Editor's Choice
Perspective | The polypill: from concept and evidence to implementation.
18 Oct, 2022 | 12:55h | UTCThe polypill: from concept and evidence to implementation – The Lancet (free registration required)
Related:
Opinion: A new important study supports wider use of the polypill
Perspective: Are Polypills and Population-based Treatment the Next Big Things?
The Polypill Revisited: Why We Still Need Population-Based Approaches in the Precision Medicine Era
Randomized Trial: Polypill for Cardiovascular Disease Prevention in an Underserved Population
Perspective: The Polypill and the Long Journey to Major Impact
Research: Low-Dose ‘Triple Pill’ Lowers Blood Pressure More Than Usual Care
Post-trial follow-up | Longer-term all-cause and cardiovascular mortality with intensive blood pressure control.
17 Oct, 2022 | 12:41h | UTCLonger-Term All-Cause and Cardiovascular Mortality With Intensive Blood Pressure Control: A Secondary Analysis of a Randomized Clinical Trial – JAMA Cardiology (free for a limited period)
Author Interview: Longer-Term All-Cause and Cardiovascular Mortality With Intensive Blood Pressure Control – JAMA
Commentaries:
Benefits of Intensive Blood Pressure Control May Not Persist After Trial Intervention – HCP Live
Related:
Study: Real-world blood pressure measurements vs. measurements taken in the SPRINT trial
Studies: Intensive versus Standard Blood-Pressure Control
Commentary on Twitter
In a secondary analysis of SPRINT, the mortality benefits of intensive BP control attenuated after the trial, while outpatient systolic BP increased by an average of 7 mm Hg for participants in the intensive treatment group. https://t.co/INSo2zYzhp #Research
— JAMA Cardiology (@JAMACardio) October 12, 2022
Health effects associated with consumption of unprocessed red meat: a Burden of Proof study.
17 Oct, 2022 | 12:39h | UTCSee also:
Homepage: The Burden of Proof Studies – Nature Medicine
The Burden of Proof studies: assessing the evidence of risk
Health effects associated with vegetable consumption: a Burden of Proof study
Effects of elevated systolic blood pressure on ischemic heart disease: a Burden of Proof study
Health effects associated with smoking: a Burden of Proof study
Commentary on Twitter
Using the Burden of Proof analytical tool, a meta-analysis found weak or no evidence of associations between unprocessed #redmeat consumption and increased risk of six #cardiometabolic disease and #cancer outcomes. @IHME_UW https://t.co/3b7Sa9zCA1
— Nature Medicine (@NatureMedicine) October 10, 2022
Health effects associated with vegetable consumption: a Burden of Proof study.
17 Oct, 2022 | 12:40h | UTCHealth effects associated with vegetable consumption: a Burden of Proof study – Nature Medicine
See also:
Homepage: The Burden of Proof Studies – Nature Medicine
The Burden of Proof studies: assessing the evidence of risk
Health effects associated with consumption of unprocessed red meat: a Burden of Proof study
Effects of elevated systolic blood pressure on ischemic heart disease: a Burden of Proof study
Health effects associated with smoking: a Burden of Proof study
Commentary on Twitter
A meta-analysis using the Burden of Proof function identified modest evidence supporting a protective role of #vegetable consumption and #ischemicheartdisease, #stroke and esophageal cancer, but not type 2 #diabetes. @IHME_UW https://t.co/1w8OAELSvU
— Nature Medicine (@NatureMedicine) October 10, 2022
Effects of elevated systolic blood pressure on ischemic heart disease: a Burden of Proof study.
17 Oct, 2022 | 12:37h | UTCSee also:
Homepage: The Burden of Proof Studies – Nature Medicine
The Burden of Proof studies: assessing the evidence of risk
Health effects associated with vegetable consumption: a Burden of Proof study
Health effects associated with consumption of unprocessed red meat: a Burden of Proof study
Health effects associated with smoking: a Burden of Proof study
Commentary on Twitter
A systematic review using the Burden of Proof meta-analytic method found a significant harmful effect between high systolic #bloodpressure and #ischemicheartdisease. @IHME_UW https://t.co/hewQ9nsCTh
— Nature Medicine (@NatureMedicine) October 10, 2022
Health effects associated with smoking: a Burden of Proof study.
17 Oct, 2022 | 12:36h | UTCHealth effects associated with smoking: a Burden of Proof study – Nature Medicine
See also:
Homepage: The Burden of Proof Studies – Nature Medicine
The Burden of Proof studies: assessing the evidence of risk
Health effects associated with vegetable consumption: a Burden of Proof study
Health effects associated with consumption of unprocessed red meat: a Burden of Proof study
Effects of elevated systolic blood pressure on ischemic heart disease: a Burden of Proof study
Commentary on Twitter
A meta-analysis using the Burden of Proof method reported consistent evidence supporting harmful associations between #smoking and 28 different #health outcomes. @IHME_UW https://t.co/0tEnMvTwG6
— Nature Medicine (@NatureMedicine) October 10, 2022
[Not published yet] Aspirin noninferior to LMW Heparin for prevention of death or pulmonary embolism after fracture surgery.
17 Oct, 2022 | 12:36h | UTC
RCTs | Thrombectomy improved recovery in basilar artery stroke but increased procedural complications and hemorrhages.
14 Oct, 2022 | 14:20h | UTCStudy 1: Trial of Endovascular Treatment of Acute Basilar-Artery Occlusion – New England Journal of Medicine (link to abstract – $ for full-text)
Study 2: Trial of Thrombectomy 6 to 24 Hours after Stroke Due to Basilar-Artery Occlusion – New England Journal of Medicine (link to abstract – $ for full-text)
Related:
Commentary on Twitter
In 340 Chinese patients with basilar-artery occlusion, endovascular treatment resulted in better neurologic outcomes than medical care. Approximately one third of patients underwent intravenous thrombolysis. https://t.co/ZqHirYnjoH pic.twitter.com/fuRV3rFWX7
— NEJM (@NEJM) October 13, 2022
Review | Facing the challenge of polypharmacy when prescribing for older people with cardiovascular disease.
14 Oct, 2022 | 14:19h | UTCRelated:
Antihypertensive Deprescribing in Older Adults: a Practical Guide – Current Hypertension Reports
Deprescribing in Palliative Cancer Care – Life
Less is More: Deprescribing Medications in Older Adults with Kidney Disease: A Review – Kidney360
Polypharmacy Management in Older Patients – Mayo Clinic Proceedings
Eliminating Medication Overload: A National Action Plan – Lown Institute
Common ED Medication Errors: Polypharmacy – emDocs
Current and future perspectives on the management of polypharmacy – BMC Family Practice
Polypharmacy—an Upward Trend with Unpredictable Effects – Deutsches Ärzteblatt international
Clinical Consequences of Polypharmacy in Elderly – Expert Opinion on Drug Safety
Special Statement | Postpartum visit checklists for normal pregnancy and complicated pregnancy.
14 Oct, 2022 | 14:18h | UTCOriginal Guideline: ACOG Postpartum Toolkit (PDF)
2022 ACC Guidance on the evaluation and disposition of acute chest pain in the ED.
13 Oct, 2022 | 13:55h | UTCCommentary: Guideline Guidance: Practical Tips for Finding, Triaging Chest Pain in the ED – TCTMD
Related:
2021 AHA/ACC Guideline for the Evaluation and Diagnosis of Chest Pain.
Navigating a Complicated World | Commentary of the new AHA/ACC Chest Pain Guidelines.
Commentary from one of the authors on Twitter (thread – click for more)
https://twitter.com/CianPMcCarthy/status/1580007497372676096
RCT | Allopurinol does not improve outcomes in patients with ischemic heart disease without previous gout.
13 Oct, 2022 | 13:53h | UTCInvited Commentary: Xanthine oxidase inhibition for cardiovascular disease prevention – The Lancet
Commentary on Twitter
Despite favorable effects on surrogate endpoints in smaller trials, in an RCT trial of 5,721 pts with CAD, allopurinol did not significantly improve cardiovascular prognosis compared to placebo https://t.co/ITW4HAwI2K @TheLancet pic.twitter.com/EggHM8flle
— Pradeep Natarajan (@pnatarajanmd) October 7, 2022
Under a Creative Commons Attribution (CC BY 4.0) License
RCT | The substitution of biomass for gas cookstoves in pregnant women’s households did not improve infants’ birth weight.
13 Oct, 2022 | 13:52h | UTCLiquefied Petroleum Gas or Biomass for Cooking and Effects on Birth Weight – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries:
LPG for cooking didn’t improve weight of newborns, finds study – The Times of India
Incidence of myocarditis/pericarditis following mRNA COVID-19 vaccination among children and younger adults in the US.
13 Oct, 2022 | 13:51h | UTC
Commentary on Twitter (thread – click for more)
Let me me perfectly clear about the evidence for myocarditis after mRNA vaccines
1. There is a notable increased incidence, age 12-39, males, with each dose (Table)https://t.co/XXQbyeLiSP pic.twitter.com/wLTZT3fppy— Eric Topol (@EricTopol) October 12, 2022
Commentary on Twitter
Let me me perfectly clear about the evidence for myocarditis after mRNA vaccines
1. There is a notable increased incidence, age 12-39, males, with each dose (Table)https://t.co/XXQbyeLiSP pic.twitter.com/wLTZT3fppy— Eric Topol (@EricTopol) October 12, 2022
Case series and systematic review | Life-threatening cardiac arrhythmia and sudden death during electronic gaming.
13 Oct, 2022 | 13:49h | UTCEditorial: Ventricular arrhythmias during electronic gaming: Sudden victory and sudden death – Heart Rhythm
News Release: Electronic gaming can trigger potentially lethal heart rhythm problems in susceptible children – Elsevier
Review | Transient ischemic attack and minor stroke: diagnosis, risk stratification and management.
13 Oct, 2022 | 13:50h | UTC
15-year benefits of sigmoidoscopy screening on colorectal cancer incidence and mortality: a pooled analysis of randomized trials.
13 Oct, 2022 | 13:48h | UTC15-Year Benefits of Sigmoidoscopy Screening on Colorectal Cancer Incidence and Mortality: A Pooled Analysis of Randomized Trials – Annals of Internal Medicine (link to abstract – $ for full-text)
News Release: One sigmoidoscopy significantly reduces long-term CRC incidence in both men and women – American College of Physicians
Related:
RCT | Effect of colonoscopy screening on risks of colorectal cancer and related death.
ACP Guideline: Screening for Colorectal Cancer in Asymptomatic Average-Risk Adults
Current and future colorectal cancer screening strategies – Nature Reviews Gastroenterology & Hepatology (if the link is paywalled, try this one in PMC)
USPSTF Statement: Start colorectal cancer screening at 45 years for most patients.
ACG Clinical Guidelines: Start colorectal cancer screening at 45
Commentary on Twitter
A pooled analysis evaluating 15-yr effect of sigmoidoscopies found that receiving 1 #sigmoidoscopy significantly reduces long-term incidence of CRC in men and women: https://t.co/QXj5VRMHeo pic.twitter.com/s82sOJmBzr
— Annals of Int Med (@AnnalsofIM) October 11, 2022
RCT | No difference in cardiovascular outcomes with evening vs. morning dosing of usual antihypertensives.
12 Oct, 2022 | 14:01h | UTCRelated Consensus Statement: Bedtime dosing of antihypertensive medications: systematic review and consensus statement: International Society of Hypertension position paper endorsed by World Hypertension League and European Society of Hypertension – Journal of Hypertension
Related study (conflicting results): Bedtime Hypertension Treatment Improves Cardiovascular Risk Reduction in Randomized Trial
USPSTF Statement | Screening for anxiety is recommended in children and adolescents aged 8 to 18 years.
12 Oct, 2022 | 13:58h | UTCEditorial: Screening for Pediatric Anxiety Disorders – JAMA
Evidence Report: Screening for Anxiety in Children and Adolescents: Evidence Report and Systematic Review for the US Preventive Services Task Force – JAMA
JAMA Patient Page: Screening for Anxiety in Children and Adolescents
Author interview: USPSTF Recommendations: Screening for Anxiety in Children and Adolescents, and Depression and Suicide Risk Screening in Children and Adolescents – JAMA
USPSTF Statement | Screening for depression and suicide risk is recommended in children and adolescents aged 12 to 18 years.
12 Oct, 2022 | 14:00h | UTCEditorial: Screening for Adolescent Depression and Suicide Risk – JAMA
JAMA Patient Page: Screening for Depression and Suicide Risk in Children and Adolescents
Author Interview: USPSTF Recommendations: Screening for Anxiety in Children and Adolescents, and Depression and Suicide Risk Screening in Children and Adolescents – JAMA
RCT | Effect of colonoscopy screening on risks of colorectal cancer and related death.
11 Oct, 2022 | 13:42h | UTCEffect of Colonoscopy Screening on Risks of Colorectal Cancer and Related Death – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries:
In gold-standard trial, invitation to colonoscopy reduced cancer incidence but not death – STAT
New study examines the effectiveness of colonoscopies – CNN
Review | Acid-base disorders in the critically ill patient.
11 Oct, 2022 | 13:41h | UTC
Estimated global proportions of persistent fatigue, cognitive, and respiratory symptoms following symptomatic COVID-19.
11 Oct, 2022 | 13:39h | UTCCommentaries:
Women And Hospitalized Patients More Prone To Long Covid, Study Finds – Forbes
Nearly two-thirds of long COVID patients are female, global study finds – UPI
Commentary on Twitter
A new @IHME_UW modeling study on #LongCovid based upon 1.2 million people with Covid from 22 countrieshttps://t.co/evMcFVJ2vU @JAMA_current pic.twitter.com/qt1bgHkaVV
— Eric Topol (@EricTopol) October 10, 2022
Perspective | Hydrochlorothiazide vs. chlorthalidone – what is the difference?
11 Oct, 2022 | 13:40h | UTCHydrochlorothiazide Versus Chlorthalidone–What is the Difference? – Circulation (free for a limited period)
Related:
Meta-analysis: Chlorthalidone vs. hydrochlorothiazide
Commentary on Twitter
There are big differences among diuretics even within the same class. So let us rethink the class effect. https://t.co/ruE4IYeFf2. Here I discuss what we know about HCTZ vs CTD. pic.twitter.com/cyljdi04v9
— Rajiv Agarwal MD, MS (@AgarwalRajivMD) October 8, 2022
Choosing Wisely | Top five list of procedures to avoid in the treatment of viral hepatitis.
7 Oct, 2022 | 14:22h | UTCSee complete lists of low-value practices: Choosing Wisely U.S. / Choosing Wisely UK / Choosing Wisely Australia AND Choosing Wisely Canada