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RCT | Povidone-iodine and chlorhexidine gluconate are similarly effective for preventing SSI in open fractures.

2 Nov, 2022 | 14:27h | UTC

Aqueous skin antisepsis before surgical fixation of open fractures (Aqueous-PREP): a multiple-period, cluster-randomised, crossover trial – The Lancet (link to abstract – $ for full-text)

News Release: Study finds antisepsis agents interchangeable in reducing infection risk in open fracture surgeries – Louisiana State University

Related:

Efficacy of different preoperative skin antiseptics on the incidence of surgical site infections: a systematic review, GRADE assessment, and network meta-analysis – The Lancet Microbe

Antiseptic Skin Agents to Prevent Surgical Site Infection After Incisional Surgery: A Randomized, Three-armed Combined Non-inferiority and Superiority Clinical Trial (NEWSkin Prep Study) – Annals of Surgery (link to abstract – $ for full-text)

Alcoholic chlorhexidine skin preparation or triclosan-coated sutures to reduce surgical site infection: a systematic review and meta-analysis of high-quality randomised controlled trials – The Lancet Infectious Diseases

Pragmatic randomized trial found similar rates of surgical site infectious with 2% alcoholic chlorhexidine skin preparation compared with povidone–iodine, or with triclosan-coated sutures compared with non-coated sutures.

 


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