Editor's Choice
#ESCCongress – RCT | A large study with 46.611 individuals between 65 and 74 years of age found that a comprehensive cardiovascular screening program did not significantly reduce the incidence of death from any cause.
29 Aug, 2022 | 12:24h | UTCFive-Year Outcomes of the Danish Cardiovascular Screening (DANCAVAS) Trial – New England Journal of Medicine (link to abstract – $ for full-text)
News Release: Cardiovascular screening may reduce risk of death and cardiovascular disease – European Society of Cardiology
Commentary on Twitter
DANCANVAS: In men age 65-74 years in Denmark, those randomized to invitation to comprehensive screening for subclinical CVD did not have signif reduced all-cause mortality at median 5.6 yrs of follow-up. #ESCCongress https://t.co/YZL87aTVHR pic.twitter.com/HfdiNuU9sK
— NEJM (@NEJM) August 27, 2022
Network Meta-Analysis | Antithrombotic therapy for symptomatic peripheral arterial disease.
26 Aug, 2022 | 13:28h | UTC
RCT | Self-measurement of blood pressure with a standard device is not enhanced by the use of a connected smartphone application.
26 Aug, 2022 | 13:29h | UTCEffectiveness of Standard vs Enhanced Self-measurement of Blood Pressure Paired With a Connected Smartphone Application: A Randomized Clinical Trial – JAMA Internal Medicine (link to abstract – $ for full-text)
News Release: For Checking Blood Pressure at Home, Basic Cuffs Are Just as Good – UC San Francisco
Commentary: App-enabled device no better than standard device for self-measuring blood pressure – ACP Internist
Commentary on Twitter
Monitoring #bloodpressure at home may help with #bloodpressurecontrol, but using an enhanced device pairing with a smartphone application appears to be no more effective than using a standard device. https://t.co/h6zREImCNv #Research pic.twitter.com/T1zWDlp2pC
— JAMA Internal Medicine (@JAMAInternalMed) August 15, 2022
Review | Incremental value of polygenic risk scores in primary prevention of coronary heart disease.
26 Aug, 2022 | 13:26h | UTCIncremental Value of Polygenic Risk Scores in Primary Prevention of Coronary Heart Disease: A Review – JAMA Internal Medicine (free for a limited period)
Related:
Cohort Study | Polygenic risk, midlife life’s simple 7, and lifetime risk of stroke.
AHA Scientific Statement | Polygenic risk scores for cardiovascular disease.
Cohort Study: A polygenic risk score may improve risk stratification of coronary artery disease.
Responsible use of polygenic risk scores in the clinic: potential benefits, risks and gaps.
RCT | HPV self-sampling among long-term non-attenders to cervical cancer screening.
26 Aug, 2022 | 13:27h | UTC
Commentary on Twitter
Pragmatic randomised controlled trial of 3 different HPV screening approaches suggests that opt-in and particularlly send-to-all self-sampling increased participation among long-term, higher-risk non-attenders: https://t.co/hBouqoBMnU #GynCSM #hsronc
— NatureRevClinOncol (@NatRevClinOncol) August 25, 2022
RCT | Efficacy of potassium supplementation on the risk of peritonitis in hypokalemic patients receiving peritoneal dialysis.
26 Aug, 2022 | 13:25h | UTCEfficacy of Potassium Supplementation in Hypokalemic Patients Receiving Peritoneal Dialysis: A Randomized Controlled Trial – American Journal of Kidney Diseases (link to abstract – $ for full-text)
Commentary on Twitter
Efficacy of Potassium Supplementation in Hypokalemic Patients Receiving Peritoneal Dialysis: A Randomized Controlled Trialhttps://t.co/DlEUJJUPr4@PD_Perls @DWJohnsonNeph #VisualAbstract pic.twitter.com/9D0VifCPMb
— AJKD (@AJKDonline) May 23, 2022
Secondary analysis of a RCT | Effects of Empagliflozin on symptoms, physical limitations, and quality of life in patients hospitalized for acute heart failure.
26 Aug, 2022 | 13:24h | UTCCommentary: Empagliflozin Offers Clinical Benefit in Heart Failure – HealthDay
Original Study: The SGLT2 inhibitor empagliflozin in patients hospitalized for acute heart failure: a multinational randomized trial – Nature Medicine
Update on the management of diabetes in long-term care facilities.
26 Aug, 2022 | 13:23h | UTC
Perspective | Double trouble with double-booking: limitations and dangers of overlapping surgery.
26 Aug, 2022 | 13:22h | UTCRelated:
Review | The effect of overlapping surgical scheduling on operating theatre productivity.
Study: Association of Overlapping Surgery with Perioperative Outcomes
Randomized Crossover Trial | In patients with diabetic neuropathic pain, amitriptyline supplemented with pregabalin, pregabalin supplemented with amitriptyline, and duloxetine supplemented with pregabalin were similarly effective.
25 Aug, 2022 | 12:14h | UTC
RCT | In patients with low-risk nasopharyngeal carcinoma, radiotherapy alone was noninferior to radiotherapy plus concurrent chemoradiotherapy on survival without disease relapse at 3 years.
25 Aug, 2022 | 12:13h | UTCEffect of Radiotherapy Alone vs Radiotherapy With Concurrent Chemoradiotherapy on Survival Without Disease Relapse in Patients With Low-risk Nasopharyngeal Carcinoma: A Randomized Clinical Trial – JAMA (free for a limited period)
Video Editor’s Note: Radiotherapy With vs Without Chemoradiotherapy in Low-risk Nasopharyngeal Carcinoma – JAMA
Editorial | Keeping meta-analyses fresh.
25 Aug, 2022 | 12:09h | UTCKeeping Meta-analyses Fresh – JAMA Network Open
RCT | Enoxaparin (40 mg/d) is superior to aspirin (100 mg/d) for the prevention of thromboembolism in patients undergoing hip or knee arthroplasty.
25 Aug, 2022 | 12:12h | UTCEffect of Aspirin vs Enoxaparin on Symptomatic Venous Thromboembolism in Patients Undergoing Hip or Knee Arthroplasty: The CRISTAL Randomized Trial – JAMA (free for a limited period)
Editorial: Thromboprophylaxis After Hip or Knee Arthroplasty – JAMA
Commentary on Twitter
In patients undergoing hip or knee arthroplasty for osteoarthritis, aspirin compared with enoxaparin resulted in a significantly higher rate of symptomatic venous thromboembolism (VTE), including below-knee VTE. #Research https://t.co/CdlbAgBttJ
— JAMA (@JAMA_current) August 23, 2022
RCT | In patients with alcohol use disorder, the percentage of heavy drinking days was reduced with a psychedelic drug.
25 Aug, 2022 | 12:10h | UTCNews Release: Psychedelic drug therapy may help treat alcohol addiction – NYU Grossman School of Medicine
Commentary on Twitter:
In adults with alcohol-dependence, two doses of #psilocybin in combination with psychotherapy produced robust decreases in drinking relative to the outcomes observed with placebo and psychotherapy. https://t.co/M8PCbfwmWn #Research pic.twitter.com/duCJUL0jhx
— JAMA Psychiatry (@JAMAPsych) August 24, 2022
Retrospective Cohort Study | Nirmatrelvir use and severe Covid-19 outcomes during the Omicron surge.
25 Aug, 2022 | 12:08h | UTC
Commentary on Twitter
During the clinical rollout of nirmatrelvir in Israel in early 2022, most patients (78%) had previous SARS-CoV-2 immunity. Benefit was seen among patients at highest risk for Covid-19 progression, such as those 65+. https://t.co/O6CxzDdIfH pic.twitter.com/ccCaCCh15i
— NEJM (@NEJM) August 24, 2022
Hospitalizations for unintentional cannabis poisonings among Canadian children surged after legalization.
25 Aug, 2022 | 12:07h | UTCOriginal Study: Edible Cannabis Legalization and Unintentional Poisonings in Children – New England Journal of Medicine ($)
USPSTF Recommendation Statement | Statin use for the primary prevention of cardiovascular disease in adults.
24 Aug, 2022 | 14:21h | UTCEditorials:
Author Interview: USPSTF Recommendation: Statin Use for the Primary Prevention of Cardiovascular Disease in Adults – JAMA
Patient Page: Statins for the Prevention of Cardiovascular Disease – JAMA
Commentary: Latest statins guidance keeps more conservative approach to preventing first stroke or heart attack – CNN
RCT | In women at risk of preterm delivery, half dose antenatal Dexamethasone was NOT noninferior compared to full dose Dexamethasone on neonatal outcomes.
24 Aug, 2022 | 14:20h | UTCNeonatal outcomes for women at risk of preterm delivery given half dose versus full dose of antenatal betamethasone: a randomised, multicentre, double-blind, placebo-controlled, non-inferiority trial – The Lancet (link to abstract – $ for full-text)
Commentary on Twitter
On 50th anniversary of Liggins & Howie's discovery of benefits of antenatal steroids for preterm birth, new study in @TheLancet confirms full dose (11.4 mg x 2) of betamethasone is necessary for optimum benefit. https://t.co/VgjtprM0W8#neoTwitter #obstetrics @EBNEO @ESPR_EBN pic.twitter.com/Cl1GbzWoRl
— Atul Malhotra (@Atul_Monash) August 19, 2022
Non-nutritive sweeteners affect human microbiomes and can alter glycemic responses.
24 Aug, 2022 | 14:17h | UTCNews Release: Non-nutritive sweeteners affect human microbiomes and can alter glycemic responses – Cell Press
Original Study: Personalized microbiome-driven effects of non-nutritive sweeteners on human glucose tolerance – Cell
Commentary on Twitter
The skinny on non-nutritive sweeteners (they are not inert) via a randomized trial & gut #microbiome assessment: impact is individualized and can impair glycemic responsehttps://t.co/B7CUPy7tMf @CellCellPress @SuezLab @EranElinav @segal_eran @WeizmannScience @Yot_Coh @Elinav_Lab pic.twitter.com/Jz7lUkWlNr
— Eric Topol (@EricTopol) August 19, 2022
Retrospective Cohort Study | Clinical and genetic risk factors for acute incident venous thromboembolism in ambulatory patients with COVID-19.
24 Aug, 2022 | 14:17h | UTC
Commentary on Twitter
Ambulatory #COVID19 was associated with a substantially increased risk of incident venous thromboembolism, but this risk was greatly reduced in fully vaccinated people with breakthrough infection. https://t.co/98zKNfEWaU #Research
— JAMA Internal Medicine (@JAMAInternalMed) August 18, 2022
Monkeypox: a clinical update for pediatricians.
24 Aug, 2022 | 14:19h | UTCMonkeypox: A clinical update for paediatricians – Journal of Pediatrics and Child Health
Related:
CDC Report | Epidemiologic and clinical characteristics of Monkeypox cases in the US.
Update on the Monkeypox Outbreak – JAMA
WHO Declares Global Public Health Emergency Over Monkeypox Virus Outbreak – Health Policy Watch
Monkeypox: A Contemporary Review for Healthcare Professionals – Open Forum Infectious Diseases
Long-term results of a RCT | Vasopressin and methylprednisolone did not improve outcomes in patients with in-hospital cardiac arrest.
24 Aug, 2022 | 14:15h | UTC
Retrospective Cohort Study | Association of COVID-19 vs. Influenza with risk of arterial and venous thrombotic events among hospitalized patients.
24 Aug, 2022 | 14:16h | UTCCommentary: Higher risk of vein blood clots in COVID vs flu patients – CIDRAP
News Release: People with Severe COVID-19 Face Increased Risk of Life-Threatening Blood Clots – Penn Medicine News
Commentary on Twitter
The risk of blood clots in hospitalized patients with Covid vs influenza was increased 60-90% within 90 days, for venous but not arterial thrombosishttps://t.co/wPHf18NYYB @JAMA_current
Retrospective, much smaller influenza cohort from 2018-2019 pic.twitter.com/sClYHF0J6U— Eric Topol (@EricTopol) August 16, 2022
Updated systematic review and critical appraisal: prediction models for diagnosis and prognosis of covid-19.
23 Aug, 2022 | 13:31h | UTCCommentary: Update to living systematic review on prediction models for diagnosis and prognosis of covid-19 – The BMJ
Commentary on Twitter
NEW update in @bmj_latest
606 prognostic models for #COVID19 identified – 29 had low risk of bias, 32 had unclear risk of bias, AND 545 HAD HIGH RISK OF BIAS!
+Poorly reported – use TRIPOD please https://t.co/tVA0xHXdRu#epitwitter #statstwitter pic.twitter.com/n71vdgY8wM
— Gary Collins ?? (@GSCollins) August 22, 2022
Update on applications and limitations of perioperative tranexamic acid.
23 Aug, 2022 | 13:30h | UTCUpdate on Applications and Limitations of Perioperative Tranexamic Acid – Anesthesia & Analgesia (free for a limited period)
Infographic: Tranexamic Acid: Current Knowns and Unknowns – Anesthesia & Analgesia (free for a limited period)