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Randomized Trials

RCT | Sublobar resection noninferior to lobal resection for peripheral stage IA non–small-cell lung cancer

9 Feb, 2023 | 14:05h | UTC

Lobar or Sublobar Resection for Peripheral Stage IA Non–Small-Cell Lung Cancer – New England Journal of Medicine (link to abstract – $ for full-text)

News Release: Less lung tissue removal needed for early-stage cancer, study finds – Weill Cornell Medical College

Related:

Survival outcomes in a prospective randomized multicenter Phase III trial comparing patients undergoing anatomical segmentectomy versus standard lobectomy for non-small cell lung cancer up to 2 cm – Lung Cancer

A guide for managing patients with stage I NSCLC: deciding between lobectomy, segmentectomy, wedge, SBRT and ablation.

Segmentectomy versus lobectomy in small-sized peripheral non-small-cell lung cancer (JCOG0802/WJOG4607L): a multicentre, open-label, phase 3, randomised, controlled, non-inferiority trial – The Lancet (link to abstract – $ for full-text)

A Meta-Analysis Comparing Lobectomy versus Segmentectomy in Stage I Non-Small Cell Lung Cancer – The Korean Journal of Thoracic and Cardiovascular Surgery

 

RCT | Pegylated Interferon Lambda reduces hospitalizations in predominantly vaccinated outpatients with Covid-19

9 Feb, 2023 | 14:03h | UTC

Early Treatment with Pegylated Interferon Lambda for Covid-19 – New England Journal of Medicine

News Release: Single-dose treatment reduces risk of COVID-19 hospitalization by half for high-risk patients in a largely vaccinated population – University Health Network

 

RCT | Pregnancy and neonatal safety of PrEP for HIV prevention initiated during pregnancy vs. afterwards

9 Feb, 2023 | 13:55h | UTC

Pregnancy and neonatal safety outcomes of timing of initiation of daily oral tenofovir disoproxil fumarate and emtricitabine pre-exposure prophylaxis for HIV prevention (CAP016): an open-label, randomised, non-inferiority trial – The Lancet HIV (link to abstract – $ for full-text)

 

RCT | Effects of Bardoxolone Methyl in Alport Syndrome

9 Feb, 2023 | 13:43h | UTC

Effects of Bardoxolone Methyl in Alport Syndrome – Clinical Journal of the American Society of Nephrology

 

Commentary on Twitter (thread – click for more)

 

RCT | Effect of the use of reinforced stapling on the occurrence of pancreatic fistula after distal pancreatectomy

9 Feb, 2023 | 13:34h | UTC

Effect of the Use of Reinforced Stapling on the Occurrence of Pancreatic Fistula After Distal Pancreatectomy: Results of the REPLAY (Reinforcement of the Pancreas in distaL pAncreatectomY) Multicenter Randomized Clinical Trial – Annals of Surgery (link to abstract – $ for full-text)

 

RCT | Gefitinib plus MTX not better than MTX alone to treat tubal ectopic pregnancy

8 Feb, 2023 | 12:43h | UTC

Combination of gefitinib and methotrexate to treat tubal ectopic pregnancy (GEM3): a multicentre, randomised, double-blind, placebo-controlled trial – The Lancet

 

Commentary from the author on Twitter (thread – click for more)

Under a Creative Commons Attribution (CC BY 4.0) license

 

Phase 2b RCT | An anti-OX40 antibody to treat moderate-to-severe atopic dermatitis

8 Feb, 2023 | 12:22h | UTC

An anti-OX40 antibody to treat moderate-to-severe atopic dermatitis: a multicentre, double-blind, placebo-controlled phase 2b study – The Lancet (link to abstract – $ for full-text)

News Release: New Treatment for Moderate to Severe Atopic Dermatitis Shows Promising Long-Term Results – Mount Sinai Health System

Commentary: Rocatinlimab Effective for Moderate-to-Severe Atopic Dermatitis – HealthDay

 

Commentary on Twitter:

 

RCT | Laser no better than sham treatment for genitourinary syndrome of menopause

8 Feb, 2023 | 12:17h | UTC

Laser versus sham for genitourinary syndrome of menopause: A randomised controlled trial – BJOG (link to abstract – $ for full-text)

Invited commentary: Laser therapy for genitourinary syndrome of menopause: Emperor’s new clothes or a meaningful advance? – BJOG

Related:

M-A | Carbon dioxide laser vs. vaginal estrogen for genitourinary syndrome of menopause.

Perspective: From vaginal laser treatment to spa breaks – it’s the great menopause gold rush.

RCT: Laser treatment not better than sham treatment on symptom severity in women with postmenopausal vaginal symptoms.

Consensus Document: The Clinical Role of LASER for Vulvar and Vaginal Treatments in Gynecology and Female Urology

 

RCT | Efficacy of a loading dose of IV salbutamol in children with severe acute asthma admitted to a PICU

8 Feb, 2023 | 12:10h | UTC

Efficacy of a loading dose of IV salbutamol in children with severe acute asthma admitted to a PICU: a randomized controlled trial – European Journal of Pediatrics

 

RCT | Medial retropharyngeal nodal region sparing radiotherapy vs. standard radiotherapy in patients with nasopharyngeal carcinoma

7 Feb, 2023 | 14:09h | UTC

Medial retropharyngeal nodal region sparing radiotherapy versus standard radiotherapy in patients with nasopharyngeal carcinoma: open label, non-inferiority, multicentre, randomised, phase 3 trial – The BMJ

 

RCT | Time-restricted eating and exercise training improve HbA1c and body composition in women with overweight/obesity

7 Feb, 2023 | 13:54h | UTC

Time-restricted eating and exercise training improve HbA1c and body composition in women with overweight/obesity: A randomized controlled trial – Cell Metabolism

News Release: Combination of time-restricted eating and high-intensity interval training can help reduce belly fat – The Norwegian University of Science and Technology/News Medical

 

Commentary on Twitter

Under a Creative Commons Attribution – NonCommercial – NoDerivs (CC BY-NC-ND 4.0) license

 

RCT | Higher complication rate after nail compared with plate fixation of ankle fractures in patients aged 60 years or older

7 Feb, 2023 | 13:50h | UTC

Higher complication rate after nail compared with plate fixation of ankle fractures in patients aged 60 years or older: a prospective, randomized controlled trial – The Bone & Joint Journal (link to abstract – $ for full-text)

 

RCT | Machine perfusion is superior to therapeutic hypothermia for reducing delayed graft function after kidney transplantation

6 Feb, 2023 | 13:28h | UTC

Hypothermia or Machine Perfusion in Kidney Donors – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Machine Perfusion of Kidneys Protects Against Delayed Graft Function – HealthDay

 

Commentary with video on Twitter

 

RCT | Postoperative delirium after Dexmedetomidine vs. Propofol sedation in older adults undergoing orthopedic lower limb surgery

6 Feb, 2023 | 13:07h | UTC

Postoperative Delirium after Dexmedetomidine versus Propofol Sedation in Healthy Older Adults Undergoing Orthopedic Lower Limb Surgery with Spinal Anesthesia: A Randomized Controlled Trial – Anesthesia

 

RCT | Routine postsurgical anesthesia visit did not improve 30-day morbidity and mortality

6 Feb, 2023 | 12:58h | UTC

Routine Postsurgical Anesthesia Visit to Improve 30-day Morbidity and Mortality: A Multicenter, Stepped-wedge Cluster Randomized Interventional Study (The TRACE Study) – Annals of Surgery

 

RCT | First-line serplulimab or placebo plus chemotherapy in PD-L1-positive esophageal squamous cell carcinoma

3 Feb, 2023 | 14:02h | UTC

First-line serplulimab or placebo plus chemotherapy in PD-L1-positive esophageal squamous cell carcinoma: a randomized, double-blind phase 3 trial – Nature Medicine

 

RCT | Efficacy and safety of intermittent fasting in people with insulin-treated Type 2 Diabetes

3 Feb, 2023 | 13:54h | UTC

Efficacy and Safety of Intermittent Fasting in People With Insulin-Treated Type 2 Diabetes (INTERFAST-2)—A Randomized Controlled Trial – Diabetes Care

Commentary: Intermittent fasting feasible with insulin-treated type 2 diabetes – medwire News

Related:

RCT | Effect of an intermittent calorie-restricted diet on Type 2 DM remission.

Consensus Statement: Effect of carbohydrate-restricted diets and intermittent fasting on obesity, type 2 diabetes mellitus, and hypertension management.

Intermittent fasting may be effective weight loss strategy in patients with type 2 diabetes

Clinical Management of Intermittent Fasting in Patients with Diabetes Mellitus

 

Randomized Crossover Trial | Efficacy of a singing intervention on communication and psychosocial functioning in chronic aphasia

3 Feb, 2023 | 13:44h | UTC

Efficacy of a multicomponent singing intervention on communication and psychosocial functioning in chronic aphasia: a randomized controlled crossover trial – Brain Communications

News Release: Singing-based group rehabilitation can support communication and speech production of stroke patients – University of Helsinki/News Medical

 

RCT | Ablation vs. anti-arrhythmic therapy for reducing all hospital episodes from recurrent atrial fibrillation

3 Feb, 2023 | 13:40h | UTC

Ablation versus anti-arrhythmic therapy for reducing all hospital episodes from recurrent atrial fibrillation: a prospective, randomized, multi-centre, open label trial – EP Europace

 

RCT | Remifentanil vs. neuromuscular blockers during rapid sequence intubation in patients at risk of aspiration

2 Feb, 2023 | 15:01h | UTC

Effect of Remifentanil vs Neuromuscular Blockers During Rapid Sequence Intubation on Successful Intubation Without Major Complications Among Patients at Risk of Aspiration: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

 

Commentary on Twitter

 

RCT | Diclofenac diethylamine 2.32% gel applied twice daily vs. 1.16% gel four times daily in patients with acute ankle sprain

2 Feb, 2023 | 14:49h | UTC

Randomized, double-blind, noninferiority study of diclofenac diethylamine 2.32% gel applied twice daily versus diclofenac diethylamine 1.16% gel applied four times daily in patients with acute ankle sprain – BMC Musculoskeletal Disorders

 

Phase 2 RCT | Lysergic acid diethylamide–assisted therapy in patients with anxiety with and without a life-threatening illness

2 Feb, 2023 | 14:45h | UTC

Lysergic Acid Diethylamide–Assisted Therapy in Patients With Anxiety With and Without a Life-Threatening Illness: A Randomized, Double-Blind, Placebo-Controlled Phase II Study – Biological Psychiatry

Commentary: LSD-assisted therapy induces rapid and lasting reductions in anxiety and depression symptoms, according to new research – PsyPost

 

RCT | Oral minocycline plus rifampicin vs. oral linezolid for complicated skin and skin structure infections caused by MRSA

2 Feb, 2023 | 14:33h | UTC

Oral minocycline plus rifampicin versus oral linezolid for complicated skin and skin structure infections caused by methicillin-resistant Staphylococcus aureus: The AIDA open label, randomized, controlled Phase 4 trial – eClinicalMedicine

 

RCT | Effects of an Extended Knee Control program for injury prevention in adolescent and adult amateur football players

1 Feb, 2023 | 13:00h | UTC

Extended Knee Control programme lowers weekly hamstring, knee and ankle injury prevalence compared with an adductor strength programme or self-selected injury prevention exercises in adolescent and adult amateur football players: a two-armed cluster-randomised trial with an additional comparison arm – British Journal of Sports Medicine

 

Commentary on Twitter

 

RCT | Assessment of infant position and timing of stylet removal to improve lumbar puncture success in neonates

31 Jan, 2023 | 14:07h | UTC

Assessment of infant position and timing of stylet removal to improve lumbar puncture success in neonates (NeoCLEAR): an open-label, 2 × 2 factorial, randomised, controlled trial – The Lancet Child & Adolescent Health

News Release: Lumbar punctures in newborn babies are more successful when performed in sitting position – Oxford Population Health

 

Commentary on Twitter

 

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