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M-A | Primary surgery vs. primary rehabilitation for treating anterior cruciate ligament injuries.

6 Sep, 2022 | 14:35h | UTC

Primary surgery versus primary rehabilitation for treating anterior cruciate ligament injuries: a living systematic review and meta-analysis – British Journal of Sports Medicine

News Release: Anterior cruciate ligament tear: Is an operation always necessary? – Judith Merkelt-Jedamzik, Hochschule für Gesundheit

Related:

RCT | Surgical reconstruction is superior to rehabilitation for patients with non-acute anterior cruciate ligament injury with persistent symptoms of instability.

Early surgical reconstruction versus rehabilitation with elective delayed reconstruction for patients with anterior cruciate ligament rupture: COMPARE randomised controlled trial – The BMJ

 

Commentary on Twitter

 

Consensus Statement | Preoperative management of cardiovascular medications.

5 Sep, 2022 | 14:42h | UTC

Preoperative Management of Cardiovascular Medications: A Society for Perioperative Assessment and Quality Improvement (SPAQI) Consensus Statement – Mayo Clinic Proceedings

Related:

Preoperative Management of Medications for Rheumatologic and HIV Diseases: Society for Perioperative Assessment and Quality Improvement (SPAQI) Consensus Statement – Mayo Clinic Proceedings

Preoperative Evaluation and Management of Patients With Select Chronic Gastrointestinal, Liver, and Renal Diseases – Mayo Clinic Proceedings

Preoperative Management of Medications for Neurologic Diseases – Mayo Clinic Proceedings

Preoperative Management of Medications for Psychiatric Diseases: Society for Perioperative Assessment and Quality Improvement Consensus Statement – Mayo Clinic Proceedings

Preoperative Management of Gastrointestinal and Pulmonary Medications: Society for Perioperative Assessment and Quality Improvement (SPAQI) Consensus Statement – Mayo Clinic Proceedings

Preoperative Management of Endocrine, Hormonal, and Urologic Medications: Society for Perioperative Assessment and Quality Improvement (SPAQI) Consensus Statement – Mayo Clinic Proceedings

Preoperative Management of Opioid and Nonopioid Analgesics: Society for Perioperative Assessment and Quality Improvement (SPAQI) Consensus Statement – Mayo Clinic Proceedings

Preoperative Management of Surgical Patients Using Dietary Supplements – Mayo Clinic Proceedings

Perioperative Evaluation and Management of Endocrine Disorders – Mayo Clinic Proceedings

Preoperative Cardiac Risk Assessment – Mayo Clinic Proceedings

Preoperative Evaluation Before Noncardiac Surgery – Mayo Clinic Proceedings

Perioperative Cardiac Risk Reduction in Noncardiac Surgery – Mayo Clinic Proceedings

Examining Risk: A Systematic Review of Perioperative Cardiac Risk Prediction Indices – Mayo Clinic Proceedings

Perioperative Venous Thromboembolism Prophylaxis – Mayo Clinic Proceedings

 

RCT | Efficacy of prednisolone for Bell Palsy in children.

5 Sep, 2022 | 14:39h | UTC

Efficacy of Prednisolone for Bell Palsy in Children: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial – Neurology (link to abstract – $ for full-text)

 

Commentary on Twitter

 

RCT | Bronchodilators don’t improve smoking-related respiratory symptoms in people without COPD.

5 Sep, 2022 | 14:40h | UTC

News Release: Bronchodilators don’t improve smoking-related respiratory symptoms in people without COPD – NIH News Releases

Original Study: Bronchodilators in Tobacco-Exposed Persons with Symptoms and Preserved Lung Function – New England Journal of Medicine (link to abstract – $ for full-text)

 

Commentary on Twitter

 

Perspective | Science, competing values, and trade-offs in public health — the example of Covid-19 and masking.

5 Sep, 2022 | 14:37h | UTC

Science, Competing Values, and Trade-offs in Public Health — The Example of Covid-19 and Masking – New England Journal of Medicine

 

FDA authorizes updated COVID boosters from Moderna and Pfizer.

5 Sep, 2022 | 14:36h | UTC

FDA authorizes updated COVID boosters from Moderna and Pfizer – CIDRAP

FDA News Release: Coronavirus (COVID-19) Update: FDA Authorizes Moderna, Pfizer-BioNTech Bivalent COVID-19 Vaccines for Use as a Booster Dose – U.S. Food & Drug Administration

 

Opinion | People with terminal cancer need to know they are dying. Doctors shouldn’t withhold that information.

5 Sep, 2022 | 14:35h | UTC

People with terminal cancer need to know they are dying. Doctors shouldn’t withhold that information – STAT

Related Study: Association of Prognostic Understanding With Health Care Use Among Older Adults With Advanced Cancer: A Secondary Analysis of a Cluster Randomized Clinical Trial – JAMA Network Open

 

Cohort Study | Habitual alcohol intake and risk of atrial fibrillation in young adults.

5 Sep, 2022 | 14:33h | UTC

Habitual Alcohol Intake and Risk of Atrial Fibrillation in Young Adults in Korea – JAMA Network Open

Invited Commentary: Self-reported Alcohol Consumption and Risk of Atrial Fibrillation – JAMA Network Open

 

A pilot study showed GnRH replacement could improve cognition in Down syndrome.

5 Sep, 2022 | 14:34h | UTC

GnRH replacement rescues cognition in Down syndrome – Science (link to abstract – $ for full-text)

News Release: A therapy found to improve cognitive function in patients with Down syndrome – INSERM

Commentary: A Hormone May Boost Cognition in Down Syndrome – Scientific American

 

2022 ACC Expert Consensus | Role of nonstatin therapies for LDL-cholesterol lowering and managing cardiovascular disease risk.

2 Sep, 2022 | 13:17h | UTC

2022 ACC Expert Consensus Decision Pathway on the Role of Nonstatin Therapies for LDL-Cholesterol Lowering in the Management of Atherosclerotic Cardiovascular Disease Risk: A Report of the American College of Cardiology Solution Set Oversight Committee – Journal of the American College of Cardiology

News Release: ACC Issues Guidance to Address New Nonstatin Therapies – American College of Cardiology

Commentary: New on the Scene Nonstatin Drugs: Experts Provide Guidance – TCTMD

 

Commentary on Twitter

 

RCT | Bedaquiline–Pretomanid–Linezolid regimens for drug-resistant tuberculosis.

2 Sep, 2022 | 13:16h | UTC

Bedaquiline–Pretomanid–Linezolid Regimens for Drug-Resistant Tuberculosis – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Three drug regimen with Linezolid 600 mg tied to better outcomes in drug-resistant TB – Medical Dialogues

 

RCT | Fractional flow reserve or intravascular ultrasonography to guide percutaneous coronary intervention.

2 Sep, 2022 | 13:15h | UTC

Fractional Flow Reserve or Intravascular Ultrasonography to Guide PCI – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Fractional Flow Reserve Noninferior to IVUS for Guiding PCI – HealthDay

 

Cohort Studies | Increased consumption of ultra-processed foods linked to increased risk of mortality and cancer.

2 Sep, 2022 | 13:15h | UTC

Study 1: Association of ultra-processed food consumption with colorectal cancer risk among men and women: results from three prospective US cohort studies – The BMJ

Study 2: Joint association of food nutritional profile by Nutri-Score front-of-pack label and ultra-processed food intake with mortality: Moli-sani prospective cohort study – The BMJ

Editorial: The trouble with ultra-processed foods – The BMJ

Commentaries:

Expert reaction to two studies looking at ultra-processed foods and heart disease, bowel cancer and death – Science Media Centre

Ultraprocessed foods linked to cancer and early death, studies find – CNN

New research gives more reasons to eat less-processed food – The Guardian

 

AHA Scientific Statement | Management of infective endocarditis in people who inject drugs.

1 Sep, 2022 | 12:00h | UTC

Management of Infective Endocarditis in People Who Inject Drugs: A Scientific Statement From the American Heart Association – Circulation

News Release: Addiction management is key to treating heart infection in people who inject drugs – American Heart Association

Top Things to Know: Infective Endocarditis in People Who Inject Drugs – American Heart Association

Video: Management of Infective Endocarditis in People who Inject Drugs – American Heart Association

Commentaries:

Infective Endocarditis in People Who Inject Drugs: A Call for Patient-Centered, Multidisciplinary Care – American Heart Association

AHA Addresses Infective Endocarditis in Injection Drug Users – HealthDay

Related: Management of Infective Endocarditis in People Who Inject Drugs – American College of Cardiology (the original article is paywalled but has an informative infographic)

 

Review | Covid-19 vaccines — immunity, variants, boosters.

1 Sep, 2022 | 11:57h | UTC

Covid-19 Vaccines — Immunity, Variants, Boosters – New England Journal of Medicine

 

After the genome—a brief history of proteomics.

1 Sep, 2022 | 11:58h | UTC

After the Genome—A Brief History of Proteomics – JAMA (free for a limited period)

Video: Proteomics 101 – JAMA

 

Commentary on Twitter

 

Risk of BA.5 infection among persons exposed to previous SARS-CoV-2 variants.

1 Sep, 2022 | 11:56h | UTC

Risk of BA.5 Infection among Persons Exposed to Previous SARS-CoV-2 Variants – New England Journal of Medicine

 

Commentary on Twitter

 

Cohort Study | Dolutegravir in pregnancy as compared with current HIV regimens.

1 Sep, 2022 | 11:55h | UTC

Dolutegravir in Pregnancy as Compared with Current HIV Regimens in the United States – New England Journal of Medicine (link to abstract – $ for full-text)

Related:

RCT | 72 weeks post-partum follow-up of dolutegravir versus efavirenz initiated in late pregnancy.

WHO Recommends Dolutegravir as Preferred HIV Treatment Option in All Populations

Week 96 results from a RCT: Efficacy and safety of dolutegravir or darunavir combined with lamivudine plus either zidovudine or tenofovir for second-line treatment of HIV infection.

RCT: Efficacy and safety of switching to the 2-drug regimen Dolutegravir/Lamivudine vs. continuing a 3- or 4-Drug regimen for maintaining virologic suppression in adults living with HIV-1.

RCT: Low-cost, easy to take antiretroviral treatment based on Dolutegravir as first- or second-Line therapy found to be non-inferior to standard care for treating HIV-1 infection in children.

RCT: Dolutegravir or Darunavir in combination with Zidovudine or Tenofovir to treat HIV.

Randomized controlled trial compared three antiretroviral regimens started in pregnant women with HIV

Randomized Trial: Switching to Dolutegravir/Lamivudine Two-Drug Regimen Noninferior to Continuing a Tenofovir Alafenamide–Based Three- or Four-Drug Regimen for Maintenance of Virologic Suppression in Adults With HIV-1

 

Commentary on Twitter

 

Reports of asymptomatic monkeypox suggest that, at the very least, some infections go unnoticed.

1 Sep, 2022 | 11:54h | UTC

Reports of Asymptomatic Monkeypox Suggest That, at the Very Least, Some Infections Go Unnoticed – JAMA

 

Guideline | Fecal immunochemical testing in patients with signs or symptoms of suspected colorectal cancer.

31 Aug, 2022 | 11:52h | UTC

Faecal immunochemical testing (FIT) in patients with signs or symptoms of suspected colorectal cancer (CRC): a joint guideline from the Association of Coloproctology of Great Britain and Ireland (ACPGBI) and the British Society of Gastroenterology (BSG) – Gut

Commentary: Guidelines update: use of FIT in colorectal cancer referrals – PULSE

 

Review/Perspective | European hypertension guideline downgrading of beta-blockers is not justified.

31 Aug, 2022 | 11:51h | UTC

Diverse pharmacological properties, trial results, comorbidity prescribing and neural pathophysiology suggest European hypertension guideline downgrading of beta-blockers is not justified – Blood Pressure

 

Systematic Review | Predictors of burnout among healthcare providers.

31 Aug, 2022 | 11:50h | UTC

Predictors of burnout among US healthcare providers: a systematic review – BMJ Open

 

Commentary on Twitter

 

RCT | Remote physician visits are noninferior to in-home physician visits for patients receiving acute hospital-level care at home (home hospital).

31 Aug, 2022 | 11:49h | UTC

Remote vs In-home Physician Visits for Hospital-Level Care at Home: A Randomized Clinical Trial – JAMA Network Open

Author Interview: Remote vs In-home Physician Visits for Hospital-Level Care at Home – JAMA

 

Commentary on Twitter

 

RCT | Outpatient convalescent plasma therapy for high-risk patients with early COVID-19.

31 Aug, 2022 | 11:48h | UTC

Outpatient convalescent plasma therapy for high-risk patients with early COVID-19. A randomized placebo-controlled trial – Clinical Microbiology and Infection

 

#ESCCongress – M-A | Radial access for coronary interventions confers lower mortality than femoral access.

30 Aug, 2022 | 12:17h | UTC

News Release: Radial access for coronary interventions confers lower mortality than femoral access – European Society of Cardiology

Original Study: Impact on Mortality and Major Bleeding of Radial Versus Femoral Artery Access for Coronary Angiography or Percutaneous Coronary Intervention: a Meta-analysis of Individual Patient Data from Seven Multicenter Randomized Clinical Trials – Circulation (free for a limited period)

Commentary: Less Death, Major Bleeding With Transradial Access: Meta-analysis – TCTMD

 

Commentary on Twitter

 

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