RCT: After third molar surgery, Ibuprofen doses above 400 mg did not significantly increase the analgesic effect, and Paracetamol 1000/codeine 60 mg was not more effective than ibuprofen 400 mg. 17 Oct, 2021 | 21:16h | UTC Analgesic effect of oral ibuprofen 400, 600, and 800 mg; paracetamol 500 and 1000 mg; and paracetamol 1000 mg plus 60 mg codeine in acute postoperative pain: a single-dose, randomized, placebo-controlled, and double-blind study – European Journal of Clinical Pharmacology