ablation Deaths Do Happen – MedPage Today (free registration required)

9 – Schizophrenia—An Overview – JAMA Psychiatry (free for a limited period)

10 – Association of Cord Plasma Biomarkers of In Utero Acetaminophen Exposure With Risk of Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder in Childhood – JAMA Psychiatry (free for a limited period)

Commentaries: NIH-funded study suggests acetaminophen exposure in pregnancy linked to higher risk of ADHD, autism – NIH News Releases (free) AND Babies at higher risk for ADHD, autism if pregnant moms took acetaminophen – Reuters (free) AND Expert reaction to study looking at paracetamol in pregnancy and autism, ADHD and other developmental disabilities in children – Science Media Centre (free)

Related Studies: Cohort Study: Associations Between Paracetamol Intake Between 18 and 32 Weeks Gestation and Neurocognitive Outcomes in the Child (free) AND Meta-Analysis: Prenatal Exposure to Acetaminophen and Risk for ADHD and Autistic Spectrum Disorder (free) AND Prenatal Exposure to Acetaminophen and Risk of ADHD (free)