Family Medicine
Review: Stroke prevention after cryptogenic stroke.
19 Oct, 2021 | 08:46h | UTCStroke Prevention After Cryptogenic Stroke – Current Cardiology Reports
Related:
Canadian Stroke Best Practice Recommendations for Acute Stroke Management
J&J COVID-19 Vaccine: FDA recommends booster shot for all adults aged 18 and older at least two months following initial vaccination with the single-shot vaccine.
17 Oct, 2021 | 21:32h | UTCCommentaries:
FDA panel endorses booster shot for J&J COVID-19 vaccine – Associated Press
FDA advisers recommend J&J Covid-19 vaccine boosters, talk mix and match boosters – CNN
[Preprint] Breakthrough SARS-CoV-2 infections in 620,000 U.S. Veterans, February 1, 2021 to August 13, 2021 – “Vaccine protection declined by mid-August 2021, decreasing from 91.9% in March to 53.9%”.
17 Oct, 2021 | 21:29h | UTCRelated:
Editorial | Covid-19 vaccination: evidence of waning immunity is overstated.
COVID vaccine effects wane over time but still prevent death and severe illness.
Perspective | What we actually know about waning immunity.
Another study shows Pfizer mRNA vaccine immunity is reduced over time.
Studies: COVID vaccine protection waning against infection but not hospitalization.
Commentary on Twitter
New on breakthrough infections in 620,000 Veterans
"Vaccine protection declined by mid-August 2021, decreasing from 91.9% in March to 53.9%"https://t.co/xonBb4aEqJ highest reduction with J&J vaccine pic.twitter.com/rbhXOREFPP— Eric Topol (@EricTopol) October 15, 2021
Management of Diabetes Mellitus in patients with CKD: Core Curriculum 2022.
17 Oct, 2021 | 21:23h | UTC
What can masks do? Part 2: What makes for a good mask study — and why most fail.
17 Oct, 2021 | 21:25h | UTCCOMMENTARY: What can masks do? Part 2: What makes for a good mask study — and why most fail – CIDRAP
See also: COMMENTARY: What can masks do? Part 1: The science behind COVID-19 protection – CIDRAP
Viewpoint: Surgical overtreatment and shared decision-making—the limits of choice. – “Payment models further incentivize surgical intervention. Fee-for-service payment plans reward surgeons for operating, not for ensuring that surgery is right for a patient”.
17 Oct, 2021 | 21:17h | UTCSurgical Overtreatment and Shared Decision-making—The Limits of Choice – JAMA Surgery (free for a limited period)
Commentary on Twitter
“Adjusting payment models to mitigate financial incentives..to overtreat is a start. However..greater focus should be given to the myriad other causes of overtreatment,” such as triggers of care cascades, write Clapp, Schwarze & @LeeAFleisher. https://t.co/f4mPsnxyVB
— Ben Harder #BlackLivesMatter (@benharder) October 14, 2021
M-A: Effectiveness and safety of non-steroidal anti-inflammatory drugs and opioid treatment for knee and hip osteoarthritis – although Etoricoxib 60 mg/day and diclofenac 150 mg/day seem to be most effective treatments, topical diclofenac 70-81 mg/day is safer and should be considered as first line treatment.
17 Oct, 2021 | 21:14h | UTCNews release: Topical pain-killers more effective, safer than opioids for knee osteoarthritis pain – St. Michael’s Hospital
Commentary: Network meta-analysis compares analgesic regimens for osteoarthritis – medwire News
Commentary on Twitter
Etoricoxib 60 mg/day and diclofenac 150 mg/day seem to be the most effective oral NSAIDs for knee and hip osteoarthritis pain and physical function, but might not be appropriate in the presence of comorbidities or for long term use, concludes #BMJResearchhttps://t.co/rrtX3BnQE5
— The BMJ (@bmj_latest) October 16, 2021
RCT: After third molar surgery, Ibuprofen doses above 400 mg did not significantly increase the analgesic effect, and Paracetamol 1000/codeine 60 mg was not more effective than ibuprofen 400 mg.
17 Oct, 2021 | 21:16h | UTC
Statins linked to reduced risk of death from COVID-19 in major population study – “Randomized studies will be needed to ascertain whether there is a causal relationship, note the researchers”.
15 Oct, 2021 | 02:47h | UTCNews release: Statins linked to reduced risk of death from COVID-19 in major population study – Karolinska Institutet
Original study: HMG-CoA reductase inhibitors and COVID-19 mortality in Stockholm, Sweden: A registry-based cohort study – PLOS Medicine
Commentaries:
Expert reaction to study looking at statins and risk of death from COVID-19 – Science Media Centre
People taking statins less likely to die from Covid, study suggests – The Guardian
Editorial: Covid-19 treatments and vaccines must be evaluated in pregnancy.
15 Oct, 2021 | 02:41h | UTCCovid-19 treatments and vaccines must be evaluated in pregnancy – The BMJ
Related:
Study shows high effectiveness of the Pfizer mRNA COVID-19 vaccine in pregnancy.
5 Crucial Things to Know About COVID-19 Vaccines and Pregnancy.
CDC Guidance: Pregnant people should be vaccinated against COVID-19.
Cohort study: Pfizer/BioNTech COVID vaccine associated with 78% lower risk of Covid-19 in pregnancy.
Commentary on Twitter
Inconsistent messaging from authorities, driven by lack of trial data, has increased covid-19 vaccine hesitancy among pregnant women@DrAllyah and colleagues argue that pregnant women should be included in drug and vaccine development from the outsethttps://t.co/P3v1ouk8tQ
— The BMJ (@bmj_latest) October 14, 2021
FDA issues food industry guidance for reduction of sodium in processed and packaged foods.
15 Oct, 2021 | 02:29h | UTCGuidance for Industry: Voluntary Sodium Reduction Goals – U.S. Food & Drug Administration
Commentaries:
FDA Issues New Guidance on Sodium Targets for Food Industry – TCTMD
Reducing Sodium Intake in the US: Healthier Lives, Healthier Future – JAMA
FDA Reduces Recommended Salt Levels in Americans’ Food – HealthDay
FDA guidance to food industry aims to reduce sodium consumption – American Heart Association
New FDA guidance aims to drastically cut salt in food supply – NBC News
Cohort study: Vaccinated pregnant patients had 90% lower risk of severe or critical Covid-19 compared with unvaccinated pregnant patients.
15 Oct, 2021 | 02:38h | UTCRelated:
Study shows high effectiveness of the Pfizer mRNA COVID-19 vaccine in pregnancy.
5 Crucial Things to Know About COVID-19 Vaccines and Pregnancy.
CDC Guidance: Pregnant people should be vaccinated against COVID-19.
Cohort study: Pfizer/BioNTech COVID vaccine associated with 78% lower risk of Covid-19 in pregnancy.
Commentary on Twitter (thread – click for more)
First dataset I have seen for vaccine efficacy in pregnant persons during #Delta era. Impressive aOR for both severe illness (0.11) and infection positivity in general (0.31)! #GetVaccinatedNow 🤰🏻💉 https://t.co/VhBHyeOWjz
— Lauren Hassen, MD MPH (@ljhassen) October 14, 2021
Systematic Review: “Formula milk trials have a high risk of bias, almost always report favorable conclusions, lack transparency, and selectively report findings”.
15 Oct, 2021 | 02:25h | UTCNews release: Formula milk trials are not reliable, warn researchers – Imperial College London
Original study: Conduct and reporting of formula milk trials: systematic review – The BMJ
WHO Report: Tuberculosis deaths rise for the first time in more than a decade due to the COVID-19 pandemic.
15 Oct, 2021 | 02:30h | UTCReport: Global tuberculosis report 2021
Commentary: Tuberculosis deaths rise for 1st time in years, due to COVID – Associated Press
Commentary on Twitter (thread – click for more)
🆕 WHO's Global TB Report reveals deaths from #tuberculosis rise for the first time in more than a decade due to the #COVID19 pandemic.
1.5 million people died in 2020 & the number will continue to rise unless urgent action is taken 👉https://t.co/RFmWYIelhq #EndTB pic.twitter.com/33G7sI8K2J
— World Health Organization (WHO) (@WHO) October 14, 2021
Former CDC director: Low sodium salt could save millions of lives.
15 Oct, 2021 | 02:27h | UTCFormer CDC director: Low sodium salt could save millions of lives – CNN
Related:
Is salt good for you after all? The evidence says no.
Systematic Review: Altered dietary salt intake for people with chronic kidney disease.
New WHO benchmarks help countries reduce salt intake and save lives.
RCT: Reduced-sodium added-potassium salt substitute reduces blood pressure in hypertensive patients
Potassium Enriched Salt Substitution Could Prevent a Large Number of Cardiovascular Deaths
Meta-Analysis: Effect of Reduction in Dietary Sodium on Blood Pressure Levels
Meta-analysis of cohort studies: High intake of fatty acid in nuts, seeds and plant oils linked to lower risk of death.
15 Oct, 2021 | 02:22h | UTCNews release: High intake of fatty acid in nuts, seeds and plant oils linked to lower risk of death – The BMJ
Commentaries:
Current evidence on dietary intakes of fatty acids and mortality – The BMJ
Commentary on Twitter
NEW research: A high intake of alpha linolenic acid, found mainly in nuts, seeds, and plant oils, is associated with a lower risk of death from all causes, and specifically from diseases of the heart and blood vessels, finds a study https://t.co/HGvg8dBUUN
— The BMJ (@bmj_latest) October 14, 2021
Systematic Review: Short-term and long-term rates of postacute sequelae of SARS-CoV-2 infection.
14 Oct, 2021 | 10:15h | UTCCommentaries:
Most COVID-19 survivors have symptoms 6 months on, review finds – CIDRAP
How many people get ‘long COVID’? More than half, researchers find – Penn State
Related:
WHO Consensus: A clinical case definition of post COVID-19 condition (Long Covid).
Characterizing long COVID: a living systematic review.
Long Covid – The illness narratives.
New guidelines to help doctors manage long COVID patients published.
M-A: More than 50 long-term effects of COVID-19. (several articles on the subject)
Commentary on Twitter
Most #COVID19 survivors have symptoms 6 months on, review finds
Data on more than 250,000 survivors reveal 54% had at least 1 symptom 6 months or more after diagnosis #LongCovidhttps://t.co/xd0lvhQFfL pic.twitter.com/65mqe7SQPg
— CIDRAP (@CIDRAP) October 13, 2021
[Preprint] In RCT with 29,949 participants, the Novavax vaccine demonstrated high overall efficacy (>90%) for the prevention of Covid-19, and all moderate-to-severe cases occurred in placebo recipients.
14 Oct, 2021 | 10:17h | UTCEfficacy and Safety of NVX-CoV2373 in Adults in the United States and Mexico – medRxiv
Commentary: Novel vaccine demonstrates high efficacy for prevention of COVID-19 – News Medical
Related:
Opinion | The mRNA vaccines are extraordinary, but Novavax is even better.
RCT: Novavax vaccine is 49.4% effective against B.1.351 SARS-CoV-2 variant.
New COVID-19 vaccines: here’s how the promising Novavax and Johnson & Johnson jabs work
Covid-19: Novavax vaccine efficacy is 86% against UK variant and 60% against South African variant
Commentary on Twitter
Remember Novavax's #COVID vaccine?
Recent data looks really good.
~30K participants enrolled in a prospective clinical trial.
The vaccine appeared to be safe & effective (>90%).
Unclear why approval is taking so long.
Preprint 👉 https://t.co/MQkJXdgJyR pic.twitter.com/217Erw2stC
— Isaac Bogoch (@BogochIsaac) October 12, 2021
Podcast with Dr Walter Willett: CardioNutrition – Why are findings from prospective, epidemiologic cohort studies important in informing dietary recommendations?
14 Oct, 2021 | 09:49h | UTC
Commentary on Twitter
In this episode of CardioNutrition, @DrOstfeld and Dr. Walter Willett discuss why findings from prospective, epidemiologic cohort studies are important in informing dietary recommendations. Learn more here: https://t.co/IfIgauGhV9 #cvPrev #cvLipids pic.twitter.com/flet8ZTwFe
— American College of Cardiology (@ACCinTouch) October 8, 2021
Survey finds patients undergoing medical imaging procedures have overall limited knowledge about medical radiation.
14 Oct, 2021 | 09:46h | UTCPatient Perceptions and Knowledge of Ionizing Radiation From Medical Imaging – JAMA Network Open
Invited commentary: It Is Time to Inform Patients of Medical Imaging Risks – JAMA Network Open
WHO advisers recommend 3rd COVID vaccine dose for highest-risk groups.
13 Oct, 2021 | 01:48h | UTCWHO advisers recommend 3rd COVID vaccine dose for highest-risk groups – CIDRAP
See also: WHO advises additional COVID shot for immunocompromised people – Reuters
A primer on what we know about mixing and matching Covid vaccines.
13 Oct, 2021 | 01:44h | UTCA primer on what we know about mixing and matching Covid vaccines – STAT
Related:
Another study shows increased immune response with heterologous Oxford-AstraZeneca/mRNA vaccination.
RCT: Mixing 2 different Covid vaccines is associated with increased risk of side effects.
USPSTF draft statement revises previous guidance and now recommends against initiating low-dose aspirin use for the primary prevention of CVD in adults aged 60 years or older.
13 Oct, 2021 | 01:36h | UTCCommentaries:
Advice shifting on aspirin use for preventing heart attacks – Associated Press
Taking aspirin to prevent heart attack may cause more harm than good, task force says – NPR
Related Randomized Trials:
Randomized Trial: Aspirin for Primary Prevention of Cardiovascular Disease
Randomized Trial: Effects of Aspirin for Primary Prevention in Persons with Diabetes
Randomized Trial: Effect of Aspirin on All-Cause Mortality in the Healthy Elderly
Related Meta-Analysis:
Meta-Analysis: Efficacy and Safety of Aspirin for Primary Prevention of Cardiovascular Events
Related Opinions:
Aspirin for Primary Prevention: Is This the End of the Road?
Evidence evolving on aspirin as prevention – ACP Internist
Commentary on Twitter
Low Dose Aspirin in the Primary Prevention of Cardiovascular Disease: #USPSTF recommends individualized decision making between 50 and 59 years, and against aspirin use in 60 years+. What a difference a few years can make, with more data and evidence. https://t.co/3nC3jpjTDq pic.twitter.com/SN8K3Z9XJj
— Muin J. Khoury (@MuinJKhoury) October 12, 2021
ACR Announces New Appropriateness Criteria for Diagnostic Exams.
13 Oct, 2021 | 01:32h | UTCAmerican College of Radiology Announces New Appropriateness Criteria – Medical Device News Magazine
New Guidance: ACR Appropriateness Criteria
RCT: Laser treatment not better than sham treatment on symptom severity in women with postmenopausal vaginal symptoms.
13 Oct, 2021 | 01:30h | UTCEffect of Fractional Carbon Dioxide Laser vs Sham Treatment on Symptom Severity in Women With Postmenopausal Vaginal Symptoms: A Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Time for a “Pause” on the Use of Vaginal Laser (free for a limited period)
Author Interview: Effect of Carbon Dioxide Laser vs Sham Therapy on Women With Postmenopausal Vaginal Symptoms
Commentary: Vagina lasering for postmenopausal women ‘may be placebo’ – The Guardian
Commentary on Twitter
In a randomized clinical trial among women with postmenopausal vaginal symptoms, treatment with fractional carbon dioxide laser vs sham treatment did not improve vaginal symptoms after 12 months https://t.co/XXv5edTLiL
— JAMA (@JAMA_current) October 12, 2021