Pediatrics – Neonatal/Perinatal
Systematic Review: “Formula milk trials have a high risk of bias, almost always report favorable conclusions, lack transparency, and selectively report findings”.
15 Oct, 2021 | 02:25h | UTCNews release: Formula milk trials are not reliable, warn researchers – Imperial College London
Original study: Conduct and reporting of formula milk trials: systematic review – The BMJ
RCT: Effect of whole-genome sequencing on the clinical management of acutely ill infants with suspected genetic disease.
28 Sep, 2021 | 09:05h | UTC
Commentaries on Twitter
This @JAMAPediatrics randomized clinical trial of acutely ill infants showed that access to whole genome sequencing doubled the proportion of patients with a precision diagnosis and a change of clinical management. https://t.co/yykog2UGLT pic.twitter.com/Gd7iuuUWII
— Muin J. Khoury (@MuinJKhoury) September 27, 2021
New study found two-times more infants in the ICU get a diagnosis and precision care when they get genomes. First-line genomes may reduce healthcare disparities by providing equitable access to dx https://t.co/FOO82Mds7D pic.twitter.com/BTb5AwsVHE
— JAMA Pediatrics (@JAMAPediatrics) September 27, 2021
Supplement: FIGO Working Group for Preterm Birth – Good Practice Recommendations.
15 Sep, 2021 | 08:56h | UTCEditorial: FIGO good practice recommendations for reducing preterm birth and improving child outcomes
FIGO good practice recommendations on modifiable causes of iatrogenic preterm birth
FIGO good practice recommendations on progestogens for prevention of preterm delivery
FIGO good practice recommendations on cervical cerclage for prevention of preterm birth
FIGO good practice recommendations on delayed umbilical cord clamping
Study shows high effectiveness of the Pfizer mRNA COVID-19 vaccine in pregnancy.
7 Sep, 2021 | 21:48h | UTCEffectiveness of the BNT162b2 mRNA COVID-19 vaccine in pregnancy – Nature Medicine
Commentaries on Twitter
NEW: Estimated vaccine effectiveness in #pregnancy from 7 through to 56 d after second dose was 96% (95% CI; 89–100%) for any documented infection, 97% (91–100%) for infections with documented symptoms & 89% (43–100%) for #COVID19-related hospitalization. https://t.co/bm950wUWGL
— All Source Pregnancy (@PregnancyAll) September 7, 2021
The Pfizer-BioNTech mRNA COVID-19 vaccine was estimated to have high vaccine effectiveness in pregnant women, which is similar to the effectiveness estimated in the general population, according to a @NatureMedicine paper. https://t.co/oz5zn7zNdq pic.twitter.com/9IP5ocxzXs
— Nature Portfolio (@NaturePortfolio) September 7, 2021
Study casts doubt on WHO guidance on antibiotics for neonatal sepsis.
3 Sep, 2021 | 09:57h | UTCStudy casts doubt on WHO guidance on antibiotics for neonatal sepsis – CIDRAP
Invited commentary: Antibiotics for neonatal sepsis in low-income and middle-income countries—where to go from here? (free registration required)
Commentary on Twitter
"WHO recommends ampicillin in combination with gentamicin for the management of clinical neonatal sepsis; however, there are persistent concerns regarding antimicrobial resistance and therapeutic failures with this treatment" #PIDTwitter #IDTwitter #medtwitter #TwitteRx https://t.co/FDlXwugouU
— Antibiotic Steward ??? Bassam Ghanem (@ABsteward) August 9, 2021
The Role of Lung Ultrasound in the Management of the Critically Ill Neonate—A Narrative Review and Practical Guide.
3 Sep, 2021 | 10:00h | UTC
Global, regional, and national estimates and trends in stillbirths from 2000 to 2019: a systematic assessment.
1 Sep, 2021 | 08:56h | UTC
Preventing stillbirth: What’s the latest evidence?
25 Aug, 2021 | 08:38h | UTCPreventing stillbirth: What’s the latest evidence? – Evidently Cochrane
Special collection: Stillbirth prevention and respectful bereavement care – Cochrane Library
Commentary on Twitter (thread – click for more)
New @CochraneLibrary Special Collection on #stillbirth prevention and respectful bereavement care: https://t.co/NW37SaUhr3 1/5#stillborn #babyloss #miscarriage #pregnancyloss #infantloss #pregnancyandinfantloss pic.twitter.com/mzIe3Sttwk
— The Cochrane Library (@CochraneLibrary) August 24, 2021
NICE Guideline: Antenatal care.
19 Aug, 2021 | 08:53h | UTCAntenatal care – National Institutes for Health and Care Excellence
Doubts raised about cooling treatment for oxygen-deprived newborns.
19 Aug, 2021 | 08:38h | UTCDoubts raised about cooling treatment for oxygen-deprived newborns – Nature
Original study: RCT: Therapeutic hypothermia may cause harm in moderate or severe neonatal encephalopathy in low-income and middle-income countries.
RCT: Therapeutic hypothermia may cause harm in moderate or severe neonatal encephalopathy in low-income and middle-income countries.
5 Aug, 2021 | 08:43h | UTCNews release: Brain injury treatment may cause harm in low and middle income nations – Imperial College London
Commentary: Hypoxic ischaemic encephalopathy in low resource settings—time to stop cooling? – The Lancet Global Health
Commentary on the Latest AAP Guidelines for the Febrile Neonate.
5 Aug, 2021 | 08:36h | UTCSmall Talk – Hot Off The Presses: The Latest AAP Guidelines for the Febrile Neonate – emDocs
Original guideline:
AAP Guideline: Evaluation and management of well-appearing febrile infants 8 to 60 days old.
Related:
Things We Do for No Reason: Lumbar Punctures in Low-Risk Febrile Infants with Bronchiolitis
RCT: Among pregnant women with primary CMV infection diagnosed before 24 weeks’ gestation, monthly infusion of CMV hyperimmune globulin did not prevent congenital cytomegalovirus infection.
30 Jul, 2021 | 11:42h | UTCA Trial of Hyperimmune Globulin to Prevent Congenital Cytomegalovirus Infection – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Hyperimmune Globulin Fails to Prevent Congenital CMV – Physician’s Weekly
Effect of systemic hydrocortisone initiated 7 to 14 days after birth in ventilated preterm infants on mortality and neurodevelopment at 2 years’ corrected age: follow-up of a randomized clinical trial.
29 Jul, 2021 | 10:57h | UTCEffect of Systemic Hydrocortisone Initiated 7 to 14 Days After Birth in Ventilated Preterm Infants on Mortality and Neurodevelopment at 2 Years’ Corrected Age: Follow-up of a Randomized Clinical Trial – JAMA (free for a limited period)
RCT showed improved outcomes with fetal surgery for severe left diaphragmatic hernia.
5 Jul, 2021 | 01:53h | UTCRandomized Trial of Fetal Surgery for Severe Left Diaphragmatic Hernia – New England Journal of Medicine (link to abstract – $ for full-text – Full text can be found here)
Commentary: Fetal Surgery Boosts Survival for Babies With Severe Birth Defect – MedPage Today (free registration required)
Widespread implementation of a low-cost telehealth service in the delivery of antenatal care during the COVID-19 pandemic enabled the reduction of in-person consultations by 50% without compromising pregnancy outcomes.
2 Jul, 2021 | 11:26h | UTCCommentary: Expanding the concept of safety in antenatal care provision – The Lancet
WHO: Caesarean section rates continue to rise, amid growing inequalities in access.
18 Jun, 2021 | 08:23h | UTCOriginal study: Trends and projections of caesarean section rates: global and regional estimates – BMJ Global Health
Commentary on Twitter (thread – click for more)
Caesarean section use continues to rise ? globally, now accounting for more than 1 in 5 of all childbirths.
C-section can put women and babies at unnecessary risk of short- and long-term health problems if performed when there is not medical need
— World Health Organization (WHO) (@WHO) June 17, 2021
M-A: Delivery room interventions for hypothermia in preterm neonates – “use of a plastic bag or wrap with a plastic cap or with heated humidified gas was associated with lower risk of major brain injury and mortality”.
1 Jun, 2021 | 08:10h | UTCDelivery Room Interventions for Hypothermia in Preterm Neonates: A Systematic Review and Network Meta-analysis – JAMA Pediatrics (link to abstract – $ for full-text)
Study suggests it is safe to discontinue antiseizure medication for most neonates with acute symptomatic seizures prior to discharge from the hospital.
27 May, 2021 | 08:14h | UTCSafety of Early Discontinuation of Antiseizure Medication After Acute Symptomatic Neonatal Seizures – JAMA Neurology (free for a limited period)
Editorial: Discontinuing Antiseizure Medication in Neonates With Acute Symptomatic Seizures—Primum non nocere – JAMA Neurology (free for a limited period)
Commentaries: Stopping Antiseizure Medication After Acute Symptomatic Neonatal Seizures Is Found to Be Safe – Neurology Today AND Babies with Seizures May Be Overmedicated – Michigan Medicine
Commentary on Twitter
New CER study on @JAMANeuro finds no difference in functional neurodevelopment or epilepsy at 24 mnths in children whose antiseizure meds was discont'd vs maintained at discharge after resolution of acute symptomatic neonatal seizures: https://t.co/yvKbrJuCvQ #ebneoalerts #neoEBM pic.twitter.com/810weSUSgb
— Evidence-Based Neo (@EBNEO) May 26, 2021
RCT: Immediate “kangaroo mother care” improves survival in infants with low birth weight compared to conventional care with “kangaroo mother care” initiated after stabilization.
27 May, 2021 | 08:18h | UTCCommentary: Immediate skin-to-skin contact after birth improves survival of pre-term babies – Karolisnka Institutet
Related: RCT: Community-initiated kangaroo mother care reduced the risk of moderate-to-severe maternal postpartum depressive symptoms among mothers of low-birth-weight infants in low-income areas in India AND WHO: New research highlights risks of separating newborns from mothers during COVID-19 pandemic AND Randomized Trial: Kangaroo Mother Care Improves Survival of Infants with Low Birthweight
Systematic Review: Oral dextrose gel reduces the risk of neonatal hypoglycemia in at‐risk infants and probably reduces the risk of major neurological disability at two years.
25 May, 2021 | 08:38h | UTCOral dextrose gel to prevent hypoglycaemia in at‐risk neonates – Cochrane Library
Summary: Oral dextrose gel for prevention of low blood glucose levels in newborn babies – Cochrane Library
Systematic Review: Surfactant therapy via thin catheter in preterm infants with or at risk of respiratory distress syndrome is associated with reduced risk of death or bronchopulmonary dysplasia, less intubation in the first 72 hours, and reduced incidence of major complications and in‐hospital mortality.
19 May, 2021 | 08:20h | UTC
Commentary on Twitter
Is giving surfactant via minimally invasive technique involving placement of a thin catheter in the trachea of a spontaneously breathing #infant effective and safe? https://t.co/0TKceRx4Oh New #SystematicReview from @CochraneNeonate looks at the evidence from 6 randomised trials. pic.twitter.com/qPB3Q0vp9E
— Cochrane UK (@CochraneUK) May 15, 2021
WHO: New report sounds the alarm on global shortage of 900 000 midwives.
6 May, 2021 | 08:45h | UTCNew report sounds the alarm on global shortage of 900 000 midwives – World Health Organization
Report: The State of the World’s Midwifery 2021 – UN sexual and reproductive health agency
Commentary on Twitter (thread – click for more)
9⃣3⃣% of #midwives are women. But too many face persistent gender discrimination that prevents them from thriving professionally.
Gender transformative policies are key to change this! ?https://t.co/qxkv16SVxp #MidwivesDay #IDM2021 pic.twitter.com/7aBBwvXFQa
— World Health Organization (WHO) (@WHO) May 5, 2021
Cohort study: Risk of developmental difficulties remains high among children born early
5 May, 2021 | 08:24h | UTCNeurodevelopmental outcomes at age 5 among children born preterm: EPIPAGE-2 cohort study – The BMJ
News release: Risk of developmental difficulties remains high among children born early – The BMJ
Commentary on Twitter
Children born preterm remain at high risk of developmental difficulties that can affect their behaviour and ability to learn, finds new research https://t.co/0A1aIQWWqk #BMJResearch
— The BMJ (@bmj_latest) May 2, 2021
RCT: Community-initiated kangaroo mother care reduced the risk of moderate-to-severe maternal postpartum depressive symptoms among mothers of low-birth-weight infants in low-income areas in India
5 May, 2021 | 08:21h | UTC
Commentary on Twitter
Skin to Skin care doesn’t only help babies; it also helps mothers!
Randomized trial of ~2k mothers from India found kangaroo care reduces postpartum depression #neoEBM #mentalhealth @JAMANetworkOpen https://t.co/6YqPQChKLe pic.twitter.com/DYAbU3Tsxu
— Abdul Razak, MD, FRCPCH (@DrAbdulRazak_MD) April 23, 2021