Wed October 30 – 10 Stories of The Day!

1 – Final Analysis of a Trial of M72/AS01_E Vaccine to Prevent Tuberculosis – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Vaccine shows promise for preventing active TB disease – Associated Press (free) AND Researchers move closer to new vaccine for killer TB – MedicalXpress (free)

2 – Efficacy and safety of anti-inflammatory agents for the treatment of major depressive disorder: a systematic review and meta-analysis of randomised controlled trials – Journal of Neurology, Neurosurgery & Psychiatry (free)

Commentaries: Expert reaction to systematic review and meta-analysis of RCTs on anti-inflammatory drugs for depression – Science Media Centre (free) AND Anti-inflammatories can curb major depressive symptoms – OnMedica (free) AND Anti-inflammatory agents can effectively and safely curb major depressive symptoms, study suggests – BMJ (free)

3 – Levofloxacin prophylaxis in patients with newly diagnosed myeloma (TEAMM): a multicentre, double-blind, placebo-controlled, randomised, phase 3 trial – The Lancet Oncology (free)

Commentaries: Reducing infection-related morbidity and mortality in patients with myeloma – The Lancet Oncology (free) AND Abx Prophylaxis Cuts Early Death in Newly Diagnosed Myeloma – MedPage Today (free)

4 – Randomized Trial of Lenalidomide Versus Observation in Smoldering Multiple Myeloma – Journal of Clinical Oncology (free)

Commentary: Lenalidomide may delay onset of myeloma-related bone, organ damage – Mayo Clinic (free)

5 – Meta-analysis comparing double versus Triple Anti-thrombotic Therapy in Patients with Atrial Fibrillation and Coronary Artery Disease – The American Journal of Cardiology (link to abstract – $ for full-text)

Commentary: Meta-analysis: Dual therapy yields less bleeding than triple therapy in AF, CAD – Healio (free registration required)

Related Randomized Trial: Dual Antithrombotic Therapy after PCI in Atrial Fibrillation (free study and commentaries)

Related Meta-Analysis: Dual vs. Triple Antithrombotic Therapy in Patients with Atrial Fibrillation following PCI (free) AND Dual Versus Triple Antithrombotic Therapy in Patients Undergoing Percutaneous Coronary Intervention (link to abstract)

6 – It’s time to talk about physician burnout and moral injury – The Lancet Psychiatry (free)

Related: Moral Injury and Burnout in Medicine: A Year of Lessons Learned (free Commentaries) AND Consensus Study – Taking Action Against Clinician Burnout: A Systems Approach to Professional Well-Being (free)

7 – The global, regional, and national burden of inflammatory bowel disease in 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017 – The Lancet Gastroenterology & Hepatology (free)

Invited Commentary: Global burden of inflammatory bowel disease (free)

8 – The global, regional, and national burden of pancreatic cancer and its attributable risk factors in 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017 – The Lancet Gastroenterology & Hepatology (free)

Invited Commentary: Pancreatic cancer: a growing burden (free)

9 – The global, regional, and national burden of stomach cancer in 195 countries, 1990–2017: a systematic analysis for the Global Burden of Disease study 2017 – The Lancet Gastroenterology & Hepatology (free)

Invited Commentary: 27 years of stomach cancer: painting a global picture (free)

10 – The global, regional, and national burden of colorectal cancer and its attributable risk factors in 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017 – The Lancet Gastroenterology & Hepatology (free)

Invited Commentary: The global challenge of colorectal cancer (free)