Randomized Trials | Page 23 of 58 | Links Medicus Content Curation & Alerts in Medicine

RCT | Bimekizumab in patients with active psoriatic arthritis and previous inadequate response or intolerance to TNFα inhibitors

19 Jan, 2023 | 14:05h | UTC

Bimekizumab in patients with active psoriatic arthritis and previous inadequate response or intolerance to tumour necrosis factor-α inhibitors: a randomised, double-blind, placebo-controlled, phase 3 trial (BE COMPLETE) – The Lancet

RCT | Effectiveness of an intervention to improve decision making for older patients with advanced CKD

19 Jan, 2023 | 14:04h | UTC

Effectiveness of an Intervention to Improve Decision Making for Older Patients With Advanced Chronic Kidney Disease: A Randomized Controlled Trial – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentary: Digital decision aid may be useful for older adults with CKD – ACP Internist

Commentary on Twitter

A #RCT of older adults w/ #CKD found use of decision-making aid DART improved decision quality & clarified treatment preferences for older adults w/ advanced CKD 6 months after intervention: https://t.co/JP0TO7givB @KerenLadin @TuftsMedicalCtr pic.twitter.com/pXPyg1iKAS

— Annals of Int Med (@AnnalsofIM) December 20, 2022

RCT | Prevention of incisional hernias by prophylactic mesh-augmented reinforcement of midline laparotomies for AAA treatment

19 Jan, 2023 | 14:03h | UTC

Prevention of Incisional Hernias by Prophylactic Mesh-augmented Reinforcement of Midline Laparotomies for Abdominal Aortic Aneurysm Treatment: Five-year Follow-up of a Randomized Controlled Trial – Annals of Surgery

RCT | Aqueous povidone-iodine vs. normal saline for intraoperative wound irrigation on the incidence of SSI after GI surgery

19 Jan, 2023 | 13:54h | UTC

Aqueous Povidone-Iodine Versus Normal Saline For Intraoperative Wound Irrigation On The Incidence Of Surgical Site Infection In Clean-Contaminated Wounds After Gastroenterological Surgery: A Single Institute, Prospective, Blinded-Endpoint, Randomized Controlled Trial – Annals of Surgery (link to abstract – $ for full-text)

Post-trial follow-up | Efficacy and safety of first-line lorlatinib vs. crizotinib in patients with advanced, ALK-positive non-small-cell lung cancer

19 Jan, 2023 | 13:49h | UTC

Efficacy and safety of first-line lorlatinib versus crizotinib in patients with advanced, ALK-positive non-small-cell lung cancer: updated analysis of data from the phase 3, randomised, open-label CROWN study – The Lancet Respiratory Medicine (link to abstract – $ for full-text)

Original Study: First-Line Lorlatinib or Crizotinib in Advanced ALK-Positive Lung Cancer – New England Journal of Medicine

Commentary on Twitter

NEW—Updated, long-term data from the CROWN study show durable benefit of lorlatinib vs crizotinib in pts w/ treatment-naive, ALK-positive #NSCLC

From Prof Benjamin Solomon & colleagues https://t.co/jfOEMRNEgl pic.twitter.com/SBaRCBEGIy

— The Lancet Respiratory Medicine (@LancetRespirMed) December 19, 2022

RCT | Nivolumab plus Ipilimumab vs. EXTREME regimen as first-line treatment for recurrent/metastatic head and neck cancer

19 Jan, 2023 | 13:41h | UTC

Nivolumab Plus Ipilimumab Versus EXTREME Regimen as First-Line Treatment for Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck: The Final Results of CheckMate 651 – Journal of Clinical Oncology

Commentary: First-Line Nivolumab/Ipilimumab vs EXTREME Regimen in Recurrent or Metastatic Head and Neck Cancer – The ASCO Post

RCT | Early high-flow nasal oxygen did not improve outcomes in hospitalized children with acute hypoxemic respiratory failure

18 Jan, 2023 | 14:34h | UTC

Effect of Early High-Flow Nasal Oxygen vs Standard Oxygen Therapy on Length of Hospital Stay in Hospitalized Children With Acute Hypoxemic Respiratory Failure: The PARIS-2 Randomized Clinical Trial – JAMA (free for a limited period)

RCT | Reduced adenoma miss rate with 9-minute vs. 6-minute withdrawal times for screening colonoscopy

18 Jan, 2023 | 14:13h | UTC

Reduced Adenoma Miss Rate With 9-Minute vs 6-Minute Withdrawal Times for Screening Colonoscopy: A Multicenter Randomized Tandem Trial – The American Journal of Gastroenterology

Commentary: Longer withdrawal time reduces miss rates in screening colonoscopy – MDedge

Commentary on Twitter

📕 #RapidRCTinAJG, accelerating the time from RCT to publication

Reduced Adenoma Miss Rate With 9-Minute vs 6-Minute Withdrawal Times for Screening Colonoscopy: A Multicenter Randomized Tandem Trial by Zhao, et al.

👉 https://t.co/SSIktB0Aoc @JasmohanBajaj @MLongMD #RedJournal pic.twitter.com/OwJhzeKYPA

— AJG – The American Journal of Gastroenterology (@AmJGastro) January 5, 2023

RCT | Does choice of patellar implant in total knee arthroplasty matter?

18 Jan, 2023 | 14:06h | UTC

Does Choice of Patellar Implant in Total Knee Arthroplasty Matter? A Randomized Comparative Trial of 3 Commonly Used Designs – The Journal of Bone and Joint Surgery (link to abstract – $ for full-text)

Commentary: To resurface the patellar: Onlay, Inlay or Onlay Oval? – Orthopedics This Week

RCT | Efficacy and safety of Risankizumab for active psoriatic arthritis

18 Jan, 2023 | 14:04h | UTC

Efficacy and safety of risankizumab for active psoriatic arthritis: 52-week results from the KEEPsAKE 2 study – Rheumatology

Commentary: Risankizumab Safe, Effective at 52 Weeks for Psoriatic Arthritis – HealthDay

RCT | Ultrasound-guided percutaneous cryoneurolysis to treat chronic postamputation phantom limb pain

17 Jan, 2023 | 13:13h | UTC

Ultrasound-guided Percutaneous Cryoneurolysis to Treat Chronic Postamputation Phantom Limb Pain: A Multicenter Randomized Controlled Trial – Anesthesiology

RCT | Withdrawal of infliximab or concomitant immunosuppressant therapy in patients with Crohn’s disease on combination therapy

17 Jan, 2023 | 13:10h | UTC

Withdrawal of infliximab or concomitant immunosuppressant therapy in patients with Crohn’s disease on combination therapy (SPARE): a multicentre, open-label, randomised controlled trial – The Lancet Gastroenterology & Hepatology

Invited commentary: Treatment withdrawal in Crohn’s disease: slowly becoming clearer – The Lancet Gastroenterology & Hepatology (free registration required)

Commentary on Twitter

New research – Louis et al – Withdrawal of infliximab or concomitant immunosuppressant therapy in patients with Crohn’s disease on combination therapy (SPARE): a multicentre, open-label, randomised controlled trialhttps://t.co/T40BmgHtem #IBD #GITwitter #medtwitter pic.twitter.com/iOIbi0WowU

— The Lancet Gastroenterology & Hepatology (@LancetGastroHep) January 12, 2023

RCT | Effect of 5% EMLA cream on postoperative sore throat in adults following general endotracheal anesthesia

17 Jan, 2023 | 13:05h | UTC

Effect of 5% EMLA Cream on Postoperative Sore Throat in Adults Following General Endotracheal Anesthesia: A Randomized Placebo-Controlled Study – Anesthesia & Analgesia (link to abstract – $ for full-text)

RCT | Fluvoxamine no better than placebo in outpatients with mild to moderate COVID-19

15 Jan, 2023 | 20:37h | UTC

Effect of Fluvoxamine vs Placebo on Time to Sustained Recovery in Outpatients With Mild to Moderate COVID-19: A Randomized Clinical Trial – JAMA

Editorial: Lack of Benefit of Fluvoxamine for COVID-19 – JAMA

Author Interview: Fluvoxamine vs Placebo and Time to Sustained Recovery From Mild or Moderate COVID-19 – JAMA

Commentary: Trial finds that fluvoxamine doesn’t speed COVID recovery – CIDRAP

Commentary on Twitter

Among outpatients with mild to moderate #COVID19, treatment with 50 mg of fluvoxamine twice daily for 10 days, compared with placebo, did not improve time to sustained recovery. https://t.co/4QgBssqFSU pic.twitter.com/RMZ6mqlx6u

— JAMA (@JAMA_current) January 12, 2023

RCT | Ecopipam for Tourette Syndrome

15 Jan, 2023 | 20:09h | UTC

Ecopipam for Tourette Syndrome: A Randomized Trial – Pediatrics

Commentary: Ecopipam May Reduce Tics in Children With Tourette Syndrome – Psychiatric News Alert

Commentary on Twitter

Ecopipam, a selective D1-like receptor antagonist, is in development for children & adolescents with Tourette syndrome. Can ecopipam achieve a clinically meaningful reduction in tics without the disadvantages of D2-like receptor antagonists? https://t.co/GXxnPsP74C #Pediatrics pic.twitter.com/14fwu4npJi

— AAP Pediatrics (@aap_peds) January 11, 2023

RCT | Lebrikizumab in combination with topical corticosteroids in adolescents and adults with moderate-to-severe atopic dermatitis

15 Jan, 2023 | 20:07h | UTC

Efficacy and Safety of Lebrikizumab in Combination With Topical Corticosteroids in Adolescents and Adults With Moderate-to-Severe Atopic Dermatitis: A Randomized Clinical Trial (ADhere) – JAMA Dermatology

Commentary on Twitter

Does blocking the IL-13 cytokine w/ lebrikizumab combined w/ topical therapy provide clinical benefit in atopic eczema? This study reflecting real-world use patterns suggests a benefit. https://t.co/apUvYO3Jqv

— JAMA Dermatology (@JAMADerm) January 13, 2023

RCT | MRI–guided vs. CT–guided stereotactic body radiotherapy for prostate cancer

15 Jan, 2023 | 20:05h | UTC

Magnetic Resonance Imaging–Guided vs Computed Tomography–Guided Stereotactic Body Radiotherapy for Prostate Cancer: The MIRAGE Randomized Clinical Trial – JAMA Oncology

News Release: MRI-guided radiotherapy produces fewer side effects and better quality of life for patients with localized prostate cancer – University of California

Commentary from the author on Twitter (thread – click for more)

Pleased to share the primary endpoint results of the randomized phase III MIRAGE trial evaluating whether aggressive margin reduction with MRI-guidance leads to reduced toxicity in the context of prostate SBRT, out today in @JAMAOncology https://t.co/5ZKElUR4uk (1/n)

— Amar Kishan (@AmarUKishan) January 12, 2023

RCT | In patients undergoing cardiac surgery, intravenous high-dose selenium did not reduce morbidity or mortality

15 Jan, 2023 | 20:00h | UTC

Effect of High-Dose Selenium on Postoperative Organ Dysfunction and Mortality in Cardiac Surgery Patients: The SUSTAIN CSX Randomized Clinical Trial – JAMA Surgery

Commentary on Twitter

In this study, high-dose sodium selenite was not effective in reducing the development of organ dysfunction and death in high-risk cardiac surgery patients. @CStoppe @CriticalCa https://t.co/H3HR1u1HhU

— JAMA Surgery (@JAMASurgery) January 12, 2023

Crossover RCT | Preliminary study showed closed-loop insulin delivery might improve glycemic control in some adults with Type 2 DM

15 Jan, 2023 | 19:56h | UTC

Fully automated closed-loop insulin delivery in adults with type 2 diabetes: an open-label, single-center, randomized crossover trial – Nature Medicine

News Release: Artificial pancreas successfully trialed for use by type 2 diabetes patients – University of Cambridge

Commentary: Artificial Pancreas Device May Help Folks With Type 2 Diabetes – HealthDay

RCT | Cosmetic results and side effects of accelerated partial-breast irradiation vs. whole-breast irradiation for low-risk invasive carcinoma of the breast

15 Jan, 2023 | 19:53h | UTC

Cosmetic Results and Side Effects of Accelerated Partial-Breast Irradiation Versus Whole-Breast Irradiation for Low-Risk Invasive Carcinoma of the Breast: The Randomized Phase III IRMA Trial – Journal of Clinical Oncology (link to abstract – $ for full-text)

Commentary from the author on Twitter

5yr results of the phase 3 #IRMAtrial: EBRT #APBI b.i.d. associated with slightly increased rate of moderate soft tissue and bone toxicity and a slightly inferior cosmesis, though overall toxicity was in an acceptable range @JCO_ASCO #BCSM @OncoAlert https://t.co/8LHE2ut3t2

— Bruno Meduri (@brunomeduri) January 9, 2023