Pediatrics – Pulmonology | Page 3 of 7 | Links Medicus Content Curation & Alerts in Medicine

Brief Review | What’s new in pediatric ventilator liberation?

5 Sep, 2022 | 14:29h | UTC

What’s new in paediatric ventilator liberation? – Intensive Care Medicine

Commentary on Twitter

Pediatric ventilator liberation, update
⚙️ assess/adjustment of MV & sedation
⚙️ prepare
⚙️ extubate
⚙️ support
Many questions unanswered! peri-extubation steroids, criteria for NIV after extubation, post-extubation rescue HFNC vs CPAP.#PedsICU #FOAMcc
?️ https://t.co/MGPStTvZh2 pic.twitter.com/AySzk9blS5

— Intensive Care Medicine (@yourICM) September 2, 2022

Study Commentary | Zinc for the prevention or treatment of respiratory tract infections: a new systematic review.

1 Sep, 2022 | 11:46h | UTC

Zinc for the prevention or treatment of respiratory tract infections: A new systematic review – Science-Based Medicine

Original Study: M-A: Zinc might help to stave off respiratory infection symptoms and cut illness duration – “But quality of evidence variable, and no clarity on optimal formulation or dose”.

Guideline | Management of preschool wheezing.

31 Aug, 2022 | 11:37h | UTC

Management of Preschool Wheezing: Guideline from the Emilia-Romagna Asthma (ERA) Study Group – Journal of Clinical Medicine

Perspective | Should less invasive surfactant administration (LISA) become routine practice in US neonatal units?

29 Aug, 2022 | 11:59h | UTC

Should less invasive surfactant administration (LISA) become routine practice in US neonatal units? – Pediatric Research

RCT: In preterm infants with respiratory distress syndrome, surfactant administration via a thin catheter did not improve outcomes.

Systematic Review: Surfactant therapy via thin catheter in preterm infants with or at risk of respiratory distress syndrome is associated with reduced risk of death or bronchopulmonary dysplasia, less intubation in the first 72 hours, and reduced incidence of major complications and in‐hospital mortality.

RCT | Mepolizumab for urban children with exacerbation-prone eosinophilic asthma.

22 Aug, 2022 | 12:09h | UTC

Mepolizumab for urban children with exacerbation-prone eosinophilic asthma in the USA (MUPPITS-2): a randomised, double-blind, placebo-controlled, parallel-group trial – The Lancet (link to abstract – $ for full-text)

Commentary: Mepolizumab Cuts Exacerbations in Children With Severe Asthma – HealthDay

International clinical practice guidelines for pediatric ventilator liberation.

16 Aug, 2022 | 13:56h | UTC

Executive Summary: International Clinical Practice Guidelines for Pediatric Ventilator Liberation, A PALISI Network Document – American Journal of Respiratory and Critical Care Medicine

M-A | The outcome of post-cardiotomy extracorporeal membrane oxygenation in neonates and pediatric patients.

4 Aug, 2022 | 13:48h | UTC

The Outcome of Post-cardiotomy Extracorporeal Membrane Oxygenation in Neonates and Pediatric Patients: A Systematic Review and Meta-Analysis – Frontiers in Pediatrics

Brief Review | Lung ultrasound for the diagnosis and management of neonatal respiratory distress syndrome.

4 Aug, 2022 | 13:45h | UTC

Lung Ultrasound for the Diagnosis and Management of Neonatal Respiratory Distress Syndrome: A Minireview – Frontiers in Pediatrics

Podcast | Caring for a pediatric patient with ARDS.

4 Aug, 2022 | 13:35h | UTC

#52: The Original “Baby Lung”: PARDS with PedsCrit – The Cribsiders

RCT | The effect of inhaled hypertonic saline on lung structure in children aged 3–6 years with cystic fibrosis.

26 Jul, 2022 | 11:50h | UTC

The effect of inhaled hypertonic saline on lung structure in children aged 3–6 years with cystic fibrosis (SHIP-CT): a multicentre, randomised, double-blind, controlled trial – The Lancet Respiratory Medicine (link to abstract – $ for full-text)

Commentary: Inhaled hypertonic saline improves structural airway changes in children with cystic fibrosis – Healio (free registration required)

RCT | Intranasal corticosteroids not beneficial for children with obstructive sleep apnea.

19 Jul, 2022 | 13:27h | UTC

A trial of intranasal corticosteroids to treat the childhood obstructive sleep apnea syndrome – CHEST (link to abstract – $ for full-text)

Commentaries:

Study does not support intranasal corticosteroids for most children with obstructive sleep apnea – Healio

Intranasal corticosteroids not recommended for most children with OSA: study – Medical Dialogues

Commentary on Twitter

In children with obstructive sleep apnea syndrome, treatment with intranasal corticosteroids did not result in significant polysomnographic, neurobehavioral, and symptom changes compared to placebo, according to research in @journal_CHEST. https://t.co/e4bt4NMv5Z pic.twitter.com/FrIBdoMABf

— American Academy of Sleep Medicine (@AASMorg) July 11, 2022

Systematic Review | Anti‐IL‐5 therapies for asthma.

14 Jul, 2022 | 12:40h | UTC

Anti‐IL‐5 therapies for asthma – Cochrane Library

Summary: Mepolizumab, reslizumab or benralizumab for people already taking inhaled steroids and long-acting beta 2-agonists for their asthma – Cochrane Library

RCT | Efficacy and safety of Elexacaftor/Tezacaftor/Ivacaftor in children 6 through 11 years of age with cystic fibrosis heterozygous for F508del and a minimal function mutation.

13 Jul, 2022 | 11:07h | UTC

Efficacy and Safety of Elexacaftor/Tezacaftor/Ivacaftor in Children 6 Through 11 Years of Age with Cystic Fibrosis Heterozygous for F508del and a Minimal Function Mutation: A Phase 3B, Randomized, Placebo-Controlled Study – American Journal of Respiratory and Critical Care Medicine (link to abstract – $ for full-text)

Effect of comprehensive smoke-free legislation on neonatal and infant mortality across 106 middle-income countries.

7 Jul, 2022 | 12:26h | UTC

Effect of comprehensive smoke-free legislation on neonatal mortality and infant mortality across 106 middle-income countries: a synthetic control study – The Lancet Public Health

FDA orders Juul to remove all its e-cigarettes from US market.

6 Jul, 2022 | 11:46h | UTC

FDA orders Juul to remove all its e-cigarettes from US market – The BMJ

RCT | Testing the effects of combining azithromycin with inhaled tobramycin for P. aeruginosa in cystic fibrosis.

6 Jul, 2022 | 11:31h | UTC

Testing the effects of combining azithromycin with inhaled tobramycin for P. aeruginosa in cystic fibrosis: a randomised, controlled clinical trial – Thorax

Commentary: Does Azithromycin antagonize the effect of inhaled tobramycin in cystic fibrosis? – Medical Dialogues

Commentary on Twitter

Original research: Testing the effects of combining azithromycin with inhaled tobramycin for P. aeruginosa in cystic fibrosis: a randomised, controlled clinical trialhttps://t.co/z9dGX52dAe pic.twitter.com/tpiOqIIQjb

— ThoraxBMJ (@ThoraxBMJ) May 23, 2022

Review | Management of pediatric acute respiratory distress syndrome.

5 Jul, 2022 | 11:42h | UTC

Management of paediatric acute respiratory distress syndrome – BJA Education

M-A | Predictors of sleep disordered breathing in children with Down syndrome.

5 Jul, 2022 | 11:33h | UTC

Predictors of sleep disordered breathing in children with Down syndrome: a systematic review and meta-analysis – European Respiratory Review

Case-Control Study: Accuracy of chest CT in distinguishing cystic pleuropulmonary blastoma from benign congenital lung malformations in children.

1 Jul, 2022 | 11:02h | UTC

Accuracy of Chest Computed Tomography in Distinguishing Cystic Pleuropulmonary Blastoma From Benign Congenital Lung Malformations in Children – JAMA Network Open

Invited Commentary: Can Computed Tomography Scans Reliably Distinguish Pleuropulmonary Blastoma From Congenital Lung Malformations? – JAMA Network Open

Commentary on Twitter

This case-control study found computed tomography does not accurately identify pleuropulmonary blastoma in children; operative management is therefore recommended to confirm pathologic diagnosis in postnatally detected cystic lesions. https://t.co/vJ7jtpTOzr

— JAMA Network Open (@JAMANetworkOpen) June 30, 2022

Cohort Study: Pfizer vaccine effectiveness against omicron in children 5 to 11 years of age.

30 Jun, 2022 | 11:21h | UTC

BNT162b2 Vaccine Effectiveness against Omicron in Children 5 to 11 Years of Age – New England Journal of Medicine

Systematic Review: Exercise versus airway clearance techniques for people with cystic fibrosis.

29 Jun, 2022 | 11:10h | UTC

Exercise versus airway clearance techniques for people with cystic fibrosis – Cochrane Library

Summary: Exercise versus airway clearance for people with cystic fibrosis – Cochrane Library

Phase 2a RCT: Vaccine efficacy in adults in a respiratory syncytial virus challenge study.

27 Jun, 2022 | 11:21h | UTC

Vaccine Efficacy in Adults in a Respiratory Syncytial Virus Challenge Study -New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Challenge Study Shows Efficacy of RSV Vaccine in Healthy Adults – HealthDay

Commentary on Twitter

A human challenge model was used to assess the safety and immunogenicity of an RSV prefusion F protein-based vaccine against RSV infection. The vaccine construct has advanced to further clinical testing.https://t.co/KKfqzCyyGF pic.twitter.com/H7i7F8KLmv

— NEJM (@NEJM) June 22, 2022