Family Medicine
An analysis of Scotland’s mortality in 114,000 SARS-CoV2–infected people revealed that the vaccine effectiveness against death from the Delta variant was 90% for the Pfizer vaccine and 91% for AstraZeneca.
21 Oct, 2021 | 10:15h | UTC
Pfizer vaccine showed estimated effectiveness of 93% against symptomatic SARS-CoV-2 Delta variant infection in adolescents.
21 Oct, 2021 | 10:17h | UTC
Commentary on Twitter
The remarkably high effectiveness (VE) of vaccination for teens vs the Delta variant in over 94,000 vaccinees and 94,000 matched controls: 93% VE vs symptomatic infection (95% CI 88,97) https://t.co/wwoXlw7PH9@NEJM pic.twitter.com/8m3fJ7avc5
— Eric Topol (@EricTopol) October 20, 2021
A case-controlled study showed Covid-19 vaccination during early pregnancy was not associated with increased risk of first-trimester miscarriage.
21 Oct, 2021 | 10:14h | UTCRelated:
Editorial: Covid-19 treatments and vaccines must be evaluated in pregnancy.
Study shows high effectiveness of the Pfizer mRNA COVID-19 vaccine in pregnancy.
5 Crucial Things to Know About COVID-19 Vaccines and Pregnancy.
CDC Guidance: Pregnant people should be vaccinated against COVID-19.
Cohort study: Pfizer/BioNTech COVID vaccine associated with 78% lower risk of Covid-19 in pregnancy.
FDA authorizes booster doses of Moderna and Johnson & Johnson vaccines, says mix and match OK.
21 Oct, 2021 | 10:09h | UTCFDA authorizes booster doses of Moderna and Johnson & Johnson vaccines, says mix and match OK – CNN
See also:
FDA OKs mixing COVID vaccines; backs Moderna, J&J boosters – Associated Press
FDA OKs Moderna, J&J boosters, along with ‘mix and match’ approach – NBC News
Instead of quarantine for Covid-exposed students, some schools are trying test-to-stay.
21 Oct, 2021 | 10:08h | UTCInstead of quarantine for Covid-exposed students, some schools are trying test-to-stay – CNN
Related:
Opinion | Data from routine Covid testing can help schools stay open this year.
Guideline: Erectile Dysfunction.
21 Oct, 2021 | 10:01h | UTC
Opinion | Understanding of research results, evidence summaries and their applicability—not critical appraisal—are core skills of medical curriculum.
21 Oct, 2021 | 09:57h | UTC
Commentary on Twitter
https://twitter.com/lucasmorin_eolc/status/1450876923798765572
Five-year follow-up of RCT: Arthroscopic subacromial decompression provided no benefit over diagnostic arthroscopy or exercise therapy on return to work in patients with shoulder impingement syndrome.
21 Oct, 2021 | 09:54h | UTCRelated:
Randomized Trial: Subacromial Decompression vs Diagnostic Arthroscopy for Shoulder Impingement
Research: Arthroscopic subacromial decompression for subacromial shoulder pain
Systematic Review: Subacromial Decompression Surgery for Rotator Cuff Disease
Systematic Review: Surgery for Rotator Cuff Tears
CDC Study: Pfizer vaccine showed 93% effectiveness against Covid-19 hospitalization among children aged 12-18 years.
20 Oct, 2021 | 10:31h | UTC
Commentary on Twitter (thread – click for more)
Vaccination reduced the risk of hospitalization among 12–18-year-olds by 93%, according to a new CDC study. No vaccinated adolescents died or were admitted to the ICU.
— Dr. Tom Frieden (@DrTomFrieden) October 19, 2021
Cohort Study: Hypertensive disorders of pregnancy are associated with a 6-fold or higher increased risk of chronic hypertension in the first years following delivery.
21 Oct, 2021 | 09:51h | UTCEditorial: Impact of hypertensive disorders of pregnancy: lessons from CONCEPTION
Commentary on Twitter
Hypertensive disorders of pregnancy and onset of chronic hypertension in France: the nationwide CONCEPTION study@escardio #EHJ #cardiotwitterhttps://t.co/OnJRP94W6v pic.twitter.com/N3dLNTD5XU
— EHJ Editor-in-Chief (@ehj_ed) October 17, 2021
Cohort Study: The effectiveness of heterologous AstraZeneca (AZ)/mRNA prime-boost vaccination was more significant (68%) compared to the effectiveness of homologous AZ/AZ vaccination (50%) against symptomatic Covid-19 infection in Sweden.
20 Oct, 2021 | 10:27h | UTCCommentary: High effectiveness of mix-and-match COVID-19 vaccines – UMEA University
Related:
A primer on what we know about mixing and matching Covid vaccines.
Another study shows increased immune response with heterologous Oxford-AstraZeneca/mRNA vaccination.
RCT: Mixing 2 different Covid vaccines is associated with increased risk of side effects.
Commentary on Twitter
Study from Sweden assessing heterogenous vaccination in 3,445,061 individuals who received AZ as the first dose and either #pfizer, #moderna, or #AZ as second dose showed the following vaccine effectiveness:
AZ/Pfizer- 67%
AZ/Moderna- 79%
AZ/AZ- 50%https://t.co/UN0pey2kJ2— Yan Leyfman, MD (@YLeyfman) October 19, 2021
Should You Mix and Match Your Booster Shot?
20 Oct, 2021 | 10:25h | UTCShould You Mix and Match Your Booster Shot? – The Atlantic
Related:
A primer on what we know about mixing and matching Covid vaccines.
Another study shows increased immune response with heterologous Oxford-AstraZeneca/mRNA vaccination.
RCT: Mixing 2 different Covid vaccines is associated with increased risk of side effects.
Global Initiative for Asthma (GINA) Strategy 2021 – Executive summary and rationale for key changes.
20 Oct, 2021 | 10:20h | UTC
RCT: In patients with Type 2 Diabetes, Tirzepatide is associated with reduced weight, improved glycemic control, and lower risk of hypoglycemia compared to insulin glargine.
20 Oct, 2021 | 10:13h | UTCTirzepatide versus insulin glargine in type 2 diabetes and increased cardiovascular risk (SURPASS-4): a randomised, open-label, parallel-group, multicentre, phase 3 trial – The Lancet (link to abstract – $ for full-text)
Related:
Review: Athletes and Hypertension.
20 Oct, 2021 | 09:52h | UTCAthletes and Hypertension – Current Cardiology Reports
Large observational study suggests Tramadol is associated with increased risk of adverse outcomes compared to Codeine.
20 Oct, 2021 | 10:11h | UTCAssociation of Tramadol vs Codeine Prescription Dispensation With Mortality and Other Adverse Clinical Outcomes – JAMA (free for a limited period)
Editorial: Tramadol, Codeine, and Risk of Adverse Outcomes – JAMA (free for a limited period)
Cohort study: Acute urinary retention may be a clinical marker of occult prostate cancer and other urogenital, colorectal, and neurological cancers.
20 Oct, 2021 | 09:50h | UTCAcute urinary retention and risk of cancer: population based Danish cohort study – The BMJ
Commentary on Twitter
This study finds that a first diagnosis of acute urinary retention in patients aged 50 years or older was a clinical marker not only for prostate cancer but also for other urogenital cancers and colorectal and neurological cancershttps://t.co/0f1Z93cqR0 @dceaarhus
— The BMJ (@bmj_latest) October 19, 2021
Long-term consequences of the misuse of ivermectin data.
19 Oct, 2021 | 09:56h | UTCLong-term consequences of the misuse of ivermectin data – The Lancet Infectious Diseases
Related:
Ivermectin: How false science created a Covid ‘miracle’ drug.
Fraudulent ivermectin studies open up new battleground between science and misinformation.
The lesson of ivermectin: meta-analyses based on summary data alone are inherently unreliable.
Ivermectin: Cochrane’s most talked about review so far, ever. Why?
Flawed ivermectin preprint highlights challenges of COVID drug studies.
Systematic review: no evidence to support the use of Ivermectin for treating or preventing COVID-19.
Why was a major study on ivermectin for covid-19 just retracted?
RCT: Ivermectin does not prevent hospitalizations in patients with COVID-19.
RCT: Ivermectin does not improve time to resolution of symptoms among adults with mild COVID-19
Commentary on Twitter
Ivermectin's data for Covid, checkered with inconsistencies, small/low quality clinical trials, and fraud, have long-term consequences for the drug's established and essential useshttps://t.co/NG6vpej8GP @TheLancetInfDis pic.twitter.com/Oz0FxUJetK
— Eric Topol (@EricTopol) October 18, 2021
Systematic Review: Colchicine for the treatment of COVID‐19 – not beneficial for hospitalized patients; inconclusive evidence for the treatment of non-hospitalized patients, “probably slightly reduces the need for hospitalization or death within 28 days compared to placebo”.
19 Oct, 2021 | 10:13h | UTCColchicine for the treatment of COVID‐19 – Cochrane Library
Related:
Commentary on Twitter
JUST PUBLISHED – Is #colchicine (often used to treat #gout) an effective treatment for people with #COVID19? ➡️ https://t.co/IF1enksFpn New @CochraneHaem systematic review includes evidence from 4 RCTS with 11,525 hospitalised & 4488 non‐hospitalised people.
— The Cochrane Library (@CochraneLibrary) October 18, 2021
Another observational study suggests Rivaroxaban is associated with higher rates of gastrointestinal bleeding than other direct oral anticoagulants.
19 Oct, 2021 | 09:47h | UTCRivaroxaban Is Associated with Higher Rates of Gastrointestinal Bleeding Than Other Direct Oral Anticoagulants: A Nationwide Propensity Score–Weighted Study – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentary: Rivaroxaban Again Linked to More Bleeding vs Other DOACs – TCTMD
Commentary on Twitter
A new study from @uni_iceland and @Landspitali finds that #Rivaroxaban is associated with a higher risk of GI bleeding compared to other direct oral anticoagulants. https://t.co/2J451CN5dD #afib #bleedingrisk #DOAC pic.twitter.com/Q6VSv5Taqg
— Annals of Int Med (@AnnalsofIM) October 13, 2021
Cluster RCT: An exercise intervention may improve academic achievement among children.
19 Oct, 2021 | 09:45h | UTC
Commentary on Twitter
Physical inactivity is an important health concern worldwide. This study examined the effects of an exercise intervention on children’s academic achievement, cognitive function, physical fitness, and other health-related outcomes: https://t.co/Pdd0qZqYNN #Pediatrics pic.twitter.com/VkyPba3Sv2
— AAP CME Journals (@AAPJournals) October 18, 2021
Guideline: Management of anticoagulants and antiplatelet agents in cutaneous surgery.
19 Oct, 2021 | 09:50h | UTC
Systematic Review: Calcium channel blockers versus other classes of drugs for hypertension – “there is moderate certainty evidence that diuretics reduce major cardiovascular events and congestive heart failure more than CCBs”.
19 Oct, 2021 | 08:56h | UTCSummary: Calcium channel blockers versus other classes of drugs for hypertension – Cochrane Library
Original Study: Calcium channel blockers versus other classes of drugs for hypertension – Cochrane Library
Commentary on Twitter
How do calcium channel blockers compare to other #antihypertensive drugs for #hypertension?💊
Our @CochraneLibrary systematic review looks at evidence from 23 RCTs involving 153,849 participants with #highbloodpressure
👉🏾https://t.co/dDLCY1RoOT#SystematicReviews #SysRev pic.twitter.com/zJ4JNRRf0L
— Cochrane Hypertension (@CochraneHTN) October 17, 2021
Podcast: Diagnosis and treatment of Celiac Disease.
19 Oct, 2021 | 08:54h | UTC#300 Celiac Disease with Dr. Amy Oxentenko – The Curbsiders
Bioethics | The Reluctant Patient and the Insistent Doctor.
19 Oct, 2021 | 08:50h | UTCThe Reluctant Patient and the Insistent Doctor – The American Journal of Medicine