Editor's Choice
Editorial | Keeping meta-analyses fresh.
25 Aug, 2022 | 12:09h | UTCKeeping Meta-analyses Fresh – JAMA Network Open
RCT | Enoxaparin (40 mg/d) is superior to aspirin (100 mg/d) for the prevention of thromboembolism in patients undergoing hip or knee arthroplasty.
25 Aug, 2022 | 12:12h | UTCEffect of Aspirin vs Enoxaparin on Symptomatic Venous Thromboembolism in Patients Undergoing Hip or Knee Arthroplasty: The CRISTAL Randomized Trial – JAMA (free for a limited period)
Editorial: Thromboprophylaxis After Hip or Knee Arthroplasty – JAMA
Commentary on Twitter
In patients undergoing hip or knee arthroplasty for osteoarthritis, aspirin compared with enoxaparin resulted in a significantly higher rate of symptomatic venous thromboembolism (VTE), including below-knee VTE. #Research https://t.co/CdlbAgBttJ
— JAMA (@JAMA_current) August 23, 2022
RCT | In patients with alcohol use disorder, the percentage of heavy drinking days was reduced with a psychedelic drug.
25 Aug, 2022 | 12:10h | UTCNews Release: Psychedelic drug therapy may help treat alcohol addiction – NYU Grossman School of Medicine
Commentary on Twitter:
In adults with alcohol-dependence, two doses of #psilocybin in combination with psychotherapy produced robust decreases in drinking relative to the outcomes observed with placebo and psychotherapy. https://t.co/M8PCbfwmWn #Research pic.twitter.com/duCJUL0jhx
— JAMA Psychiatry (@JAMAPsych) August 24, 2022
Retrospective Cohort Study | Nirmatrelvir use and severe Covid-19 outcomes during the Omicron surge.
25 Aug, 2022 | 12:08h | UTC
Commentary on Twitter
During the clinical rollout of nirmatrelvir in Israel in early 2022, most patients (78%) had previous SARS-CoV-2 immunity. Benefit was seen among patients at highest risk for Covid-19 progression, such as those 65+. https://t.co/O6CxzDdIfH pic.twitter.com/ccCaCCh15i
— NEJM (@NEJM) August 24, 2022
Hospitalizations for unintentional cannabis poisonings among Canadian children surged after legalization.
25 Aug, 2022 | 12:07h | UTCOriginal Study: Edible Cannabis Legalization and Unintentional Poisonings in Children – New England Journal of Medicine ($)
USPSTF Recommendation Statement | Statin use for the primary prevention of cardiovascular disease in adults.
24 Aug, 2022 | 14:21h | UTCEditorials:
Author Interview: USPSTF Recommendation: Statin Use for the Primary Prevention of Cardiovascular Disease in Adults – JAMA
Patient Page: Statins for the Prevention of Cardiovascular Disease – JAMA
Commentary: Latest statins guidance keeps more conservative approach to preventing first stroke or heart attack – CNN
RCT | In women at risk of preterm delivery, half dose antenatal Dexamethasone was NOT noninferior compared to full dose Dexamethasone on neonatal outcomes.
24 Aug, 2022 | 14:20h | UTCNeonatal outcomes for women at risk of preterm delivery given half dose versus full dose of antenatal betamethasone: a randomised, multicentre, double-blind, placebo-controlled, non-inferiority trial – The Lancet (link to abstract – $ for full-text)
Commentary on Twitter
On 50th anniversary of Liggins & Howie's discovery of benefits of antenatal steroids for preterm birth, new study in @TheLancet confirms full dose (11.4 mg x 2) of betamethasone is necessary for optimum benefit. https://t.co/VgjtprM0W8#neoTwitter #obstetrics @EBNEO @ESPR_EBN pic.twitter.com/Cl1GbzWoRl
— Atul Malhotra (@Atul_Monash) August 19, 2022
Non-nutritive sweeteners affect human microbiomes and can alter glycemic responses.
24 Aug, 2022 | 14:17h | UTCNews Release: Non-nutritive sweeteners affect human microbiomes and can alter glycemic responses – Cell Press
Original Study: Personalized microbiome-driven effects of non-nutritive sweeteners on human glucose tolerance – Cell
Commentary on Twitter
The skinny on non-nutritive sweeteners (they are not inert) via a randomized trial & gut #microbiome assessment: impact is individualized and can impair glycemic responsehttps://t.co/B7CUPy7tMf @CellCellPress @SuezLab @EranElinav @segal_eran @WeizmannScience @Yot_Coh @Elinav_Lab pic.twitter.com/Jz7lUkWlNr
— Eric Topol (@EricTopol) August 19, 2022
Retrospective Cohort Study | Clinical and genetic risk factors for acute incident venous thromboembolism in ambulatory patients with COVID-19.
24 Aug, 2022 | 14:17h | UTC
Commentary on Twitter
Ambulatory #COVID19 was associated with a substantially increased risk of incident venous thromboembolism, but this risk was greatly reduced in fully vaccinated people with breakthrough infection. https://t.co/98zKNfEWaU #Research
— JAMA Internal Medicine (@JAMAInternalMed) August 18, 2022
Monkeypox: a clinical update for pediatricians.
24 Aug, 2022 | 14:19h | UTCMonkeypox: A clinical update for paediatricians – Journal of Pediatrics and Child Health
Related:
CDC Report | Epidemiologic and clinical characteristics of Monkeypox cases in the US.
Update on the Monkeypox Outbreak – JAMA
WHO Declares Global Public Health Emergency Over Monkeypox Virus Outbreak – Health Policy Watch
Monkeypox: A Contemporary Review for Healthcare Professionals – Open Forum Infectious Diseases
Long-term results of a RCT | Vasopressin and methylprednisolone did not improve outcomes in patients with in-hospital cardiac arrest.
24 Aug, 2022 | 14:15h | UTC
Retrospective Cohort Study | Association of COVID-19 vs. Influenza with risk of arterial and venous thrombotic events among hospitalized patients.
24 Aug, 2022 | 14:16h | UTCCommentary: Higher risk of vein blood clots in COVID vs flu patients – CIDRAP
News Release: People with Severe COVID-19 Face Increased Risk of Life-Threatening Blood Clots – Penn Medicine News
Commentary on Twitter
The risk of blood clots in hospitalized patients with Covid vs influenza was increased 60-90% within 90 days, for venous but not arterial thrombosishttps://t.co/wPHf18NYYB @JAMA_current
Retrospective, much smaller influenza cohort from 2018-2019 pic.twitter.com/sClYHF0J6U— Eric Topol (@EricTopol) August 16, 2022
Updated systematic review and critical appraisal: prediction models for diagnosis and prognosis of covid-19.
23 Aug, 2022 | 13:31h | UTCCommentary: Update to living systematic review on prediction models for diagnosis and prognosis of covid-19 – The BMJ
Commentary on Twitter
NEW update in @bmj_latest
606 prognostic models for #COVID19 identified – 29 had low risk of bias, 32 had unclear risk of bias, AND 545 HAD HIGH RISK OF BIAS!
+Poorly reported – use TRIPOD please https://t.co/tVA0xHXdRu#epitwitter #statstwitter pic.twitter.com/n71vdgY8wM
— Gary Collins ?? (@GSCollins) August 22, 2022
Update on applications and limitations of perioperative tranexamic acid.
23 Aug, 2022 | 13:30h | UTCUpdate on Applications and Limitations of Perioperative Tranexamic Acid – Anesthesia & Analgesia (free for a limited period)
Infographic: Tranexamic Acid: Current Knowns and Unknowns – Anesthesia & Analgesia (free for a limited period)
Much anticipated Alzheimer Disease prevention trial finds no clinical benefit from drug targeting amyloid; highlights need to consider other approaches.
23 Aug, 2022 | 13:29h | UTCMuch Anticipated Alzheimer Disease Prevention Trial Finds No Clinical Benefit From Drug Targeting Amyloid; Highlights Need to Consider Other Approaches – JAMA (free for a limited period)
Commentary on Twitter
The hypothesis that amyloid deposits in the brain cause Alzheimer disease has gotten many hits over the years, as one antiamyloid treatment after another failed to show a clinical benefit. Time to move on? @RitaRubin writes about the debate. https://t.co/913A0WWcR7
— JAMA (@JAMA_current) August 17, 2022
A cohort study of patients with mild traumatic brain injury found that 56% of patients had incomplete recovery after 6 months.
23 Aug, 2022 | 13:27h | UTCCommentary: Incomplete Recovery Common 6 Months After Mild TBI – Medscape (free registration required)
Commentary on Twitter (thread – click for more)
1/?Mild Traumatic Brain Injury (TBI) isn’t “Mild” ?
Our daughter fell off a high diving board headfirst to cement years ago. Though she had 2 cracks through her foramen magnum, her GCS was 15 & CT had no bleeding.
“She’s OK,” they said.
Wrong answer ?#TrackTBI Data… pic.twitter.com/1FZuRnt4so— WesElyMD (@WesElyMD) August 22, 2022
Study Commentary | Non-sterile gloves for suturing traumatic lacerations?
23 Aug, 2022 | 13:29h | UTCNon-Sterile Gloves for Suturing Traumatic Lacerations? – RebelEM
Original Study: Non-sterile gloves and dressing versus sterile gloves, dressings and drapes for suturing of traumatic wounds in the emergency department: a non-inferiority multicentre randomised controlled trial – Emergency Medicine Journal (link to abstract – $ for full-text)
Risk of myocarditis after sequential doses of COVID-19 vaccine vs. after SARS-CoV-2 infection by age and sex.
23 Aug, 2022 | 13:25h | UTCNews Release: Myocarditis risk significantly higher after COVID-19 infection vs. after a COVID-19 vaccine – Circulation
M-A | Incidence and mortality of non-AIDS-defining cancers among people living with HIV.
23 Aug, 2022 | 13:26h | UTCRelated: Study: Cancer Patients with HIV Infection Have Worse Outcomes
M-A | Incubation period of COVID-19 caused by unique SARS-CoV-2 strains.
23 Aug, 2022 | 13:24h | UTC
WHO makes new recommendations for Ebola treatments, calls for improved access.
22 Aug, 2022 | 12:26h | UTCNews Release: WHO makes new recommendations for Ebola treatments, calls for improved access – World Health Organization
Guideline: Therapeutics for Ebola virus disease – World Health Organization
Commentary on Twitter (thread – click for more)
WHO publishes its first guideline for #Ebola virus disease therapeutics: recommends the use of two monoclonal antibodies.
WHO calls on the global community to increase access to these lifesaving medicines.
? https://t.co/tstO3pBYlf pic.twitter.com/ZrDg43TyL2
— World Health Organization (WHO) (@WHO) August 19, 2022
Guideline Summary | Recommendations for the outpatient drug treatment of patients with COVID-19.
22 Aug, 2022 | 12:25h | UTC
AHA Scientific Statement | Cardiovascular effects of home dialysis therapies.
22 Aug, 2022 | 12:24h | UTCTop Things to Know: CV Effects of Home Dialysis Therapies – American Heart Association
Commentaries:
AHA Urges More Home-Based Dialysis in Advanced Kidney Failure – TCTMD
Commentary on Twitter (thread – click for more)
1/
Our @AHAScience Scientific Statement on the cardiovascular impact of home dialysis therapies is now out in @CircAHAhttps://t.co/h7PBHe5zZjHere are the key points in a very brief ?
— Bourne Auguste (@bourneauguste) August 15, 2022
Consensus Statement | Preoperative management of medications for rheumatologic and HIV diseases.
22 Aug, 2022 | 12:22h | UTCRelated:
Preoperative Management of Medications for Neurologic Diseases – Mayo Clinic Proceedings
Preoperative Management of Surgical Patients Using Dietary Supplements – Mayo Clinic Proceedings
Perioperative Evaluation and Management of Endocrine Disorders – Mayo Clinic Proceedings
Preoperative Cardiac Risk Assessment – Mayo Clinic Proceedings
Preoperative Evaluation Before Noncardiac Surgery – Mayo Clinic Proceedings
Perioperative Cardiac Risk Reduction in Noncardiac Surgery – Mayo Clinic Proceedings
Perioperative Venous Thromboembolism Prophylaxis – Mayo Clinic Proceedings
Editorial | Rise of intravenous nutrition products among professional team sport athletes: reasons to be concerned?
22 Aug, 2022 | 12:20h | UTCRise of intravenous nutrition products among professional team sport athletes: reasons to be concerned? – British Journal of Sports Medicine (free for a limited period)
News Release: IV nutrition risks becoming the norm for athletes, despite no evidence it works – BMJ Newsroom
Commentary: More Athletes Are Getting Their Nutrition Through an IV. This Should Stop, Experts Say – HealthDay
Commentary on Twitter
IV nutrition risks becoming the norm for athletes, despite no evidence it works, warn @pedlarcr and colleagues in @BJSM_BMJ https://t.co/RRou2U8u9x
Used to be considered treatment of ‘last resort’
‘Food first’ and ‘no needle’ messages need to be amplified, urge experts pic.twitter.com/XeaRyHiVEH— BMJ (@bmj_company) August 17, 2022