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Pediatrics (all articles)

Cohort Study: Short-term outcomes of corticosteroid monotherapy in multisystem inflammatory syndrome in children.

30 Mar, 2022 | 10:40h | UTC

Short-term Outcomes of Corticosteroid Monotherapy in Multisystem Inflammatory Syndrome in Children – JAMA Pediatrics

 

Commentary on Twitter

 

Review: Sudden cardiac death in congenital heart disease.

30 Mar, 2022 | 10:17h | UTC

Sudden cardiac death in congenital heart disease – European Heart Journal

 

Commentary on Twitter

 

Systematic Review: Probiotics for treatment of chronic constipation in children.

30 Mar, 2022 | 10:12h | UTC

Probiotics for treatment of chronic constipation in children – Cochrane Library

Summary: Probiotics for treatment of chronic constipation in children – Cochrane Library

 

Burden of non-communicable diseases among adolescents aged 10–24 years in the EU, 1990–2019: a systematic analysis of the Global Burden of Diseases Study 2019.

30 Mar, 2022 | 09:55h | UTC

Burden of non-communicable diseases among adolescents aged 10–24 years in the EU, 1990–2019: a systematic analysis of the Global Burden of Diseases Study 2019 – The Lancet Child & Adolescent Health

Invited Commentary: 30-year NCD burden data for EU adolescents merit close attention – The Lancet Child & Adolescent Health (free registration required)

 

Commentary on Twitter (thread – click for more)

 

Cohort Study: Prenatal occupational disinfectant exposure linked to increased risk of childhood allergies.

30 Mar, 2022 | 08:48h | UTC

Prenatal occupational disinfectant exposure and childhood allergies: the Japan Environment and Children’s study – Occupational & Environmental Medicine

Commentary: Disinfectant use by pregnant women may increase risk for asthma and eczema in children – BMJ/News Medical

 

Commentary on Twitter

 

Myocarditis and pericarditis after COVID-19 vaccination: clinical management guidance for healthcare professionals.

29 Mar, 2022 | 10:09h | UTC

Myocarditis and pericarditis after COVID-19 vaccination: clinical management guidance for healthcare professionals – UK Health Security Agency

Related:

Myocarditis following a third Pfizer vaccination dose in military recruits in Israel.

Myocarditis following COVID-19 BNT162b2 vaccination among adolescents in Hong Kong.

[Preprint] Post-marketing active surveillance of myocarditis and pericarditis following vaccination with COVID-19 mRNA vaccines in persons aged 12-39 years in Italy.

Myocarditis after BNT162b2 vaccination in Israeli adolescents.

Myocarditis cases reported after mRNA-Based COVID-19 vaccination in the US from December 2020 to August 2021.

A case-control study showed an increased risk of myocarditis after COVID-19 vaccination with a messenger RNA vaccine compared to an inactivated virus vaccine.

[Preprint] Risk of myocarditis following sequential COVID-19 vaccinations by age and sex.

Risks of myocarditis, pericarditis, and cardiac arrhythmias associated with COVID-19 vaccination vs. SARS-CoV-2 infection.

Case series with 139 adolescents and young adults with suspected myocarditis following mRNA vaccination showed most cases had a mild clinical course and rapid resolution of symptoms.

Heart-inflammation risk from Pfizer COVID vaccine is very low.

Large cohort study with over 2.5 million individuals showed the incidence of myocarditis after the Pfizer vaccine was 2.13 cases per 100,000 persons.

Study with over 5.1 million vaccinated individuals showed the incidence of myocarditis after the receipt of the Pfizer vaccine was low and more common after the second dose in young male recipients.

Large Observational study shows Pfizer Covid vaccine is mostly safe but is associated with increased risk of myocarditis, adenopathy, appendicitis, and herpes zoster.

 

Cohort Study: Preconception paternal use of metformin linked to increased risk of congenital problems in offspring.

29 Mar, 2022 | 10:04h | UTC

Preconception Antidiabetic Drugs in Men and Birth Defects in Offspring: A Nationwide Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries:

Paternal metformin use associated with major birth defects if used during period of sperm development – American College of Physicians

Expert reaction to study of birth defects and diabetic men using metformin during sperm development – Science Media Centre

 

Scientists find that the impact of social media on wellbeing varies across adolescence.

29 Mar, 2022 | 09:56h | UTC

News Release: Scientists find that the impact of social media on wellbeing varies across adolescence – University of Cambridge

Original Study: Windows of developmental sensitivity to social media – Nature Communications

Commentaries:

Negative impact of social media affects girls and boys at different ages – study – University of Oxford

Teenage social media use linked to less life-satisfaction for some – BBC

Social media may affect girls’ mental health earlier than boys’, study finds – The Guardian

Expert reaction to study on social media use and wellbeing over adolescence – Science Media Centre

 

Guideline: Treatment of unspecific back pain in children and adolescents.

29 Mar, 2022 | 09:52h | UTC

Treatment of Unspecific Back Pain in Children and Adolescents: Results of an Evidence-Based Interdisciplinary Guideline – Children

 

Association of antipsychotic drug exposure in pregnancy with risk of neurodevelopmental disorders: a national birth cohort study.

29 Mar, 2022 | 08:46h | UTC

Association of Antipsychotic Drug Exposure in Pregnancy With Risk of Neurodevelopmental Disorders: A National Birth Cohort Study – JAMA Internal Medicine (free for a limited period)

Commentary: Antipsychotic Use During Pregnancy Generally Not Associated With Neurodevelopmental Risks – Psychiatric News Alert

 

RCT: Effects of freshly irradiated vs. irradiated and stored red blood cell transfusion on cerebral oxygenation in preterm infants.

29 Mar, 2022 | 08:44h | UTC

Effects of Freshly Irradiated vs Irradiated and Stored Red Blood Cell Transfusion on Cerebral Oxygenation in Preterm Infants: A Randomized Clinical Trial – JAMA Pediatrics (free for a limited period)

Editorial: Use of Irradiated Red Blood Cell Transfusions in Newborns to Improve Intracerebral Saturation – JAMA Pediatrics (free for a limited period)

 

Commentary on Twitter

 

M-A: Glycerin suppositories and enemas in premature infants.

29 Mar, 2022 | 08:35h | UTC

Glycerin Suppositories and Enemas in Premature Infants: A Meta-analysis – Pediatrics (link to abstract – $ for full-text)

 

Commentary on Twitter

 

European clinical guidelines for Tourette syndrome and other tic disorders.

29 Mar, 2022 | 08:26h | UTC

Summary statement

Part I: assessment

Part II: psychological interventions

Part III: pharmacological treatment

Part IV: deep brain stimulation

Related: Guideline: Treatment of Tics in People with Tourette Syndrome and Chronic Tic Disorders

 

Moderna to ask FDA to authorize Covid-19 vaccine in children 6 months to 6 years.

28 Mar, 2022 | 10:01h | UTC

Moderna to ask FDA to authorize Covid-19 vaccine in children 6 months to 6 years – STAT

 

The prevalence of penicillin allergy labeling ranged from 0.9% to 10.2% across practices in a large pediatric cohort, raising questions regarding the validity of those labels and the unnecessary use of second-line antibiotics that may follow.

28 Mar, 2022 | 09:48h | UTC

Factors Associated With Penicillin Allergy Labels in Electronic Health Records of Children in 2 Large US Pediatric Primary Care Networks – JAMA Network Open

Related: A pharmacist-led penicillin allergy assessment program can delabel many “penicillin allergic” patients through allergy histories and penicillin skin testing. The program was associated with reduced use of high Clostridioides difficile infection–risk antibiotics.

M-A: Most patients with allergy to Penicillin can be given Cefazolin

Systematic review: Safety and efficacy of de-labelling penicillin allergy in adults using direct oral challenge

Penicillin allergy labels increase second-line broad-spectrum antibiotic prescribing for pediatric respiratory tract infections

Podcast: A Clinical Pharmacologist’s Perspective on Penicillin Allergy

Study: Development and Validation of a Penicillin Allergy Clinical Decision Rule

Consensus Recommendations: Management of a Surgical Patient with a Label of Penicillin Allergy

Practical Guide for Pharmacists to Successfully Implement Penicillin Allergy Skin Testing

NICE: Double Check Patients with ‘Penicillin Allergy’ to Avoid Increased MRSA Risk

Cohort Study: Risk of Meticillin Resistant Staphylococcus Aureus and Clostridium Difficile in Patients with a Documented Penicillin Allergy

 

Commentary on Twitter

 

Retrospective Cohort: A population-based study in Sweden and Norway did not find an increased risk of pregnancy complications after COVID-19 vaccination.

28 Mar, 2022 | 09:51h | UTC

Association of SARS-CoV-2 Vaccination During Pregnancy With Pregnancy Outcomes – JAMA

See also: Association of COVID-19 Vaccination in Pregnancy With Adverse Peripartum Outcomes – JAMA

Editorial: COVID-19 mRNA Vaccines During Pregnancy: New Evidence to Help Address Vaccine Hesitancy – JAMA

News Release: No increase in pregnancy complications after COVID-19 vaccination – Karolinska Institutet

 

Review | Imaging findings of gastrointestinal tract tumors in children and adolescents.

25 Mar, 2022 | 08:38h | UTC

Imaging findings of gastrointestinal tract tumors in children and adolescents – Insights into Imaging

 

Cohort Study: Risk of mental health problems in children and youths following concussion.

25 Mar, 2022 | 08:29h | UTC

Risk of Mental Health Problems in Children and Youths Following Concussion – JAMA Network Open

Commentaries:

Contextual Considerations for the Increased Risk of Mental Health Problems Following Concussion in Youth – JAMA Network Open

Concussion Linked to Mental Health Issues Among Children Aged 5 to 18 Years – HealthDay

 

Food protein-induced enterocolitis syndrome: A large French multicentric experience.

25 Mar, 2022 | 08:27h | UTC

Food protein-induced enterocolitis syndrome: A large French multicentric experience – Clinical and Translational Allergy

 

RCT: Among premature infants with a gestational age of less than 30 weeks and intubated for at least 7 days at 14 to 28 days, hydrocortisone did not improve survival without bronchopulmonary dysplasia.

24 Mar, 2022 | 09:58h | UTC

Hydrocortisone to Improve Survival without Bronchopulmonary Dysplasia – New England Journal of Medicine (link to abstract – $ for full-text)

See also: Visual Abstract

Related:

Randomized Trial: Effect of Hydrocortisone on Mortality or Bronchopulmonary Dysplasia Among Very Preterm Infants Receiving Mechanical Ventilation

Systematic Review: Late (after 6 days) systemic postnatal corticosteroids for prevention of bronchopulmonary dysplasia in preterm infants.

Systematic Review: Early (started within six days) systemic postnatal corticosteroids for preventing bronchopulmonary dysplasia in preterm infants.

State of the Art Review: Diagnosis and management of bronchopulmonary dysplasia.

M-A: Assessment of postnatal corticosteroids for the prevention of bronchopulmonary dysplasia in preterm neonates

ERS Guideline on Long-term Management of Children with Bronchopulmonary Dysplasia

 

Commentary on Twitter

 

Test-negative, case-control study: effectiveness of the Pfizer vaccine against COVID-19 in adolescents.

24 Mar, 2022 | 09:44h | UTC

Effectiveness of BNT162b2 against COVID-19 in adolescents – The Lancet Infectious Diseases

 

Commentary on Twitter

 

Oral dextrose gel for the treatment of hypoglycemia in newborn infants.

24 Mar, 2022 | 08:28h | UTC

Oral dextrose gel for the treatment of hypoglycaemia in newborn infants – Cochrane Library

Summary: Oral dextrose gel for the treatment of newborn infants with low blood glucose levels – Cochrane Library

 

Higher cigarette taxes could reduce child deaths, first global estimates suggest.

24 Mar, 2022 | 08:25h | UTC

News Release: Higher cigarette taxes reduce child deaths, first global estimates suggest – Imperial College London

Original Study: Cigarette taxation and neonatal and infant mortality: A longitudinal analysis of 159 countries – PLOS Global Public Health

 

Review: Are we overlooking alcohol use by younger children?

24 Mar, 2022 | 08:21h | UTC

Are we overlooking alcohol use by younger children? – BMJ Paediatrics Open

 

Study suggests an association of strabismus with mood disorders, schizophrenia, and anxiety disorders among children.

24 Mar, 2022 | 08:14h | UTC

Association of Strabismus With Mood Disorders, Schizophrenia, and Anxiety Disorders Among Children – JAMA Pediatrics (link to abstract – $ for full-text)

Commentary: Moderate Associations ID’d for Strabismus, Mental Health Disorders – HealthDay

 

Commentary on Twitter

 

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