Randomized Trials
RCT | Early extracorporeal CPR did not improve outcomes in patients with refractory out-of-hospital cardiac arrest
30 Jan, 2023 | 01:18h | UTCEarly Extracorporeal CPR for Refractory Out-of-Hospital Cardiac Arrest – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Early Extracorporeal CPR for Out-of-Hospital Cardiac Arrest – American College of Cardiology
Commentary on Twitter
In a randomized trial, patients with out-of-hospital cardiac arrest who received extracorporeal CPR and those who received conventional CPR had similar results for survival and favorable neurologic outcomes. https://t.co/Irw8nrV8AA pic.twitter.com/lOPsBzhP3O
— NEJM (@NEJM) January 27, 2023
RCT | Effects of once-weekly prophylaxis with Efanesoctocog Alfa in patients with severe Hemophilia A
30 Jan, 2023 | 01:14h | UTCEfanesoctocog Alfa Prophylaxis for Patients with Severe Hemophilia A – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Once-Weekly Efanesoctocog Alfa Beneficial in Severe Hemophilia A – HealthDay
Commentary on Twitter with a video summary
Efanesoctocog alfa is a new class of factor VIII replacement for hemophilia A that has a longer half-life than other factor VIII products, thus allowing once-weekly dosing. New research findings are summarized in a short video. https://t.co/YuXzifUh8m pic.twitter.com/POCAAfeEni
— NEJM (@NEJM) January 27, 2023
RCT | Disposable elevator cap duodenoscopes reduce microbial contamination during ERCP
30 Jan, 2023 | 00:49h | UTC
Commentary on Twitter
In this RCT of 520 ERCP patients, disposable elevator cap duodenoscopes reduced persistent contamination (RR 0.34, 95% CI 0.16–0.75), with no differences in performance (technical success 94.6% vs. 90.7%, P=.13) or safety outcomes. https://t.co/km87WyxsvR
— JAMA Internal Medicine (@JAMAInternalMed) January 26, 2023
RCT | Effect of second-stage pushing timing on postpartum pelvic floor morbidity
30 Jan, 2023 | 00:31h | UTCEffect of Second-Stage Pushing Timing on Postpartum Pelvic Floor Morbidity: A Randomized Controlled Trial – Obstetrics & Gynecology (free for a limited period)
Commentary on Twitter
How does timing of pushing in obstetrics impact future pelvic floor health? #freearticle https://t.co/VPZgVt8JnU pic.twitter.com/gSiTGN1Vdv
— The Green Journal (@greenjrnl) January 24, 2023
RCT | Sodium bicarbonate over 2 years was not beneficial for kidney transplant recipients with metabolic acidosis
27 Jan, 2023 | 12:23h | UTCSodium bicarbonate for kidney transplant recipients with metabolic acidosis in Switzerland: a multicentre, randomised, single-blind, placebo-controlled, phase 3 trial – The Lancet (link to abstract – $ for full-text)
RCT | Duration of prophylactic levetiracetam after surgery for brain tumor
27 Jan, 2023 | 12:06h | UTC
Commentary on Twitter
#NEULatestArticle #NEUVisualAbstract Duration of Prophylactic Levetiracetam After Surgery for Brain Tumor: A Prospective Randomized Trial https://t.co/O8wAgwK0SL by Rahman et al @UFHealth @CNS_Update @DKondziolkaCNS @IsaacYangMD #Seizures #BrainTumor pic.twitter.com/ALVEw91oiZ
— Neurosurgery Publications (@NeurosurgeryCNS) October 6, 2022
RCT | High-dose steroid in low pain responders undergoing total knee arthroplasty
27 Jan, 2023 | 12:08h | UTC
M-A | Microsurgery vs. microsurgery with preoperative embolization for brain arteriovenous malformation treatment
27 Jan, 2023 | 12:05h | UTC
RCT | Shoulder stretching vs. shoulder muscle strength training for the prevention of baseball-related arm injuries
27 Jan, 2023 | 11:57h | UTC
Commentary on Twitter
Shoulder stretching versus shoulder muscle strength training for the prevention of baseball-related arm injuries: a randomized, active-controlled, open-label, non-inferiority studyhttps://t.co/9tsPkWyVdU pic.twitter.com/eihYv5EdRE
— Physio Meets Science (@PhysioMeScience) December 22, 2022
RCT | Curettage plus platelet-rich plasma gel vs. curettage plus phenol application in treatment of pilonidal sinus disease
26 Jan, 2023 | 12:05h | UTCComparison of Curettage Plus Platelet-Rich Plasma Gel and Curettage Plus Phenol Application in Treatment of Pilonidal Sinus Disease: A Randomized Trial – Diseases of the Colon & Rectum (link to abstract – $ for full-text)
See also: Visual Abstract
RCT | Postoperative adjuvant hepatic arterial infusion chemotherapy with FOLFOX in hepatocellular carcinoma with microvascular invasion
26 Jan, 2023 | 12:03h | UTC
RCT | Preoperative chemotherapy reduced recurrence in operable colon cancer
25 Jan, 2023 | 11:29h | UTCEditorial: FOxTROT: Are We Ready to Dance? – Journal of Clinical Oncology
News Release: Chemotherapy before surgery cuts risk of colon cancer returning, trial finds – Cancer Research UK
Commentary: New treatment strategy cuts risk of bowel cancer returning by 28% – The Guardian
Commentary from one of the authors on Twitter (thread – click for more)
🥁🥁🥁Tweetorial
FOxTROT, the 1st ph 3 RCT of neoadjuvant chemo (NAC) in locally advanced colon cancer
We report that NAC is
✅deliverable and safe
✅led to statistically significant reduction in cancer recurrence than upfront surgery
A 🧵 (1/14)#crcsmhttps://t.co/y1hU6qWdXF— Jenny Seligmann (@JenSeligmann) January 20, 2023
RCT | Monitoring of cerebral tissue oxygen saturation to guide oxygen delivery in preterm neonates did not improve outcomes
25 Jan, 2023 | 11:23h | UTC
RCT | 2 days of postoperative antibiotics is noninferior to 5 days in patients with complex appendicitis
24 Jan, 2023 | 14:33h | UTC2 days versus 5 days of postoperative antibiotics for complex appendicitis: a pragmatic, open-label, multicentre, non-inferiority randomised trial – The Lancet (link to abstract – $ for full-text)
Commentary: Trial supports shorter postoperative antibiotics for complex appendicitis – CIDRAP
Commentary on Twitter
https://twitter.com/TheLancet/status/1615998251945050112
RCT | Intracorporeal vs. extracorporeal anastomosis in robotic right colectomy
24 Jan, 2023 | 14:17h | UTCIntracorporeal Versus Extracorporeal Anastomosis in Robotic Right Colectomy: A Multicenter, Triple-blind, Randomized Clinical Trial – Annals of Surgery (link to abstract – $ for full-text)
RCT | Standard threshold laser versus subthreshold micropulse laser for adults with diabetic macular edema
24 Jan, 2023 | 14:02h | UTCOriginal Publication: Diabetic Macular Edema and Diode Subthreshold Micropulse Laser: A Randomized Double-Masked Noninferiority Clinical Trial – Ophthalmology
RCT | Effects of a web-guided system for self-treatment of recurrent benign paroxysmal positional vertigo
23 Jan, 2023 | 13:43h | UTCEffect of Self-treatment of Recurrent Benign Paroxysmal Positional Vertigo: A Randomized Clinical Trial – JAMA Neurology (free for a limited period)
Related Video: Web-Guided Canalith Reposition Maneuver – JAMA
Commentary: Web-Based System Works Well for Diagnosis, Treatment of Recurrent Vertigo – HealthDay
Commentary on Twitter
Patients may benefit from treating benign paroxysmal positional vertigo themselves using a web-guided system. https://t.co/9Hjwb0XGnl
— JAMA Neurology (@JAMANeuro) January 20, 2023
RCT | Adjuvant S-1 compared with observation in resected biliary tract cancer
23 Jan, 2023 | 13:24h | UTCAdjuvant S-1 compared with observation in resected biliary tract cancer (JCOG1202, ASCOT): a multicentre, open-label, randomised, controlled, phase 3 trial – The Lancet (link to abstract – $ for full-text)
Commentary on Twitter
New @TheLancet – Nakachi et al – Adjuvant S-1 compared with observation in resected biliary tract cancer (JCOG1202, ASCOT): a multicentre, open-label, randomised, controlled, phase 3 trial https://t.co/E6y7a9dWNf#gitwitter #biliarytractcancer #onctwitter @OncoAlert #JCOG pic.twitter.com/WEBFXjIWce
— The Lancet Gastroenterology & Hepatology (@LancetGastroHep) January 20, 2023
RCT | Small study suggests hybrid ablation is more effective than repeated catheter ablation in persistent atrial fibrillation
23 Jan, 2023 | 13:23h | UTC
RCT | Oral ibuprofen and oral ketorolac are similarly effective for children with acute traumatic pain
20 Jan, 2023 | 14:47h | UTC
RCT | Routine use of endometrial receptivity testing to guide the timing of frozen embryo transfer did not improve the rates of live birth
20 Jan, 2023 | 14:45h | UTCEffect of Timing by Endometrial Receptivity Testing vs Standard Timing of Frozen Embryo Transfer on Live Birth in Patients Undergoing In Vitro Fertilization: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)
Commentary on Twitter
Study findings do not support routine use of receptivity testing to guide the timing of embryo transfer during in vitro fertilization. https://t.co/p8jqTpRAfV #Research
— JAMA (@JAMA_current) December 6, 2022
An overview of methodological considerations regarding adaptive stopping, arm dropping, and randomization in clinical trials
20 Jan, 2023 | 14:27h | UTC
Commentary from the author on Twitter
Now online in @JClinEpi (OA): https://t.co/Ton5G8x2sH
In this manuscript we provide an overview of the key methodological considerations for (multi-arm, multi-stage) clinical trials using adaptive stopping, arm dropping, and randomisation with a worked example. Details below 1/— Anders Granholm (@andersgranholm) November 16, 2022
Under a Creative Commons Attribution (CC BY 4.0) License
RCT | Bilateral ultrasound-guided erector spinae plane block vs. wound infiltration for postoperative analgesia in lumbar spinal fusion surgery
20 Jan, 2023 | 14:18h | UTC
RCT | No difference in survival with Torsemide vs. Furosemide after discharge of patients hospitalized with heart failure
19 Jan, 2023 | 14:26h | UTCEffect of Torsemide vs Furosemide After Discharge on All-Cause Mortality in Patients Hospitalized With Heart Failure: The TRANSFORM-HF Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: TRANSFORM-HF—Can We Close the Loop on Diuretics in Heart Failure? – JAMA (free for a limited period)
News Release: Comparison of diuretics shows no difference in heart failure survival – NIH/National Heart, Lung and Blood Institute
Commentary on Twitter
Among patients discharged after hospitalization for heart failure, torsemide compared with furosemide did not result in a significant difference in all-cause mortality over 12 months. https://t.co/EwoVzRigkS pic.twitter.com/5dvhJ1oVaf
— JAMA (@JAMA_current) January 17, 2023
RCT | SPONGE-assisted vs. Trendelenburg position surgery in laparoscopic sigmoid and rectal cancer surgery
19 Jan, 2023 | 14:06h | UTCSPONGE-assisted vs. Trendelenburg position surgery in laparoscopic sigmoid and rectal cancer surgery (SPONGE trial): randomized clinical trial – British Journal of Surgery (link to abstract – $ for full-text)