Editor's Choice
A multinational Delphi consensus to end the COVID-19 public health threat.
4 Nov, 2022 | 14:01h | UTCA multinational Delphi consensus to end the COVID-19 public health threat – Nature
Phase 2 RCT | Single-dose Psilocybin for a treatment-resistant episode of major depression.
4 Nov, 2022 | 13:57h | UTCSingle-Dose Psilocybin for a Treatment-Resistant Episode of Major Depression – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries:
Largest trial to date shows that psilocybin reduces depression symptoms – King’s College London
Related:
Research: “Magic mushrooms” for treatment-resistant depression
Commentary on Twitter
A single 25-mg dose of psilocybin was more effective than a 1-mg dose at alleviating treatment-resistant depression over a period of 3 weeks. The effect was attenuated at 12 weeks. https://t.co/sM1mISArvb pic.twitter.com/9YRaxfcpNT
— NEJM (@NEJM) November 2, 2022
RCT | Once-weekly Semaglutide effective for weight loss in adolescents with obesity.
4 Nov, 2022 | 13:59h | UTCOnce-Weekly Semaglutide in Adolescents with Obesity – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries:
STEP TEENS: High-dose semaglutide weight loss benefits shown in adolescents – medwire News
Trial Shows Weight-Loss Drug Works in Teens – HealthDay
Commentary on Twitter
In this trial, adolescents with obesity assigned to weekly subcutaneous semaglutide plus lifestyle intervention had a greater reduction in BMI than those who received lifestyle intervention alone. https://t.co/yiFseP38xa pic.twitter.com/uRqkFfon1s
— NEJM (@NEJM) November 2, 2022
RCT | Discontinuing RAS inhibitors in patients with advanced CKD did not result in a slower decline in eGFR.
4 Nov, 2022 | 13:55h | UTCRenin–Angiotensin System Inhibition in Advanced Chronic Kidney Disease – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary on Twitter
In this randomized trial, the discontinuation of renin–angiotensin system inhibitors in patients with advanced chronic kidney disease did not lead to a significant between-group difference in the long-term rate of decline in the eGFR. #KidneyWk https://t.co/81EIwG5FQ0 pic.twitter.com/nHNmzlPbHV
— NEJM (@NEJM) November 3, 2022
Perspective | Monkeypox — A sobering sentinel for pandemic preparedness and sexual health system capacity.
4 Nov, 2022 | 13:53h | UTCRelated:
Monkeypox – New England Journal of Medicine
Monkeypox: disease epidemiology, host immunity and clinical interventions.
Monkeypox: A clinical update for paediatricians – Journal of Pediatrics and Child Health
CDC Report | Epidemiologic and clinical characteristics of Monkeypox cases in the US.
Update on the Monkeypox Outbreak – JAMA
WHO Declares Global Public Health Emergency Over Monkeypox Virus Outbreak – Health Policy Watch
Monkeypox: A Contemporary Review for Healthcare Professionals – Open Forum Infectious Diseases
Commentary on Twitter
The monkeypox pandemic has highlighted lessons learned — and sometimes ignored — from Covid-19 and has illustrated the inadequacy of sexual health infrastructure and pandemic preparedness in the United States. https://t.co/jXuYoH9Wn2 pic.twitter.com/KcTqBuyEXi
— NEJM (@NEJM) November 2, 2022
Cohort Study | Covid-19 vaccine effectiveness among children and adolescents in Qatar.
4 Nov, 2022 | 13:51h | UTC
Commentary on Twitter
The 10-µg dose of BNT162b2 led to modest, rapidly waning protection against Covid-19 in children 5 to 11 years old. The 30-µg dose in adolescents gave greater, more durable protection; more so in 12-to-14-year-olds than in 15-to-17-year-olds. https://t.co/ddcqiR8jvO pic.twitter.com/M8oSFYoFlw
— NEJM (@NEJM) November 2, 2022
M-A | Blood pressure lowering and prevention of dementia.
4 Nov, 2022 | 13:46h | UTCNews Release: Best evidence yet that lowering blood pressure can prevent dementia – George Institute for Global Health
Commentary: Meta-Analysis Shows Decrease in Dementia Risk With HTN Treatment – HealthDay
RCT | Clinical and cost-effectiveness of single stage compared vs. two-stage revision for hip prosthetic joint infection.
4 Nov, 2022 | 13:49h | UTC
RCT | Oral antimicrobial prophylaxis reduced surgical site infection after elective colorectal surgery.
4 Nov, 2022 | 13:48h | UTC
RCT | Routine sterile glove and instrument change at the time of abdominal wound closure to prevent surgical site infection.
3 Nov, 2022 | 14:13h | UTCCommentary: Experts pave the way for safer surgery to address global elective waiting lists – University of Birmingham
Commentary on Twitter (thread – click for more)
Surgical site infection (SSI) remains the most common complication of surgery around the world.
This trial aimed to test whether a routine change of gloves & instruments before wound closure reduced abdominal SSI: https://t.co/cFM3nN7Hcs 🧵 1/4
— The Lancet (@TheLancet) November 1, 2022
2022 ACC/AHA Guideline for the diagnosis and management of aortic disease.
3 Nov, 2022 | 14:21h | UTCNews Release: ACC, AHA Issue Aortic Disease Guideline – American Heart Association
USPSTF Statement | Hormone therapy is not recommended for the prevention of chronic conditions in postmenopausal women.
3 Nov, 2022 | 14:19h | UTCEditorial: Menopausal Hormone Therapy for Prevention of Chronic Conditions: When Is Enough, Enough? – JAMA
JAMA Patient Page: Menopausal Hormone Therapy for Prevention of Chronic Conditions
Author Interview: USPSTF Recommendation: Hormone Therapy for Prevention of Postmenopausal Chronic Conditions – JAMA
Commentary: USPSTF: Hormone Therapy Not Advised for Primary Prevention of Chronic Conditions – HealthDay
RCT | Electroacupuncture shortened the duration of postoperative ileus after laparoscopic surgery for colorectal cancer.
3 Nov, 2022 | 14:17h | UTCElectroacupuncture vs Sham Electroacupuncture in the Treatment of Postoperative Ileus After Laparoscopic Surgery for Colorectal Cancer: A Multicenter, Randomized Clinical Trial – JAMA Surgery (free for a limited period)
Invited Commentary: Will Acupuncture Be the Next Addition to Enhanced Recovery After Surgery Protocols? – JAMA Surgery (free for a limited period)
Commentary on Twitter
Results of this trial show that electroacupuncture is effective in promoting gastrointestinal function recovery within the Enhanced Recovery After Surgery protocol. #Research https://t.co/vniYwqvwHH
— JAMA Surgery (@JAMASurgery) November 2, 2022
Development, measurement, and validation of the surgical preparedness index across 1632 hospitals in 119 countries.
3 Nov, 2022 | 14:12h | UTCCommentary: Experts pave the way for safer surgery to address global elective waiting lists – University of Birmingham
Commentary on Twitter
https://twitter.com/NIHR_GSU/status/1587455307009105920
Under a Creative Commons Attribution (CC BY 4.0) License
M-A | Effect of pulmonary rehabilitation in dyspnea, exercise capacity, fatigue, and quality of life in patients with COVID-19.
3 Nov, 2022 | 14:09h | UTC
Comparative risk of thrombosis with thrombocytopenia or thromboembolic events with different covid-19 vaccines.
3 Nov, 2022 | 14:10h | UTC
Phase 2 RCT | A single injection of a monoclonal antibody was 88% effective for malaria prevention over 6 months.
2 Nov, 2022 | 14:30h | UTCSafety and Efficacy of a Monoclonal Antibody against Malaria in Mali – New England Journal of Medicine (link to abstract – $ for full-text)
News Release: Monoclonal antibody prevents malaria infection in African adults – National Institutes of Health
Commentary: Monoclonal antibody infusion 88% effective against malaria – CIDRAP
Related Study: Phase 1 Study | Low-dose subcutaneous or intravenous monoclonal antibody can prevent malaria in a human challenge model.
Commentary on Twitter
In this phase 2 trial in Mali, an antimalarial monoclonal antibody (CIS43LS) at the higher dose (40 mg per kilogram) was approximately 88% effective at preventing P. falciparum infection as compared with placebo. #TropMed22 https://t.co/UGeBHOPhKY pic.twitter.com/uFX7w3qV0G
— NEJM (@NEJM) November 1, 2022
NICE Guideline | Osteoarthritis in over 16s: diagnosis and management.
2 Nov, 2022 | 14:29h | UTC
NICE Guideline Update | Lung cancer: diagnosis and management.
2 Nov, 2022 | 14:28h | UTCLung cancer: diagnosis and management – National Institute for Health and Care Excellence
RCT | Povidone-iodine and chlorhexidine gluconate are similarly effective for preventing SSI in open fractures.
2 Nov, 2022 | 14:27h | UTCAqueous skin antisepsis before surgical fixation of open fractures (Aqueous-PREP): a multiple-period, cluster-randomised, crossover trial – The Lancet (link to abstract – $ for full-text)
Related:
Antiseptic Skin Agents to Prevent Surgical Site Infection After Incisional Surgery: A Randomized, Three-armed Combined Non-inferiority and Superiority Clinical Trial (NEWSkin Prep Study) – Annals of Surgery (link to abstract – $ for full-text)
RCT | Intensive BP control after thrombectomy for ischemic stroke is associated with increased risk of poor functional outcomes.
2 Nov, 2022 | 14:26h | UTCIntensive blood pressure control after endovascular thrombectomy for acute ischaemic stroke (ENCHANTED2/MT): a multicentre, open-label, blinded-endpoint, randomised controlled trial – The Lancet (link to abstract – $ for full-text)
Commentary on Twitter (thread – click for more)
1/ A #MorningPaper from @TheLancet on #Stroke. This large study randomised 821 patients into aggressive BP management (sBP <120mmHg) vs 140-180mmHg. Trial stopped early due to safety concerns. @neuro_at_ic @e1v1m1 @SomaBanerjee73 @StrokeImperialhttps://t.co/vnvnnI1KLq
— Kevin Tsang (@drtintin99) October 29, 2022
ERAS Guidelines for perioperative care for liver surgery.
1 Nov, 2022 | 12:16h | UTCRelated:
Complete List of Enhanced Recovery After Surgery (ERAS) Society Guidelines
ACCP Guideline | Perioperative management of antithrombotic therapy.
1 Nov, 2022 | 12:18h | UTCExecutive Summary: Perioperative Management of Antithrombotic Therapy: An American College of Chest Physicians Clinical Practice Guideline – CHEST
Commentary on Twitter
2022 guideline for perioperative management of VKAs, heparin bridging, DOACs & antiplatelets
Pts requiring elective surgery, in general,🛑💊 before surgery
👉VKAs 3-5d
👉DOACS 1-2d
👉P2Y12 receptor inhibitors 3-7d✅drug specificshttps://t.co/RYNrEOovRe @SCCM_Surgery @SCCM_CPP— Lauren R. Sorce, PhD, RN, CPNP-AC/PC, FAAN, FCCM (@SCCMPresident) August 26, 2022
M-A | Safety and efficacy of interrupting dual antiplatelet therapy one month following percutaneous coronary intervention.
1 Nov, 2022 | 12:14h | UTC
Commentary on Twitter
Interrupting DAPT after 1 month post PCI:
Meta-analysis of 4 RCTs, >25000 pts
Events between 31days and 1yr:
Less bleeding (1.1 vs 1.5%) but no difference in death (1.3 vs 1.6%), MI (1.4 vs 1.2%), ST (0.3 vs 0.2%) or stroke (0.5 vs 0.6%) https://t.co/rdNgCg032B #cardiotwitter pic.twitter.com/yLWREcDzYe— Heeraj Bulluck (@DrHBulluck) October 30, 2022
Under a http://creativecommons.org/licenses/by/4.0/ license
WHO Guidelines on mental health at work.
1 Nov, 2022 | 12:15h | UTCGuidelines on mental health at work – World Health Organization
News Release: WHO and ILO call for new measures to tackle mental health issues at work – World Health Organization
Commentary on Twitter (thread – click for more)
Work affects #MentalHealth & well-being.
1 in 6 working-age adults are estimated to have a mental disorder.
Globally, 12 billion working days are lost every year on account of #depression and anxiety.
🆕 WHO recommended guidelines to protect #MentalHealthAtWork ⬇️
— World Health Organization (WHO) (@WHO) September 28, 2022